Lysosomal Enzyme Disorders

Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.

Synonym
Lysosomal Enzyme Disorders
Lysosomal Storage Diseases

Excerpt	Reference
"Over 40 lysosomal storage diseases are known and they have a collective incidence of approximately 1 in 7000-8000 live births."	( Vellodi, A; Winchester, B; Young, E, 2000)
"Lysosomal storage diseases are rare and coexistence of more than one in a family can present a diagnostic challenge as illustrated by this study."	( Cooper, A; Forsyth, JM; Guy, R; Morton, RE, 2001)
"Glycosphingolipid lysosomal storage diseases are a small but challenging group of human disorders to treat."	( Butters, TD; Dwek, RA; Platt, FM, 2003)
"Lysosomal storage diseases are clinically heterogeneous with respect to their age of onset, progression of symptoms and the particular organs involved."	( Gieselmann, V, 2005)
"The glycolipid lysosomal storage diseases are a collection of rare, inherited disorders of metabolism associated with heterogeneous pathologies and reduced life expectancy."	( Butters, TD, 2007)
"Lysosomal storage diseases are a group of disorders caused by defects in enzymes responsible for degradation of particular compounds in lysosomes."	( Jakóbkiewicz-Banecka, J; Wegrzyn, A; Wegrzyn, G, 2007)
"Lysosomal storage diseases are a group of disorders where accumulation of catabolites is manifested in the lysosomes of different cell types."	( Blomqvist, M; Gieselmann, V; Månsson, JE, 2011)
"Most lysosomal storage diseases are caused by defects in genes encoding for acidic hydrolases."	( Balducci, C; Beccari, T; Duvet, S; Franken, S; Gieselmann, V; Hartmann, D; Klein, K; Lecointe, K; Matzner, U; Paciotti, S; Persichetti, E; Roberti, R, 2012)
"Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells."	( Baranova, E; Callewaert, N; De Visscher, C; Fudalej, F; Geysens, S; Hulpiau, P; Nerinckx, W; Piens, K; Pynaert, G; Remaut, H; Stout, J; Tännler, S; Tiels, P; Valevska, A; Van Hecke, A; Vervecken, W, 2012)
"Lysosomal storage diseases are chronic, progressive and typically have a devastating impact on the patient and the family."	( Brzozka, Z; Kutter, JP; Kwapiszewska, K; Kwapiszewski, R, 2015)

Excerpt	Reference
"Glycosphingolipid lysosomal storage diseases are a small but challenging group of human disorders to treat."	( Butters, TD; Dwek, RA; Platt, FM, 2003)
"The therapeutic options for lysosomal storage diseases (LSDs) have expanded greatly over the past decade, although for many disorders there is still no effective treatment."	( Jeyakumar, M; Platt, FM, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (1.02)	23.3326
1990's	116 (29.67)	12.5806
2000's	97 (24.81)	18.1394
2010's	133 (34.02)	28.8240
2020's	41 (10.49)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	1	0
quinacrine	low	2	0
carbamates	low	1	0
carnitine	low	3	0
chlorine	low	3	0
coumarin	low	1	0
lactic acid	low	2	0
dimethyl sulfoxide	low	2	0
glycine	low	3	0
iodine	low	1	0
pyridine	low	1	0
trimethyloxamine	low	1	0
urea	low	1	0
1-anilino-8-naphthalenesulfonate	low	4	0
acetyl-dl-leucine	low	1	0
ambroxol	low	2	0
amiodarone	low	4	0
amitriptyline	low	1	0
amlexanox	low	1	0
antipyrine	low	1	0
azathioprine	low	2	0
busulfan	medium	4	1
chlorcyclizine	low	1	0
chloroquine	low	5	0
chlorpromazine	low	1	0
citalopram	low	1	0
clomipramine	low	2	0
clonidine	low	1	0
diazepam	low	1	0
valproic acid	low	2	0
ethylenediamine	low	1	0
fluoxetine	low	1	0
gentamicin	low	2	0
haloperidol	low	1	0
hydroxychloroquine	low	4	0
hydroxyurea	low	1	0
hydroxyzine	low	1	0
lidocaine	low	1	0
imipramine	low	3	0
lauric acid	low	1	0
maprotiline	low	1	0
edaravone	low	1	0
meclizine	low	1	0
perhexiline	low	1	0
phenobarbital	low	1	0
prilocaine	low	1	0
promazine	low	1	0
propranolol	low	1	0
suramin	low	3	0
tilorone	low	3	0
thyroxine	low	1	0
prednisone	low	3	0
alanine	low	2	0
serine	low	2	0
chloramphenicol	low	1	0
lysine	low	1	0
sucrose	low	4	0
adenosine diphosphate	low	2	0
galactose	low	4	0
tyrosine	low	1	0
cysteamine	low	4	0
leucine	low	4	0
colchicine	low	2	0
mannitol	low	1	0
asparagine	low	1	0
histidine	low	1	0
arginine	low	2	0
methylamine	low	2	0
trichloroacetic acid	low	1	0
dichloroacetic acid	low	1	0
cyclizine	low	1	0
xanthenes	low	1	0
pyridostigmine bromide	low	1	0
pyrroles	low	2	0
isobutylene	low	1	0
acridines	low	1	0
hydrazine	low	1	0
betamethasone	low	1	0
chlorphentermine	low	1	0
alpha-aminopyridine	low	1	0
acetylcysteine	low	1	0
erythromycin	low	1	0
durapatite	low	1	0
sodium hydroxide	low	1	0
d-alpha tocopherol	low	1	0
glycidyl trimethylammonium chloride	low	1	0
fluorescein-5-isothiocyanate	low	2	0
mannose	low	3	0
streptomycin	low	1	0
vidarabine	low	1	0
iprindole	low	1	0
mercury	low	1	0
gold	low	1	0
acetylglucosamine	low	36	0
galactose	low	2	0
4-chloro-7-nitrobenzofurazan	low	1	0
trolamine salicylate	low	2	0
1-deoxynojirimycin	low	20	0
daunorubicin	low	2	0
alkenes	low	1	0
s-adenosylmethionine	low	2	0
acetylgalactosamine	low	2	0
amikacin	low	1	0
diltiazem	low	1	0
1-methyl-4-phenylpyridinium	low	1	0
colforsin	low	1	0
miglustat	low	17	0
swainsonine	low	3	0
castanospermine	low	1	0
simvastatin	low	1	0
trospectomycin	low	1	0
adenosine	low	1	0
acridine orange	low	1	0
bts 54 524	low	1	0
fluorodeoxyglucose f18	low	1	0
leupeptin	low	2	0
n-formylglycine	low	1	0
7-ketocholesterol	low	1	0
glucuronic acid	low	1	0
n-tert-butylhydroxylamine	low	1	0
lobeline	low	1	0
