Sick Sinus Node Syndrome

A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.

Synonym
Sinus Node Dysfunction
Sinus Node Disease
Sick Sinus Syndrome
Sick Sinus Node Syndrome

Excerpt	Reference
"The evolution of sick sinus syndrome is slow, and its clinical and electrocardiographic manifestations are intermittent."	( Andres, F; Cosín, J; Hernandiz, A; Olagüe, J; Solaz, J, 1992)
"Sinus node dysfunction is a recognized problem following surgery for congenital heart disease."	( Garson, A; Gillette, PC; Marcus, B, 1991)
"In these patients sinus node dysfunction is caused by autonomic dysregulation."	( Kasper, W; Meinertz, T; Meyer, J; Pop, T; Steppert, C; Treese, N, 1984)
"Postoperative sinus node dysfunction is usually transient."	( Heinz, G, 1993)
"Sick sinus syndrome is a clinical term used to describe the clinical signs of sinus node dysfunction."	( Bonagura, JD; Corcoran, BM; Dukes-McEwan, J; French, A; Hitchcock, LS; Luis Fuentes, V; Martin, MW; Moneva-Jordan, A, 2001)
"Sick sinus syndrome is caused by sinus node dysfunction that renders it unable to function as a pacemaker."	( Cho, H; Chung, S; Kim, KO; Lee, K, 2011)
"Sick Sinus Syndrome is a common and refractory arrhythmia, needing further study in which setting up a credible sinus node damage model is important."	( Bao, MJ; Li, HB; Liu, RX; Wang, NN; Wang, YL; Xu, LY, 2012)

Excerpt	Reference
"Patients with sick sinus syndrome have global and regional disturbances of the adrenergic innervation of the left ventricular myocardium."	( Chrysostomakis, SI; Karkavitsas, NS; Marketou, ME; Prassopoulos, VK; Simantirakis, EN; Vardas, PE; Velidaki, AA, 2002)

Excerpt	Reference
"After 6 courses of CHOP therapy, sick sinus syndrome with syncope suddenly developed in the patient."	( Fujii, S; Fujiwara, T; Kikuchi, T; Miyata, A; Osada, T, 1998)
"177 consecutive patients with sick sinus syndrome (mean (SD) age 74 (9) years, 104 women) were randomly assigned to treatment with one of three pacemakers: AAIR (n = 54), DDDR with a short rate adaptive AV delay (n = 60) (DDDR-s); or DDDR with a fixed long AV delay (n = 63) (DDDR-l)."	( Andersen, HR; Kristensen, L; Mortensen, PT; Nielsen, JC; Pedersen, AK; Pedersen, OL, 2004)
"In patients with sick sinus syndrome, the effectiveness of atrial fibrillation treatment after pacemaker implantation is influenced by enlargement of the left and the right atria, increased interventricular septum thickness, and grade II mitral regurgitation."	( Aganauskiene, J; Aidietiene, S; Aidietis, A; Bagdonas, K; Barysiene, J; Jezovas, V; Jurkuvenas, P; Kaireviciūte, D; Laucevicius, A; Marinskis, G, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	166 (37.81)	23.3326
1990's	102 (23.23)	12.5806
2000's	73 (16.63)	18.1394
2010's	80 (18.22)	28.8240
2020's	18 (4.10)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
formaldehyde	low	2	0
niacinamide	medium	3	1
nitrous oxide	low	1	0
urea	low	1	0
phenytoin	low	1	0
etofylline	low	1	0
theophylline	medium	12	3
amiodarone	low	12	0
aspirin	medium	8	2
atenolol	medium	3	1
bencyclane	medium	1	1
bepridil	low	2	0
bisoprolol	low	2	0
verapamil	medium	19	1
carbamazepine	low	5	0
cifenline	low	1	0
cilostazol	medium	6	1
cimetidine	low	2	0
clonazepam	low	1	0
deferoxamine	low	1	0
desipramine	low	1	0
pentetic acid	low	1	0
dipyridamole	low	1	0
disopyramide	low	9	0
donepezil	low	1	0
ethacrynic acid	low	1	0
fentanyl	low	2	0
flecainide	low	3	0
fluconazole	low	1	0
fluorouracil	low	1	0
fluoxetine	low	1	0
halothane	low	2	0
hydralazine	medium	3	1
lidocaine	low	6	0
imipramine	low	1	0
isoetharine	low	1	0
isoflurane	low	1	0
isoproterenol	low	19	0
isradipine	low	2	0
ketamine	low	1	0
losartan	medium	1	1
meperidine	low	1	0
metaproterenol	low	1	0
metoprolol	low	1	0
mexiletine	low	2	0
apnea	low	2	0
neostigmine	low	4	0
nifedipine	low	4	0
nimodipine	low	1	0
nitroglycerin	low	1	0
nortriptyline	low	1	0
oxonic acid	low	1	0
papaverine	low	1	0
pilsicainide	low	1	0
pindolol	medium	2	2
potassium iodide	low	1	0
