Page last updated: 2024-09-27

Hoarding Disorder

Disordered behavior associated with clinically significant distress or impairment in social, occupational or other important areas of functioning and persistent difficulty parting with possessions due to a perceived need to save the items and distress associated with discarding them. (from DSM-V) The quantity of collected items sets the behavior apart from normal collecting behaviors.

Synonyms(2)

Synonym
Hoarding Disorder
Obsessive Hoarding

Research Excerpts

Overview

ExcerptReference
"In this case report hoarding disorder is described in a 12-year-old boy who suffered from obsessive collection of things."( Andersen, TMG; Thomsen, PH, 2017)

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's17 (85.00)28.8240
2020's3 (15.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
clonazepam0low10
fluoxetine0low20
haloperidol0low10
lamotrigine0low10
methylphenidate0medium41
cyclohexanol0medium11
atomoxetine hydrochloride0low20
aripiprazole0low10
venlafaxine hydrochloride0medium21
sertraline0low10
fluvoxamine0low10
naltrexone0low10
quetiapine fumarate0low10
minocycline0low10

Protein Targets (371)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
5-hydroxytryptamine receptor 3E0202
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
SMAD family member 21001
Fumarate hydratase3003
USP1 protein, partial2002
PPM1D protein2002
SMAD family member 31001
TDP1 protein7007
GLI family zinc finger 37007
Microtubule-associated protein tau1001
AR protein5005
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor5005
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha5005
G3003
cytochrome P450 2D67007
polyprotein3003
67.9K protein2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
euchromatic histone-lysine N-methyltransferase 25005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 23003
potassium voltage-gated channel subfamily H member 2 isoform d5005
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
geminin8008
peripheral myelin protein 224004
histone acetyltransferase KAT2A isoform 11001
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 20101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit4004
5-hydroxytryptamine receptor 3B0202
Bile salt export pump0707
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p533003
ATP-dependent translocase ABCB10506
Cytochrome P450 3A40405
5-hydroxytryptamine receptor 1A0314
5-hydroxytryptamine receptor 2C0505
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
D(2) dopamine receptor0428
5-hydroxytryptamine receptor 2A0505
Alpha-1B adrenergic receptor0505
Alpha-2C adrenergic receptor0505
D0505
5-hydroxytryptamine receptor 1A0303
Glutamate receptor 24004
Muscarinic acetylcholine receptor M30404
D(1A) dopamine receptor0304
D(4) dopamine receptor0316
D(1B) dopamine receptor0304
Alpha-1D adrenergic receptor0505
Alpha-1D adrenergic receptor0303
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C0808
D(4) dopamine receptor0505
Histamine H1 receptor0101
Sodium-dependent serotonin transporter012315
5-hydroxytryptamine receptor 7 0202
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
Histamine H1 receptor0404
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0327
5-hydroxytryptamine receptor 2B0505
Alpha-1A adrenergic receptor0505
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 60404
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein4004
D(2) dopamine receptor0606
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily H member 2010010
5-hydroxytryptamine receptor 3D0202
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0202
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10404
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0202
cytochrome P450 2C9, partial3003
glp-1 receptor, partial3003
cytochrome P450 family 3 subfamily A polypeptide 44004
IDH12002
Sodium-dependent noradrenaline transporter 010212
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit pi1102
Gamma-aminobutyric acid receptor subunit delta0303
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10303
Gamma-aminobutyric acid receptor subunit beta-11102
Gamma-aminobutyric acid receptor subunit beta-10303
Gamma-aminobutyric acid receptor subunit delta1102
Gamma-aminobutyric acid receptor subunit gamma-20303
Gamma-aminobutyric acid receptor subunit gamma-21102
Gamma-aminobutyric acid receptor subunit alpha-51102
Gamma-aminobutyric acid receptor subunit alpha-31102
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-11102
Gamma-aminobutyric acid receptor subunit alpha-21102
Gamma-aminobutyric acid receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit beta-30303
Gamma-aminobutyric acid receptor subunit gamma-31102
Gamma-aminobutyric acid receptor subunit alpha-61102
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50303
Gamma-aminobutyric acid receptor subunit alpha-30303
Gamma-aminobutyric acid receptor subunit alpha-20303
Gamma-aminobutyric acid receptor subunit beta-20303
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit alpha-11102
Gamma-aminobutyric acid receptor subunit beta-31102
Gamma-aminobutyric acid receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit epsilon0303
Gamma-aminobutyric acid receptor subunit alpha-60303
Gamma-aminobutyric acid receptor subunit gamma-10303
GABA theta subunit1102
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit epsilon1102
Gamma-aminobutyric acid receptor subunit theta0303
aryl hydrocarbon receptor1001
thioredoxin reductase3003
caspase 7, apoptosis-related cysteine protease2002
regulator of G-protein signaling 43003
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
Histone H2A.x1001
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor2002
D(1A) dopamine receptor5005
chromobox protein homolog 12002
caspase-31001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 13003
lamin isoform A-delta101001
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40606
Potassium channel subfamily K member 20202
Albumin0022
Sodium channel protein type 1 subunit alpha0202
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0505
Cytochrome P450 2C80101
Cytochrome P450 2D60405
Muscarinic acetylcholine receptor M10606
Cytochrome P450 2C9 0505
Angiotensin-converting enzyme0505
Dipeptidyl peptidase 40101
Alpha-2B adrenergic receptor0606
Alpha-2B adrenergic receptor0202
Acetylcholinesterase0101
Alpha-2C adrenergic receptor0202
Acetylcholinesterase0101
Alpha-2A adrenergic receptor0202
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0505
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
5-hydroxytryptamine receptor 2B0404
Sodium-dependent serotonin transporter0505
Cytochrome P450 2C190202
D(1A) dopamine receptor3104
Cytochrome P450 2J20404
Gastrin/cholecystokinin type B receptor 0101
Sodium-dependent dopamine transporter 08210
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Cytochrome P450 1B10101
Sigma intracellular receptor 20404
Sigma non-opioid intracellular receptor 10202
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Transporter0202
Nuclear receptor subfamily 3 group C member 3 0404
Beta-2 adrenergic receptor0101
Ataxin-24004
Sigma non-opioid intracellular receptor 10707
Sigma non-opioid intracellular receptor 10606
Transporter0303
GLS protein2002
arylsulfatase A2002
activating transcription factor 61001
survival motor neuron protein isoform d1001
Cytochrome P450 1A2 0101
Tryptophan 5-hydroxylase 10101
D(3) dopamine receptor0404
D(1B) dopamine receptor0404
Sodium channel protein type 5 subunit alpha0303
ATP-dependent phosphofructokinase2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
15-lipoxygenase, partial1001
ATAD5 protein, partial2002
NFKB1 protein, partial1001
Thrombopoietin1001
thyroid stimulating hormone receptor1001
nonstructural protein 12002
glucocerebrosidase1001
Adenylate cyclase type 1 0101
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor1001
cytochrome P450 3A4 isoform 11001
transient receptor potential cation channel subfamily V member 11001
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Cocaine esterase0101
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Beta-1 adrenergic receptor0101
D(2) dopamine receptor0202
Adenylate cyclase type 30101
UDP-glucuronosyltransferase 1A40001
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0202
Adenosine receptor A10101
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
Histamine H1 receptor0202
C-8 sterol isomerase0101
Delta-type opioid receptor0314
Mu-type opioid receptor0314
5-hydroxytryptamine receptor 2C 0101
Kappa-type opioid receptor0314
5-hydroxytryptamine receptor 2A0101
Mu-type opioid receptor0439
Glutamate receptor ionotropic, NMDA 1 0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0203
Adenylate cyclase type 80101
Kappa-type opioid receptor0304
Histamine H2 receptor1002
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 431001
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
D0101
ATPase family AAA domain-containing protein 51001
Sodium channel protein type 2 subunit alpha0202
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0202
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0202
GALC protein1001
Bloom syndrome protein isoform 11001
mitogen-activated protein kinase 11001
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Albumin0011
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
Histidine decarboxylase0011
UDP-glucuronosyltransferase 1A1 0001
Delta-type opioid receptor0214
Kappa-type opioid receptor0213
Delta-type opioid receptor0226
Kappa-type opioid receptor0216
Nociceptin receptor0101
Mu-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A80001
Chain A, Beta-lactamase1001
phosphopantetheinyl transferase1001
Smad31001
vitamin D3 receptor isoform VDRA1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Transcriptional activator protein LuxR0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
Envelope glycoprotein0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]