desethylamiodarone	low	1	0
1-phenyl-2-decanoylamino-3-morpholino-1-propanol	low	1	0
benzyl-alpha-n-acetylgalactosamine	low	1	0
2-acetamido-1,5-imino-1,2,5-trideoxy-d-glucitol	low	1	0
celastrol	low	1	0
n-acetylglucosaminylasparagine	low	31	0
naadp	low	2	0
e 64	low	1	0
1,2,3,4-tetrahydroxy-nor-tropane	low	1	0
methotrexate	low	2	0
kifunensine	low	1	0
cl 246738	low	1	0
proline	low	1	0
5-diazo-4-oxonorvaline	low	1	0
hydroxyl radical	low	1	0
homonojirimycin	low	1	0
3,6-bis(2-(diethylamino)ethoxy)acridine	low	1	0
migalastat	low	3	0
taurochenodeoxycholic acid	low	1	0
leupeptins	low	3	0
glycogen	low	7	0
n-acetylneuraminic acid	low	31	0
mannose-6-phosphate	low	14	0
bradykinin	low	1	0
glucosamine	low	2	0
elastin	low	2	0
tartaric acid	low	1	0
c(alpha)-formylglycine	low	1	0
betadex	low	1	0
tretinoin	low	1	0
cocaine	low	1	0
keratan sulfate	low	1	0
isofagomine	low	3	0
texas red	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
n-nonyl-1-deoxynojirimycin	low	1	0
cholestane-3,5,6-triol	low	1	0
glycosides	low	1	0
malonyl coenzyme a	low	1	0
fludarabine	low	1	0
4-(benzenesulfonamido)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide	low	1	0
fumonisin b1	low	1	0
tamoxifen	low	2	0
nadp	low	2	0
krn 7000	low	1	0
dermatan sulfate	low	1	0
cystine	low	3	0
sch 23390	low	1	0
safingol	low	1	0
sodium borohydride	low	1	0
myelin basic protein	low	1	0
N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide	low	1	0
sphingosine	low	7	0
psychosine	low	5	0
hymecromone	low	2	0
genistein	low	6	0
amphotericin b	low	1	0
daidzein	low	1	0
ellagic acid	low	1	0
coenzyme q10	low	1	0
1-monooleoyl-rac-glycerol	low	1	0
sirolimus	low	1	0
n-acetylglucosamine thiazoline	low	1	0
oregon green 488 carboxylic acid	low	1	0
lysophosphatidylglycerol	low	1	0
su 5402	low	1	0
lysophosphatidylcholines	low	1	0
turanose	low	1	0
cysteine	low	8	0
n-acetylsphingosine	low	1	0
isoglobotrihexosylceramide	low	1	0
n-caproylsphingosine	low	1	0
dolichols	low	2	0
bafilomycin a1	low	2	0
sphingosyl beta-glucoside	low	1	0
globotriaosyl lysosphingolipid	low	1	0
cdw17 antigen	low	2	0
i(3)so3-galactosylceramide	low	9	0
beta-escin	low	1	0
lactacystin	low	1	0
gadolinium dtpa	low	1	0
rebaudioside a	low	1	0
staurosporine	low	1	0
n-octyl-beta-valienamine	low	1	0
ursodoxicoltaurine	low	1	0
flag peptide	low	1	0
ogt2378	medium	1	1
g(m2) ganglioside	low	10	0
gentamicin sulfate	low	1	0
psd 502	low	1	0
u 18666a	low	2	0
g(m1) ganglioside	low	5	0
alpha-synuclein	low	8	0
oxadiazoles	low	1	0
ptc 124	low	1	0
acid phosphatase	low	4	0
nad	low	1	0
glucagon	low	1	0
oligonucleotides	low	1	0
oritavancin	low	1	0
cellulose	low	1	0
endothelin-1	low	2	0
phosphatidylcholines	low	2	0
dihydroceramide	low	1	0
ubiquinone	low	1	0
5'-deoxy-5'-phosphonomethyladenosine phosphate	low	2	0
eliglustat	low	1	0
psychosine-3'-sulfate ester	low	2	0
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	low	3	0
neurotensin	low	1	0
glycolipids	low	31	0
piperidines	medium	2	1
galactocerebroside	low	1	0
interleukin-8	low	1	0
hydroxocobalamin	low	1	0
eliglustat tartrate	low	3	0
heparitin sulfate	low	3	0
minocycline	low	1	0
warfarin	low	1	0
transforming growth factor beta	low	1	0
phytoestrogens	low	1	0
globotriaosylceramide	low	3	0
g(m3) ganglioside	low	3	0
vitamin b 12	low	2	0
cyclosporine	low	3	0
muramidase	low	2	0
chondroitin sulfates	low	1	0
clozapine	low	1	0
cytarabine	low	1	0
cytidylyl-3'-5'-guanosine	low	1	0
eye	low	1	0
metallothionein	low	2	0
leptin	low	1	0

Protein Targets (1,860)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	5	0	0	5
thioredoxin reductase	30	0	0	30
USP1 protein, partial	27	0	0	27
TDP1 protein	51	0	0	51
vitamin D3 receptor isoform VDRA	18	0	0	18
importin subunit beta-1 isoform 1	6	0	0	6
flap endonuclease 1	15	0	0	15
serine/threonine-protein kinase PLK1	6	0	0	6
snurportin-1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	16	0	0	16
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	41	0	0	41
DNA polymerase kappa isoform 1	17	0	0	17
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	4	2	7
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	2	0	2
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	2	3	5
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	1	2
Mitogen-activated protein kinase 14	0	2	1	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	22	0	0	22
glucocerebrosidase	20	0	0	20
Alpha-mannosidase	0	2	0	2
alpha-galactosidase	10	0	0	10
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	8	0	0	8
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	6	0	6
Trehalase	0	3	0	3
Lysosomal acid glucosylceramidase	0	16	1	19
Alpha-galactosidase A	0	2	0	2
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	3	0	3
Lysosomal alpha-glucosidase	0	6	0	6
Beta-glucosidase A	0	2	0	2
Sucrase-isomaltase, intestinal	0	3	0	3
Alpha-1B adrenergic receptor	0	22	2	24
Sucrase-isomaltase, intestinal	0	4	0	4
Alpha-1D adrenergic receptor	0	17	2	19
Beta-glucosidase	0	2	0	2
Protein-lysine 6-oxidase	0	7	0	7
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	3	0	3
Glycogen debranching enzyme	0	3	0	3
Alpha-glucosidase MAL32	0	2	0	2
Alpha-1A adrenergic receptor	0	24	3	27
Oligo-1,6-glucosidase IMA1	0	2	0	2
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	2	0	2
Spike glycoprotein	22	2	6	30
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	2	0	2
Lactase-phlorizin hydrolase	0	4	0	4
