fluoxetine has been researched along with Serotonin Syndrome in 44 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient who manifested signs of serotonin syndrome during an intravenous anesthetic with remifentanil and propofol is presented." | 7.79 | Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil. ( Buck, NS; Davis, JJ; Greis, PE; Johnson, KB; Swenson, JD, 2013) |
| "This case report describes a patient with treatment-resistant depression treated with fluoxetine and olanzapine who developed serotonin syndrome." | 7.72 | Serotonin syndrome associated with fluoxetine and olanzapine. ( Chopra, P; Ng, C; Schweitzer, I, 2004) |
| "To describe a patient who developed serotonin syndrome on four separate occasions as a result of monotherapy with two different selective serotonin receptor inhibitors (fluoxetine and cetalopram)." | 7.71 | Serotonin syndrome presenting as hypotonic coma and apnea: potentially fatal complications of selective serotonin receptor inhibitor therapy. ( Chechani, V, 2002) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 5.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "He had a generalised tonic/clonic seizure at 6 hours postingestion." | 5.48 | Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( Lee-Kelland, R; Mappa, P; Zehra, S, 2018) |
| "Serotonin syndrome is usually reported by the use of a combination of drugs." | 5.35 | Can fluoxetine alone cause serotonin syndrome in adolescents? ( Ghanizadeh, A; Ghanizadeh, M; Seifoori, M, 2008) |
| "We report here the case of a patient with fluoxetine and selegiline induced serotonin syndrome, which presented as encephalopathy, generalized myoclonias, fever, stiffness and sweating, complicated with acute renal failure, rhabdomyolysis and disseminated intravascular coagulation findings." | 4.81 | [Serotonin syndrome: report of a fatal case and review of the literature]. ( Bilbao Garay, J; Castilla Castellano, V; Dhimes Tejada, P; Mesa Plaza, N, 2002) |
| "A 21-year-old female with a history of generalized anxiety disorder and major depression presented with increased depressive symptoms over several months while taking fluoxetine 20 mg daily." | 3.96 | A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy. ( Blake, CS; Hudd, TR; Nguyen, TT; Rimola-Dejesus, Y; Zaiken, K, 2020) |
| "Even small doses of fentanyl administered to patients taking multiple serotonergic medications and herbal supplements may trigger serotonin syndrome." | 3.85 | Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. ( Naranjo, J; Pollard, EM; Sprung, J; Warner, MA; Warner, ME; Weingarten, TN, 2017) |
| "A patient who manifested signs of serotonin syndrome during an intravenous anesthetic with remifentanil and propofol is presented." | 3.79 | Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil. ( Buck, NS; Davis, JJ; Greis, PE; Johnson, KB; Swenson, JD, 2013) |
| " Her mother had been taking fluoxetine (20 mg daily) during the second and third trimesters of her pregnancy." | 3.74 | Prolonged neonatal complications after in utero exposure to fluoxetine. ( Alehan, F; Gürakan, B; Saygi, S; Tarcan, A, 2008) |
| "This study investigated whether rasagiline and selegiline (MAO-B inhibitors) induce serotonin syndrome in fluoxetine-treated rats." | 3.74 | Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline. ( Blaugrund, E; Cohen, S; Eliash, S; Fine, T; Litinetsky, L; Speiser, Z, 2008) |