practolol	medium	3	1
procainamide	low	2	0
procaterol	low	1	0
propafenone	medium	5	1
propofol	low	2	0
propranolol	medium	52	1
sevoflurane	low	1	0
sotalol	medium	3	1
tegafur	low	1	0
prednisolone	low	6	0
spironolactone	low	1	0
aldosterone	low	2	0
prednisone	low	2	0
phenylephrine	low	3	0
methoxamine	low	2	0
cytarabine	low	2	0
methylprednisolone	low	5	0
isosorbide dinitrate	medium	1	1
meglumine	low	2	0
dexamethasone 21-phosphate	low	4	0
aminophylline	low	4	0
galantamine	low	1	0
dihydralazine	medium	1	1
malondialdehyde	low	1	0
lithium carbonate	low	7	0
sodium hydroxide	low	2	0
amiloride	low	1	0
iridium	low	2	0
plutonium	low	1	0
technetium	low	1	0
magnesium sulfate	low	1	0
ozone	low	1	0
moricizine	low	3	0
etoposide	low	1	0
dobutamine	low	1	0
methyldopa	low	1	0
diltiazem	low	2	0
vecuronium bromide	low	1	0
prenalterol	medium	3	1
idarubicin	low	1	0
nicorandil	medium	1	1
pergolide	low	1	0
fomesafen	low	5	0
ranolazine	low	1	0
remifentanil	low	1	0
3-iodobenzylguanidine	medium	4	1
adenosine	medium	15	1
propisomide	low	1	0
fluorodeoxyglucose f18	low	2	0
talinolol	low	1	0
amezinium	low	2	0
iridium oxide	low	2	0
fibrinogen	low	1	0
lopinavir	low	1	0
higenamine	low	2	0
landiolol	low	1	0
iodofiltic acid	low	1	0
mosapride	low	1	0
zd 7288	low	1	0
methotrexate	low	1	0
ivabradine	low	2	0
xamoterol	medium	1	1
technetium tc 99m pentetate	low	1	0
ec 27	low	1	0
biotin	low	1	0
angiotensin ii	low	6	0
atropine	low	85	0
dronedarone	low	1	0
lacosamide	low	3	0
benzofurans	low	3	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
ritonavir	low	1	0
lanatosides	low	1	0
ouabain	low	2	0
quinidine	medium	8	1
digitoxin	low	3	0
ergonovine	low	2	0
sodium bicarbonate	low	1	0
propylthiouracil	low	1	0
digoxin	medium	9	1
lithium	low	12	0
nitinol	low	1	0
codeine	low	1	0
dihydrocodeine	low	1	0
lead	low	1	0
thallium	low	1	0
butorphanol	low	1	0
cefotaxime	low	1	0
ajmaline	low	7	0
emerin	low	2	0
ergoline	low	1	0
ticagrelor	low	1	0
apixaban	low	1	0
oxadiazoles	low	1	0
losartan potassium	low	1	0
pituitrin	low	1	0
atrial natriuretic factor	medium	13	1
angiotensinogen	low	1	0
endothelin-1	low	1	0
quetiapine fumarate	low	1	0
cardiovascular agents	low	7	0
piperidines	low	2	0
allapinin	low	1	0
natriuretic peptide, brain	medium	16	6
minocycline	low	1	0
warfarin	medium	8	3
tigecycline	low	1	0
s 1 (combination)	low	1	0
aconitine	low	1	0
exudates	low	2	0
cyclic gmp	low	3	0
ganciclovir	low	1	0

Protein Targets (1,245)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	7	0	0	7
thioredoxin reductase	39	0	0	39
GLS protein	29	0	0	29
Thrombopoietin	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	13	0	0	13
cytochrome P450 2D6 isoform 1	11	0	0	11
cytochrome P450 2C19 precursor	12	0	0	12
ras-related protein Rab-9A	10	0	0	10
histone acetyltransferase KAT2A isoform 1	14	0	0	14
lethal factor (plasmid)	11	0	0	11
POU domain, class 2, transcription factor 1	0	0	0	5
Spike glycoprotein	30	0	1	31
ATP-dependent phosphofructokinase	23	0	0	23
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	53	0	0	53
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	27	0	0	27
glucocorticoid receptor [Homo sapiens]	37	0	0	37
retinoid X nuclear receptor alpha	28	0	0	28
estrogen nuclear receptor alpha	61	0	0	61
NPYLR7B	0	0	4	4
arylsulfatase A	27	0	0	27
IDH1	18	0	0	18
Histone H2A.x	21	0	0	21
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	12	0	0	12
flap endonuclease 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	20	0	0	20
peripheral myelin protein 22	29	0	0	29
survival motor neuron protein isoform d	16	0	0	16
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Rap guanine nucleotide exchange factor 3	6	0	0	6
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	5	0	5
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	9	3	13
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	21	0	0	21
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	2	2
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	5	1	7
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	6	5	13
