fluoxetine has been researched along with trazodone in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (18.37) | 18.7374 |
| 1990's | 40 (40.82) | 18.2507 |
| 2000's | 21 (21.43) | 29.6817 |
| 2010's | 16 (16.33) | 24.3611 |
| 2020's | 3 (3.06) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Baumann, MH; Hufeisen, SJ; McBride, A; Rauser, L; Roth, BL; Rothman, RB; Savage, JE | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Beaumont, K; Di, L; Maurer, TS; Smith, DA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Marek, GJ; McDougle, CJ; Price, LH; Seiden, LS | 1 |
| Cohen, LJ; Grothe, DR | 1 |
| Altemus, M; Cizza, G; Gold, PW | 1 |
| Dean, A; Jick, H; Ulcickas, M | 1 |
| Hellerstein, DJ; Hemlock, C; Kasch, K; Rosenthal, J; Samstag, L; Schupak, C; Winston, A; Yanowitch, P | 1 |
| Hawkins, JW | 1 |
| Cole, JO; Glass, L; Nierenberg, AA | 1 |
| Salzman, C | 1 |
| Bakish, D | 1 |
| Kafka, MP | 1 |
| Sullivan, M | 1 |
| Beasley, CM; Bosomworth, JC; Dornseif, BE; Pultz, JA; Sayler, ME | 1 |
| Fudge, JL; Garvey, MJ; Kelly, MW; Perry, PJ | 1 |
| Metz, A; Shader, RI | 1 |
| Dunner, DL; Garvey, MJ; Kyhl, J; Perry, PJ; Rush, AJ | 1 |
| Bodkin, JA; Cole, JO | 1 |
| Breitner, JC; Figiel, GS; Krishnan, KR; Nemeroff, CB | 1 |
| Halaris, A; Saran, A | 1 |
| Andia, AM; Swerdlow, NR | 1 |
| Cook, BL; Dunner, FJ; Garvey, MJ; Kelly, MW; Perry, PJ; Winokur, G | 1 |
| Hudson, JI; Keck, PE; McElroy, SL; Pope, HG | 1 |
| Aranow, AB; Bell, IR; Cole, JO; Grady, TA; Hudson, JI; Laage, TA; Pope, HG | 1 |
| Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A | 1 |
| Awad, AG | 1 |
| Ostrow, D | 1 |
| Debus, JR; Himmel, C; Polatin, P; Rush, AJ; Tyler, D; Weissenburger, J | 1 |
| Brown, TM; Evans, DL; Golden, RN; Miller, H | 1 |
| Cole, JO; Dessain, E; Katz, DL; O'Neil, P; Schatzberg, AF | 1 |
| Dahms, JL; Seiden, LS; Shaughnessy, RA | 1 |
| Hrdina, PD | 1 |
| Lapierre, Y; Mehta, G; Surphlis, W; Telner, J | 1 |
| Poshivalov, VP; Valdman, AV | 1 |
| Gershon, S; Kelwala, S; Stanley, M | 1 |
| Shopsin, B | 1 |
| Bastide, P; Coudert, P; Rubat, C; Tronche, P | 1 |
| Adler, LA; Nierenberg, AA; Peselow, E; Rosenthal, M; Zornberg, G | 1 |
| Lauterbach, EC | 1 |
| Hellerstein, DJ; Hemlock, C; Kasch, K; Rosenthal, J; Samstag, LW; Winston, A; Yanowitch, P | 1 |
| Jackson, CW; Lydiard, RB; Morton, WA | 1 |
| Tanquary, J | 1 |
| Bryant, SG; Fisher, S; Kent, TA | 1 |
| Short, DD; Workman, EA | 1 |
| Balon, R | 1 |
| Terao, T | 1 |
| Davis, G; Engelman, JC; Goldstein, I; Pescatori, ES | 1 |
| Sandler, NH | 1 |
| George, TP; Godleski, LS | 1 |
| Bril, T; Demedts, P; Maes, M; Neels, H; Van de Vyvere, J; Vandoolaeghe, E; Wauters, A | 1 |
| Desnyder, R; Maes, M; Vandoolaeghe, E | 1 |