Oxysterols receptor LXR-alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	3	0	3
Lysosomal acid glucosylceramidase	0	2	0	2
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	3	0	3
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	7	0	7
Putative alpha-glucosidase	0	2	0	2
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	12	0	15
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 3	0	5	0	6
Solute carrier family 22 member 3	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Sodium-dependent serotonin transporter	0	29	3	32
Solute carrier family 22 member 1	0	3	0	4
Solute carrier family 22 member 2	0	2	0	3
Diacylglycerol kinase alpha	0	1	0	1
Protein O-GlcNAcase	0	2	0	2
Beta-hexosaminidase subunit alpha	0	2	0	2
Beta-hexosaminidase subunit beta	0	2	0	2
Beta-N-acetylhexosaminidase	0	1	0	1
Chain A, Glucosylceramidase	3	0	0	3
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
ClpP	2	0	0	2
ATAD5 protein, partial	17	0	0	17
STE24	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
CAAX prenyl protease 2 isoform 2	0	0	0	1
chromobox protein homolog 1	32	0	0	32
Trypsin	0	1	0	2
Alpha-synuclein	4	1	0	5
Fatty-acid amide hydrolase 1	3	0	0	3
NPYLR7B	0	0	3	3
Replicase polyprotein 1ab	0	4	6	10
Rap guanine nucleotide exchange factor 3	10	0	0	10
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
acetylcholinesterase	16	0	0	16
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	9	0	0	9
pregnane X receptor	8	0	0	8
phosphopantetheinyl transferase	16	0	0	16
RAR-related orphan receptor gamma	33	0	0	33
NFKB1 protein, partial	9	0	0	9
Microtubule-associated protein tau	20	0	0	20
Thrombopoietin	10	0	0	10
AR protein	48	0	0	48
regulator of G-protein signaling 4	19	0	0	19
glucocorticoid receptor [Homo sapiens]	38	0	0	38
retinoic acid nuclear receptor alpha variant 1	39	0	0	39
retinoid X nuclear receptor alpha	34	0	0	34
farnesoid X nuclear receptor	24	0	0	24
estrogen nuclear receptor alpha	58	0	0	58
vitamin D (1,25- dihydroxyvitamin D3) receptor	28	0	0	28
arylsulfatase A	14	0	0	14
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	17	0	0	17
thyroid hormone receptor beta isoform a	18	0	0	18
thyroid hormone receptor beta isoform 2	40	0	0	40
heat shock protein beta-1	11	0	0	11
peripheral myelin protein 22	26	0	0	26
survival motor neuron protein isoform d	13	0	0	13
muscarinic acetylcholine receptor M1	16	0	0	16
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	30	0	0	30
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	17	0	0	17
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	17	2	24
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Telomerase reverse transcriptase	0	2	0	2
Amyloid-beta precursor protein	0	6	0	6
Reverse transcriptase/RNaseH	0	3	0	3
Chain A, Ferritin light chain	13	0	0	13
Smad3	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
DNA topoisomerase 2-alpha	0	0	1	3
Acetylcholinesterase	0	6	0	6
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
IDH1	19	0	0	19
Histone H2A.x	20	0	0	20
glycogen synthase kinase-3 beta isoform 1	0	0	4	4
mitogen-activated protein kinase 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	22	0	0	22
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	7	1	8
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	6	0	6
Insulin receptor	0	1	1	3
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	3	6
Platelet-derived growth factor receptor beta	0	2	1	4
Adenosine receptor A3	0	10	3	14
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 2	0	1	1	2
Endoplasmin	0	1	1	3
Glutamate receptor 2	20	0	0	20
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	1	7
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	6	3	10
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	2	3
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	9
Adenosine receptor A2a	0	3	2	7
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	5	0	6
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	1	2
Adenosine deaminase	0	0	0	3
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	5	0	6
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	5	0	6
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	5	0	6
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	9	4	13
Delta-type opioid receptor	0	7	3	10
Kappa-type opioid receptor	0	7	3	10
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	1	2	3
P2X purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	2	2
P2X purinoceptor 5	0	0	2	2
P2X purinoceptor 6	0	0	2	2
P2X purinoceptor 3	0	1	2	3
Inositol monophosphatase 1	11	0	0	11
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	1	1	2
P2Y purinoceptor 11	0	1	2	3
P2Y purinoceptor 12	0	0	2	2
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	17	0	0	17
Carbonic anhydrase 1	0	6	0	12
Carbonic anhydrase 2	0	8	2	17
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	8	2	12
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
thyroid stimulating hormone receptor	16	0	0	16
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	2	0	2
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Kappa-type opioid receptor	0	1	1	2
Mu-type opioid receptor	0	2	1	3
Tyrosine-protein kinase	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
cytochrome P450 2D6	25	0	0	25
cytochrome P450 2D6 isoform 1	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
lamin isoform A-delta10	34	0	0	34
Cytochrome P450 2D6	0	12	2	15
TAR DNA-binding protein 43	6	0	0	6