Adenosine receptor A2b	0	2	1	5
Adenosine receptor A2b	0	2	1	4
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	3	12
Adenosine receptor A2a	0	6	1	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
thyroid hormone receptor beta isoform a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	16	0	0	17
geminin	47	0	0	47
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	5	3	9
Androgen receptor	0	8	0	9
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Guanine nucleotide-binding protein G	6	0	0	6
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
acid sphingomyelinase	3	0	0	3
acetylcholinesterase	16	0	0	16
TDP1 protein	57	0	0	57
aldehyde dehydrogenase 1 family, member A1	28	0	0	28
thyroid stimulating hormone receptor	19	0	0	19
glucocerebrosidase	6	0	0	6
alpha-galactosidase	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	48	0	0	48
Bloom syndrome protein isoform 1	15	0	0	15
lysosomal alpha-glucosidase preproprotein	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
thyroid hormone receptor beta isoform 2	32	0	0	32
huntingtin isoform 2	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	37	0	0	37
lamin isoform A-delta10	52	0	0	52
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	22	0	26
Bile salt export pump	0	74	0	74
Prothrombin	0	2	0	3
Coagulation factor X	0	3	0	3
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Cellular tumor antigen p53	33	0	0	33
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Trypsin-3	0	2	0	2
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	10	0	10
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	36	0	36
Sodium channel protein type 5 subunit alpha	0	18	0	18
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	11	0	12
Solute carrier family 22 member 2	0	10	0	10
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
USP1 protein, partial	17	0	0	17
Microtubule-associated protein tau	18	0	0	18
ATP-binding cassette sub-family C member 3	0	57	0	57
Multidrug resistance-associated protein 4	0	57	0	59
Canalicular multispecific organic anion transporter 1	0	57	0	58
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
phosphopantetheinyl transferase	17	0	0	17
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
RAR-related orphan receptor gamma	33	0	0	33
SMAD family member 2	15	0	0	15
ATAD5 protein, partial	16	0	0	16
Fumarate hydratase	11	0	0	11
NFKB1 protein, partial	9	0	0	9
PPM1D protein	9	0	0	9
SMAD family member 3	15	0	0	15
caspase 7, apoptosis-related cysteine protease	8	0	0	8
estrogen receptor 2 (ER beta)	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	30	0	0	30
progesterone receptor	28	0	0	28
EWS/FLI fusion protein	27	0	0	27
retinoic acid nuclear receptor alpha variant 1	34	0	0	34
estrogen-related nuclear receptor alpha	44	0	0	44
farnesoid X nuclear receptor	18	0	0	18
pregnane X nuclear receptor	41	0	0	41
G	23	0	0	23
cytochrome P450 2D6	32	0	0	32
polyprotein	11	0	0	11
peroxisome proliferator-activated receptor delta	19	0	0	19
peroxisome proliferator activated receptor gamma	24	0	0	24
caspase-3	8	0	0	8
thyroid stimulating hormone receptor	15	0	0	15
v-jun sarcoma virus 17 oncogene homolog (avian)	22	0	0	22
cellular tumor antigen p53 isoform a	9	0	0	9
cytochrome P450 2C9 precursor	9	0	0	9
D(1A) dopamine receptor	18	0	0	18
chromobox protein homolog 1	29	0	0	29
potassium voltage-gated channel subfamily H member 2 isoform d	20	0	0	20
heat shock protein beta-1	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	12	0	0	12
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
cytochrome P450 3A4 isoform 1	22	0	0	22
muscarinic acetylcholine receptor M1	17	0	0	17
Gamma-aminobutyric acid receptor subunit pi	22	4	6	32
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Solute carrier organic anion transporter family member 1A4	0	3	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	18	0	18
5-hydroxytryptamine receptor 4	0	24	0	24
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	23	0	0	23