| Demedts, P; Maes, M; Neels, H; Van Hunsel, F; Vandoolaeghe, E; Wauters, A | 1 |
| Belandres, PV; Braverman, SE; Patterson, DE | 1 |
| Hatsuda, S; Matsubara, M; Miura, K; Murakami, H; Nakazawa, K; Ohara, M; Sugita, S; Suzuki, S; Terashima, M | 1 |
| Demedts, P; Maes, M; Meltzer, HY; Neels, H; Vandoolaeghe, E; Wauters, A; Westenberg, H | 1 |
| Bhatara, VS; Fogas, BS; Kallepalli, BR; Misra, LK; Tervo, RC | 1 |
| Buesching, DP; Copley-Merriman, C; Croghan, TW; Crown, WE; Engelhart, L; Lair, TJ; Melfi, CA; Obenchain, RL | 1 |
| Lin, A; Maes, M; Scharpé, S; Vandoolaeghe, E; Verkerk, R | 1 |
| Stolp-Smith, KA; Wainberg, MC | 1 |
| Giovannini, MG; Pazzagli, M; Pepeu, G | 1 |
| Hatsuda, S; Hayashi, T; Kimura, H; Matsubara, M; Miura, K; Mori, T; Murakami, H; Ohara, M; Ohta, T; Sugita, S; Suzuki, S; Terashima, M | 1 |
| Michael, A; O'Donnell, EA | 1 |
| Darko, W; Guharoy, R; Lehman, D; Pappas, V; Rose, F | 1 |
| Isbister, GK; Whyte, IM | 1 |
| Garrido Barral, A; González Moneo, MJ | 1 |
| Conca, A; Hubmann, MR; König, P; Moll, W; Waschgler, R | 1 |
| Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM | 1 |
| Lebert, F | 1 |
| Abdel-Salam, OM; Arbid, MS; Baiuomy, AR | 1 |
| Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G | 1 |
| Conca, A; König, P; Moll, W; Prapotnik, M; Waschgler, R | 1 |
| Carney, SM; Geddes, JR; Goodwin, GM; Taylor, MJ | 1 |
| Albertazzi, P | 1 |
| Davis, MP | 1 |
| Dubois, B; Le Ber, I | 1 |
| Papakostas, GI; Shelton, RC | 1 |
| Asarnow, JR; Birmaher, B; Brent, DA; Clarke, G; Emslie, GJ; Keller, MB; Porta, G; Ryan, N; Shamseddeen, W; Wagner, KD | 1 |
| Ali, AS; Ali, SA; Salim, S | 1 |
| Chibireva, MD; Matveeva, VL; Nigmatullina, RR | 1 |
| Amin, R | 1 |
| Naranjo, J; Pollard, EM; Sprung, J; Warner, MA; Warner, ME; Weingarten, TN | 1 |
| Baldwin, DS; Everitt, H; Lipinska, G; Malizia, AL; Manson, CC; Mayers, A; Stuart, B; Wilson, S | 1 |
| Lin, CM; Little, K; Reynolds, PM | 1 |
| Calder, CD | 1 |
| Bonds, JA; Brooker, SM; Kessler, JA; McGuire, TL; Peng, CY; Rawat, R; Tsai, YH; Tunc-Ozcan, E | 1 |
| Eap, CB; Favre, L; Frantz, J; Garin, P; Vandenberghe, F; Vionnet, N | 1 |
| Keidan, L; Pick, CG; Schreiber, S | 1 |
17 review(s) available for fluoxetine and trazodone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Fluoxetine; Humans; Serotonin; Trazodone | 1992 |
Major depression: its recognition and treatment. Part 2. Second-generation and newer antidepressants.
Topics: Antidepressive Agents; Bupropion; Clomipramine; Depression; Female; Fluoxetine; Humans; Male; Maprotiline; Selective Serotonin Reuptake Inhibitors; Trazodone | 1992 |
Monoamine oxidase inhibitors and atypical antidepressants.
