Blepharospasm

Synonym
Blepharospasm

Excerpt	Reference
"Blepharospasm is a focal dystonia characterized by involuntary cocontraction of the eyelid protractors, causing spasmodic closure of the eyelids."	( Castelnovo, G; Collombier, L; De Verdal, M; Renard, D, 2017)
"Blepharospasm is one of the components of drug-induced Meige's syndrome which is reported to be caused by typical antipsychotics."	( Arora, T; Maharshi, V; Nagar, P; Rehan, HS, 2017)
"Blepharospasm is a focal dystonia involving chiefly the orbicularis oculi and periocular muscles resulting in involuntary sustained eyelid closure."	( Jankovic, J; Vijayakumar, D; Wijemanne, S, 2017)
"Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids."	( Etgen, T; Gaser, C; Mühlau, M; Sander, D, 2006)
"Blepharospasm is an adult-onset focal dystonia that causes involuntary blinking and eyelid spasms."	( Berardelli, A; Fabbrini, G; Fiaschi, A; Fiorio, M; Gambarin, M; Moretto, G; Scontrini, A; Stanzani, C; Tinazzi, M, 2008)
"Essential blepharospasm is considered to be an incomplete form of Meige dystonic syndrome."	( Bettez, M; Lavertu, P, 1986)
"Blepharospasm is a chronic condition characterized by involuntary spasmodic closure of the eyelid(s)."	( Barkemeyer, CA; Brantley, PJ; Carnrike, CL; Faulstich, ME, 1985)

Excerpt	Reference
"Botulinum toxin is a treatment used to treat blepharospasm by preventing muscle contraction; but it is not always effective."	( Song, A; Song, J; Song, M; Sung, J, 2022)
"Administering botulinum toxin for the treatment of blepharospasm in patients A and B yielded the expected results; adding oxymetazoline hydrochloride ophthalmic solution (0."	( Song, A; Song, J; Song, M; Sung, J, 2022)
"Botulinum neurotoxin A treatment relieved blepharospasm in all patients."	( Lee, SY; Lew, H; Park, DI; Shin, HM, 2013)
"The myotoxic drug doxorubicin can treat blepharospasm and hemifacial spasm permanently when injected directly into the eyelid of patients."	( McLoon, LK; Ozel, B; Wirtschafter, J, 1995)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	66 (28.95)	23.3326
1990's	59 (25.88)	12.5806
2000's	47 (20.61)	18.1394
2010's	44 (19.30)	28.8240
2020's	12 (5.26)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
choline	low	2	0
creatine	low	1	0
glycine	low	1	0
dihydroxyphenylalanine	low	1	0
kynurenine	low	1	0
uric acid	low	1	0
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	low	1	0
acetazolamide	low	1	0
apraclonidine	low	2	0
azathioprine	low	1	0
baclofen	medium	4	1
biperiden	low	1	0
bupivacaine	medium	1	1
carbamazepine	medium	4	1
citalopram	low	2	0
clomipramine	low	1	0
clonazepam	medium	7	1
clonidine	low	2	0
cyproheptadine	low	2	0
diazepam	low	1	0
valproic acid	low	3	0
edrophonium	low	1	0
etizolam	low	1	0
brl 42810	low	1	0
fluorouracil	low	1	0
fluoxetine	low	2	0
haloperidol	medium	5	2
lidocaine	medium	8	5
2-propanol	low	1	0
kynurenic acid	low	1	0
lamotrigine	low	3	0
lorazepam	medium	1	1
mephenesin	low	2	0
methyl salicylate	low	1	0
methylphenidate	low	1	0
metoclopramide	low	1	0
benoxinate	medium	1	1
oxymetazoline	low	1	0
perazine	low	1	0
piracetam	low	1	0
pirenzepine	low	1	0
procaine	medium	1	1
risperidone	low	3	0
spiperone	low	1	0
sulpiride	low	2	0
tegafur	low	1	0
trifluoperazine	low	1	0
trihexyphenidyl	medium	8	2
zolpidem	low	1	0
prednisolone	low	4	0
prednisone	low	3	0
pilocarpine	low	3	0
aspartic acid	low	2	0
physostigmine	medium	3	1
apomorphine	medium	5	1
tetrabenazine	medium	6	1
bromodeoxyuridine	low	1	0
levodopa	medium	13	1
tyrosine	low	1	0
lactose	low	1	0
methionine	low	1	0
valine	low	1	0
methylprednisolone	low	3	0
benzohydrol	low	1	0
pyridostigmine bromide	low	3	0
deanol	medium	2	1
cyclohexanol	low	1	0
thiazoles	low	1	0
2h-benzo(a)quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-	low	1	0
2-aminopurine	low	1	0
hexacosanoic acid	low	1	0
gluconic acid	medium	1	1
copper gluconate	medium	1	1
hematoporphyrin	low	1	0
lithium carbonate	low	1	0
pimozide	low	1	0
fluorescein	low	4	0
o-chlorobenzylidenemalonitrile	low	1	0
tridihexethyl	medium	1	1
gold	low	1	0
lisuride	medium	1	1
fludarabine phosphate	low	1	0
tramadol	low	1	0
vidarabine phosphate	low	1	0
tobramycin	low	1	0
vecuronium bromide	low	1	0