Thyroid hormone receptor alpha	0	1	0	1
Integrin beta-3	7	1	0	8
Tyrosine-protein kinase Fyn	0	3	0	3
ATP-dependent translocase ABCB1	0	9	0	9
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	7	2	13
Muscarinic acetylcholine receptor M4	0	6	1	10
ATP-dependent translocase ABCB1	0	27	3	45
Integrin alpha-IIb	7	1	0	8
Beta-1 adrenergic receptor	0	21	11	32
Muscarinic acetylcholine receptor M5	0	8	1	12
Alpha-2A adrenergic receptor	0	16	3	22
Cytochrome P450 2C8	0	5	0	5
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	9	2	15
Beta-3 adrenergic receptor	0	12	11	23
D(2) dopamine receptor	0	12	2	14
Gamma-aminobutyric acid receptor subunit beta-1	22	4	6	32
Alpha-1B adrenergic receptor	0	15	1	16
Lethal factor	0	2	0	2
Alpha-2B adrenergic receptor	0	16	1	20
Thyroid hormone receptor beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	22	4	6	32
Gamma-aminobutyric acid receptor subunit gamma-2	22	4	6	32
Gamma-aminobutyric acid receptor subunit alpha-5	22	4	6	32
Gamma-aminobutyric acid receptor subunit alpha-3	22	4	6	32
Muscarinic acetylcholine receptor M3	0	9	2	14
ATP-dependent translocase ABCB1	0	9	0	10
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	10	1	11
D(4) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	22	4	6	32
Gamma-aminobutyric acid receptor subunit alpha-2	22	4	6	32
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	16	2	18
Histamine H2 receptor	0	8	0	8
Endothelin-1 receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	19	2	21
5-hydroxytryptamine receptor 2C	0	26	2	28
Gamma-aminobutyric acid receptor subunit alpha-4	22	4	6	32
Gamma-aminobutyric acid receptor subunit gamma-3	22	4	6	32
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	22	4	6	32
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	19	2	21
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	12	4	16
D(3) dopamine receptor	0	14	0	14
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	10	0	12
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	9	1	10
Kappa-type opioid receptor	0	11	2	13
5-hydroxytryptamine receptor 2B	0	20	1	21
C-C chemokine receptor type 2	0	4	0	4
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	16	1	17
Histamine H2 receptor	15	5	2	25
D(1A) dopamine receptor	10	0	0	10
5-hydroxytryptamine receptor 6	0	15	1	16
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	22	5	6	33
Gamma-aminobutyric acid receptor subunit beta-3	22	4	6	32
Gamma-aminobutyric acid receptor subunit beta-2	22	4	6	32
Sodium channel protein type 7 subunit alpha	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	18	0	18
Sodium-dependent dopamine transporter	0	13	1	14
Voltage-dependent L-type calcium channel subunit alpha-1S	0	18	0	18
Voltage-dependent L-type calcium channel subunit alpha-1C	0	22	0	23
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	12	0	12
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	22	4	6	32
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	23	0	0	23
Sodium channel protein type 2 subunit alpha	0	7	0	7
Ataxin-2	33	0	0	33
Sigma non-opioid intracellular receptor 1	0	16	1	17
Gamma-aminobutyric acid receptor subunit epsilon	22	4	6	32
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	8	0	8
Sodium channel protein type 11 subunit alpha	0	6	0	6
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	6	0	6
Sodium channel protein type 10 subunit alpha	0	6	0	6
cytochrome P450 2C9, partial	23	0	0	23
DNA polymerase kappa isoform 1	10	0	0	10
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	5	2	7
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	6	0	6
Type-1 angiotensin II receptor	0	5	4	11
Type-2 angiotensin II receptor	0	5	0	5
Type-2 angiotensin II receptor	0	3	0	3
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
Coagulation factor X	0	1	0	1
neuropeptide S receptor isoform A	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	6	0	0	6
hypothetical protein, conserved	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	35	0	0	35
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	17	0	0	17