Topics: Aged; Antidepressive Agents; Bupropion; Depressive Disorder; Fluoxetine; Humans; Methylphenidate; Monoamine Oxidase Inhibitors; Psychiatric Status Rating Scales; Trazodone | 1992 |
Antidepressant drug side effects.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Fluoxetine; Humans; Monoamine Oxidase Inhibitors; Trazodone | 1990 |
Therapeutic effects of serotonin uptake inhibitors in depression.
Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine | 1986 |
The new antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Fluoxetine; Maprotiline; Nomifensine; Seizures; Trazodone | 1988 |
Recent studies on selective serotonergic antidepressants: trazodone, fluoxetine, and fluvoxamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Oximes; Serotonin; Serotonin Antagonists; Trazodone | 1987 |
History of antidepressants: successes and failures.
Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Depressive Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Fluoxetine; History, 20th Century; Humans; Monoamine Oxidase Inhibitors; Propiophenones; Psychopharmacology; Receptors, Adrenergic; Receptors, Serotonin; Trazodone; Zimeldine | 1983 |
Atypical antidepressants versus imipramine in the treatment of major depression: a meta-analysis.
Topics: Antidepressive Agents; Bupropion; Depressive Disorder; Fluoxetine; Humans; Imipramine; Trazodone | 1993 |
[Latest therapies for treating dementia].
Topics: Adult; Aged; Alzheimer Disease; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clinical Trials as Topic; Cognition; Cohort Studies; Controlled Clinical Trials as Topic; Dementia, Vascular; Donepezil; Female; Fluoxetine; Galantamine; Haloperidol; Hormone Replacement Therapy; Humans; Hydroxychloroquine; Indans; Middle Aged; Nootropic Agents; Piperidines; Placebos; Practice Guidelines as Topic; Quality of Life; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone | 2002 |
[Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias].
Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Dementia; Depression; Fluoxetine; Humans; Neuropsychological Tests; Paroxetine; Placebos; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone | 2003 |
Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Aged; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Meta-Analysis as Topic; Psychiatric Status Rating Scales; Sex Characteristics; Tetrahydrofolates; Trazodone; Treatment Outcome | 2004 |
Noradrenergic and serotonergic modulation to treat vasomotor symptoms.
Topics: Citalopram; Cyclohexanols; Female; Fluoxetine; Hot Flashes; Humans; Menopause; Mianserin; Mirtazapine; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Trazodone; Venlafaxine Hydrochloride | 2006 |
[Frontotemporal dementia].
Topics: Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Aphasia, Primary Progressive; Brain; Cell Cycle Proteins; Dementia; Diagnosis, Differential; Fluoxetine; Frontal Lobe; Humans; Microtubule-Associated Proteins; Middle Aged; Parkinsonian Disorders; Selective Serotonin Reuptake Inhibitors; Temporal Lobe; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Trazodone; Valosin Containing Protein | 2007 |
Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder.
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Depressive Disorder, Major; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Drug Resistance; Drug Therapy, Combination; Fluoxetine; Humans; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Serotonin 5-HT2 Receptor Antagonists; Thiazoles; Trazodone; Triazoles | 2008 |
Antidepressants for insomnia in adults.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Fluoxetine; Humans; Mianserin; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone | 2018 |
20 trial(s) available for fluoxetine and trazodone
| Article | Year |
|---|---|
Fluoxetine versus trazodone: efficacy and activating-sedating effects.
Topics: Adult; Akathisia, Drug-Induced; Ambulatory Care; Anxiety; Depressive Disorder; Dizziness; Double-Blind Method; Female; Fluoxetine; Humans; Male; Placebos; Psychiatric Status Rating Scales; Rhinitis; Sleep; Sleep Initiation and Maintenance Disorders; Trazodone; Tremor | 1991 |
A comparison of the effect of fluoxetine and trazodone on the cognitive functioning of depressed outpatients.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fluoxetine; Humans; Memory, Short-Term; Paired-Associate Learning; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Serial Learning; Trazodone | 1990 |
A report of trazodone-associated laboratory abnormalities.
