| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID180894 | The dose at which the animals show 50% responses on drug-appropriate lever | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
| N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID258814 | Ratio of permeability from basolateral to apical over apical to basolateral side of the MDCK cell transfected with human MDR1 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258791 | Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID6563 | Binding affinity towards human 5-hydroxytryptamine 6 receptor | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
| Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). |
| AID258786 | Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID1815949 | Stability in human liver mitochondria assessed as compound remaining in presence of MAO-A and MAO-B measured after 60 mins | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID1815952 | Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID230152 | The compound evaluated for its receptor selectivity at [125I]- DOI- labeled receptors versus 5-HT2C receptors | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. |
| AID197150 | The ability to inhibit the 5-HT-induced contraction of isolated rat fundus muscle was determined | 1982 | Journal of medicinal chemistry, Nov, Volume: 25, Issue:11
| Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives. |
| AID1229589 | Displacement of [3H]DOB from rat 5HT2A receptor expressed in mouse NIH/3T3 cells after 30 mins by liquid scintillation counting analysis | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID4781 | Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ket as radioligand. | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID258813 | Permeability from basolateral to apical side of the MDCK cell transfected with human MDR1 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258812 | Permeability from apical to basolateral side of the MDCK cell transfected with human MDR1 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID1583476 | Induction of head-twitch response in iv dosed C57BL/6J mouse assessed as reduction in hallucinogenic potential measured after 20 mins | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Identification of Psychoplastogenic |
| AID1146450 | Competitive antagonist activity at 5-HT serotonin receptor in Sprague-Dawley rat stomach fundus model assessed as inhibition of 5-HT-induced contractile response | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues. |
| AID6671 | Agonistic activity against rat 5-HT7 adenyl cyclase expressed by HEK293 cells | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site. |
| AID258821 | Lowering of intraocular pressure in lasered cynomolgus monkey after 6 hrs at 300 ug | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID1229575 | Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID5397 | Affinity against 5-hydroxytryptamine 2A receptor (K) labeled with [3H]ketanserin. | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. |
| AID1583474 | Induction of acute behavioural changes in wild type zebrafish Singapore at 7 days post-fertilization stage after 1 hr by imaging analysis | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Identification of Psychoplastogenic |
| AID1229576 | Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay relative to melatonin | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID258790 | Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID3739 | Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand | 1992 | Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
| 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
| AID6666 | Binding affinity at rat 5-hydroxytryptamine 7 receptor. | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site. |
| AID1229572 | Selectivity ratio of Ki for human melatonin receptor-1 to Ki for human melatonin receptor-2 | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID4527 | Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors. |
| AID6518 | Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radioligand | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5
| 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. |
| AID1782619 | Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay | 2021 | ACS medicinal chemistry letters, Dec-09, Volume: 12, Issue:12
| The Psychedelic Renaissance: Addressing Potential Adverse Effects in a Therapeutic Setting. |
| AID172082 | The behavior disruption data as percent change in response from drug versus saline at dose 2mg/kg, expressed as B/P (burst/premature). | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID4212 | Affinity on 5-hydroxytryptamine 1A receptor labeled by [3H]8-OH-DPAT | 1992 | Journal of medicinal chemistry, May-29, Volume: 35, Issue:11
| Benzofuran bioisosteres of hallucinogenic tryptamines. |
| AID172075 | The behavior disruption data as percent change in response from drug versus saline at dose 1mg/Kg, expressed as L (Late). | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID4530 | Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand | 1992 | Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
| 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
| AID1229570 | Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID4035 | Binding affinity towards 5-hydroxytryptamine 1A receptor | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
| N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID5496 | Compound was tested for binding affinity using [3H]MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate. | 1999 | Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
| Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. |
| AID4797 | Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligand | 1992 | Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