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 1	0	7	0	7
Carbonic anhydrase 2	0	7	1	8
Fatty acid-binding protein, liver	0	3	0	3
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	1	1	8
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
Beta-1 adrenergic receptor	0	1	6	9
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	21	15	37
5-hydroxytryptamine receptor 1A	0	23	5	29
Alpha-1D adrenergic receptor	0	9	2	15
Alpha-1A adrenergic receptor	0	3	4	11
Alpha-1B adrenergic receptor	0	2	3	9
TAR DNA-binding protein 43	6	0	0	6
Beta-2 adrenergic receptor	0	2	7	11
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
GLI family zinc finger 3	42	0	0	42
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
activating transcription factor 6	19	0	0	19
67.9K protein	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	22	0	0	22
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Cytochrome P450 2C9	0	26	0	26
Cytochrome P450 2J2	0	17	0	17
Inositol monophosphatase 1	8	0	0	8
Envelope glycoprotein	0	0	2	2
ATPase family AAA domain-containing protein 5	18	0	0	18
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
apical membrane antigen 1, AMA1	4	0	0	4
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	15	0	0	15
insulin-degrading enzyme isoform 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Beta-1 adrenergic receptor	0	4	1	5
Chain A, Beta-lactamase	17	0	0	17
Vpr	3	0	0	3
Bile salt export pump	0	11	0	11
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2B6	0	0	1	1
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Albumin	0	2	6	12
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	4	0	5
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 7	0	1	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	3	0	5
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Solute carrier family 22 member 11	0	2	0	3
Solute carrier family 22 member 8	0	3	0	3
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
endonuclease IV	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
peripheral myelin protein 22 isoform 1	11	0	0	11
M-phase phosphoprotein 8	9	0	0	9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	8	0	8
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	6	0	6
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	8	0	8
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	9	0	10
Solute carrier family 22 member 2	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	4	0	4
Cytochrome P450 3A4	0	18	0	21
Cytochrome P450 2D6	0	13	0	13
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Histamine H1 receptor	0	0	2	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	6	0	6
Multidrug and toxin extrusion protein 1	0	10	0	10
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	1	6
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Cytochrome P450 2D1	0	3	0	3
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Delta-type opioid receptor	0	6	0	6
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Cytochrome P450 2D4	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Phosphodiesterase	0	3	0	3
Multidrug resistance-associated protein 5	0	1	0	2
glp-1 receptor, partial	15	0	0	15
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Solute carrier family 22 member 3	0	4	0	4
Solute carrier family 22 member 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	9	0	10
Tryptophan 5-hydroxylase 1	0	1	0	1
Angiotensin-converting enzyme	0	4	0	4
5-hydroxytryptamine receptor 2A	0	11	0	11
Alpha-2C adrenergic receptor	0	7	3	13
Sodium-dependent dopamine transporter	0	6	0	6
5-hydroxytryptamine receptor 1B	0	18	0	18
5-hydroxytryptamine receptor 1D	0	5	0	5
5-hydroxytryptamine receptor 1F	0	5	0	5
5-hydroxytryptamine receptor 2B	0	8	0	8
5-hydroxytryptamine receptor 6	0	4	0	4
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	9	0	9
5-hydroxytryptamine receptor 7	0	4	0	4
5-hydroxytryptamine receptor 5A	0	4	0	4
5-hydroxytryptamine receptor 5B	0	4	0	4
5-hydroxytryptamine receptor 3A	0	5	0	5
