fluoxetine has been researched along with dextromethorphan in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Achamallah, NS | 1 |
| Alderman, J; Chung, M; Harris, S; Harrison, W; Messig, M; Preskorn, SH | 1 |
| Cheung, SW; Joffe, RT; Otton, SV; Sellers, EM; Wu, D | 1 |
| Alfaro, CL; Ereshefsky, L; Lam, YW; Simpson, J | 2 |
| Cai, WM; Chen, B; Zhang, YD; Zhou, Y | 1 |
| Albano, D; Amchin, J; Ereshefsky, L; Klockowski, PM; Taylor, K; Zarycranski, W | 1 |
| Alfaro, CL; Ereshefsky, L; Gaedigk, A; Lam, YW; Simpson, J | 1 |
| Eich, P; Eichhorn, M | 1 |
| Hou, YN; Liu, HC; Wang, N; Yu, Y | 1 |
| Balsara, JJ; Gaikwad, RV; Gaonkar, RK; Jadhav, JH; Jadhav, SA; Thorat, VM | 1 |
| Haining, RL; Yu, AM | 1 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
| Hallifax, D; Houston, JB | 1 |
| Frank, JG; Keller, A; Nuwayhid, SJ; Werling, LL | 1 |
| Brown, HS; Chadwick, A; Houston, JB | 1 |
| Curcio, R; Nicoli, R; Rudaz, S; Veuthey, JL | 1 |
| Chang, CP; Hou, CC; Lin, MT; Yang, HH | 1 |
| Jurica, J; Sabova, M; Sulcova, A; Zahradnikova, L; Zendulka, O | 1 |
| Davis, C; Foti, RS; Isoherranen, N; Kunze, KL; Lutz, JD; Sager, JE | 1 |
| Beyer, RP; Fiehn, O; Gaedigk, A; Gana Fomban, CL; Isoherranen, N; Leeder, JS; Lin, YS; Lutz, JD; Pearce, RE; Senn, T; Shireman, LM; Tay-Sontheimer, J; Thummel, KE; Witten, D | 1 |
| Butler, MI; Cotter, DR; Williams, D | 1 |
1 review(s) available for fluoxetine and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
5 trial(s) available for fluoxetine and dextromethorphan
| Article | Year |
|---|---|
Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine.
Topics: 1-Naphthylamine; Antidepressive Agents; Chromatography, High Pressure Liquid; Desipramine; Dextromethorphan; Drug Interactions; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Sertraline | 1994 |
CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine, fluvoxamine, paroxetine, or sertraline.
Topics: Adult; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Female; Fluoxetine; Fluvoxamine; Humans; Male; Paroxetine; Reference Values; Sertraline | 1999 |
CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations.
Topics: Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Fluoxetine; Humans; Isoenzymes; Paroxetine; Phenotype; Selective Serotonin Reuptake Inhibitors; Sertraline; Venlafaxine Hydrochloride | 2000 |
Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe.
Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Cyclohexanols; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Female; Fluoxetine; Humans; Male; Metabolic Clearance Rate; Phenotype; Selective Serotonin Reuptake Inhibitors; Time Factors; Urinalysis; Venlafaxine Hydrochloride | 2001 |
CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6.
Topics: Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Fluoxetine; Fluvoxamine; Genotype; Humans; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline | 2002 |
22 other study(ies) available for fluoxetine and dextromethorphan
| Article | Year |
|---|---|
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Visual hallucinations after combining fluoxetine and dextromethorphan.
Topics: Adult; Antitussive Agents; Dextromethorphan; Drug Interactions; Female; Fluoxetine; Hallucinations; Humans; Visual Perception | 1992 |
Inhibition by fluoxetine of cytochrome P450 2D6 activity.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Fluoxetine; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Multiple Sclerosis; Oxidation-Reduction; Oxycodone; Phenotype; Selective Serotonin Reuptake Inhibitors | 1993 |
Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Area Under Curve; Asian People; China; Cytochrome P-450 CYP2D6; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Fluoxetine; Half-Life; Humans; Isomerism; Male; Middle Aged; Phenotype; Propafenone; Reference Values; Selective Serotonin Reuptake Inhibitors | 1999 |
[Dextromethorphane intoxication under co-medication with cytochrome P450-inhibitor fluoxetin: prolonged and accentuated signs of intoxication].
Topics: Adult; Antitussive Agents; Cytochrome P-450 Enzyme Inhibitors; Depressive Disorder, Major; Dextromethorphan; Drug Overdose; Female; Fluoxetine; Humans; Lorazepam; Metabolic Clearance Rate; Suicide, Attempted | 2002 |
Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes.
Topics: Analgesics, Opioid; Animals; Dextromethorphan; Fluoxetine; Male; Microsomes, Liver; Propafenone; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol | 2003 |
Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antitussive Agents; Behavior, Animal; Buspirone; Central Nervous System; Dexfenfluramine; Dextromethorphan; Fluoxetine; Male; Propranolol; Rats; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Syndrome | 2005 |
Expression, purification, and characterization of mouse CYP2d22.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Cloning, Molecular; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dealkylation; Dextromethorphan; Enzyme Inhibitors; Fluoxetine; Insecta; Ketoconazole; Kinetics; Methadone; Mice; Molecular Sequence Data; Molecular Weight; Quinidine; Sequence Homology, Amino Acid; Substrate Specificity | 2006 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.
Topics: Algorithms; Amines; Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dextromethorphan; Fluoxetine; Fluvoxamine; Hepatocytes; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Imipramine; In Vitro Techniques; Kinetics; Male; Models, Biological; Propranolol; Quinine; Rats; Rats, Sprague-Dawley | 2007 |
A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder.
Topics: Affective Symptoms; Amitriptyline; Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Brain; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluoxetine; Male; Memantine; Membranes; Radioligand Assay; Rats; Receptors, Neurotransmitter | 2007 |
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide | 2007 |
Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Fluoxetine; Humans; Isoenzymes; Mass Spectrometry; Pharmaceutical Preparations; Quinidine; Recombinant Proteins; Solutions; Venlafaxine Hydrochloride | 2009 |
Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats.
Topics: Acute Lung Injury; Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Dextromethorphan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluoxetine; Heat Stroke; Hemodynamics; Inflammation Mediators; Lung; Male; Piperazines; Pneumonia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Time Factors | 2012 |
Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats.
Topics: Animals; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Brain; Cognition; Dextromethorphan; Dopamine Agents; Drug Interactions; Drug Therapy, Combination; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluoxetine; Liver; Male; Memantine; Models, Animal; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2011 |
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Drug Interactions; Female; Fluoxetine; Half-Life; Hepatocytes; Humans; Lovastatin; Male; Midazolam; Models, Statistical; Omeprazole; Stereoisomerism | 2014 |
Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Topics: Adolescent; Adult; Biomarkers; Child; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Female; Fluoxetine; Healthy Volunteers; Humans; Male; Metabolomics | 2014 |
Cough Suppressant and Fluoxetine in the Treatment of Pseudobulbar Affect: A Case Report.
Topics: Antitussive Agents; Brain Stem; Crying; Dextromethorphan; Drug Therapy, Combination; Female; Fluoxetine; Humans; Middle Aged | 2016 |