Topics: Double-Blind Method; Erythrocyte Count; Female; Fluoxetine; Hematocrit; Hemoglobins; Humans; Male; Reference Values; Trazodone | 1990 |
A comparative trial of fluoxetine versus trazodone in outpatients with major depression.
Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; Random Allocation; Trazodone | 1989 |
Pharmacological treatment of kleptomania and bulimia nervosa.
Topics: Adult; Bulimia; Clinical Trials as Topic; Disruptive, Impulse Control, and Conduct Disorders; Drug Therapy, Combination; Female; Fluoxetine; Follow-Up Studies; Humans; Tranylcypromine; Trazodone | 1989 |
The new generation antidepressants: promising innovations or disappointments?
Topics: Alprazolam; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trials as Topic; Depressive Disorder; Dopamine; Drug Evaluation; Fluoxetine; Humans; Maprotiline; Nomifensine; Norepinephrine; Propiophenones; Propylamines; Receptors, Neurotransmitter; Serotonin; Trazodone; Zimeldine | 1985 |
Fluoxetine versus trazodone in the treatment of outpatients with major depression.
Topics: Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Dizziness; Double-Blind Method; Fluoxetine; Humans; Personality Inventory; Psychiatric Status Rating Scales; Random Allocation; Trazodone; Weight Loss | 1988 |
Effects of antidepressants on thinking styles in depressed inpatients.
Topics: Adult; Antidepressive Agents; Clinical Trials as Topic; Cognition; Female; Fluoxetine; Humans; Imipramine; Male; Mood Disorders; Personality Tests; Thinking; Trazodone | 1988 |
History of antidepressants: successes and failures.
Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Depressive Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Fluoxetine; History, 20th Century; Humans; Monoamine Oxidase Inhibitors; Propiophenones; Psychopharmacology; Receptors, Adrenergic; Receptors, Serotonin; Trazodone; Zimeldine | 1983 |
Trazodone for antidepressant-associated insomnia.
Topics: Adult; Bupropion; Confidence Intervals; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoxetine; Humans; Male; Placebos; Sleep; Sleep Initiation and Maintenance Disorders; Trazodone | 1994 |
Long-term treatment of double depression: a preliminary study with serotonergic antidepressants.
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newborn; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Trazodone | 1994 |
Comparison of manic switch onset during fluoxetine and trazodone treatment.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Trazodone | 1993 |
Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process.
Topics: Acute-Phase Reaction; Adrenergic beta-Antagonists; Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Erythrocyte Count; Erythrocyte Indices; Female; Ferritins; Fluoxetine; Hematocrit; Hemoglobinometry; Humans; Iron; Male; Middle Aged; Pindolol; Transferrin; Trazodone | 1996 |
Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Personality Inventory; Pindolol; Serotonin Antagonists; Trazodone | 1996 |
Lower total serum protein, albumin, and beta- and gamma-globulin in major and treatment-resistant depression: effects of antidepressant treatments.
Topics: Acute-Phase Proteins; Adrenergic beta-Antagonists; Adult; Aged; Alpha-Globulins; Antidepressive Agents, Second-Generation; Beta-Globulins; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; gamma-Globulins; Humans; Male; Middle Aged; Pindolol; Serum Albumin; Trazodone; Treatment Failure | 1996 |
Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Personality Inventory; Pindolol; Piperazines; Trazodone; Treatment Outcome | 1997 |
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine; Asparagine; Aspartic Acid; Depressive Disorder, Major; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acids; Female; Fluoxetine; Glycine; Histidine; Humans; Male; Middle Aged; Personality Inventory; Pindolol; Prognosis; Selective Serotonin Reuptake Inhibitors; Serine; Taurine; Threonine; Trazodone; Treatment Outcome | 1998 |
Therapeutic drug monitoring of trazodone: are there pharmacokinetic interactions involving citalopram and fluoxetine?
Topics: Adult; Antidepressive Agents; Citalopram; Drug Interactions; Drug Monitoring; Female; Fluoxetine; Humans; Male; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Trazodone | 2004 |
Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Aged; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Meta-Analysis as Topic; Psychiatric Status Rating Scales; Sex Characteristics; Tetrahydrofolates; Trazodone; Treatment Outcome | 2004 |
Adjunctive sleep medications and depression outcome in the treatment of serotonin-selective reuptake inhibitor resistant depression in adolescents study.