propiconazole	low	8	0
agreal	low	1	0
fomesafen	low	9	0
finasteride	low	1	0
aripiprazole	low	1	0
venlafaxine hydrochloride	low	1	0
n-acetylaspartic acid	low	1	0
fluorodeoxyglucose f18	low	7	0
nicotine	medium	2	1
tandospirone	low	1	0
deoxyglucose	low	1	0
mosapride	low	1	0
imatinib mesylate	low	1	0
atropine	low	2	0
isomethyleugenol	low	1	0
flunarizine	low	1	0
benztropine	low	1	0
capsaicin	low	1	0
nadp	low	1	0
lithium	low	2	0
raclopride	low	2	0
zeaxanthin	low	1	0
lutein	low	1	0
humulene	low	1	0
phenylephrine hydrochloride	low	2	0
levetiracetam	low	1	0
latanoprost	low	1	0
lysophosphatidic acid	low	1	0
phosphorus	low	1	0
pregabalin	low	1	0
phosphocreatine	low	1	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	medium	1	1
alpha-synuclein	low	1	0
jaw	medium	4	1
sodium hypochlorite	low	1	0
sodium pertechnetate tc 99m	low	1	0
quetiapine fumarate	low	1	0
cardiovascular agents	low	1	0
chlortetracycline	low	1	0
oxytetracycline, anhydrous	low	1	0
salicylates	low	1	0
mobic	low	1	0
cyclosporine	low	2	0
clozapine	low	3	0
olanzapine	low	4	0
allopurinol	low	1	0
eye	low	8	0
carbidopa	low	4	0

Protein Targets (1,045)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Dihydropteridine reductase	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	2
Chain A, Beta-lactamase	14	0	0	14
thioredoxin reductase	30	0	0	30
aldehyde dehydrogenase 1 family, member A1	22	0	0	22
IDH1	14	0	0	14
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	3	0	3
Guanine nucleotide-binding protein G	4	0	0	4
TAR DNA-binding protein 43	8	0	0	8
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
Sodium-dependent dopamine transporter	0	19	1	20
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	31	0	0	31
GLI family zinc finger 3	35	0	0	35
AR protein	50	0	0	50
retinoic acid nuclear receptor alpha variant 1	31	0	0	31
retinoid X nuclear receptor alpha	21	0	0	21
estrogen nuclear receptor alpha	50	0	0	50
peroxisome proliferator-activated receptor delta	22	0	0	22
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	21	0	0	21
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform a	10	0	0	10
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
lamin isoform A-delta10	34	0	0	34
Voltage-dependent calcium channel gamma-2 subunit	23	0	0	23
Glutamate receptor 2	24	1	1	27
cytochrome P450 2D6	28	0	0	28
5-hydroxytryptamine receptor 2A	0	35	2	39
Synaptic vesicular amine transporter	0	4	1	5
Synaptic vesicular amine transporter	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
cytochrome P450 family 3 subfamily A polypeptide 4	24	0	0	24
glucocorticoid receptor [Homo sapiens]	37	0	0	37
estrogen-related nuclear receptor alpha	40	0	0	40
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	23	0	0	23
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	46	0	0	46
Bloom syndrome protein isoform 1	16	0	0	16
geminin	37	0	0	37
peripheral myelin protein 22	24	0	0	24
survival motor neuron protein isoform d	12	0	0	12
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	16	9	2	27
ATP-binding cassette sub-family C member 3	0	37	0	37
Multidrug resistance-associated protein 4	0	37	0	37
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	3	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	54	0	54
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	14
Carbonic anhydrase 2	0	5	1	13
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	5	0	5
Carbonic anhydrase 3	0	3	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	12	0	15
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	19	1	20
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	3
Cytochrome P450 2D6	0	12	0	13
Cytochrome P450 2A6	0	6	2	8
Cytochrome P450 2C9	0	12	0	13
5-hydroxytryptamine receptor 2A	0	20	3	23
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	16	9	2	27
Translocator protein	0	4	1	6
Gamma-aminobutyric acid receptor subunit delta	16	9	2	27
Gamma-aminobutyric acid receptor subunit gamma-2	16	9	4	29
Gamma-aminobutyric acid receptor subunit alpha-5	16	9	2	27
Gamma-aminobutyric acid receptor subunit alpha-3	16	9	2	27
Cannabinoid receptor 1	0	4	1	5
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 4	0	2	1	6
Carbonic anhydrase 6	0	3	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	16	9	2	27