Voltage-dependent N-type calcium channel subunit alpha-1B	0	4	0	4
5-hydroxytryptamine receptor 4	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
5-hydroxytryptamine receptor 3B	0	5	0	5
Histamine H3 receptor	0	1	0	1
Transporter	0	5	0	5
Histamine H3 receptor	0	3	0	3
Chain A, Cruzipain	6	0	0	6
STAT3, partial	0	3	0	3
Smad3	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	7	0	0	7
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	5	0	6
Sodium/potassium-transporting ATPase subunit beta-1	0	5	0	6
Replicase polyprotein 1ab	0	8	1	9
Sodium/potassium-transporting ATPase subunit alpha-3	0	3	0	4
Sodium/potassium-transporting ATPase subunit beta-2	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	5	0	6
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	3	0	4
Sodium/potassium-transporting ATPase subunit gamma	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-4	0	3	0	4
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
PAX8	0	0	0	2
thioredoxin glutathione reductase	4	0	0	4
tumor necrosis factor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	7	0	8
Solute carrier organic anion transporter family member 1B1	0	7	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
ADP-ribose glycohydrolase MACROD2	0	1	0	1
Luciferase	10	0	0	10
aryl hydrocarbon receptor	13	0	0	13
Aspartate aminotransferase, cytoplasmic	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	1	10
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Ferritin light chain	7	0	0	7
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
nonstructural protein 1	10	0	0	10
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
snurportin-1	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	8	0	0	8
caspase-1 isoform alpha precursor	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	3	0	3
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	8	0	8
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	6	0	6
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Caspase-7	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	8	0	8
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Single-stranded DNA cytosine deaminase	3	0	0	3
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	2	0	2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	3
GALC protein	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Carbonic anhydrase 12	0	2	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	0	4
Carbonic anhydrase 7	0	2	0	2
Carbonic anhydrase 9	0	4	0	4
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
Acetylcholinesterase	0	6	0	6
Acetylcholinesterase	0	3	0	3
Amyloid-beta precursor protein	2	1	0	3
Cholinesterase	0	7	0	7
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	10	3	14
Liver carboxylesterase 1	0	1	0	2
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
Choline O-acetyltransferase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Beta-secretase 1	0	1	0	1
Cholinesterase	0	7	0	7
Cholinesterase	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	0	6
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	4	0	4
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Chain A, GLUTATHIONE TRANSFERASE A1-1	0	1	0	1
Chain A, Glutathione S-transferase P1-1	0	1	0	1
Chain A, Glutathione S-transferase P1-1	0	1	0	1
Chain B, Glutathione S-transferase P1-1	0	1	0	1
Nrf2	1	0	0	1
WRN	1	0	0	1
perilipin-5	0	3	0	3
perilipin-1	0	3	0	3
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Glutathione S-transferase A1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
60 kDa chaperonin	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	3	1	4
60 kDa heat shock protein, mitochondrial	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 6	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
UDP-glucose 4-epimerase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
14 kDa phosphohistidine phosphatase	0	2	0	2
large T antigen	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	5
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	6	1	7