histone acetyltransferase KAT2A isoform 1	15	0	0	15
ATP-binding cassette sub-family C member 3	0	30	0	30
Multidrug resistance-associated protein 4	0	31	0	32
Bile salt export pump	0	43	0	45
Canalicular multispecific organic anion transporter 1	0	29	0	29
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Chain A, Beta-lactamase	13	0	0	13
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
SMAD family member 2	9	0	0	9
Fumarate hydratase	18	0	0	18
PPM1D protein	13	0	0	13
SMAD family member 3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	14	0	0	14
thyroid stimulating hormone receptor	21	0	0	21
estrogen receptor 2 (ER beta)	26	0	0	26
nuclear receptor subfamily 1, group I, member 3	32	0	0	32
progesterone receptor	20	0	0	20
EWS/FLI fusion protein	28	0	0	28
estrogen-related nuclear receptor alpha	43	0	0	43
pregnane X nuclear receptor	34	0	0	34
G	18	0	0	18
polyprotein	18	0	0	18
peroxisome proliferator-activated receptor delta	28	0	0	28
peroxisome proliferator activated receptor gamma	27	0	0	27
caspase-3	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
cellular tumor antigen p53 isoform a	15	0	0	15
cytochrome P450 2C9 precursor	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
huntingtin isoform 2	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	40	0	0	40
cytochrome P450 3A4 isoform 1	20	0	0	20
lethal factor (plasmid)	23	0	0	23
Gamma-aminobutyric acid receptor subunit pi	20	4	2	26
Polyunsaturated fatty acid lipoxygenase ALOX15B	15	1	0	16
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
5-hydroxytryptamine receptor 4	0	28	0	28
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	28	0	0	28
HLA class I histocompatibility antigen, B alpha chain	18	0	0	18
Thyroid hormone receptor alpha	0	2	0	2
Cellular tumor antigen p53	31	0	0	31
Integrin beta-3	9	0	0	9
Tyrosine-protein kinase Fyn	0	5	1	6
ATP-dependent translocase ABCB1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	28	0	28
Muscarinic acetylcholine receptor M2	0	25	2	27
Muscarinic acetylcholine receptor M4	0	25	1	26
ATP-dependent translocase ABCB1	0	19	4	29
Integrin alpha-IIb	9	0	0	9
Beta-1 adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M5	0	28	0	28
Alpha-2A adrenergic receptor	0	28	3	32
Cytochrome P450 2C8	0	3	0	3
Thyroid hormone receptor alpha	0	1	1	2
Thyroid hormone receptor beta	0	1	1	2
Muscarinic acetylcholine receptor M1	0	29	2	31
Beta-3 adrenergic receptor	0	6	1	7
D(2) dopamine receptor	0	24	2	32
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	20	4	2	26
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	26	2	29
Thyroid hormone receptor beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	20	4	2	26
Gamma-aminobutyric acid receptor subunit gamma-2	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-5	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-3	20	4	2	26
Muscarinic acetylcholine receptor M3	0	28	2	30
ATP-dependent translocase ABCB1	0	4	0	4
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	21	1	25
D(4) dopamine receptor	0	10	1	16
Gamma-aminobutyric acid receptor subunit gamma-1	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-2	20	4	2	26
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Sodium-dependent noradrenaline transporter	0	30	1	31
Histamine H2 receptor	0	20	0	20
Endothelin-1 receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	32	1	35
5-hydroxytryptamine receptor 2C	0	29	2	31
Gamma-aminobutyric acid receptor subunit alpha-4	20	4	2	26
Gamma-aminobutyric acid receptor subunit gamma-3	20	4	2	26
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	20	4	2	26
B2 bradykinin receptor	0	6	1	9
Melanocortin receptor 4	0	6	0	6
C-8 sterol isomerase	0	3	0	3
Melanocortin receptor 5	0	6	0	6
D(3) dopamine receptor	0	22	1	28
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	7	0	7
Squalene synthase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	26	2	28
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	6	0	6
Histamine H2 receptor	20	3	0	26
D(1A) dopamine receptor	11	2	0	13
5-hydroxytryptamine receptor 6	0	22	1	24
Carnitine O-palmitoyltransferase 1, liver isoform	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	20	4	2	26
Gamma-aminobutyric acid receptor subunit beta-3	20	4	2	26
Gamma-aminobutyric acid receptor subunit beta-2	20	4	2	26
Sodium channel protein type 7 subunit alpha	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
Sodium-dependent dopamine transporter	0	23	1	24
Potassium voltage-gated channel subfamily H member 2	0	27	0	27
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	9	0	9
Sodium channel protein type 5 subunit alpha	0	8	0	8
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Sodium channel protein type 9 subunit alpha	0	7	0	7
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	20	4	2	26
Carnitine O-palmitoyltransferase 1, muscle isoform	0	2	0	2
Inositol hexakisphosphate kinase 1	18	0	0	18
Sodium channel protein type 2 subunit alpha	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	28	0	28
Gamma-aminobutyric acid receptor subunit epsilon	20	4	2	26
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	8	0	8
Sodium channel protein type 11 subunit alpha	0	6	0	6
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	6	0	6
Sodium channel protein type 10 subunit alpha	0	6	0	6
cytochrome P450 2C9, partial	18	0	0	18
GLS protein	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	29	0	0	29