Topics: Adolescent; Cognitive Behavioral Therapy; Combined Modality Therapy; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Depressive Disorder, Major; Drug Interactions; Drug Resistance; Female; Fluoxetine; Humans; Male; Paroxetine; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sleep Wake Disorders; Trazodone; Treatment Outcome; Venlafaxine Hydrochloride | 2012 |
63 other study(ies) available for fluoxetine and trazodone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergonovine; Norfenfluramine; Receptors, Serotonin; Serotonin Antagonists | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Volume of Distribution in Drug Design.
Topics: Drug Design; Half-Life; Pharmacokinetics | 2015 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro.
Topics: Animals; Arginine Vasopressin; Desipramine; Fluoxetine; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Reference Values; Trazodone | 1992 |
Comparison of frequencies of suicidal tendencies among patients receiving fluoxetine, lofepramine, mianserin, or trazodone.
Topics: Adolescent; Adult; Aged; Fluoxetine; Humans; Lofepramine; Mianserin; Middle Aged; Suicide; Suicide, Attempted; Trazodone; United Kingdom | 1992 |
A preliminary study of serotonergic antidepressants in treatment of dysthymia.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Trazodone | 1992 |
Nonsedating treatments for Alzheimer's patients with behavioral problems.
Topics: Alzheimer Disease; Buspirone; Fluoxetine; Humans; Selegiline; Sleep; Trazodone | 1992 |
Possible trazodone potentiation of fluoxetine: a case series.
Topics: Adult; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Sleep Wake Disorders; Trazodone | 1992 |
Fluoxetine potentiation by buspirone: three case histories.
Topics: Adult; Buspirone; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Trazodone; Tryptophan | 1991 |
Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Fluoxetine; Humans; Imipramine; Lithium; Male; Masturbation; Middle Aged; Paraphilic Disorders; Psychiatric Status Rating Scales; Sexual Behavior; Sexual Dysfunctions, Psychological; Trazodone | 1991 |
Integrated treatment of a woman with chronic hand pain.
Topics: Adult; Combined Modality Therapy; Depressive Disorder; Female; Fluoxetine; Hand; Hand Injuries; Humans; Patient Care Team; Physical Therapy Modalities; Postoperative Complications; Psychotherapy; Reflex Sympathetic Dystrophy; Sick Role; Trazodone | 1991 |
Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine.
Topics: Adult; Depression; Drug Interactions; Female; Fluoxetine; Humans; Sleep Initiation and Maintenance Disorders; Trazodone | 1990 |
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases; Delirium; Depressive Disorder; Female; Fluoxetine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nortriptyline; Risk Factors; Trazodone | 1989 |
Panic attack precipitated by fluoxetine.
Topics: Adult; Alprazolam; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Panic Disorder; Psychiatric Status Rating Scales; Trazodone | 1989 |
Trazodone-fluoxetine combination for treatment of obsessive-compulsive disorder.
Topics: Adult; Drug Therapy, Combination; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Trazodone | 1989 |
Elevated antidepressant plasma levels after addition of fluoxetine.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Drug Combinations; Female; Fluoxetine; Humans; Male; Trazodone | 1989 |
New antidepressants--the serotonin reuptake inhibitors.
Topics: Brain; Depressive Disorder; Fluoxetine; Humans; Propylamines; Receptors, Serotonin; Trazodone; Zimeldine | 1987 |
Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule.
Topics: Animals; Antidepressive Agents; Bupropion; Clozapine; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Haloperidol; Male; Propiophenones; Rats; Rats, Inbred Strains; Reinforcement Schedule; Trazodone; Zimeldine | 1985 |
Inhibition of sodium-dependent [3H]imipramine binding in rat brain by serotonin and serotonin uptake inhibitors.
Topics: Animals; Cell Membrane; Cerebral Cortex; Clomipramine; Fluoxetine; Imipramine; Male; Rats; Receptors, Serotonin; Serotonin; Sodium; Trazodone | 1988 |
Pharmaco-ethological analysis of antidepressant drug effects.