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	5	0	5
Mu-type opioid receptor	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	4	0	4
Potassium voltage-gated channel subfamily D member 2	0	3	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
pregnane X receptor	4	0	0	4
hemoglobin subunit beta	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Potassium channel subfamily K member 2	0	4	2	6
Dipeptidyl peptidase 4	0	1	0	1
Alpha-2B adrenergic receptor	0	7	2	9
Alpha-2C adrenergic receptor	0	7	2	9
Alpha-2A adrenergic receptor	0	7	2	9
Alpha-1D adrenergic receptor	0	10	1	11
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Cytochrome P450 2C19	0	8	0	9
D(2) dopamine receptor	0	5	1	6
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Transporter	0	1	0	1
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	2	0	2
Vascular endothelial growth factor receptor 3	0	2	0	2
Vascular endothelial growth factor receptor 2	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Parkin	5	0	0	5
pyruvate kinase	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Lactoperoxidase	0	1	0	1
hexokinase-4 isoform 1	4	0	0	4
glucokinase regulatory protein	4	0	0	4
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Snq2p	0	0	0	1
Cytochrome P450 1A2	0	5	0	6
5-hydroxytryptamine receptor 1A	0	5	2	7
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	2	0	2
D(3) dopamine receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	1	0	2
D(1B) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	1	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(2) dopamine receptor	0	1	0	1
beta-2 adrenergic receptor	5	0	0	5
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Beta-2 adrenergic receptor	0	4	1	8
Beta-1 adrenergic receptor	0	7	4	15
Beta-2 adrenergic receptor	0	1	1	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Vasopressin V1a receptor	0	0	1	1
Beta-2 adrenergic receptor	0	3	1	4
Taste receptor type 2 member 38	0	0	2	3
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	5	6
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
15-lipoxygenase, partial	7	0	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 18	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Procathepsin L	0	0	1	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Protease	0	4	2	8
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
Angiotensin-converting enzyme 2	0	0	1	1
Protease	0	4	3	7
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Thromboxane A2 receptor	0	1	0	2
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
Platelet glycoprotein VI	0	1	1	3
Type-1 angiotensin II receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	2	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Protein-arginine deiminase type-4	0	3	0	3
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Glucocorticoid receptor	0	8	3	16
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Platelet-activating factor receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
Kruppel-like factor 5	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
D	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Gamma-aminobutyric acid	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	1	4
Angiotensin-converting enzyme	0	1	0	1
Renin	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
Sterol O-acyltransferase 1	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Vasopressin V1a receptor	0	3	1	4
Sodium/bile acid cotransporter	0	2	0	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Voltage-gated sodium channel Nav1.5 cardiac isoform	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Adenosine receptor A1	0	2	0	2
Vasopressin V2 receptor	0	0	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
P2Y purinoceptor 13	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (439)

Protein Targets (1,245)

Sick Sinus Node Syndrome

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (439)

Drugs Studied (193)

Protein Targets (1,245)