Gamma-aminobutyric acid receptor subunit alpha-2	16	9	2	27
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	6
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	16	9	2	27
Gamma-aminobutyric acid receptor subunit gamma-3	16	9	2	27
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	16	9	2	27
Adenosine receptor A2a	0	1	2	5
5-hydroxytryptamine receptor 2B	0	18	2	20
Sodium-dependent serotonin transporter	0	7	0	7
Delta-type opioid receptor	0	6	0	6
Cytochrome P450 2C19	0	5	0	6
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	1	9
Carbonic anhydrase	0	1	0	3
Kappa-type opioid receptor	0	3	0	3
Carbonic anhydrase 7	0	3	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	5	2	0	7
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	4
D(2) dopamine receptor	0	30	6	37
Gamma-aminobutyric acid receptor subunit alpha-1	16	9	4	29
Gamma-aminobutyric acid receptor subunit beta-3	16	9	2	27
Gamma-aminobutyric acid receptor subunit beta-2	16	9	4	29
Cholinesterase	0	4	0	5
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	6	1	10
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	6	2	9
Carbonic anhydrase 9	0	3	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	2	7
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	16	9	2	27
Canalicular multispecific organic anion transporter 1	0	35	0	35
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase 15	0	2	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	16	9	2	27
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	8
pregnane X nuclear receptor	34	0	0	34
potassium voltage-gated channel subfamily H member 2 isoform d	23	0	0	23
interleukin 8	5	0	0	5
TDP1 protein	47	0	0	47
thyroid stimulating hormone receptor	20	0	0	20
estrogen receptor 2 (ER beta)	19	0	0	19
progesterone receptor	26	0	0	26
transcriptional regulator ERG isoform 3	6	0	0	6
thyroid hormone receptor beta isoform 2	33	0	0	33
ras-related protein Rab-9A	5	0	0	5
Polyphenol oxidase 2	0	1	0	3
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	28	0	0	28
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
USP1 protein, partial	11	0	0	11
NFKB1 protein, partial	7	0	0	7
GLS protein	19	0	0	19
cytochrome P450 2D6 isoform 1	18	0	0	18
D(1A) dopamine receptor	19	0	0	19
chromobox protein homolog 1	27	0	0	27
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	25	0	0	25
Solute carrier family 22 member 1	0	11	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15B	11	0	0	11
Voltage-dependent L-type calcium channel subunit alpha-1F	0	7	0	7
5-hydroxytryptamine receptor 4	0	34	0	34
Albumin	0	0	9	9
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	23	0	23
Muscarinic acetylcholine receptor M2	0	25	3	31
Muscarinic acetylcholine receptor M4	0	30	2	34
Muscarinic acetylcholine receptor M1	0	15	1	19
Muscarinic acetylcholine receptor M3	0	14	1	18
Muscarinic acetylcholine receptor M4	0	15	1	19
Muscarinic acetylcholine receptor M5	0	14	1	18
Muscarinic acetylcholine receptor M5	0	33	1	36
Alpha-2A adrenergic receptor	0	38	3	41
Muscarinic acetylcholine receptor M2	0	16	1	21
Muscarinic acetylcholine receptor M1	0	32	6	42
Angiotensin-converting enzyme	0	18	0	18
D(2) dopamine receptor	0	36	10	54
Alpha-2B adrenergic receptor	0	35	2	37
Alpha-2C adrenergic receptor	0	31	2	33
5-hydroxytryptamine receptor 1A	0	31	2	33
Muscarinic acetylcholine receptor M3	0	33	2	37
D(1A) dopamine receptor	0	24	3	31
D(1B) dopamine receptor	0	8	0	11
UDP-glucuronosyltransferase 1A4	0	0	0	5
Sodium-dependent noradrenaline transporter	0	28	1	29
Histamine H2 receptor	0	19	2	21
Alpha-1D adrenergic receptor	0	32	3	35
5-hydroxytryptamine receptor 2C	0	38	2	40
5-hydroxytryptamine receptor 1B	0	24	1	25
5-hydroxytryptamine receptor 1D	0	9	1	10
5-hydroxytryptamine receptor 1F	0	9	1	10
5-hydroxytryptamine receptor 6	0	3	0	3
Histamine H1 receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	29	3	32
5-hydroxytryptamine receptor 7	0	11	1	12
5-hydroxytryptamine receptor 5A	0	3	0	3
5-hydroxytryptamine receptor 5B	0	3	0	3
Histamine H1 receptor	0	28	5	35
D(3) dopamine receptor	0	33	7	48
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	7	0	9
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	7	0	7