atrial natriuretic peptide receptor 2 precursor	8	0	0	8
Albumin	0	0	7	7
High affinity nerve growth factor receptor	0	1	3	4
Muscarinic acetylcholine receptor M1	0	9	0	9
Muscarinic acetylcholine receptor M3	0	8	0	8
Muscarinic acetylcholine receptor M4	0	8	0	8
5-hydroxytryptamine receptor 2C	0	16	0	17
Muscarinic acetylcholine receptor M5	0	9	0	9
Muscarinic acetylcholine receptor M2	0	8	0	8
Angiotensin-converting enzyme	0	13	0	13
5-hydroxytryptamine receptor 2A	0	16	0	16
Alpha-2C adrenergic receptor	0	21	3	25
5-hydroxytryptamine receptor 1A	0	25	2	28
D(1B) dopamine receptor	0	8	0	11
UDP-glucuronosyltransferase 1A4	0	1	0	8
Alpha-1D adrenergic receptor	0	26	2	29
5-hydroxytryptamine receptor 1B	0	19	0	19
5-hydroxytryptamine receptor 1D	0	8	0	8
5-hydroxytryptamine receptor 1F	0	8	0	8
5-hydroxytryptamine receptor 2B	0	15	1	16
5-hydroxytryptamine receptor 6	0	4	0	4
Histamine H1 receptor	0	7	0	7
5-hydroxytryptamine receptor 7	0	7	0	7
5-hydroxytryptamine receptor 5A	0	4	0	4
5-hydroxytryptamine receptor 5B	0	4	0	4
Histamine H1 receptor	0	21	2	25
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	5	0	5
5-hydroxytryptamine receptor 7	0	10	0	10
Voltage-dependent N-type calcium channel subunit alpha-1B	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	4	1	5
5-hydroxytryptamine receptor 4	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	12	0	12
5-hydroxytryptamine receptor 3B	0	5	0	5
Histamine H3 receptor	0	5	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Luciferase	16	0	0	16
hypothetical protein, conserved	1	0	0	1
pyruvate kinase	3	0	0	3
aryl hydrocarbon receptor	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
NPC intracellular cholesterol transporter 1 precursor	8	0	0	8
histone deacetylase 9 isoform 3	6	0	0	6
pyruvate kinase PKM isoform a	1	0	0	1
ras-related protein Rab-9A	9	0	0	9
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Endothelin receptor type B	1	1	0	2
Endothelin-1 receptor	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	1	1	2
ATPase family AAA domain-containing protein 5	16	0	0	16
G-protein coupled receptor 35	0	1	2	3
Serine/threonine-protein kinase TBK1	0	1	1	2
Chain A, Cruzipain	4	0	0	4
interleukin 8	5	0	0	5
tumor necrosis factor	1	0	0	1
Cytochrome P450 1A2	0	2	2	5
Cytochrome P450 2C9	0	14	1	16
Cytochrome P450 2C19	0	4	1	7
Nuclear receptor ROR-gamma	7	1	1	9
Aurora kinase B	0	2	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	6
GLI family zinc finger 3	33	0	0	33
67.9K protein	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
Cytochrome P450 2J2	0	10	0	11
Nicotinate phosphoribosyltransferase	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
cytochrome P450 2C19 precursor	9	0	0	9
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Cationic amino acid transporter 3	0	2	0	2
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	3	0	3
thioredoxin glutathione reductase	3	0	0	3
P53	2	0	0	2
activating transcription factor 6	16	0	0	16
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	2	0	0	2
M-phase phosphoprotein 8	9	0	0	9
muscleblind-like protein 1 isoform 1	5	0	0	5
Bile salt export pump	0	7	0	9
Protein-arginine deiminase type-4	0	6	0	6
V-type proton ATPase subunit S1	0	1	0	1
Vacuolar proton pump subunit B	0	1	0	1
Proteasome subunit beta type-11	0	2	0	3
Calpain-9	0	2	0	2
Proteasome subunit alpha type-7	0	2	0	3
Cathepsin B	0	6	0	6
Replicase polyprotein 1ab	0	8	6	14
Replicase polyprotein 1ab	0	10	6	16
Aromatase	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	3	0	4
Proteasome subunit alpha type-1	0	2	0	3
Proteasome subunit alpha type-2	0	2	0	3
Proteasome subunit alpha type-3	0	2	0	3
Proteasome subunit alpha type-4	0	2	0	3
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	2	0	3
Proteasome subunit beta type-9	0	2	0	3
Proteasome subunit alpha type-5	0	2	0	3
Proteasome subunit beta type-4	0	2	0	3
Proteasome subunit beta type-6	0	2	0	3
Proteasome subunit beta type-5	0	5	0	6
Proteasome subunit beta type-10	0	2	0	3
Cathepsin K	0	2	0	2
Proteasome subunit beta type-3	0	2	0	3
Proteasome subunit beta type-2	0	3	0	4
Proteasome subunit alpha type-6	0	2	2	5
Proteasome subunit alpha-type 8	0	2	0	3
Proteasome subunit beta type-7	0	2	0	3
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, D-MALTODEXTRIN BINDING PROTEIN	0	0	1	1
Chain A, Limit Dextrinase	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain B, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, Alpha-hemolysin	0	0	1	1
Chain B, Alpha-hemolysin	0	0	1	1
Chain C, Alpha-hemolysin	0	0	1	1
Chain D, Alpha-hemolysin	0	0	1	1
Chain E, Alpha-hemolysin	0	0	1	1
Chain F, Alpha-hemolysin	0	0	1	1
Chain G, Alpha-hemolysin	0	0	1	1
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	4	1	7
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
ORF73	0	0	1	1
Angiotensin-converting enzyme	0	2	0	3
B2 bradykinin receptor	0	1	0	1
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	3	3
glp-1 receptor, partial	8	0	0	8
apical membrane antigen 1, AMA1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Matrix metalloproteinase-9	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	5	0	8
Carbonic anhydrase 3	0	3	0	5
Carbonic anhydrase 4	0	6	0	8
Carbonic anhydrase 6	0	3	0	5
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Carbonic anhydrase 7	0	4	0	6
Carbonic anhydrase 9	0	6	1	11