Topics: Aggression; Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Fluoxetine; Imipramine; Iproniazid; Male; Mice; Motor Activity; Reserpine; Social Behavior; Trazodone | 1986 |
Second generation antidepressants.
Topics: Antidepressive Agents, Tricyclic; Catecholamines; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nomifensine; Serotonin; Trazodone | 1980 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine | 1995 |
Reversible intermittent rhythmic myoclonus with fluoxetine in presumed Pick's disease.
Topics: Affective Disorders, Psychotic; Brain; Dementia; Dose-Response Relationship, Drug; Electroencephalography; Fluoxetine; Haloperidol; Humans; Male; Middle Aged; Myoclonus; Serotonin; Trazodone | 1994 |
Pharmacologic management of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Antidepressive Agents; Anxiety Disorders; Clomipramine; Depression; Dopamine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Synaptic Transmission; Trazodone | 1994 |
Trichotillomania and body dysmorphic disorder.
Topics: Adult; Buspirone; Delusions; Drug Therapy, Combination; Fluoxetine; Humans; Male; Trazodone; Trichotillomania | 1994 |
Postmarketing surveillance by patient self-monitoring: trazodone versus fluoxetine.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Data Collection; Depressive Disorder; Female; Fluoxetine; Humans; Incidence; Interviews as Topic; Male; Middle Aged; Monitoring, Physiologic; Risk; Telephone; Trazodone | 1993 |
Fluoxetine-induced sexual dysfunction and yohimbine.
Topics: Drug Therapy, Combination; Fluoxetine; Humans; Male; Penile Erection; Priapism; Sexual Dysfunctions, Psychological; Trazodone; Yohimbine | 1993 |
Priapism of the clitoris: a case report following trazodone use.
Topics: Adjustment Disorders; Adult; Clitoris; Depression; Female; Fluoxetine; Humans; Muscle Contraction; Muscle, Smooth; Phenylpropanolamine; Trazodone; Vulvar Diseases | 1993 |
Tardive dyskinesia associated with fluoxetine.
Topics: Adult; Clomipramine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Trazodone | 1996 |
Possible serotonin syndrome with trazodone addition to fluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy, Generalized; Fluoxetine; Humans; Male; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Syndrome; Trazodone | 1996 |
Speech dysfunction due to trazodone--fluoxetine combination in traumatic brain injury.
Topics: Adult; Brain Injuries; Depressive Disorder; Dysarthria; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Trazodone | 1997 |
[A study of the effects of antidepressants on the GABAA receptor and its complex based on the drug actions on the power-spectral changes of rat hippocampal EEG induced by GABA antagonists and inverse agonists].
Topics: Animals; Antidepressive Agents; Carbolines; Depression, Chemical; Desipramine; Electroencephalography; Fluoxetine; GABA Antagonists; Hippocampus; Imipramine; Male; Norepinephrine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Trazodone | 1997 |
Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Depressive Disorder; Female; Fluoxetine; Humans; Male; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Time Factors; Trazodone | 1997 |
Effect of antidepressant therapy on health care utilization and costs in primary care.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cohort Studies; Depressive Disorder; Drug Costs; Fees, Medical; Female; Fluoxetine; Health Services Misuse; Humans; Male; Mental Health Services; Middle Aged; Primary Health Care; Trazodone; United States | 1997 |
Antidepressant exacerbation of spasticity.
Topics: Adjustment Disorders; Adult; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fluoxetine; Humans; Male; Muscle Spasticity; Neurologic Examination; Quadriplegia; Spinal Cord Injuries; Trazodone | 1999 |
Trazodone increases extracellular serotonin levels in the frontal cortex of rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Carrier Proteins; Cerebral Cortex; Fluoxetine; Ketanserin; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Trazodone | 1999 |
Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes.
Topics: Animals; Antidepressive Agents; Desipramine; Electroencephalography; Fluoxetine; Fourier Analysis; GABA Antagonists; Hippocampus; Imipramine; Male; Nortriptyline; Pentylenetetrazole; Rats; Rats, Wistar; Trazodone | 2000 |
Fluoxetine-induced sexual dysfunction reversed by trazodone.
