Page last updated: 2024-09-27

Daytime Urinary Incontinence

Involuntary discharge of URINE during the daytime while one is awake.

Synonyms(3)

Synonym
Daytime Wetting
Diurnal Enuresis
Daytime Urinary Incontinence

Research Excerpts

Overview

ExcerptReference
"Daytime wetting is a common problem with various causes that can usually be identified through a careful history, thorough physical examination, and urinalysis."( Leung, AK; Robson, WL, 2006)

Treatment

ExcerptReference
"To investigate if children with daytime urinary incontinence (DUI) and overactive bladder (OAB) refractory to standard urotherapy and medicinal treatment, would experience improvement in symptoms after add-on treatment with transcutaneous electrical nerve stimulation (TENS)."( Breinbjerg, A; Hagstrøm, S; Kamperis, K; Pedersen, N; Rittig, S; Thorsteinsson, K, 2022)

Research

Studies (18)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's8 (44.44)18.1394
2010's8 (44.44)28.8240
2020's2 (11.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
caffeine0low10
fluoxetine0low10
gabapentin0low10
imipramine0low20
oxybutynin0low30
propiverine0low10
risperidone0low10
cyclohexanol0low10
thiazoles0low10
ephedrine0medium11
phenylpropanolamine0low10
s,n,n'-tripropylthiocarbamate0medium11
venlafaxine hydrochloride0low10
s200980low10
deamino arginine vasopressin0low60
mirabegron0low10
tolterodine tartrate0low10
technetium tc 99m dimercaptosuccinic acid0low10
olanzapine0low10
pyrimidinones0low10