5-hydroxytryptamine receptor 2B	0	35	1	36
Alpha-1A adrenergic receptor	0	22	2	24
Histamine H2 receptor	14	2	0	20
5-hydroxytryptamine receptor 6	0	26	0	27
5-hydroxytryptamine receptor 7	0	9	0	9
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	7	0	7
Potassium voltage-gated channel subfamily H member 2	0	31	0	31
Voltage-dependent L-type calcium channel subunit alpha-1S	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Sodium channel protein type 5 subunit alpha	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	9	0	9
5-hydroxytryptamine receptor 4	0	5	0	6
Nuclear receptor subfamily 3 group C member 3	0	17	0	17
Sodium channel protein type 2 subunit alpha	0	5	0	5
Ataxin-2	28	0	0	28
Sigma non-opioid intracellular receptor 1	0	25	0	25
5-hydroxytryptamine receptor 3B	0	7	0	7
Sodium channel protein type 3 subunit alpha	0	6	0	6
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Histamine H3 receptor	0	6	0	6
Sodium channel protein type 10 subunit alpha	0	5	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
Luciferase	14	0	0	14
acetylcholinesterase	20	0	0	20
phosphopantetheinyl transferase	15	0	0	15
Microtubule-associated protein tau	20	0	0	20
regulator of G-protein signaling 4	15	0	0	15
farnesoid X nuclear receptor	19	0	0	19
peroxisome proliferator activated receptor gamma	23	0	0	23
aryl hydrocarbon receptor	18	0	0	18
thyroid stimulating hormone receptor	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
cellular tumor antigen p53 isoform a	8	0	0	8
cytochrome P450 2C19 precursor	13	0	0	13
cytochrome P450 2C9 precursor	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
vitamin D3 receptor isoform VDRA	8	0	0	8
mitogen-activated protein kinase 1	17	0	0	17
nuclear receptor ROR-gamma isoform 1	13	0	0	13
cytochrome P450 3A4 isoform 1	16	0	0	16
lethal factor (plasmid)	13	0	0	13
Integrin beta-3	4	0	0	4
Integrin alpha-IIb	4	0	0	4
5-hydroxytryptamine receptor 1A	0	13	7	20
Tryptophan 5-hydroxylase 1	0	2	0	2
Alpha-1B adrenergic receptor	0	18	1	19
D	0	16	0	16
D(3) dopamine receptor	0	15	1	17
Alpha-2B adrenergic receptor	0	14	2	16
D(2) dopamine receptor	0	7	0	7
D(4) dopamine receptor	0	16	4	25
Alpha-2C adrenergic receptor	0	13	2	15
Alpha-2A adrenergic receptor	0	13	2	15
Alpha-1D adrenergic receptor	0	18	1	19
D(1B) dopamine receptor	0	11	0	11
D(4) dopamine receptor	0	13	1	14
Spike glycoprotein	25	0	2	27
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	2	0	2
D	0	6	0	6
ATPase family AAA domain-containing protein 5	19	0	0	19
ATP-dependent phosphofructokinase	22	0	0	22
Adenosine receptor A2b	0	0	2	2
Alpha-1A adrenergic receptor	0	11	3	14
Alpha-1B adrenergic receptor	0	9	3	12
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
5-hydroxytryptamine receptor 3E	0	4	1	5
SMAD family member 2	8	0	0	8
Fumarate hydratase	8	0	0	8
PPM1D protein	6	0	0	6
SMAD family member 3	8	0	0	8
EWS/FLI fusion protein	18	0	0	18
G	12	0	0	12
polyprotein	8	0	0	8
67.9K protein	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
lysosomal alpha-glucosidase preproprotein	6	0	0	6
mu-type opioid receptor isoform MOR-1	0	0	2	2
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
histone acetyltransferase KAT2A isoform 1	13	0	0	13
5-hydroxytryptamine receptor 2A	0	0	2	2
neuropeptide S receptor isoform A	5	0	0	5
Solute carrier family 22 member 2	0	5	0	6
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 3B	0	4	1	5
Interferon beta	18	0	0	18
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
ATP-dependent translocase ABCB1	0	7	0	12
Neuronal acetylcholine receptor subunit alpha-4	4	5	2	12
Neuronal acetylcholine receptor subunit beta-2	4	5	2	12
Histamine H1 receptor	0	5	1	6
5-hydroxytryptamine receptor 7	0	9	0	9
5-hydroxytryptamine receptor 3A	0	5	1	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Inositol monophosphatase 1	11	0	0	11
5-hydroxytryptamine receptor 3D	0	4	1	5
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	4	1	5
Inositol hexakisphosphate kinase 1	12	0	0	12
Multidrug and toxin extrusion protein 1	0	7	0	7
cytochrome P450 2C9, partial	12	0	0	12
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, Ferritin light chain	7	0	0	7
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	6	1	10
