fluoxetine has been researched along with Astrocytoma, Grade IV in 6 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 7.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| " However, vital safety and efficacy issues related to combined therapy with temozolomide, the first-line cytostatic in patients diagnosed with glioblastoma multiforme, and antidepressant drugs have yet to be addressed." | 3.85 | Antidepressant drugs can modify cytotoxic action of temozolomide. ( Bielecka, AM; Obuchowicz, E, 2017) |
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 3.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| "The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible." | 1.62 | Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. ( Armando, AM; Bi, J; Cloughesy, TF; Cravatt, BF; Curtis, EJ; Furnari, FB; Gimple, RC; Gu, Y; Jing, H; Khan, A; Koga, T; Kornblum, HI; Miki, S; Mischel, PS; Prager, B; Quehenberger, O; Reed, A; Rich, JN; Rzhetsky, A; Tang, J; Wainwright, DA; Wong, IT; Wu, S; Yang, H; Zhang, W, 2021) |
| "Temozolomide (TMZ) is a cytotoxic agent of the imidazotetrazine class, chemically related to dacarbazine." | 1.35 | Tuberculosis in a patient on temozolomide: a case report. ( de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Elkamhawy, A | 1 |
| Viswanath, AN | 1 |
| Pae, AN | 1 |
| Kim, HY | 1 |
| Heo, JC | 1 |
| Park, WK | 1 |
| Lee, CO | 1 |
| Yang, H | 2 |
| Kim, KH | 1 |
| Nam, DH | 1 |
| Seol, HJ | 1 |
| Cho, H | 1 |
| Roh, EJ | 1 |
| Bi, J | 1 |
| Khan, A | 1 |
| Tang, J | 1 |
| Armando, AM | 1 |
| Wu, S | 1 |
| Zhang, W | 1 |
| Gimple, RC | 1 |
| Reed, A | 1 |
| Jing, H | 1 |
| Koga, T | 1 |
| Wong, IT | 1 |
| Gu, Y | 1 |
| Miki, S | 1 |
| Prager, B | 1 |
| Curtis, EJ | 1 |
| Wainwright, DA | 1 |
| Furnari, FB | 1 |
| Rich, JN | 1 |
| Cloughesy, TF | 1 |
| Kornblum, HI | 1 |
| Quehenberger, O | 1 |
| Rzhetsky, A | 1 |
| Cravatt, BF | 1 |
| Mischel, PS | 1 |
| Radin, DP | 1 |
| Purcell, R | 1 |
| Lippa, AS | 1 |
| Liu, KH | 1 |
| Yang, ST | 1 |
| Lin, YK | 1 |
| Lin, JW | 1 |
| Lee, YH | 1 |
| Wang, JY | 1 |
| Hu, CJ | 1 |
| Lin, EY | 1 |
| Chen, SM | 1 |
| Then, CK | 1 |
| Shen, SC | 1 |
| Bielecka, AM | 1 |
| Obuchowicz, E | 1 |
| de Paiva, TF | 1 |
| de Barros e Silva, MJ | 1 |
| Rinck, JA | 1 |
| Fanelli, MF | 1 |
| Gimenes, DL | 1 |
6 other studies available for fluoxetine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship | 2015 |
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; | 2021 |
Oncolytic Properties of Ampakines
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Fluoxetine; Glioblastoma; H | 2018 |
Fluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium-dependent apoptosis.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Brain Neoplasms; Calcium; Cell Surviva | 2015 |
Antidepressant drugs can modify cytotoxic action of temozolomide.
Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Division; | 2017 |
Tuberculosis in a patient on temozolomide: a case report.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Ant | 2009 |