| 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
| AID258785 | Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258787 | Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID1782621 | Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as maximal effect by FLIPR calcium flux assay relative to control | 2021 | ACS medicinal chemistry letters, Dec-09, Volume: 12, Issue:12
| The Psychedelic Renaissance: Addressing Potential Adverse Effects in a Therapeutic Setting. |
| AID258820 | Lowering of intraocular pressure in lasered cynomolgus monkey after 3 hrs at 300 ug | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID5396 | Affinity against 5-hydroxytryptamine 2A receptor (D) labeled with [125I]DOI. | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. |
| AID258788 | Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258816 | Passive diffusion permeability from basolateral to apical side of the MDCK cell transfected with human MDR1 in presence of cyclosporin A | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID4773 | Binding affinity against 5-hydroxytryptamine 1C receptor | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID1131175 | Antagonist activity at 5-HT1 receptor in Sprague-Dawley rat assessed as inhibition of 5-HT-induced stomach fundus contraction | 1979 | Journal of medicinal chemistry, Nov, Volume: 22, Issue:11
| Bufotenine esters. |
| AID1229574 | Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay relative to melatonin | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID172080 | The behavior disruption data as percent change in response from drug versus saline at dose 2mg/Kg, expressed as E (efficient) | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID258817 | Ratio of passive diffusion permeability from basolateral to apical over apical to basolateral side of the MDCK cell transfected with MDR1 in presence of cyclosporin A | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID4699 | Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Central serotonin receptors as targets for drug research. |
| AID4557 | Binding affinity against 5-hydroxytryptamine 1D receptor | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID1229588 | Displacement of [3H]8-OH DPAT from rat 5HT1A receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID4735 | Binding affinity against 5-hydroxytryptamine 1B receptor | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID4741 | Binding affinity towards 5-hydroxytryptamine 1C receptor using [3H]mesulergine as radioligand | 1992 | Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
| 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
| AID4411 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models. |
| AID1815951 | Stability in rat brain homogenate assessed as half life | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID172076 | The behavior disruption data as percent change in response from drug versus saline at dose 1 mg/kg, expressed as B/P (burst/premature). | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID1146451 | Antagonist activity at 5-HT serotonin receptor (unknown origin) | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8
| Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues. |
| AID4780 | Binding affinity against 5-hydroxytryptamine 2 receptor using [125I]DOI as radioligand. | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID258815 | Passive diffusion permeability from apical to basolateral side of the MDCK cell transfected with human MDR1 in presence of cyclosporin A | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID5817 | The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus | 1982 | Journal of medicinal chemistry, Jan, Volume: 25, Issue:1
| 2,3-dihydro and carbocyclic analogues of tryptamines: interaction with serotonin receptors. |
| AID1815947 | Stability in human liver mitochondria assessed as half life in presence of MAO-A and MAO-B | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID5273 | Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Central serotonin receptors as targets for drug research. |
| AID5270 | Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligand | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Central serotonin receptors as targets for drug research. |
| AID5108 | Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]- 1-(4-bromo-2,5-dimethoxy-phenyl)-2-aminopropane (D) as radioligand | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
| N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID1583472 | Induction of dendritogenesis in Sprague-Dawley rat cortical neurons assessed as increase in dendritic arbor complex at 1 nM after 1 hr supplemented with fresh neurobasal medium measured after 71 hrs by Alexa Fluor 488 dye based imaging analysis | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Identification of Psychoplastogenic |
| AID4096 | Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Central serotonin receptors as targets for drug research. |
| AID5741 | Affinity against 5-hydroxytryptamine 2C receptor in J1 cells transfected with the rat 5-HT2C gene labeled with [3H]mesulergine. | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. |
| AID1229573 | Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID1073062 | Inhibition of Electric eel AChE assessed as amount of thiocholine released using acetylthiocholine iodide as substrate after 6 mins by Ellman's method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents. |
| AID5109 | Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]- ketanserin as radioligand | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
| N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID1229571 | Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. |