| "To describe a patient who developed serotonin syndrome on four separate occasions as a result of monotherapy with two different selective serotonin receptor inhibitors (fluoxetine and cetalopram)." | 3.71 | Serotonin syndrome presenting as hypotonic coma and apnea: potentially fatal complications of selective serotonin receptor inhibitor therapy. ( Chechani, V, 2002) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 1.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "He had a generalised tonic/clonic seizure at 6 hours postingestion." | 1.48 | Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( Lee-Kelland, R; Mappa, P; Zehra, S, 2018) |
| "Serotonin syndrome is a potential side effect of some psychotropic medications in common use today." | 1.36 | Serotonin syndrome in the deployed setting. ( Jensen, J; Lawyer, TI; Welton, RS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (9.09) | 18.2507 |
| 2000's | 23 (52.27) | 29.6817 |
| 2010's | 14 (31.82) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| McKeirnan, KC | 1 |
| Vaitla, K | 1 |
| Gilbert, R | 1 |
| Anderson, CB | 1 |
| Undeberg, MR | 1 |
| Pande, CK | 1 |
| O'Halloran, A | 1 |
| Stewart, RW | 1 |
| Nguyen, A | 1 |
| Canares, T | 1 |
| Christodoulos, IN | 1 |
| Chyou, TY | 1 |
| Nishtala, PS | 1 |
| Warner, ME | 1 |
| Naranjo, J | 1 |
| Pollard, EM | 1 |
| Weingarten, TN | 2 |
| Warner, MA | 1 |
| Sprung, J | 2 |
| Little, K | 1 |
| Lin, CM | 1 |
| Reynolds, PM | 1 |
| Lee-Kelland, R | 1 |
| Zehra, S | 1 |
| Mappa, P | 1 |
| Hudd, TR | 1 |
| Blake, CS | 1 |
| Rimola-Dejesus, Y | 1 |
| Nguyen, TT | 1 |
| Zaiken, K | 1 |
| Haberzettl, R | 1 |
| Fink, H | 1 |
| Bert, B | 1 |
| Larson, KJ | 1 |
| Wittwer, ED | 1 |
| Nicholson, WT | 1 |
| Price, DL | 1 |
| Morris, R | 1 |
| Matthes, J | 1 |
| Adler, AR | 1 |
| Charnin, JA | 1 |
| Quraishi, SA | 1 |
| Raguveer, V | 1 |
| Varshney, A | 1 |
| D'Ambrosio, JC | 1 |
| Rosenbaum, HK | 1 |
| Gillman, PK | 2 |
| Alehan, F | 1 |
| Saygi, S | 1 |
| Tarcan, A | 1 |
| Gürakan, B | 1 |
| Ghanizadeh, A | 1 |
| Ghanizadeh, M | 1 |
| Seifoori, M | 1 |
| Liu, PT | 1 |
| Argento, V | 1 |
| Skudlarska, B | 1 |
| Blagodatny, M | 1 |
| Lawyer, TI | 1 |
| Jensen, J | 1 |
| Welton, RS | 1 |
| Rittmannsberger, H | 1 |
| Werl, R | 1 |
| Shioda, K | 2 |
| Nisijima, K | 2 |
| Kasai, M | 1 |
| Yoshino, T | 2 |
| Kato, S | 2 |
| Davis, JJ | 1 |
| Buck, NS | 1 |
| Swenson, JD | 1 |
| Johnson, KB | 1 |
| Greis, PE | 1 |
| Lange-Asschenfeldt, C | 1 |
| Weigmann, H | 1 |
| Hiemke, C | 1 |
| Mann, K | 1 |
| Tissot, TA | 1 |
| Birmes, P | 1 |
| Coppin, D | 1 |
| Schmitt, L | 1 |
| Lauque, D | 1 |
| Finfgeld, DL | 1 |
| Chopra, P | 1 |
| Ng, C | 1 |
| Schweitzer, I | 1 |
| Thomas, CR | 1 |
| Rosenberg, M | 1 |
| Blythe, V | 1 |
| Meyer, WJ | 1 |
| Speiser, Z | 1 |
| Fine, T | 1 |
| Litinetsky, L | 1 |
| Eliash, S | 1 |
| Blaugrund, E | 1 |
| Cohen, S | 1 |
| Bonetto, N | 1 |
| Santelli, L | 1 |
| Battistin, L | 1 |
| Cagnin, A | 1 |
| Chirwa, I | 1 |
| Savage, M | 1 |
| Sarwar, A | 1 |
| Norris, A | 1 |
| Evans, RW | 1 |
| Benazzi, F | 1 |
| Lu, ML | 1 |
| Lane, HY | 1 |
| Chang, WH | 1 |
| Shuster, J | 1 |
| Kesavan, S | 1 |
| Sobala, GM | 1 |
| Chambost, M | 1 |
| Liron, L | 1 |
| Peillon, D | 1 |
| Combe, C | 1 |
| Smith, DL | 1 |
| Wenegrat, BG | 1 |
| Borsini, F | 1 |
| Brambilla, A | 1 |
| Cesana, R | 1 |
| Grippa, N | 1 |
| Gonzalez-Pinto, A | 1 |
| Imaz, H | 1 |
| De Heredia, JL | 1 |
| Gutierrez, M | 1 |
| Micó, JA | 1 |
| DeSilva, KE | 1 |
| Le Flore, DB | 1 |
| Marston, BJ | 1 |
| Rimland, D | 1 |
| Chechani, V | 1 |
| Bilbao Garay, J | 1 |
| Mesa Plaza, N | 1 |
| Castilla Castellano, V | 1 |
| Dhimes Tejada, P | 1 |
4 reviews available for fluoxetine and Serotonin Syndrome
| Article | Year |
|---|---|
Hypothermia as a Possible Symptom of Serotonin Toxicity: A Case Report.
Topics: Fluoxetine; Humans; Hypothermia; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndr | 2023 |
Serotonin syndrome: a brief review.
Topics: Antidepressive Agents, Second-Generation; Citalopram; Diagnosis, Differential; Female; Fluid Therapy | 2003 |
Serotonin syndrome and the use of SSRIs.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Drug Therapy, Combination; Fem | 2004 |
[Serotonin syndrome: report of a fatal case and review of the literature].
Topics: Aged; Antiparkinson Agents; Carbidopa; Depressive Disorder, Major; Drug Combinations; Drug Synergism | 2002 |
40 other studies available for fluoxetine and Serotonin Syndrome
| Article | Year |
|---|---|
Case 2: Agitation and Abnormal Movements in a 14-year-old Boy.
Topics: Adolescent; Dopamine Uptake Inhibitors; Dyskinesias; Fluoxetine; Humans; Lisdexamfetamine Dimesylate | 2019 |
Safety of fluoxetine use in children and adolescents: a disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Antidepressive Agents, Second-Generation; Anxie | 2020 |
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome.
Topics: Aged; Curcuma; Dietary Supplements; Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Midazolam | 2017 |
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H | 2018 |
Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis.
Topics: Adolescent; Depressive Disorder; Diagnosis, Differential; Drug Overdose; Fluoxetine; Humans; Male; R | 2018 |
A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy.
Topics: Anxiety; Depressive Disorder, Major; Female; Fluoxetine; Humans; Hydroxyzine; Paroxetine; Selective | 2020 |
The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Selective Serotonin Reupt | 2015 |
Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy.
Topics: Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Methylene Blue; Middle Aged; Myoclonus; Senti | 2015 |
Serotonin syndrome in a breast-fed neonate.
Topics: Adult; Bottle Feeding; Breast Feeding; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newb | 2015 |
Serotonin Syndrome: The Potential for a Severe Reaction Between Common Perioperative Medications and Selective Serotonin Reuptake Inhibitors.
Topics: Adult; Anesthesia; Drug Interactions; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibit | 2015 |
Serotonin Syndrome: Difficult to Diagnose but Critical to Treat.
Topics: Adult; Antipsychotic Agents; Cyproheptadine; Diagnosis, Differential; Female; Fluoxetine; Humans; Pe | 2015 |
Patient Safety and Methylene Blue-Associated Severe Serotonin Toxicity.
Topics: Drug Interactions; Fluoxetine; Humans; Methylene Blue; Monoamine Oxidase; Monoamine Oxidase Inhibito | 2016 |
Prolonged neonatal complications after in utero exposure to fluoxetine.
Topics: Adult; Diagnosis, Differential; Female; Fluoxetine; Humans; Infant, Newborn; Neonatal Abstinence Syn | 2008 |
Can fluoxetine alone cause serotonin syndrome in adolescents?
Topics: Adolescent; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome | 2008 |
Serotonin syndrome in an octogenarian after switch from fluoxetine to duloxetine.
Topics: Aged, 80 and over; Duloxetine Hydrochloride; Fluoxetine; Humans; Male; Selective Serotonin Reuptake | 2009 |
Serotonin syndrome in the deployed setting.
Topics: Adult; Fluoxetine; Humans; Iraq War, 2003-2011; Male; Military Personnel; Selective Serotonin Reupta | 2010 |
Does aripiprazole protect from serotonin syndrome?