Carbonic anhydrase 13	0	3	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	3	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	5
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
L-ornithine N(5)-monooxygenase	0	1	1	2
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L1	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L3	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	1	3
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	0	1	0	1
Heat shock factor protein 1	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Regulator of G-protein signaling 17	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 15	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L5	0	1	0	1
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
50S ribosomal protein L36 2	0	3	1	4
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Apoptosis regulator Bcl-2	0	0	1	1
Bcl-2-like protein 1	0	0	1	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 15	0	2	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	2	6	8
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	2	6	8
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	6	6
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	5	6	11
Replicase polyprotein 1a	0	2	6	8
Replicase polyprotein 1ab	0	2	6	8
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	2	1	3
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Beta-secretase 1	0	3	0	3
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	2	0	2
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	6	8
Cysteine proteinase falcipain 2a	0	4	0	4
Cysteine proteinase falcipain 2a	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	3
Adenylate cyclase type 1	0	4	0	4
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Potassium channel subfamily K member 2	0	4	0	4
Albumin	0	0	6	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Major prion protein	0	1	1	2
5-hydroxytryptamine receptor 1A	0	9	0	9
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Sphingomyelin phosphodiesterase	0	2	0	2
D	0	13	0	15
D(3) dopamine receptor	0	12	0	12
Alpha-2B adrenergic receptor	0	13	2	15
D(2) dopamine receptor	0	6	0	6
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	13	2	15
Alpha-2A adrenergic receptor	0	13	2	15
Sodium-dependent dopamine transporter	0	12	0	12
D(1B) dopamine receptor	0	9	0	9
Adenylate cyclase type 2	0	4	1	5
Adenylate cyclase type 4	0	4	0	4
Trypanothione reductase	0	8	0	8
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	2	1	3
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	5	1	6
Adenylate cyclase type 8	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	3	0	3
D(2) dopamine receptor	0	14	0	16
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	6	2	10
Glutamate receptor ionotropic, NMDA 2B	0	6	2	10
Glutamate receptor ionotropic, NMDA 2C	0	6	2	10
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	6	2	10
Adenylyl cyclase 7	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	6	2	10
D	0	6	0	6
Glutamate receptor ionotropic, NMDA 3A	0	6	2	10
Sodium-dependent noradrenaline transporter	0	3	0	3
Tryptophan 5-hydroxylase 1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	10	0	11
Sigma intracellular receptor 2	0	4	0	4
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	6	0	6
Transporter	0	8	0	8
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	2	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
Alpha-1A adrenergic receptor	0	1	1	2
Amine oxidase [flavin-containing] A	0	4	1	5
Amine oxidase [flavin-containing] B	0	5	0	5
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	4	3	8
Alpha-1B adrenergic receptor	0	3	2	6
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Nischarin	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Beta-2 adrenergic receptor	0	6	0	7
Beta-1 adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Histamine H4 receptor	0	2	1	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	1	6
Liver carboxylesterase 1	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	1	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
endonuclease IV	4	0	0	4
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
caspase-1 isoform alpha precursor	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	1	0	4
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	1	2
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Solute carrier family 2, facilitated glucose transporter member 1	0	1	1	2
Adenylate cyclase type 8	0	1	1	2
Adenylate cyclase type 1	0	2	1	3
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
GALC protein	2	0	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Cytochrome P450 2A6	0	2	0	3
Aldo-keto reductase family 1 member B1	0	5	0	5
UDP-glucuronosyltransferase 2B7	0	3	0	6
UDP-glucuronosyltransferase 1-6	0	1	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	4	0	5
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Substance-P receptor	0	2	0	3
UDP-glucuronosyltransferase 2B10	0	1	0	1
Quinone oxidoreductase	0	0	0	2
Sorbitol dehydrogenase	0	2	0	2
Induced myeloid leukemia cell differentiation protein Mcl-1	0	4	0	4
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Glutathione S-transferase P	0	2	0	2
Alpha-tocopherol transfer protein	0	0	1	1
Neuraminidase	0	2	0	2
Parkin	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
rac GTPase-activating protein 1 isoform a	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Estrogen receptor	0	6	2	9