| AID230151 | The compound evaluated for its receptor selectivity at [125I]- DOI- labeled receptors versus [3H]- ketanserin- labeled receptors, | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. |
| AID1583473 | Inhibition of 5HT2A receptor-mediated psycho-plastogenic activity in Sprague-Dawley rat cortical neurons assessed as decrease in dendritic arbor complexity at 1 uM pretreated with ketanserin for 1 hr followed by compound addition and ketanserin addition a | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Identification of Psychoplastogenic |
| AID1815950 | Stability in rat brain homogenate assessed as compound remaining measured after 120 mins | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID6520 | Binding affinity against human 5-hydroxytryptamine 6 receptor stably transfected to HEK 293 human embryonic kidney cells using [3H]-lysergic acid diethylamide as radioligand | 2000 | Bioorganic & medicinal chemistry letters, Oct-16, Volume: 10, Issue:20
| N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. |
| AID1815948 | Stability in human liver mitochondria assessed as intrinsic clearance in presence of MAO-A and MAO-B | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4
| Improved Metabolically Stable 5-HT Receptor Modulators and the Development of New Antidepressants. |
| AID4701 | Evaluated for binding affinity towards 5-hydroxytryptamine 1B receptor | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
| N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID5219 | Affinity on 5-hydroxytryptamine 2 receptor labeled by [125I]DOI | 1992 | Journal of medicinal chemistry, May-29, Volume: 35, Issue:11
| Benzofuran bioisosteres of hallucinogenic tryptamines. |
| AID258819 | Lowering of intraocular pressure in lasered cynomolgus monkey after 1 hr at 300 ug | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID258789 | Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID3999 | Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]OH-DPAT displacement. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? |
| AID172081 | The behavior disruption data as percent change in response from drug versus saline at dose 2mg/Kg, expressed as L (Late). | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID1131176 | Chloroform to aqueous buffer partition coefficient, log P of the compound at pH 7.4 by shake flask method | 1979 | Journal of medicinal chemistry, Nov, Volume: 22, Issue:11
| Bufotenine esters. |
| AID5495 | Compound was tested for binding affinity at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate using [125I]-2,5-Dimethoxy -4-iodoamphetamine (DOI). | 1999 | Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
| Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. |
| AID258811 | Distribution coefficient at pH 7.4 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
| AID4798 | Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligand | 1992 | Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
| 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
| AID3695 | Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Central serotonin receptors as targets for drug research. |
| AID276365 | Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. |
| AID6678 | Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
| Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). |
| AID3499 | Binding affinity against 5-hydroxytryptamine 1A receptor | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
| Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
| AID172074 | The behavior disruption data as percent change in response from drug versus saline at dose 1mg/Kg, expressed as E (efficient) | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID624230 | Agonists at Human 5-Hydroxytryptamine receptor 5-ht1e | 1993 | Proceedings of the National Academy of Sciences of the United States of America, Jan-15, Volume: 90, Issue:2
| Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. |
| AID1346739 | Human 5-HT1F receptor (5-Hydroxytryptamine receptors) | 1993 | Proceedings of the National Academy of Sciences of the United States of America, Jan-15, Volume: 90, Issue:2
| Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. |
| AID1346603 | Human 5-ht1e receptor (5-Hydroxytryptamine receptors) | 1993 | Proceedings of the National Academy of Sciences of the United States of America, Jan-15, Volume: 90, Issue:2
| Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. |
| AID1345154 | Rat 5-HT6 receptor (5-Hydroxytryptamine receptors) | 1998 | Journal of neurochemistry, Nov, Volume: 71, Issue:5
| Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. |
| AID1346603 | Human 5-ht1e receptor (5-Hydroxytryptamine receptors) | 2004 | Bioorganic & medicinal chemistry, May-15, Volume: 12, Issue:10
| Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation. |
| AID624216 | Agonists at Human 5-Hydroxytryptamine receptor 5-HT2C | 1999 | Journal of neurochemistry, May, Volume: 72, Issue:5
| High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. |
| AID1346893 | Human 5-HT2C receptor (5-Hydroxytryptamine receptors) | 1999 | Journal of neurochemistry, May, Volume: 72, Issue:5
| High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. |
| AID1345235 | Rat 5-HT7 receptor (5-Hydroxytryptamine receptors) | 1993 | The Journal of biological chemistry, Aug-25, Volume: 268, Issue:24
| Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. |
| AID624233 | Agonists at Human 5-Hydroxytryptamine receptor 5-HT1F | 1993 | Proceedings of the National Academy of Sciences of the United States of America, Jan-15, Volume: 90, Issue:2
| Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. |
| AID624230 | Agonists at Human 5-Hydroxytryptamine receptor 5-ht1e | 2004 | Bioorganic & medicinal chemistry, May-15, Volume: 12, Issue:10
| Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |