| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4-iodo-2,5-dimethoxyphenylisopropylamine
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist. 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4. | 2.69 | 3 | 0 | amphetamines;
dimethoxybenzene;
organoiodine compound | |
3,4-methylenedioxyamphetamine
3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally. | 1.99 | 1 | 0 | benzodioxoles | |
amphetamine
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.. 1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.. amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine. | 2.41 | 1 | 0 | primary amine | |
fluoxetine
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group. | 2.04 | 1 | 0 | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | |
ketanserin
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.. ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group. | 1.97 | 1 | 0 | aromatic ketone;
organofluorine compound;
piperidines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist |
mescaline
Mescaline: Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.. mescaline : A phenethylamine alkaloid that is phenethylamine substituted at positions 3, 4 and 5 by methoxy groups. | 1.99 | 1 | 0 | methoxybenzenes;
phenethylamine alkaloid;
primary amino compound | hallucinogen |
mmda
MMDA: RN given refers to parent cpd; structure | 1.99 | 1 | 0 | | |
2,5-dimethoxy-4-ethylamphetamine
2,5-dimethoxy-4-ethylamphetamine: psychedelic agent; ethyl homolog of dimethoxymethylamphetamine; RN given refers to parent cpd without isomeric designation | 2.39 | 2 | 0 | amphetamines | |
2,4,5-trimethoxyphenylisopropylamine
2,4,5-trimethoxyphenylisopropylamine: RN given refers to parent cpd; structure | 2.69 | 3 | 0 | | |
4-methoxyamphetamine
4-methoxyamphetamine: para-methoxy derivative to amphetamine with hallucinogenic properties; minor descriptor (75-86); on line & INDEX MEDICUS search AMPHETAMINES (75-86); RN given refers to parent compound without isomeric designation | 1.99 | 1 | 0 | | |
2,5-dimethoxy-4-bromoamphetamine
2,5-dimethoxy-4-bromoamphetamine: RN given refers to (alpha)-isomer; a serotonin agonist that interferes with Meth A tumor growth in mice by selective vasoconstrictive action | 2.69 | 3 | 0 | | |
2,5-dimethoxyamphetamine
2,5-dimethoxyamphetamine: RN given refers to parent cpd without isomeric designation | 2.69 | 3 | 0 | | |
2,5-dimethoxy-4-methylamphetamine
2,5-Dimethoxy-4-Methylamphetamine: A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD. | 2.39 | 2 | 0 | | |
2-(4-bromo-2,5-dimethoxyphenyl)ethylamine
2-(4-bromo-2,5-dimethoxyphenyl)ethylamine: behaves as a partial agonist toward both alpha1-adrenergic & 5-HT(2) serotonergic receptors. 2,5-dimethoxy-4-bromophenethylamine : A 2-arylethylamine compound where the aryl moiety is 4-bromo-2,5-dimethoxyphenyl. | 1.99 | 1 | 0 | 2-arylethylamine | |
n-hydroxy-1-(3,4-methylenedioxyphenyl)-2-aminopropane
N-hydroxy-1-(3,4-methylenedioxyphenyl)-2-aminopropane: RN given refers to parent cpd | 1.99 | 1 | 0 | | |
3,4-methylenedioxyethamphetamine
3,4-methylenedioxyethamphetamine: legal replacement for MDMA; RN given for (+-)-isomer; structure given in first source. 1-(1,3-benzodioxol-5-yl)-N-ethylpropan-2-amine : A secondary amino compound that is N-ethylisopropylamine in which a hydrogen of one of the isopropyl methyl groups has been replaced by a 3,4-methylenedioxyphenyl group. | 1.99 | 1 | 0 | benzodioxoles;
secondary amino compound | |
1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane
1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane: structure given in first source; RN given refers to parent cpd | 2.39 | 2 | 0 | | |
n-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine
N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine: structure given in first source; RN given refers to (+-)-isomer | 1.99 | 1 | 0 | | |
1-(3,4-methylenedioxyphenyl)-2-butanamine
1-(3,4-methylenedioxyphenyl)-2-butanamine: RN given refers to cpd without isomeric designation; structure given in first source | 1.99 | 1 | 0 | benzodioxoles | |
ah 7921
AH 7921: RN given refers to parent cpd; structure | 2.17 | 1 | 0 | | |
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | 2.04 | 1 | 0 | cinchona alkaloid | alpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker |
2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine
2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine: RN given refers to parent cpd without isomeric designation; structure | 1.99 | 1 | 0 | | |
4-iodo-2,5-dimethoxy-beta-phenethylamine
4-iodo-2,5-dimethoxy-beta-phenethylamine: structure in first source | 1.99 | 1 | 0 | | |
2,5-dimethoxy-4-ethylthiophenethylamine
2,5-dimethoxy-4-ethylthiophenethylamine: structure in first source | 1.99 | 1 | 0 | | |
2,5-dimethoxy-4-n-propylthiophenethylamine
2,5-dimethoxy-4-n-propylthiophenethylamine: structure in first source | 1.99 | 1 | 0 | | |