fluoxetine and naloxone

fluoxetine has been researched along with naloxone in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19906 (16.22)18.7374
1990's7 (18.92)18.2507
2000's12 (32.43)29.6817
2010's10 (27.03)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM1
Topliss, JG; Yoshida, F1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Margalit, D; Segal, M1
Lemaire, I; Lemaire, S; Tseng, R1
Cherkin, A; Flood, JF; Smith, GE1
Maickel, RP; Spratto, GR; Tocco, DR1
Bemis, KG; Hymson, DL; Hynes, MD; Lochner, MA1
Cerrito, F; Preziosi, P; Vacca, M1
Bastide, P; Coudert, P; Rubat, C; Tronche, P1
Hagan, MM; Moss, DE1
Crosbie, GV; Grice, JE; Hockings, GI; Jackson, RV; Torpy, DJ; Walters, MM1
Backer, MM; Pick, CG; Schreiber, S1
Cabello, CE; Hagan, MM; Hanscom, DR; Holguin, FD; Moss, DE1
Casarosa, E; Genazzani, AR; Luisi, S; Parrini, D; Petraglia, F; Rubino, S; Spinetti, A; Stomati, M1
Hassanpour, M; Nayebi, AR; Rezazadeh, H1
Casarosa, E; Florio, P; Genazzani, AD; Genazzani, AR; Lombardi, I; Luisi, M; Petraglia, F; Quirici, B1
Jain, NK; Kulkarni, SK; Singh, VP1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A; Singh, VP1
Cador, M; Koob, GF; Stinus, L; Zorrilla, EP1
Dziedzicka-Wasylewska, M; Filip, M; Inan, SY; Przegaliński, E; Wydra, K1
Chen, JY; Chen, YA; Tao, PL; Wu, CC; Yeh, GC1
Forray, MI; Gysling, K; Sotomayor, R1
Anjaneyulu, M; Chopra, K1
Alfinito, PD; Cosmi, S; Deecher, DC; Leventhal, L; Maswood, N1
Audi, EA; Biesdorf, C; Graeff, FG; Roncon, CM; Santana, RG; Zangrossi, H1
Naranjo, J; Pollard, EM; Sprung, J; Warner, MA; Warner, ME; Weingarten, TN1
Davoudi, S; Dolatshahi, M; Ghorbanzadeh, B; Naserzadeh, R; Paridar, Y1
Keidan, L; Pick, CG; Schreiber, S1

Reviews

2 review(s) available for fluoxetine and naloxone

ArticleYear
The role of receptor binding in drug discovery.
    Journal of natural products, 1993, Volume: 56, Issue:4

    Topics: Animals; Drug Design; Humans; Receptors, Drug

1993
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for fluoxetine and naloxone

ArticleYear
Diurnal effects of fluoxetine and naloxone on the human hypothalamic-pituitary-adrenal axis.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:6

    Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Chronotherapy; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Female; Fluoxetine; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Injections, Intravenous; Male; Middle Aged; Naloxone; Pituitary-Adrenal System

1997
Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13, Issue:1

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Androstenedione; Area Under Curve; beta-Endorphin; Climacteric; Clonidine; Dehydroepiandrosterone; Estradiol; Estrone; Female; Fluoxetine; Humans; Middle Aged; Multivariate Analysis; Naloxone; Narcotic Antagonists; Prospective Studies; Radioimmunoassay; Selective Serotonin Reuptake Inhibitors; Somatostatin; Testosterone

1999

Other Studies

33 other study(ies) available for fluoxetine and naloxone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations

2002
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus.
    Psychopharmacology, 1979, Apr-11, Volume: 62, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Clonidine; Cyproheptadine; Ditiocarb; Electric Stimulation; Fluoxetine; Hydroxydopamines; Locus Coeruleus; Male; Naloxone; Rats; Reserpine; Self Stimulation

1979
Systemic administration of beta-endorphin: potent hypotensive effect involving a serotonergic pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:12

    Topics: Blood Pressure; Dose-Response Relationship, Drug; Endorphins; Fenclonine; Fluoxetine; Naloxone; Neural Pathways; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1978
Memory enhancement in mice: role of drug dose and training-testing interval.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Arecoline; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Fluoxetine; Male; Memory; Memory, Short-Term; Mice; Naloxone; Peptide Fragments; Piribedil; Time Factors

1988
Differential analgetic actions of amphetamine enantiomers in the mouse: a drug-drug interaction study.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 278, Issue:2

    Topics: Amphetamine; Analgesics; Animals; Dextroamphetamine; Dopamine; Drug Interactions; Fenclonine; Fluoxetine; Male; Metergoline; Mice; Morphine; Naloxone; Norepinephrine; Pimozide; Serotonin; Stereoisomerism

1985
Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors.
    Life sciences, 1985, Jun-17, Volume: 36, Issue:24

    Topics: Animals; Binding, Competitive; Brain; Discrimination, Psychological; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Fluoxetine; Male; Morphine; Naloxone; Pain; Propylamines; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin

1985
Effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist, mCPP.
    Life sciences, 1983, May-23, Volume: 32, Issue:21

    Topics: 5-Hydroxytryptophan; Animals; Corticosterone; Fluoxetine; Male; Naloxone; Piperazines; Prolactin; Rats; Rats, Inbred Strains