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Sexual Dysfunctions, Psychological; Trazodone | 2000 |
Myoclonus secondary to the concurrent use of trazodone and fluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Drug Synergism; Fluoxetine; HIV Infections; Humans; Male; Myoclonus; Selective Serotonin Reuptake Inhibitors; Trazodone; Tremor | 2001 |
Misdiagnosis of myoclonus in antidepressant induced serotonin excess.
Topics: Antidepressive Agents; Diagnostic Errors; Drug Interactions; Fluoxetine; Humans; Myoclonus; Selective Serotonin Reuptake Inhibitors; Trazodone | 2001 |
Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Chromatography, High Pressure Liquid; Citalopram; Clozapine; Fluoxetine; Humans; Maprotiline; Trazodone | 2002 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Imipramine; Inflammation; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sertraline; Trazodone | 2003 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Edema; Fluoxetine; Foot; Imipramine; Indomethacin; Inflammation; Lactones; Melatonin; Pyrazoles; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Time Factors; Trazodone | 2004 |
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride | 2004 |
Does trazodone have a role in palliating symptoms?
Topics: Antidepressive Agents, Second-Generation; Depression; Drug Interactions; Fluoxetine; Humans; Neoplasms; Palliative Care; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone | 2007 |
5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.
Topics: Allylbenzene Derivatives; Animals; Benzyl Compounds; Dioxolanes; Dose-Response Relationship, Drug; Fish Proteins; Fluoxetine; Melanins; Melanophores; Metergoline; Pigments, Biological; Pyrogallol; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Sumatriptan; Tilapia; Trazodone; Yohimbine | 2013 |
[The influence of selective serotonin re-uptake inhibitor fluoxetine on inotropic function of myocardium in the ontogenesis of rats].
Topics: Age Factors; Animals; Animals, Newborn; Cardiotonic Agents; Dose-Response Relationship, Drug; Female; Fluoxetine; Heart Ventricles; Myocardial Contraction; Myocardium; Pregnancy; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Trazodone | 2014 |
Fluoxetine and Trazodone Combination Pharmacotherapy Resulting in Severe Irritability, Anger, Anxiety, and Anorexia: Probable Adverse Drug Interaction.
Topics: Adult; Anger; Anorexia; Antidepressive Agents, Second-Generation; Anxiety; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Trazodone; Young Adult | 2016 |
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome.
Topics: Aged; Curcuma; Dietary Supplements; Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Midazolam; Naloxone; Perioperative Period; Serotonin Agents; Serotonin Syndrome; Time Factors; Trazodone; Young Adult | 2017 |
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; Humans; Male; Olanzapine; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Serotonin Syndrome; Time Factors; Trazodone; Young Adult | 2018 |
Animal Behavior Case of the Month.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior Therapy; Behavior, Animal; Dogs; Environment; Fear; Fluoxetine; Gabapentin; Male; Selective Serotonin Reuptake Inhibitors; Trazodone | 2019 |
Hippocampal BMP signaling as a common pathway for antidepressant action.
Topics: Aging; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bone Morphogenetic Proteins; Dentate Gyrus; Duloxetine Hydrochloride; Electroconvulsive Therapy; Fluoxetine; Ganglia, Spinal; Hippocampus; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Signal Transduction; Stress, Psychological; Trazodone; Vilazodone Hydrochloride | 2021 |
The Influence of a Roux-en-Y Gastric Bypass on Plasma Concentrations of Antidepressants.
Topics: Adult; Antidepressive Agents; Duloxetine Hydrochloride; Escitalopram; Female; Fluoxetine; Gastric Bypass; Humans; Obesity, Morbid; Prospective Studies; Retrospective Studies; Trazodone | 2023 |
Treatment-Resistant Depression (TRD): Is the Opioid System Involved?
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Mianserin; Mice; Mirtazapine; Moclobemide; Naloxone; Reboxetine; Trazodone; Venlafaxine Hydrochloride | 2023 |