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Aripiprazole; Borderline Pers | 2012 |
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models.
Topics: 5-Hydroxytryptophan; Animals; Brain; Clorgyline; Disease Models, Animal; Fluoxetine; Glutamic Acid; | 2012 |
Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Fluoxetine; Humans; Intraoperative Complications; | 2013 |
Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology.
Topics: Adult; Analgesics, Opioid; Female; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Sero | 2002 |
Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use.
Topics: Adult; Analgesics, Opioid; Cholangiopancreatography, Endoscopic Retrograde; Diabetes Mellitus, Type | 2003 |
Fluoxetine + hydromorphone: serotonin syndrome?
Topics: Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; France; Humans; Hydromorphone; Nar | 2004 |
Serotonin syndrome associated with fluoxetine and olanzapine.
Topics: Benzodiazepines; Fluoxetine; Humans; Male; Middle Aged; Olanzapine; Selective Serotonin Reuptake Inh | 2004 |
Serotonin syndrome and linezolid.
Topics: Acetamides; Anti-Infective Agents; Burns; Child, Preschool; Depression; Drug Interactions; Female; F | 2004 |
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Body Temperature; Dopamine; Extracellular Fluid | 2004 |
Making sense of serotonin toxicity reports, a comment on Chopra et Al. (World J Biol Psychiatry 2004, 5: 114-115).
Topics: Benzodiazepines; Fluoxetine; Humans; Olanzapine; Selective Serotonin Reuptake Inhibitors; Serotonin | 2004 |
Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline.
Topics: Animals; Behavior, Animal; Brain; Drug Therapy, Combination; Fluoxetine; Indans; Male; Methamphetami | 2008 |
Serotonin syndrome and rhabdomyolysis induced by concomitant use of triptans, fluoxetine and hypericum.
Topics: Adult; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypericum; Migraine Disorders; Rhabdom | 2007 |
Serotonin syndrome secondary to fluoxetine precipitated by radiation induced cerebral vasculopathy.
Topics: Aged; Cerebral Arteries; Endothelium, Vascular; Fluoxetine; Humans; Male; Selective Serotonin Reupta | 2008 |
Triptans and serotonin syndrome.
Topics: Adult; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypericum; Migraine Disorders; Rhabdom | 2008 |
Serotonin syndrome with mirtazapine-fluoxetine combination.
Topics: Adrenergic alpha-Antagonists; Aged; Antidepressive Agents, Tricyclic; Depression; Drug Interactions; | 1998 |
Selective serotonin reuptake inhibitor syndrome: precipitated by concomitant clozapine?
Topics: Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluoxe | 1999 |
Serotonin syndrome alert.
Topics: Fluoxetine; Humans; Male; Middle Aged; Patient Education as Topic; Selective Serotonin Reuptake Inhi | 1999 |
Serotonin syndrome with fluoxetine plus tramadol.
Topics: Adult; Analgesics, Opioid; Drug Interactions; Female; Fluoxetine; Humans; Selective Serotonin Reupta | 1999 |
[Serotonin syndrome during fluoxetine poisoning in a patient taking moclobemide].
Topics: Adult; Anesthetics, Intravenous; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, | 2000 |
A case report of serotonin syndrome associated with combined nefazodone and fluoxetine.
Topics: Antidepressive Agents, Second-Generation; Bipolar Disorder; Drug Therapy, Combination; Fluoxetine; H | 2000 |
Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepressive Agents, Secon | 2001 |
Mania and tramadol-fluoxetine combination.
Topics: Aged; Analgesics, Opioid; Bipolar Disorder; Depressive Disorder; Drug Therapy, Combination; Female; | 2001 |
Serotonin syndrome in HIV-infected individuals receiving antiretroviral therapy and fluoxetine.
Topics: Adult; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Cytochrome P-450 Enzyme System; De | 2001 |
Serotonin syndrome presenting as hypotonic coma and apnea: potentially fatal complications of selective serotonin receptor inhibitor therapy.
Topics: Adult; Apnea; Coma; Female; Fluoxetine; Humans; Serotonin Receptor Agonists; Serotonin Syndrome | 2002 |