Hoarding Disorder

Disordered behavior associated with clinically significant distress or impairment in social, occupational or other important areas of functioning and persistent difficulty parting with possessions due to a perceived need to save the items and distress associated with discarding them. (from DSM-V) The quantity of collected items sets the behavior apart from normal collecting behaviors.

Synonyms(2)

Synonym
Hoarding Disorder
Obsessive Hoarding

Research Excerpts

Overview

Excerpt	Reference
"In this case report hoarding disorder is described in a 12-year-old boy who suffered from obsessive collection of things."	( Andersen, TMG; Thomsen, PH, 2017)

Research

Studies (20)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	17 (85.00)	28.8240
2020's	3 (15.00)	9.53

Drug	Relationship Strength	Studies	Trials
clonazepam	low	1	0
fluoxetine	low	2	0
haloperidol	low	1	0
lamotrigine	low	1	0
methylphenidate	medium	4	1
cyclohexanol	medium	1	1
atomoxetine hydrochloride	low	2	0
aripiprazole	low	1	0
venlafaxine hydrochloride	medium	2	1
sertraline	low	1	0
fluvoxamine	low	1	0
naltrexone	low	1	0
quetiapine fumarate	low	1	0
minocycline	low	1	0

Protein Targets (371)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
acetylcholinesterase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
SMAD family member 2	1	0	0	1
Fumarate hydratase	3	0	0	3
USP1 protein, partial	2	0	0	2
PPM1D protein	2	0	0	2
SMAD family member 3	1	0	0	1
TDP1 protein	7	0	0	7
GLI family zinc finger 3	7	0	0	7
Microtubule-associated protein tau	1	0	0	1
AR protein	5	0	0	5
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	4	0	0	4
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	6	0	0	6
estrogen nuclear receptor alpha	5	0	0	5
G	3	0	0	3
cytochrome P450 2D6	7	0	0	7
polyprotein	3	0	0	3
67.9K protein	2	0	0	2
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	5	0	0	5
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	8	0	0	8
peripheral myelin protein 22	4	0	0	4
histone acetyltransferase KAT2A isoform 1	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
5-hydroxytryptamine receptor 3B	0	2	0	2
Bile salt export pump	0	7	0	7
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	3	0	0	3
ATP-dependent translocase ABCB1	0	5	0	6
Cytochrome P450 3A4	0	4	0	5
5-hydroxytryptamine receptor 1A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	5	0	5
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
D(2) dopamine receptor	0	4	2	8
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-1B adrenergic receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	5	0	5
D	0	5	0	5
5-hydroxytryptamine receptor 1A	0	3	0	3
Glutamate receptor 2	4	0	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	3	0	4
D(4) dopamine receptor	0	3	1	6
D(1B) dopamine receptor	0	3	0	4
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1D adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	8	0	8
5-hydroxytryptamine receptor 2C	0	8	0	8
D(4) dopamine receptor	0	5	0	5
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	12	3	15
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H1 receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	2	0	2
D(3) dopamine receptor	0	3	2	7
5-hydroxytryptamine receptor 2B	0	5	0	5
Alpha-1A adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 6	0	4	0	4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Spike glycoprotein	4	0	0	4
D(2) dopamine receptor	0	6	0	6
Inositol monophosphatase 1	2	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
5-hydroxytryptamine receptor 3D	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	4	0	4
Multidrug and toxin extrusion protein 1	0	1	0	1
Histamine H3 receptor	0	2	0	2
cytochrome P450 2C9, partial	3	0	0	3
glp-1 receptor, partial	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
IDH1	2	0	0	2
Sodium-dependent noradrenaline transporter	0	10	2	12
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	1	1	0	2
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	1	1	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
GABA theta subunit	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	1	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
aryl hydrocarbon receptor	1	0	0	1
thioredoxin reductase	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	5	0	0	5
chromobox protein homolog 1	2	0	0	2
caspase-3	1	0	0	1
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
lamin isoform A-delta10	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	5	0	5
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	4	0	5
Muscarinic acetylcholine receptor M1	0	6	0	6
Cytochrome P450 2C9	0	5	0	5
Angiotensin-converting enzyme	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	5	0	5
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent serotonin transporter	0	5	0	5
Cytochrome P450 2C19	0	2	0	2
D(1A) dopamine receptor	3	1	0	4
Cytochrome P450 2J2	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	8	2	10
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Transporter	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Beta-2 adrenergic receptor	0	1	0	1
Ataxin-2	4	0	0	4
Sigma non-opioid intracellular receptor 1	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	6	0	6
Transporter	0	3	0	3
GLS protein	2	0	0	2
arylsulfatase A	2	0	0	2
activating transcription factor 6	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
D(3) dopamine receptor	0	4	0	4
D(1B) dopamine receptor	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	3	0	3
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
ATAD5 protein, partial	2	0	0	2
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
nonstructural protein 1	2	0	0	2
glucocerebrosidase	1	0	0	1
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Cocaine esterase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Beta-1 adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Adenosine receptor A1	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
Histamine H1 receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	3	1	4
Mu-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 2C	0	1	0	1
Kappa-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Mu-type opioid receptor	0	4	3	9
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Adenylate cyclase type 8	0	1	0	1
Kappa-type opioid receptor	0	3	0	4
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
D	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
GALC protein	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Albumin	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Histidine decarboxylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	2	6
Kappa-type opioid receptor	0	2	1	6
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, Beta-lactamase	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
Smad3	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Envelope glycoprotein	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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