| Assay ID | Title | Year | Journal | Article |
|---|
| AID221097 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 15 min, in mice at 0.5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID64942 | Affinity at dopamine D2 receptor from rat striatum using [3H]spiroperidol as radioligand (For haloperidol Ki(nM)= 1.5+/-1.2) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID37171 | Affinity towards alpha-1 adrenergic receptor from rat cortex using [3H]prazosin radioligand (For prazosin Ki(nM)= 0.5+/-0.01) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID6039 | Affinity at 5-hydroxytryptamine 3 receptor from rat frontal cortex using [3H]granisetron as radioligand (For granisetron = Ki(nM)=0.3+/-0.01) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221564 | Effect on immobility time in the forced swimming test (FST) in mice at 0.1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221102 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 30 min, in mice at 0.5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID87455 | Percent increase in the Forskolin-Stimulated cAMP formation, in HeLa cells transfected with the 5-HT 1A receptor at 1 uM concentration | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID599142 | Binding affinity to 5HT1A receptor | 2008 | European journal of medicinal chemistry, Feb, Volume: 43, Issue:2
| A chemometric study of the 5-HT(1A) receptor affinities presented by arylpiperazine compounds. |
| AID4523 | Affinity at 5-hydroxytryptamine 1D receptor from calf caudate using [3H]5-HT as radioligand (For sumatriptan = Ki(nM)-12+/-1.9) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227282 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-1 (SB-1) at 1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID222340 | Antidepressant-like activity in the forced swimming test (FST) in mice at 10 mg/kg dose; Antidepressant like activity | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID225227 | Affinity at muscarinic receptor from rat cortex using [3H]-QNB as radioligand (For atropine Ki(nM)= 3.5+/-0.3) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221565 | Effect on immobility time in the forced swimming test (FST) in mice at 1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221096 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 15 min, in mice at 0.1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221101 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 30 min, in mice at 0.1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID218545 | Affinity at beta-adrenoceptor from rat cortex using [3H]DHA as radioligand (For DHA Ki(nM)= 3.5+/-0.3) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID222334 | Antidepressant-like activity in the forced swimming test (FST) in mice at 0.1 mg/kg dose; Antidepressant like activity | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227285 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-2 (SB-2) at 1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID477794 | Antagonist activity at 5HT1A | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT1A receptor ligands. |
| AID221561 | Effect on immobility time in the forced swimming test (FST) in mice at 0 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221099 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 15 min, in mice at 5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227283 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-1 (SB-1) at 10 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID87448 | Effect on Forskolin-Stimulated cAMP formation, in HeLa cells transfected with the 5-HT 1A receptor at 1 uM concentration | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227286 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-2 (SB-2) at 10 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID204684 | Binding affinity towards Serotonin transporter from rat cortex measured using [3H]paroxetine | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221095 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 15 min, in mice at 0.01 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID4059 | Binding affinity to 5-hydroxytryptamine 1A receptor (5-HT 1A receptor, serotonin receptor) from rat cortex using [3H]8-OH-DPAT as radioligand | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID87447 | Effect (1 uM) on Forskolin-Stimulated cAMP formation, in HeLa cells transfected with the 5-HT 1A receptor | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID36950 | Affinity towards alpha-2 adrenoceptor from rat cortex using [3H]-clonidine as radioligand (For clonidine Ki(nM)= 0.5+/-0.01) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221104 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 30 min, in mice at 5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221563 | Effect on immobility time in the forced swimming test (FST) in mice at 0.01 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID222329 | Antidepressant-like activity in the forced swimming test (FST) in mice at 0.001 mg/kg dose; Antidepressant like activity | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221106 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 60 min, in mice at 0.1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221105 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 60 min, in mice at 0.01 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221107 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 60 min, in mice at 0.5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221109 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 60 min, in mice at 5 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID87450 | Percent increase in the Forskolin-Stimulated cAMP formation, in HeLa cells transfected with the 5-HT 1A receptor [compound (1 uM)] | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221566 | Effect on immobility time in the forced swimming test (FST) in mice at 10 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221100 | Time-dependent effect on 8-OH-DPAT-induced hypothermia (change in body temperature) after 30 min, in mice at 0.01 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID222337 | Antidepressant-like activity in the forced swimming test (FST) in mice at 1 mg/kg dose; Antidepressant like activity | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID5105 | Affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex using [3H]ketanserin as radioligand (For ketanserin = Ki(nM)=0.7+/-0.09) | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227290 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-3 (SB-3) at 10 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID222331 | Antidepressant-like activity in the forced swimming test (FST) in mice at 0.01 mg/kg dose; Antidepressant like activity | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID221562 | Effect on immobility time in the forced swimming test (FST) in mice at 0.001 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| AID227288 | Effect on helpless behavior in rats and the number of escape failures was determined in shuttle-box session-3 (SB-) at 1 mg/kg dose | 2001 | Journal of medicinal chemistry, Feb-01, Volume: 44, Issue:3
| New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |