Page last updated: 2024-09-27

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Disorder characterized by symptoms of CATATONIA; HYPOVENTILATION; DYSKINESIAS; ENCEPHALITIS; and SEIZURES followed by a reduced CONSCIOUSNESS. It is often followed by a viral-like prodrome. Many cases are self-limiting and respond well to IMMUNOMODULATORY THERAPIES against the NMDA RECEPTORS antibodies.

Synonyms(9)

Synonym
Anti-NMDAR Encephalitis
Non-paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Paraneoplastic Anti-NMDAR Encephalitis
Paraneoplastic Anti-NMDA Receptor Encephalitis
Paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Non-paraneoplastic Anti-NMDA Receptor Encephalitis
Anti-NMDA Receptor Encephalitis
Non-paraneoplastic Anti-NMDAR Encephalitis
Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Research

Studies (213)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's136 (63.85)28.8240
2020's77 (36.15)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
glycine0low10
kynurenine0low10
nitrous oxide0low10
uric acid0low40
2-amino-5-phosphonovalerate0low10
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid0low20
phenytoin0low20
amantadine0low10
azathioprine0low20
benserazide0low10
clonazepam0low10
clonidine0low10
diazepam0low20
valproic acid0low50
fentanyl0low10
flumazenil0low20
fluoxetine0low10
glyphosate0low10
haloperidol0low10
hydroxychloroquine0low10
isoflurane0low10
ketamine0low10
lorazepam0low20
midazolam0low30
phenobarbital0low10
piracetam0low10
propofol0low60
risperidone0low10
sevoflurane0low20
trihexyphenidyl0low10
zolpidem0low20
prednisolone0low40
prednisone0low70
penicillin g0low10
pentylenetetrazole0low10
triiodothyronine0medium21
serine0low10
aspartic acid0low40
sucrose0low10
tetrabenazine0low10
levodopa0low10
leucine0low10
tryptophan0low20
methylprednisolone0low490
thiazoles0low10
methamphetamine0low10
n-methylaspartate0low130
bromocriptine0low10
glutamic acid0low40
tramadol0low40
etoposide0low10
atracurium0low10
remifentanil0low60
ziprasidone0low10
cisatracurium0low10
n-acetylaspartic acid0low20
fluorodeoxyglucose f180low220
d-aspartic acid0low30
homocysteine0low10
deoxyglucose0low10
ro 8-05760low10
methotrexate0low90
bortezomib0low130
carboplatin0low10
meropenem0low10
mycophenolic acid0low30
zithromax0low10
dimethyl fumarate0low10
methimazole0low10
methyl prednisolonate0low10
bilirubin0low10
coenzyme q100low10
levetiracetam0low30
topiramate0low10
dexmedetomidine0low20
dextromethorphan0low10
cysteine0low10
remimazolam0low40
rivaroxaban0low10
perampanel0low10
ro 16-01540low10
24-hydroxycholesterol0low10
ubiquinone0low10
quetiapine fumarate0low20
piperidines0low20
interleukin-80low10
exudates0low20
acyclovir0low110
clozapine0low10
ganciclovir0low10
olanzapine0low70
technetium tc 99m bicisate0low10
gq1b ganglioside0low10

Protein Targets (1,090)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE150015
euchromatic histone-lysine N-methyltransferase 2300030
Bloom syndrome protein isoform 1150015
peripheral myelin protein 22 isoform 17007
D(1A) dopamine receptor7007
lamin isoform A-delta10260026
Glutamate receptor 10729
Glutamate receptor ionotropic, NMDA 1 018325
Glutamate receptor ionotropic, kainate 30505
Glutamate receptor ionotropic, NMDA 2A 018325
Glutamate receptor ionotropic, NMDA 2B019326
Glutamate receptor ionotropic, NMDA 2C018325
Glutamate receptor ionotropic, NMDA 2D018325
Glutamate receptor ionotropic, NMDA 3B018325
Glutamate receptor ionotropic, NMDA 3A018325
ATP-dependent phosphofructokinase130013
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein9009
Chain B, HADH2 protein9009
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain8008
Thymidine kinase 0202
thioredoxin reductase200020
phosphopantetheinyl transferase150015
GLS protein160016
TDP1 protein310031
Smad33003
thyroid stimulating hormone receptor150015
EWS/FLI fusion protein170017
arylsulfatase A150015
activating transcription factor 66006
Histone H2A.x100010
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
Solute carrier family 22 member 1 09013
ATP-binding cassette sub-family C member 3026026
Multidrug resistance-associated protein 4026027
Solute carrier family 22 member 60102
Bile salt export pump0707
Bile salt export pump034034
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20002
Cytochrome P450 2C9 09010
Cytochrome P450 2J20607
Disintegrin and metalloproteinase domain-containing protein 172002
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60004
Thymidine kinase 0101
Solute carrier family 22 member 80204
Canalicular multispecific organic anion transporter 1026027
Thymidine kinase0101
chromobox protein homolog 1140014
flap endonuclease 18008
Glutamate receptor ionotropic, NMDA 2D0606
Glutamate receptor ionotropic, NMDA 3B0606
Integrin beta-31113
Integrin alpha-IIb1113
Glutamate receptor 2126220
Glutamate receptor 30628
Glutamate receptor 40628
Glutamate receptor ionotropic, kainate 10516
Glutamate receptor 10112
Glutamate receptor 20101
Glutamate receptor ionotropic, kainate 10314
Glutamate receptor ionotropic, kainate 20516
Glutamate receptor 10527
Glutamate receptor 20426
Glutamate receptor 30314
Excitatory amino acid transporter 10506
Excitatory amino acid transporter 20405
Excitatory amino acid transporter 30405
Glutamate receptor 40415
Glutamate receptor ionotropic, kainate 40404
Glutamate receptor ionotropic, NMDA 10808
Glutamate receptor ionotropic, NMDA 2A0808
Glutamate receptor ionotropic, kainate 20314
Glutamate receptor ionotropic, kainate 30202
Glutamate receptor ionotropic, NMDA 2B0808
Glutamate receptor ionotropic, NMDA 2C0606
Glutamate receptor ionotropic, kainate 40101
Glutamate receptor ionotropic, kainate 50202
Glutamate receptor ionotropic, kainate 50404
Glutamate receptor ionotropic, NMDA 3A0606
Glutamate receptor 40101
Glutamate receptor 30101
acetylcholinesterase100010
RAR-related orphan receptor gamma140014
NFKB1 protein, partial4004
GLI family zinc finger 3210021
AR protein310031
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 4120012
estrogen nuclear receptor alpha310031
putative alpha-glucosidase1001
thyroid hormone receptor beta isoform 2220022
heat shock protein beta-17007
peripheral myelin protein 22190019
histone acetyltransferase KAT2A isoform 17007
Solute carrier family 22 member 20305
Matrix protein 20112
Matrix protein 20123
Spike glycoprotein110213
Solute carrier family 22 member 10202
Multidrug and toxin extrusion protein 10404
Solute carrier family 22 member 20101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE9009
aldehyde dehydrogenase 1 family, member A1120012
cytochrome P450 2C19 precursor7007
lethal factor (plasmid)6006
Metabotropic glutamate receptor 60135
Excitatory amino acid transporter 40202
Glutamate transporter homolog0022
Carbonic anhydrase 10409
Carbonic anhydrase 205313
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Metabotropic glutamate receptor 10135
Metabotropic glutamate receptor 20135
Carbonic anhydrase-like protein, putative0004
Carbonic anhydrase 40203
NPYLR7B0011
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
interleukin 82002
SMAD family member 25005
ATAD5 protein, partial9009
Fumarate hydratase8008
SMAD family member 35005
Microtubule-associated protein tau100010
thioredoxin glutathione reductase4004
nuclear receptor subfamily 1, group I, member 3200020
glucocorticoid receptor [Homo sapiens]200020
retinoic acid nuclear receptor alpha variant 1190019
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha260026
farnesoid X nuclear receptor130013
pregnane X nuclear receptor220022
G150015
polyprotein8008
P531001
peroxisome proliferator-activated receptor delta140014
peroxisome proliferator activated receptor gamma140014
IDH15005
aryl hydrocarbon receptor110011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a180018
thyroid stimulating hormone receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)100010
cellular tumor antigen p53 isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 1190019
DNA polymerase iota isoform a (long)100010
geminin220022
survival motor neuron protein isoform d8008
cytochrome P450 3A4 isoform 19009
M-phase phosphoprotein 87007
muscleblind-like protein 1 isoform 15005
muscarinic acetylcholine receptor M1120012
Gamma-aminobutyric acid receptor subunit pi913325
Voltage-dependent calcium channel gamma-2 subunit120012
Interferon beta180018
HLA class I histocompatibility antigen, B alpha chain 150015
Cellular tumor antigen p53190019
Gamma-aminobutyric acid receptor subunit beta-1913325
Gamma-aminobutyric acid receptor subunit delta913325
Gamma-aminobutyric acid receptor subunit gamma-2913426
Gamma-aminobutyric acid receptor subunit alpha-5913325
Gamma-aminobutyric acid receptor subunit alpha-3913325
Gamma-aminobutyric acid receptor subunit gamma-1913325
Gamma-aminobutyric acid receptor subunit alpha-2913325
Gamma-aminobutyric acid receptor subunit alpha-4913325
Gamma-aminobutyric acid receptor subunit gamma-3913325
Gamma-aminobutyric acid receptor subunit alpha-6913325
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-1913426
Gamma-aminobutyric acid receptor subunit beta-3913325
Gamma-aminobutyric acid receptor subunit beta-2913426
GABA theta subunit913325
Inositol hexakisphosphate kinase 1150015
ATPase family AAA domain-containing protein 5160016
Ataxin-2180018
Gamma-aminobutyric acid receptor subunit epsilon913325
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial150015
vitamin D3 receptor isoform VDRA9009
serine/threonine-protein kinase mTOR isoform 16006
Zinc finger protein mex-50011
POsterior Segregation0011
Genome polyprotein0101
Replicase polyprotein 1ab0628
D(1A) dopamine receptor3104
Hexokinase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, 2-oxoglutarate Oxygenase9009
Chain A, Cruzipain3003
USP1 protein, partial5005
DNA polymerase kappa isoform 18008
caspase-1 isoform alpha precursor2002
Caspase-72002
Inositol monophosphatase 15005
Solute carrier organic anion transporter family member 1B30609
Solute carrier organic anion transporter family member 1B10406
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
PPM1D protein3003
caspase 7, apoptosis-related cysteine protease6006
estrogen receptor 2 (ER beta)110011
progesterone receptor180018
cytochrome P450 family 3 subfamily A polypeptide 4180018
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
caspase-36006
nuclear receptor subfamily 1, group I, member 25005
Caspase-72002
caspase-32002
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30404
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120205
Prothrombin0225
Chymotrypsinogen A0101
Carbonic anhydrase 30204
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40205
Carbonic anhydrase 60205
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0216
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70205
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10202
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10404
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90317
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130202
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20404
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150204
Histone deacetylase 80404
Histone deacetylase 60404
Carbonic anhydrase 140205
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0205
Genome polyprotein 0213
dopamine D1 receptor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
5-hydroxytryptamine receptor 4014014
ATP-dependent translocase ABCB10404
ATP-dependent translocase ABCB1010016
Beta-1 adrenergic receptor0202
Cytochrome P450 3A4014017
5-hydroxytryptamine receptor 1A09312
Alpha-2A adrenergic receptor016218
D(2) dopamine receptor013221
Androgen receptor0505
Alpha-2B adrenergic receptor016117
Alpha-2C adrenergic receptor015217
D0909
D(3) dopamine receptor0808
5-hydroxytryptamine receptor 1A015116
Alpha-2B adrenergic receptor011112
ATP-dependent translocase ABCB10404
D(1A) dopamine receptor011013
Alpha-2C adrenergic receptor011112
Alpha-2A adrenergic receptor011112
Alpha-1D adrenergic receptor017118
D(1B) dopamine receptor0606
5-hydroxytryptamine receptor 2A014118
5-hydroxytryptamine receptor 2C015217
5-hydroxytryptamine receptor 1B0909
D(4) dopamine receptor0707
D(3) dopamine receptor012117
Alpha-synuclein2103
5-hydroxytryptamine receptor 2B013114
5-hydroxytryptamine receptor 6011012
D(2) dopamine receptor013114
cytochrome P450 2D6100010
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Gamma-aminobutyric acid receptor subunit pi0909
Gamma-aminobutyric acid receptor subunit delta0909
Gamma-aminobutyric acid receptor subunit alpha-10506
Gamma-aminobutyric acid receptor subunit beta-10506
Neuronal acetylcholine receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit alpha-20506
Gamma-aminobutyric acid receptor subunit alpha-30506
Neuronal acetylcholine receptor subunit beta-20303
Gamma-aminobutyric acid receptor subunit alpha-1011617
Gamma-aminobutyric acid receptor subunit beta-1010212
Gamma-aminobutyric acid receptor subunit gamma-2011516
Gamma-aminobutyric acid receptor subunit alpha-40506
Gamma-aminobutyric acid receptor subunit gamma-20506
Gamma-aminobutyric acid receptor subunit beta-3011415
Translocator protein0202
Translocator protein0303
Cholecystokinin receptor type A0202
Gastrin/cholecystokinin type B receptor0202
Gamma-aminobutyric acid receptor subunit alpha-5010616
Gamma-aminobutyric acid receptor subunit alpha-3010515
Gamma-aminobutyric acid receptor subunit alpha-2010414
Gamma-aminobutyric acid receptor subunit beta-2010414
Gamma-aminobutyric acid receptor subunit alpha-4010212
Gamma-aminobutyric acid receptor subunit epsilon0909
Gamma-aminobutyric acid receptor subunit alpha-6010212
Gamma-aminobutyric acid receptor subunit gamma-10909
Gamma-aminobutyric acid receptor subunit gamma-30909
Gamma-aminobutyric acid receptor subunit theta0909
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
Beta-1 adrenergic receptor 0112
Alpha-1B adrenergic receptor 0022
cytochrome P450 2D6 isoform 17007
cytochrome P450 2C9 precursor5005
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0112
Solute carrier family 22 member 30303
Alpha-1B adrenergic receptor013114
Alpha-1A adrenergic receptor0022
Amine oxidase [flavin-containing] A0202
Alpha-1D adrenergic receptor013114
Amine oxidase [flavin-containing] B0202
Adenosine receptor A2b0011
Adenosine receptor A2a0012
Alpha-2B adrenergic receptor0001
Delta-type opioid receptor0404
Alpha-1A adrenergic receptor0819
Alpha-1B adrenergic receptor0718
Alpha-1A adrenergic receptor013215
Histamine H2 receptor5006
5-hydroxytryptamine receptor 70303
Mu-type opioid receptor0404
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Nischarin0101
Chain A, JmjC domain-containing histone demethylation protein 3A6006
5-hydroxytryptamine receptor 3E0303
Luciferase7007
hypoxia-inducible factor 1 alpha subunit6006
glucocerebrosidase3003
bromodomain adjacent to zinc finger domain 2B5005
Adenylate cyclase type 1 0202
potassium voltage-gated channel subfamily H member 2 isoform d9009
DNA polymerase beta3003
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor3003
nuclear receptor ROR-gamma isoform 1100010
short transient receptor potential channel 6 isoform 10011
transient receptor potential cation channel subfamily V member 12002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1F0505
5-hydroxytryptamine receptor 3B0303
Albumin0055
Aldo-keto reductase family 1 member B10909
Muscarinic acetylcholine receptor M2010111
Muscarinic acetylcholine receptor M4010111
Muscarinic acetylcholine receptor M10404
Muscarinic acetylcholine receptor M30404
Muscarinic acetylcholine receptor M40404
5-hydroxytryptamine receptor 2C011012
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M5013013
Calmodulin-10101
Beta-2 adrenergic receptor0404
Cytochrome P450 2D60507
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M1012214
Angiotensin-converting enzyme0808
5-hydroxytryptamine receptor 2A012012
Beta-1 adrenergic receptor0303
D(2) dopamine receptor0404
Muscarinic acetylcholine receptor M3013114
Endothelin receptor type B0101
D(4) dopamine receptor09114
D(1B) dopamine receptor0305
Adenylate cyclase type 30202
UDP-glucuronosyltransferase 1A40104
Sodium-dependent noradrenaline transporter 09211
Sodium-dependent dopamine transporter0718
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Histamine H2 receptor0606
Adenosine receptor A10304
Beta-3 adrenergic receptor0202
Adenylate cyclase type 20202
Adenylate cyclase type 40202
5-hydroxytryptamine receptor 1D0303
5-hydroxytryptamine receptor 1F0303
5-hydroxytryptamine receptor 2B010111
Histamine H1 receptor0314
Histamine H1 receptor0404
Sodium-dependent serotonin transporter012315
Sodium-dependent serotonin transporter0505
5-hydroxytryptamine receptor 7 0303
Cytochrome P450 2C190304
5-hydroxytryptamine receptor 2C 0303
5-hydroxytryptamine receptor 70505
5-hydroxytryptamine receptor 2A0303
Histamine H1 receptor010316
5-hydroxytryptamine receptor 3A0101
Adenylate cyclase type 80202
5-hydroxytryptamine receptor 3A0303
5-hydroxytryptamine receptor 5A0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0404
D(2) dopamine receptor0202
D(3) dopamine receptor0202
Gastrin/cholecystokinin type B receptor0202
D(2) dopamine receptor0202
Calmodulin 0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0505
Sodium-dependent dopamine transporter 0314
5-hydroxytryptamine receptor 2B0303
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Potassium voltage-gated channel subfamily H member 2016016
5-hydroxytryptamine receptor 40202
Voltage-dependent L-type calcium channel subunit alpha-1S0505
Voltage-dependent L-type calcium channel subunit alpha-1C0505
Transporter0606
Cholecystokinin receptor type A0202
5-hydroxytryptamine receptor 1A0202
Nuclear receptor subfamily 3 group C member 3 0707
5-hydroxytryptamine receptor 3D0303
Adenylyl cyclase 7 0202
5-hydroxytryptamine receptor 3C0303
D0303
Sigma non-opioid intracellular receptor 1012012
Histamine H4 receptor0112
5-hydroxytryptamine receptor 3B0101
Sigma non-opioid intracellular receptor 10606
Transporter0404
Histamine H3 receptor0303
Neuronal acetylcholine receptor subunit alpha-30202
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Neuronal acetylcholine receptor subunit beta-40202
Cytochrome P450 2D30101
Taste receptor type 2 member 460011
Sigma non-opioid intracellular receptor 109110
Cytochrome P450 2D40101
Gamma-aminobutyric acid 0213
glp-1 receptor, partial9009
Fatty acid-binding protein, liver0303
Alpha-1-acid glycoprotein 10001
Albumin0027
Translocator protein0315
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit delta0213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit gamma-30213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-30213
Neuronal acetylcholine receptor subunit alpha-70404
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit pi0213
Sphingosine-1-phosphate lyase 10202
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit theta0213
Gamma-aminobutyric acid receptor subunit gamma-10213
Kelch-like ECH-associated protein 10011
Nuclear factor erythroid 2-related factor 20011
67.9K protein5005
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
nuclear factor erythroid 2-related factor 2 isoform 28008
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0202
Regulatory protein E20011
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Polyunsaturated fatty acid lipoxygenase ALOX150404
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0204
Serum paraoxonase/arylesterase 10101
Caspase-30101
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Nuclear receptor subfamily 1 group I member 20033
Delta-type opioid receptor0505
Mu-type opioid receptor0617
Kappa-type opioid receptor0303
Mu-type opioid receptor07310
Delta-type opioid receptor0303
Kappa-type opioid receptor0304
Kappa-type opioid receptor0505
Mu-type opioid receptor0101
endonuclease IV3003
TAR DNA-binding protein 436006
NPC intracellular cholesterol transporter 1 precursor1001
huntingtin isoform 22002
ras-related protein Rab-9A1001
Sodium-dependent noradrenaline transporter0101
Potassium channel subfamily K member 20202
Cytochrome P450 2C80202
Dipeptidyl peptidase 40101
Acetylcholinesterase0101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10202
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Cytochrome P450 1B10101
Sigma intracellular receptor 20202
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0023
thyroid hormone receptor beta isoform a4004
transcriptional regulator ERG isoform 35005
neuropeptide S receptor isoform A3003
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Histone deacetylase 40303
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10405
Histone deacetylase 70303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
ClpP2002
Transitional endoplasmic reticulum ATPase0101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Metabotropic glutamate receptor 50113
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate carboxypeptidase 20101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glycine receptor subunit alpha-10022
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10404
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
15-lipoxygenase, partial3003
Thrombopoietin1001
nonstructural protein 12002
Cocaine esterase0202
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
UDP-glucuronosyltransferase 1A90105
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70305
C-8 sterol isomerase0101
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 4 subunit alpha0304
5-hydroxytryptamine receptor 2A0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Sodium channel protein type 7 subunit alpha0101
Sodium channel protein type 5 subunit alpha0303
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20202
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Protease 0529
Sodium channel protein type 2 subunit alpha0303
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Spike glycoprotein0022
Replicase polyprotein 1ab0022
Transmembrane protease serine 20022
Procathepsin L0022
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0224
Cyclic GMP-AMP synthase0101
Angiotensin-converting enzyme 2 0022
Toll-like receptor 90101
Toll-like receptor 70101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
Acetylcholinesterase0303
Rap guanine nucleotide exchange factor 31001
Cholinesterase0303
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Phospholipase A-2-activating protein0202
chaperonin-containing TCP-1 beta subunit homolog1001
Synaptic vesicle glycoprotein 2A0202
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA12002
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 13003
snurportin-13003
DNA polymerase eta isoform 12002
Polyphenol oxidase 20204
Epidermal growth factor receptor0101
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Tyrosinase0101
Carbonic anhydrase0103
Solute carrier family 15 member 10202
Carbonic anhydrase0103
SLC16A10 protein0002
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0103
Monocarboxylate transporter 100002
Carbonic anhydrase 130104
phosphoglycerate kinase1001
Chain A, protease0101
Chain B, protease0101
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, PROTEASE RETROPEPSIN0101
Chain B, PROTEASE RETROPEPSIN0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
CAAX prenyl protease 1 homolog0101
Plasmepsin V 0202
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Protease 0437
Neuronal acetylcholine receptor subunit alpha-60101
Beta-lactamase 0002
Beta-lactamase 0002
Metallo-beta-lactamase type 20013
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0002
Metallo-beta-lactamase0002
streptokinase A precursor0033
Beta-lactamase0002
Beta-lactamase SHV-10002
Beta-lactamase0002
Beta-lactamase TEM0103
B2 metallo-beta-lactamase 0002
Metallo-beta-lactamase VIM-130002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Beta-lactamase 0002
Metallo-beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0002
Beta-lactamase 0013
Metallo-b-lactamase 0002
Beta-lactamase IMP-1 0002
BlaVIM-1 0002
Beta-lactamase 0002
Carbapenem-hydrolyzing beta-lactamase KPC0002
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0013
Beta-lactamase 0002
Beta-lactamase VIM-1 0002
Solute carrier family 22 member 30101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Synaptic vesicular amine transporter0314
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0203
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
UDP-glucuronosyltransferase 1-60102
UDP-glucuronosyltransferase 2B10 0101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Inosine-5'-monophosphate dehydrogenase 20202
Inosine-5'-monophosphate dehydrogenase 1 0202
Peroxisome proliferator-activated receptor gamma0033
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80002
Rap guanine nucleotide exchange factor 41001
lysosomal alpha-glucosidase preproprotein1001
FAD-linked sulfhydryl oxidase ALR0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Guanine nucleotide-binding protein G2002
Beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Aldo-keto reductase family 1 member B10101
Chain A, Beta-lactamase2002
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0303
Glutamine synthetase0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Multidrug and toxin extrusion protein 20202
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, Endothiapepsin0101
Chain A, Endothiapepsin0101
Solute carrier organic anion transporter family member 2B1 0202
Gag-Pol polyprotein0101
Cytochrome P450 1A20101
Cytochrome P450 3A50101
Substance-K receptor0202
Thromboxane-A synthase 0101
Vasopressin V1a receptor0202
Thromboxane-A synthase0001
Sodium/bile acid cotransporter0101
Chain A, Activated Factor Xa Heavy Chain0101
Coagulation factor X0202
Coagulation factor XII0101
Suppressor of tumorigenicity 14 protein0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase 0101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40102
Solute carrier organic anion transporter family member 1A50001
Transthyretin0001
Thyroid hormone receptor alpha0224
Thyroid hormone receptor beta0224
Proliferating cell nuclear antigen0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Myeloperoxidase0101
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Aspartate aminotransferase, cytoplasmic0101
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]