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	2	0	0	3
Androgen receptor	0	1	0	3
Tyrosinase	0	2	0	2
Urease subunit alpha	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Estrogen receptor	0	0	1	1
Urease subunit beta	0	3	0	3
Substance-K receptor	0	2	0	2
Estrogen receptor beta	0	6	2	8
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Prenyltransferase homolog	0	0	0	2
Estrogen receptor beta	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	2
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	4
Trace amine-associated receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Translocator protein	0	3	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Papain	0	3	0	3
Calpain-1 catalytic subunit	0	1	0	1
Neutrophil elastase	0	1	0	1
Pro-cathepsin H	0	2	0	2
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Cathepsin S	0	1	0	1
Cruzipain	0	3	0	3
Calpain-1 catalytic subunit	0	2	0	2
Dipeptidyl peptidase 1	0	1	0	1
Liver carboxylesterase	0	1	0	1
Cysteine protease	0	2	0	2
Cysteine protease falcipain-3	0	2	0	2
Cysteine protease falcipain-3	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	1	0	5
UDP-glucuronosyltransferase 2B17	0	0	0	1
UDP-glucuronosyltransferase 1A7	0	0	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Mcl-1	0	1	0	1
acetyl-CoA acetyltransferase/HMG-CoA reductase	0	1	0	1
unnamed protein product	0	1	0	1
heat shock 70kDa protein 1A	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
mothers against decapentaplegic homolog 3 isoform 1	0	1	0	1
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
dual specificity protein phosphatase 6	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Aurora kinase A	0	1	1	2
Acetylcholinesterase	0	3	0	4
NUAK family SNF1-like kinase 1	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Renin	0	1	0	1
Nucleophosmin	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	1	2
Insulin-like growth factor 1 receptor	0	2	1	3
Hepatocyte growth factor receptor	0	1	1	2
Glutathione S-transferase Mu 1	0	1	0	1
Cyclin-dependent kinase 4	0	2	1	3
Proto-oncogene tyrosine-protein kinase Src	0	3	1	4
Macrophage migration inhibitory factor	0	2	0	2
Serine/threonine-protein kinase B-raf	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	2	1	3
Casein kinase II subunit alpha	0	1	0	1
Casein kinase II subunit alpha'	0	1	1	2
5'-nucleotidase	0	2	0	2
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	1	2
G1/S-specific cyclin-D1	0	2	0	2
RAC-alpha serine/threonine-protein kinase	0	2	1	3
Bifunctional epoxide hydrolase 2	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	2	0	2
Receptor-type tyrosine-protein kinase FLT3	0	1	1	2
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
Squalene monooxygenase	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	1	2
Ephrin type-B receptor 4	0	1	1	2
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Cyclin-A1	0	1	0	1
Lactoperoxidase	0	0	0	1
Cholinesterase	0	3	0	4
DNA primase	0	3	0	3
Angiopoietin-1 receptor	0	1	0	1
Focal adhesion kinase 1	0	1	1	2
Tyrosine-protein kinase Lyn	0	1	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	1	2
ELAV-like protein 3	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
5'-nucleotidase	0	1	0	1
Tyrosine-protein kinase Fgr	0	1	0	1
Integrase	0	2	0	2
Thioredoxin reductase 3	0	1	0	1
Glutathione S-transferase	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Translin-associated protein X	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
phosphoglycerate kinase	1	0	0	1
M17 leucyl aminopeptidase	0	1	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Cytochrome P450 1B1	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0	1	0	1
Protein farnesyltransferase subunit beta	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
thyrotropin-releasing hormone receptor	3	0	0	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	4
P-selectin	0	1	0	1
Beta-galactosidase	0	4	0	4
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
BRCA1	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Pancreatic triacylglycerol lipase	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Cyclin-dependent kinase 1	0	1	1	2
Sialidase	0	1	0	1
Steroid hormone receptor ERR1	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Protein kinase C alpha type	0	3	1	4
Amine oxidase [flavin-containing] A	0	1	0	1
Thromboxane-A synthase	0	2	0	2
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	1	2
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase SYK	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	1	2
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Sialidase-2	0	2	0	2
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Dihydrofolate reductase	0	3	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
nonstructural protein 1	2	0	0	2
Cocaine esterase	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	3	0	3
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Alpha-galactosidase	0	1	0	1
Beta-galactosidase	0	2	0	2
Prothrombin	0	1	0	1
Beta-galactosidase	0	3	0	3
Neutral alpha-glucosidase C	0	1	0	1
Neutral alpha-glucosidase C	0	1	0	1
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Stromelysin-1	0	1	1	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Genome polyprotein	0	1	0	1
Caspase-7	2	0	0	2
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Oleandomycin glycosyltransferase	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Glycogen phosphorylase, liver form	0	1	1	2