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	1	9
Glutamate receptor ionotropic, NMDA 2C	0	5	1	9
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	5	1	9
Glutamate receptor ionotropic, NMDA 3B	0	5	1	9
Glutamate receptor ionotropic, NMDA 3A	0	5	1	9
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	2	1	3
ATAD5 protein, partial	18	0	0	18
thioredoxin glutathione reductase	3	0	0	3
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	7	0	0	7
hemoglobin subunit beta	2	0	0	2
DNA polymerase iota isoform a (long)	9	0	0	9
M-phase phosphoprotein 8	9	0	0	9
Bile salt export pump	0	6	0	6
Nuclear receptor ROR-gamma	7	0	0	7
Protein-arginine deiminase type-4	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Sodium-dependent dopamine transporter	0	11	1	12
Angiotensin-converting enzyme 2	0	0	2	2
flap endonuclease 1	9	0	0	9
Chain A, Cruzipain	3	0	0	3
relaxin receptor 1 isoform 1	1	0	0	1
pregnane X receptor	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Thymidine kinase, cytosolic	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	5	3	8
Potassium channel subfamily K member 9	0	1	0	1
Acetylcholinesterase	0	3	0	4
L-lactate dehydrogenase A chain	0	2	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Cytochrome P450 3A5	0	1	0	2
Cannabinoid receptor 1	0	6	1	9
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cannabinoid receptor 2	0	4	2	8
Mu-type opioid receptor	0	9	2	11
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Delta-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	3	0	3
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Transient receptor potential cation channel subfamily V member 1	0	3	2	6
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	2	4
Transient receptor potential cation channel subfamily V member 2	0	2	2	4
G-protein coupled receptor 55	0	1	2	3
Diacylglycerol lipase-alpha	0	1	0	1
15-lipoxygenase, partial	6	0	0	6
glucocerebrosidase	6	0	0	6
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Transient receptor potential cation channel subfamily V member 1	0	3	1	4
Lysine-specific histone demethylase 1A	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Acetylcholinesterase	0	8	0	9
Prostaglandin G/H synthase 1	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Vpr	3	0	0	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	6	0	6
Sodium channel protein type 2 subunit alpha	0	7	0	7
Sodium channel protein type 3 subunit alpha	0	5	0	5
UDP-glucuronosyltransferase 2B7	0	2	0	5
Cytochrome P450 2J2	0	9	0	10
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-5	0	3	2	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-9	0	3	2	6
Solute carrier family 22 member 1	0	3	0	5
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	3	2	6
Solute carrier family 22 member 2	0	2	0	4
endonuclease IV	5	0	0	5
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Estrogen receptor 1	0	1	0	1
PINK1	1	0	0	1
Parkin	2	0	0	2
estrogen receptor beta isoform 1	0	1	0	1
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cruzipain	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
Sodium-dependent noradrenaline transporter	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	0	6
Transporter	0	8	1	10
Thrombopoietin	5	0	0	5
caspase 7, apoptosis-related cysteine protease	5	0	0	5
caspase-3	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
Trypanothione reductase	0	4	0	4
Trypanothione reductase	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	1
Envelope glycoprotein	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	9	4	13
Gamma-aminobutyric acid receptor subunit beta-1	0	9	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	3	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	9	2	11
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Cholecystokinin receptor type A	1	2	0	3
Gastrin/cholecystokinin type B receptor	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	9	4	13
Gamma-aminobutyric acid receptor subunit alpha-3	0	9	3	12
Gamma-aminobutyric acid receptor subunit alpha-2	0	9	3	12
Gamma-aminobutyric acid receptor subunit beta-2	0	9	3	12
Gamma-aminobutyric acid receptor subunit alpha-4	0	9	1	10
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	9	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Nischarin	0	2	0	2