1983
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:2

    Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine

1995
Effect of naloxone and antidepressants on hyperphagia produced by peptide YY.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: Animals; Antidepressive Agents; Clomipramine; Dose-Response Relationship, Drug; Feeding Behavior; Female; Fluoxetine; Gastrointestinal Hormones; Injections, Intraperitoneal; Injections, Intraventricular; Naloxone; Peptide YY; Peptides; Rats; Rats, Sprague-Dawley

1993
Interactions between different antidepressants and morphine alter gastrointestinal transit in mice.
    Life sciences, 1997, Volume: 61, Issue:9

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Gastrointestinal Transit; Male; Mianserin; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Rats

1997
Combined naloxone and fluoxetine on deprivation-induced binge eating of palatable foods in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Appetite Depressants; Dietary Carbohydrates; Dietary Fats; Feeding Behavior; Fluoxetine; Food Deprivation; Food Preferences; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Time Factors

1997
Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Analgesics, Opioid; Animals; Drug Synergism; Fluoxetine; Formaldehyde; Injections, Intraperitoneal; Male; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Time Factors

2001
Neuroendocrine effects of raloxifene hydrochloride in postmenopausal women.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; beta-Endorphin; Clonidine; Drug Interactions; Female; Fluoxetine; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Neurosecretory Systems; Postmenopause; Pregnanolone; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Selective Serotonin Reuptake Inhibitors

2001
Fluoxetine suppresses morphine tolerance and dependence: modulation of NO-cGMP/DA/serotoninergic pathways.
    Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:4

    Topics: Animals; Arginine; Body Weight; Cyclic GMP; Depression, Chemical; Diarrhea; Dopamine; Drug Interactions; Drug Tolerance; Female; Fluoxetine; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Selective Serotonin Reuptake Inhibitors; Serotonin; Substance Withdrawal Syndrome

2003
Paradoxical effects of opioid antagonist naloxone on SSRI-induced analgesia and tolerance in mice.
    Pharmacology, 2003, Volume: 69, Issue:3

    Topics: Analgesics; Animals; Citalopram; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Fluoxetine; Injections, Intraperitoneal; Injections, Spinal; Mice; Naloxone; Narcotic Antagonists; Selective Serotonin Reuptake Inhibitors

2003
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1

    Topics: Acamprosate; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Avoidance Learning; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Implants; Fluoxetine; Lisuride; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome; Taurine

2005
Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Adrenergic Uptake Inhibitors; Analgesics, Opioid; Animals; Antidepressive Agents; Biogenic Monoamines; Conditioning, Operant; Cyclohexanols; Cyclopropanes; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Male; Milnacipran; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Nomifensine; Rats; Rats, Wistar; Reboxetine; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Sodium Chloride; Tramadol; Venlafaxine Hydrochloride

2004
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal-Fetal Exchange; Morphine Dependence; Naloxone; Narcotic Antagonists; Pregnancy; Pregnancy Complications; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome

2005
Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area.
    Journal of neuroscience research, 2005, Jul-01, Volume: 81, Issue:1

    Topics: Analysis of Variance; Animals; Dopamine; Drug Administration Schedule; Extracellular Fluid; Fluoxetine; gamma-Aminobutyric Acid; Male; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neural Pathways; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Septum of Brain; Serotonin; Statistics, Nonparametric; Ventral Tegmental Area

2005
Possible involvement of cholinergic and opioid receptor mechanisms in fluoxetine mediated antinociception response in streptozotocin-induced diabetic mice.
    European journal of pharmacology, 2006, May-24, Volume: 538, Issue:1-3

    Topics: Analgesics; Animals; Atropine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fluoxetine; Male; Mice; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Receptors, Muscarinic; Receptors, Opioid; Secologanin Tryptamine Alkaloids; Serotonin Antagonists

2006
The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.
    Neuroendocrinology, 2006, Volume: 84, Issue:5

    Topics: Animals; Body Temperature Regulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluoxetine; Hot Flashes; Morphine Dependence; Naloxone; Ovariectomy; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Telemetry

2006
The panicolytic-like effect of fluoxetine in the elevated T-maze is mediated by serotonin-induced activation of endogenous opioids in the dorsal periaqueductal grey.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Fluoxetine; Male; Maze Learning; Motor Activity; Naloxone; Opioid Peptides; Panic Disorder; Periaqueductal Gray; Rats; Rats, Wistar; Serotonin

2012
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2017, Volume: 64, Issue:9

    Topics: Aged; Curcuma; Dietary Supplements; Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Midazolam; Naloxone; Perioperative Period; Serotonin Agents; Serotonin Syndrome; Time Factors; Trazodone; Young Adult

2017
Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of simvastatin in mice: Without tolerance and withdrawal syndrome.
    Neuroscience letters, 2020, 01-01, Volume: 714

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Tolerance; Fluoxetine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Locomotion; Mice; Morphine; Naloxone; Narcotic Antagonists; Open Field Test; Receptors, Opioid; Simvastatin; Substance Withdrawal Syndrome; Swimming

2020
Treatment-Resistant Depression (TRD): Is the Opioid System Involved?
    International journal of molecular sciences, 2023, Jul-06, Volume: 24, Issue:13

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Mianserin; Mice; Mirtazapine; Moclobemide; Naloxone; Reboxetine; Trazodone; Venlafaxine Hydrochloride

2023