Glycogen phosphorylase, liver form	0	1	0	1
Chain A, ALPHA1,2-MANNOSIDASE	0	1	0	1
Chain A, ALPHA1,2-MANNOSIDASE	0	1	0	1
Chain A, Alpha-mannosidase II	0	1	0	1
Chain A, PUTATIVE ALPHA-1,2-MANNOSIDASE	0	1	0	1
Chain A, Putative Alpha-1,2-mannosidase	0	1	0	1
Chain B, Alpha-1,2-mannosidase	0	1	0	1
Chain A, PUTATIVE ALPHA-1,2-MANNOSIDASE	0	1	0	1
Alpha-1,2-mannosidase family protein	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase, putative	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Glycoside hydrolase family 92	0	2	0	2
Glycoside hydrolase family 92	0	2	0	2
Alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase, putative	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase, putative	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Putative alpha-1,2-mannosidase	0	2	0	2
Alpha-1,2-mannosidase family protein	0	2	0	2
Splicing factor 3B subunit 3	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Free fatty acid receptor 4	0	0	1	1
G-protein coupled receptor 84	0	1	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Cathepsin B	0	1	0	1
Prothrombin	0	1	0	1
Plasminogen	0	1	0	1
Cationic trypsin	0	1	0	1
Serine protease hepsin	0	1	0	1
Plasminogen	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin B	0	1	0	1
Trypsin-3	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Transmembrane protease serine 6	0	1	0	1
Cysteine protease	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	1	2
Acetylcholine-binding protein	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	2	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
Alpha-mannosidase 2C1	0	2	0	2
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Gag-Pol polyprotein	0	1	0	1
Alpha-galactosidase	0	3	0	3
Beta-galactosidase	0	1	0	1
Beta-galactosidase	0	1	0	1
Alpha-galactosidase C	0	1	0	1
Sucrase-isomaltase	0	3	0	3
Ceramide glucosyltransferase	0	3	0	3
Beta-galactosidase	0	3	0	3
Lysosomal alpha-glucosidase	0	3	0	3
Non-lysosomal glucosylceramidase	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Chain A, Beta-n-acetylhexosaminidase	0	1	0	1
Chain A, N-acetyl-beta-D-glucosaminidase	0	1	0	1
Chain A, ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D	0	0	1	1
Beta-N-acetylhexosaminidase	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
putative alpha-glucosidase	1	0	0	1
Galactocerebrosidase	0	1	0	1
Probable alpha-glucosidase Os06g0675700	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Beta-2 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Flavin reductase (NADPH)	0	0	1	1
N	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	2	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	0	1	1
Sphingosine kinase 1	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Adenylate cyclase type 9	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
D(1) dopamine receptor	0	1	0	1
Adenylate cyclase type 7	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
D	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	2	1	3
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	2	1	3
Tyrosine-protein kinase Lck	0	1	1	2
Eukaryotic translation initiation factor 4E	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	1	1	2
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	2	1	3
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	2	1	3
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Protein kinase C zeta type	0	2	1	3
Protein kinase C delta type	0	2	1	3
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	2	0	2
Estrogen receptor	0	0	2	3
Protein kinase C delta type	0	2	0	2
Protein kinase C epsilon type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Estrogen receptor beta	0	0	2	3
Protein kinase C eta type	0	2	0	2
Sphingosine kinase 2	0	1	0	1
Protein kinase C theta type	0	2	0	2
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C eta type	0	2	0	2
P2X purinoceptor 2	0	1	1	2
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
Protein kinase C epsilon type	0	2	0	2
Serine/threonine-protein kinase D1	0	2	0	2
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
P2X purinoceptor 7	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Chain A, Alpha-mannosidase Ii	0	1	0	1
Chain A, ALPHA-MANNOSIDASE II	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Lysosomal alpha-mannosidase	0	1	0	1
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA	0	2	0	2
Alpha-mannosidase 2	0	1	0	1
alpha-1,2-Mannosidase	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
Progesterone receptor	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Substance-P receptor	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Chain A, Prostatic Acid Phosphatase	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Sodium/bile acid cotransporter	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Ileal sodium/bile acid cotransporter	0	2	0	2
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	1	1	2
Bile salt export pump	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Neuronal acetylcholine receptor subunit beta-4	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-3	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Phospholipase A2	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (391)

Protein Targets (1,860)

Lysosomal Enzyme Disorders

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (391)

Drugs Studied (289)

Protein Targets (1,860)