Nischarin	0	2	0	2
Adenylate cyclase type 1	0	2	0	2
Calmodulin-1	0	1	1	2
Beta-2 adrenergic receptor	0	4	0	4
Beta-1 adrenergic receptor	0	3	0	3
Endothelin receptor type B	0	3	0	3
Adenylate cyclase type 3	0	2	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
Adenylate cyclase type 8	0	2	0	2
5-hydroxytryptamine receptor 5A	0	3	0	3
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
D(2) dopamine receptor	0	5	0	5
Calmodulin	0	0	2	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	5	0	5
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Histamine H4 receptor	0	3	2	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	3
huntingtin isoform 2	4	0	0	4
chaperonin GroEL	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Glycogen phosphorylase, brain form	0	2	0	2
Glycogen phosphorylase, muscle form	0	2	0	2
Histone-lysine N-methyltransferase SETD7	0	2	0	2
glp-1 receptor, partial	13	0	0	13
Gamma-aminobutyric acid	0	1	1	2
Fatty acid-binding protein, liver	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	2	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
DNA polymerase kappa isoform 1	10	0	0	10
Epidermal growth factor receptor	0	3	0	3
Glutamate receptor 1	1	1	1	4
Glutamate receptor 3	1	1	1	4
Glutamate receptor 4	1	1	1	4
Caspase-7	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Transient receptor potential cation channel subfamily A member 1	0	0	2	3
Glycine receptor subunit alpha-1	0	0	4	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
dopamine D1 receptor	3	0	0	3
Cholinesterase	0	3	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Acetylcholinesterase	0	3	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	2	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Adenosine receptor A3	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	5	0	0	5
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Dipeptidyl peptidase 4	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	2	0	2
Protease	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Tyrosine-protein kinase ABL1	0	1	1	2
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Chymotrypsinogen A	0	1	0	1
alpha-galactosidase	3	0	0	3
Mitogen-activated protein kinase 13	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, kainate 1	0	1	0	2
Aryl hydrocarbon receptor	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Glutamate receptor ionotropic, kainate 2	0	1	0	2
Glutamate receptor ionotropic, kainate 3	0	1	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Glutamate receptor ionotropic, kainate 5	0	1	0	2
Vesicular glutamate transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
G-protein coupled receptor 35	0	2	1	3
Histamine H3 receptor	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	6	0	0	6
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
DNA polymerase eta isoform 1	3	0	0	3
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
phosphoglycerate kinase	2	0	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	3
Beta-1 adrenergic receptor	0	2	0	2
inositol monophosphatase 1	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Lysophosphatidic acid receptor 6	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 1	0	0	2	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 5	0	0	1	1
Lysophosphatidic acid receptor 2	0	0	1	1
Lysophosphatidic acid receptor 3	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Myeloperoxidase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Smad3	5	0	0	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	2	0	2
DNA polymerase III, partial	1	0	0	1
XBP1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
WD repeat-containing protein 48	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
alternatively spliced Trp4	0	0	1	1
5-hydroxytryptamine receptor 1E	0	1	0	1
sphingosine 1-phosphate receptor 3	0	1	0	1
Beta-casein	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
Protein Rev	0	0	1	1
Genome polyprotein	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (228)

Protein Targets (1,045)

Blepharospasm

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (228)

Drugs Studied (156)

Protein Targets (1,045)