Protein Targets (453)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
5-hydroxytryptamine receptor 3E0202
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma5005
SMAD family member 21001
Fumarate hydratase2002
USP1 protein, partial5005
PPM1D protein1001
SMAD family member 31001
TDP1 protein7007
GLI family zinc finger 38008
Microtubule-associated protein tau2002
AR protein6006
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor3003
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha6006
G5005
cytochrome P450 2D67007
polyprotein2002
67.9K protein2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
euchromatic histone-lysine N-methyltransferase 2100010
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)6006
lysosomal alpha-glucosidase preproprotein3003
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d5005
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 26006
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
geminin100010
peripheral myelin protein 226006
histone acetyltransferase KAT2A isoform 14004
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A3003
Solute carrier family 22 member 20303
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit4004
5-hydroxytryptamine receptor 3B0202
Bile salt export pump012012
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p535005
ATP-dependent translocase ABCB10204
Cytochrome P450 3A40405
5-hydroxytryptamine receptor 1A0448
5-hydroxytryptamine receptor 2C0909
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
D(2) dopamine receptor010111
5-hydroxytryptamine receptor 2A0909
Alpha-1B adrenergic receptor0707
Alpha-2C adrenergic receptor0707
D0404
5-hydroxytryptamine receptor 1A0707
Glutamate receptor 24004
Muscarinic acetylcholine receptor M3011011
D(1A) dopamine receptor0505
D(4) dopamine receptor0404
D(1B) dopamine receptor0101
Alpha-1D adrenergic receptor0808
Alpha-1D adrenergic receptor0707
5-hydroxytryptamine receptor 2A012012
5-hydroxytryptamine receptor 2C010010
D(4) dopamine receptor0303
Histamine H1 receptor0303
Sodium-dependent serotonin transporter013215
5-hydroxytryptamine receptor 7 0303
5-hydroxytryptamine receptor 70404
Alpha-1A adrenergic receptor0516
Histamine H1 receptor010111
Alpha-1B adrenergic receptor0303
D(3) dopamine receptor09110
5-hydroxytryptamine receptor 2B0909
Alpha-1A adrenergic receptor0808
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 60707
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0303
Spike glycoprotein8008
D(2) dopamine receptor0707
Inositol monophosphatase 13003
Potassium voltage-gated channel subfamily H member 20909
5-hydroxytryptamine receptor 3D0202
Multidrug and toxin extrusion protein 20303
5-hydroxytryptamine receptor 3C0202
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 1010010
Multidrug and toxin extrusion protein 10303
Histamine H3 receptor0303
cytochrome P450 2C9, partial5005
thioredoxin reductase6006
GLS protein5005
D(1A) dopamine receptor5005
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70101
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60101
Cytochrome P450 2B60002
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40103
Sodium-dependent noradrenaline transporter 012113
Sodium-dependent dopamine transporter0505
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C190304
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Sodium-dependent dopamine transporter 010111
Acetylcholine receptor subunit delta0101
ATP-dependent phosphofructokinase6006
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase1001
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 14004
thyroid hormone receptor beta isoform a3003
DNA polymerase beta1001
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)1001
Potassium channel subfamily K member 20112
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0202
Adenosine receptor A10304
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0012
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase2002
Chain A, Cruzipain1001
endonuclease IV1001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor 10101
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK11001
cytochrome P450 family 3 subfamily A polypeptide 44004
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
Histone H2A.x2002
estrogen receptor beta isoform 10101
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 12002
flap endonuclease 12002
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 82002
lamin isoform A-delta106006
Gamma-aminobutyric acid receptor subunit pi1203
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M40707
Muscarinic acetylcholine receptor M50909
Alpha-2A adrenergic receptor0707
Muscarinic acetylcholine receptor M108110
Gamma-aminobutyric acid receptor subunit beta-11203
Alpha-2B adrenergic receptor0808
Gamma-aminobutyric acid receptor subunit delta1203
Gamma-aminobutyric acid receptor subunit gamma-21214
Gamma-aminobutyric acid receptor subunit alpha-51203
Gamma-aminobutyric acid receptor subunit alpha-31203
Gamma-aminobutyric acid receptor subunit gamma-11203
Gamma-aminobutyric acid receptor subunit alpha-21203
Cruzipain0101
Gamma-aminobutyric acid receptor subunit alpha-41203
Gamma-aminobutyric acid receptor subunit gamma-31203
5-hydroxytryptamine receptor 1B0505
Gamma-aminobutyric acid receptor subunit alpha-61203
Mu-type opioid receptor0202
Gamma-aminobutyric acid receptor subunit alpha-11214
Gamma-aminobutyric acid receptor subunit beta-31203
Gamma-aminobutyric acid receptor subunit beta-21214
GABA theta subunit1203
Sigma non-opioid intracellular receptor 10606
Gamma-aminobutyric acid receptor subunit epsilon1203
aryl hydrocarbon receptor2002
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
caspase 7, apoptosis-related cysteine protease1001
regulator of G-protein signaling 44004
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor1001
caspase-31001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 12002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Sodium-dependent noradrenaline transporter0202
5-hydroxytryptamine receptor 40606
Albumin0022
Sodium channel protein type 1 subunit alpha0101
Cytochrome P450 2C80101
Cytochrome P450 2D60303
Cytochrome P450 2C9 0202
Angiotensin-converting enzyme0505
Dipeptidyl peptidase 40101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Alpha-2B adrenergic receptor0606
Acetylcholinesterase0101
Alpha-2C adrenergic receptor0606
Alpha-2A adrenergic receptor0606
Prostaglandin G/H synthase 10101
Potassium voltage-gated channel subfamily C member 10101
Gamma-aminobutyric acid receptor subunit beta-30213
5-hydroxytryptamine receptor 2B0808
Gamma-aminobutyric acid receptor subunit alpha-50213
Sodium-dependent serotonin transporter0404
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40213
D(1A) dopamine receptor2002
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Gamma-aminobutyric acid receptor subunit alpha-60213
Cytochrome P450 1B10101
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10202
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0202
Transporter0303
Nuclear receptor subfamily 3 group C member 3 0505
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Ataxin-22002
Gamma-aminobutyric acid receptor subunit gamma-30202
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0505
thioredoxin glutathione reductase1001
thyroid stimulating hormone receptor4004
Bloom syndrome protein isoform 13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
survival motor neuron protein isoform d2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial2002
Hsf1 protein0023
arylsulfatase A2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Snq2p0001
activating transcription factor 61001
cytochrome P450 2D6 isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Solute carrier family 22 member 30101
Major prion protein0011
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Muscarinic acetylcholine receptor M50101
Sphingomyelin phosphodiesterase0101
D(3) dopamine receptor0303
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor1102
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Envelope glycoprotein0011
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0101
Solute carrier family 22 member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Sodium channel protein type 2 subunit alpha0101
5-hydroxytryptamine receptor 3B0101
Sodium channel protein type 3 subunit alpha0101
Solute carrier family 22 member 20101
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
vitamin D3 receptor isoform VDRA1001
FAD-linked sulfhydryl oxidase ALR0001
Muscarinic acetylcholine receptor M20416
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Disintegrin and metalloproteinase domain-containing protein 171001
Amyloid-beta precursor protein0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
Mu-type opioid receptor0101
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Phenylethanolamine N-methyltransferase0001
Alpha-1B adrenergic receptor0101
Guanine nucleotide-binding protein G1001
Synaptic vesicle glycoprotein 2A0101
Smad31001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 1A0101
Melatonin receptor type 1A0213
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]