fluoxetine has been researched along with Delayed Effects, Prenatal Exposure in 125 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Excerpt | Relevance | Reference |
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"to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 8.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
"The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 7.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
" We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD)." | 7.85 | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. ( De Long, NE; Hardy, DB; Holloway, AC; Ma, N, 2017) |
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 7.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
"Several epidemiological studies have reported an association between arsenic exposure and increased rates of psychiatric disorders, including depression, in exposed populations." | 7.80 | Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism. ( Allan, AM; Solomon, BR; Tyler, CR; Ulibarri, AL, 2014) |
"In contrast to the adult, fluoxetine exposure in utero induces pulmonary hypertension in the fetal rat as a result of a developmentally regulated increase in pulmonary vascular smooth muscle proliferation." | 7.74 | Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat. ( Belik, J; Fornaro, E; Li, D; Pan, J, 2007) |
"Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation." | 7.74 | Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. ( Costa, LC; Lisboa, SF; Moreira, EG; Oliveira, PE; Venâncio, EJ, 2007) |
"The aim of the present study was to compare the toxic effects of fluoxetine (F) (8 and 16 mg/kg) and venlafaxine (V) (40 and 80 mg/kg) administered during the third week of pregnancy on early development of rats." | 7.70 | Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy. ( Altenburg, SP; da-Silva, VA; Lindsey, CJ; Malheiros, LR; Thomaz, TG, 1999) |
"We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5." | 5.37 | [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats]. ( Akulova, VK; Fedotova, YO; Ordian, NÉ; Pivina, SG, 2011) |
"Fluoxetine-treated dams gave birth to litters 15% smaller than usual and to pups of reduced weight (until postnatal day 7)." | 5.37 | Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. ( Afrasiab-Middelman, A; Dederen, JP; Homberg, JR; Jonkers, M; Kiliaan, AJ; Korte-Bouws, GA; Martens, GJ; Olivier, JD; Peeters, EJ; Roelofs, JJ; Schubert, D; Vallès, A; van Heesch, F, 2011) |
"Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 5.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
" By chronically exposing pregnant/lactating mice to MeHg, we found persistent behavioural changes in the male offspring, which exhibited depression-like behaviour that could be reversed by chronic treatment with the antidepressant fluoxetine." | 4.89 | Long-lasting neurotoxic effects of exposure to methylmercury during development. ( Bose, R; Ceccatelli, S; Edoff, K; Onishchenko, N; Spulber, S, 2013) |
"During and following pregnancy, women are at high risk of experiencing depression, for which fluoxetine (FLX; brand names Prozac, Sarafem, Rapiflux) is the most commonly prescribed treatment." | 4.89 | Long-term outcomes of developmental exposure to fluoxetine: a review of the animal literature. ( Dyck, RH; Kiryanova, V; McAllister, BB, 2013) |
"There is no conclusive evidence for increased risk for malformations but paroxetine and possibly fluoxetine use in early pregnancy may be associated with a small increased risk for cardiovascular malformations." | 4.86 | Risks associated with in utero and lactation exposure to selective serotonin reuptake inhibitors (SSRIs). ( Ellfolk, M; Malm, H, 2010) |
" In particular, we treated female and male rats with fluoxetine (FLX 15 mg/kg dissolved in drinking water) during prenatal or early postnatal life, and we evaluated different pathological-like phenotypes (cognitive deficit, anhedonia, and anxiety) by exposing the rats to a battery of behavioral tests during adolescence and adulthood." | 4.31 | Perinatal serotonergic manipulation shapes anhedonic and cognitive behaviors in a sex- and age-dependent manner: Identification of related biological functions at central and peripheral level. ( Brivio, P; Calabrese, F; Dolci, B; Fumagalli, F; Gallo, MT, 2023) |
"During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are usually the first-line treatment." | 4.12 | Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring. ( Brandão, LEM; Câmara, DA; Cavalcante, JS; de Aquino, ACQ; Engelberth, RCJG; Fiuza, FP; Lima, RH; Linhares, SSG; Meurer, YDSR, 2022) |
" The selective serotonin reuptake inhibitor fluoxetine (FLX) is the first-line antidepressant drug prescribed during pregnancy." | 4.12 | Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats. ( Biancardi, V; Bícego, KC; Funk, GD; Gargaglioni, LH; Marques, DA; Patrone, LGA; Vicente, MC, 2022) |
"Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy." | 4.02 | Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats. ( Hoehn, M; Homberg, JR; Schubert, D; Van der Knaap, N; Wiedermann, D, 2021) |
"to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 4.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
" Furthermore, stressed dams were treated with different doses of fluoxetine (FLX; 5, 10and 25 mg/kg) during pregnancy and the postpartum period." | 4.02 | Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring. ( Amani, M; Homberg, JR; Houwing, DJ; Salari, AA, 2021) |
"Fluoxetine is often prescribed to treat depression during pregnancy." | 4.02 | Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring. ( Ampuero, E; de Vries, EF; Díaz-Galarce, R; Donoso-Ramos, JP; Doorduin, J; Linsambarth, S; Moraga-Amaro, R; Pacheco, R; Peña, F; Stehberg, J; Ugalde, V; Wyneken, U, 2021) |
" In this regard, we chronically treated normal female mice with different dosages (0, 10, and 20 mg/kg) of fluoxetine (FLU) for 2 weeks before mating them with drug-free male mice and then tested the offspring for anxiety/depression-like behaviors with the elevated plus maze and the tail-suspension test after exposing to acute or chronic stress in adult period." | 3.91 | Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring. ( Li, J; Si, J; Suo, L; Yang, C; Zhang, Y, 2019) |
"The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 3.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
"We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period." | 3.88 | Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats. ( Butkevich, IP; Mikhailenko, VA, 2018) |
"Fluoxetine (FLX) is an antidepressant from the selective serotonin reuptake inhibitor class that has largely been used for the treatment of depression in pregnancy." | 3.88 | Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring's brain and affects the social interaction of rat. ( Estrada, VB; Francis-Oliveira, J; Gomes, MV; Moreira, EG; Pelosi, GG; Silva, AS; Toffoli, LV; Veríssimo, LF, 2018) |
"Our goal was to find out the impact of two antidepressant drugs with various mechanisms of action - imipramine and fluoxetine, on the frontal cortex mitochondria-enriched fraction in an animal model of depression based on the prenatal stress procedure." | 3.88 | Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. ( Basta-Kaim, A; Chamera, K; Głombik, K; Kotarska, K; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2018) |
"The study aimed to evaluate if maternal exposure to fluoxetine (FLX) during pregnancy and lactation would result in altered aortic reactivity in adult offspring." | 3.88 | Intrauterine and lactational exposure to fluoxetine enhances endothelial modulation of aortic contractile response in adult female rats. ( Akamine, EH; Carvalho, MHC; Ceravolo, GS; Echem, C; Gerardin, DCC; Higashi, CM; Lucchetti, BFC; Moreira, EG; Pelosi, GG; Pinge-Filho, P; Sartoretto, SM, 2018) |
" We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD)." | 3.85 | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. ( De Long, NE; Hardy, DB; Holloway, AC; Ma, N, 2017) |
" To this end, pregnant female dams were exposed to saline or fluoxetine (FLX) throughout pregnancy, and the behavior of the offspring was examined." | 3.83 | Prenatal exposure to selective serotonin reuptake inhibitors (SSRI) increases aggression and modulates maternal behavior in offspring mice. ( Avitsur, R; Levy, S; Svirsky, N, 2016) |
"Fluoxetine (FLX) is an antidepressant worldwide prescribed throughout life stages, including pregnancy and breastfeeding." | 3.83 | Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine? ( Barbosa, DS; Ceravolo, GS; Gameiro, JG; Higachi, L; Higashi, CM; Matsumoto, AK; Moreira, EG; Moura, KF; Oliveira, LC, 2016) |
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 3.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
"Several epidemiological studies have reported an association between arsenic exposure and increased rates of psychiatric disorders, including depression, in exposed populations." | 3.80 | Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism. ( Allan, AM; Solomon, BR; Tyler, CR; Ulibarri, AL, 2014) |
"Fluoxetine is an antidepressant that has been largely used for treatment of depression in pregnancy." | 3.80 | Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation. ( Gomes, MV; Moreira, EG; Oliveira, JF; Pelosi, GG; Rodrigues, GM; Silva, AS; Toffoli, LV, 2014) |
" Her mother had been taking fluoxetine (20 mg daily) during the second and third trimesters of her pregnancy." | 3.74 | Prolonged neonatal complications after in utero exposure to fluoxetine. ( Alehan, F; Gürakan, B; Saygi, S; Tarcan, A, 2008) |
"Three groups of female rats received either distilled water or doses of fluoxetine 8 and 12 mg/kg orally from the 6th to the 20th day of pregnancy." | 3.74 | Developmental and behavioral consequences of prenatal fluoxetine. ( Ashok, KP; Bairy, I; Bairy, KL; Madhyastha, S; Malini, S, 2007) |
"Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation." | 3.74 | Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. ( Costa, LC; Lisboa, SF; Moreira, EG; Oliveira, PE; Venâncio, EJ, 2007) |
"In contrast to the adult, fluoxetine exposure in utero induces pulmonary hypertension in the fetal rat as a result of a developmentally regulated increase in pulmonary vascular smooth muscle proliferation." | 3.74 | Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat. ( Belik, J; Fornaro, E; Li, D; Pan, J, 2007) |
" Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) antidepressant, has been widely prescribed for depression during pregnancy and/or lactation." | 3.74 | Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice. ( de Faria, MJ; Gerardin, DC; Gouvêa, TS; Moreira, EG; Morimoto, HK, 2008) |
" In this study, we report that the depression-like behavior in MeHg-exposed male mice is reversed by chronic treatment with the antidepressant fluoxetine." | 3.74 | Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. ( Castrén, E; Ceccatelli, S; Karpova, N; Onishchenko, N; Sabri, F, 2008) |
" Her mother was on 20 mg of fluoxetine throughout her pregnancy." | 3.73 | Fluoxetine withdrawal syndrome in the newborn. ( Anbu, AT; Theodore, A, 2006) |
" However, maternal use of high doses of fluoxetine throughout pregnancy may be associated with a risk for low birth weight." | 3.72 | Birth outcomes after prenatal exposure to antidepressant medication. ( Altshuler, L; Haynes, D; Hendrick, V; Hwang, S; Smith, LM; Suri, R, 2003) |
"The aim of the present study was to compare the toxic effects of fluoxetine (F) (8 and 16 mg/kg) and venlafaxine (V) (40 and 80 mg/kg) administered during the third week of pregnancy on early development of rats." | 3.70 | Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy. ( Altenburg, SP; da-Silva, VA; Lindsey, CJ; Malheiros, LR; Thomaz, TG, 1999) |
"Prospectively identified fluoxetine-exposed pregnancies were evaluated to determine whether fluoxetine, a serotonin reuptake inhibitor commonly used for the treatment of depression and obsessive-compulsive disorder, might be associated with neonatal complications after maternal fluoxetine exposure during the third trimester through delivery." | 3.69 | Effects of third trimester fluoxetine exposure on the newborn. ( Goldstein, DJ, 1995) |
" We found that these effects were differential between female mice dosed lactationally or peripartally, and there were also impacts on maternal mammary gland at weaning in both of these groups." | 1.91 | In utero, lactational, or peripartal fluoxetine administration has differential implications on the murine maternal skeleton. ( Brettingen, LJ; Charles, JF; Fricke, HP; Hernandez, LL; Krajco, CJ; Perry, MJ; Reisner, MA; Wake, LA, 2023) |
" The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol." | 1.46 | Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol. ( Czaja, N; Kus, K; Nowakowska, E; Ratajczak, P; Zaprutko, T, 2017) |
"Women with major depressive disorder during pregnancy often use selective serotonin reuptake inhibitors (SSRIs) antidepressants." | 1.46 | Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: role for glucocorticoid insensitivity. ( Avitsur, R, 2017) |
" On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression." | 1.46 | Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Chamera, K; Głombik, K; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2017) |
"Stress during pregnancy is associated with lifetime negative consequences for the offspring." | 1.46 | Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? ( Avitsur, R, 2017) |
"Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation." | 1.43 | In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring. ( Anselmo-Franci, JA; Ceravolo, GS; de Azevedo Camin, N; Dos Santos, AH; Gerardin, DC; Kiss, AC; Mesquita, Sde F; Moreira, EG; Pelosi, GG; Vieira, ML, 2016) |
"The long-term use of fluoxetine via oral route by pregnant and lactating rats modifies the mandibular bone mass." | 1.42 | Effects of treatment with fluoxetine on mandibular development: A morphological study in rats. ( Baratella-Evêncio, L; Correia-Leite de Marcelos, PG; Cruz Perez, DE; de Moraes Ramos-Perez, FM; Evêncio Neto, J; Regueira, LS; Santiago-Jaegger, IM, 2015) |
"Major depression is one of the most prevalent mental disorders in the population." | 1.40 | Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. ( Lin, YL; Wang, S, 2014) |
"Fluoxetine-treated dams gave birth to litters 15% smaller than usual and to pups of reduced weight (until postnatal day 7)." | 1.37 | Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. ( Afrasiab-Middelman, A; Dederen, JP; Homberg, JR; Jonkers, M; Kiliaan, AJ; Korte-Bouws, GA; Martens, GJ; Olivier, JD; Peeters, EJ; Roelofs, JJ; Schubert, D; Vallès, A; van Heesch, F, 2011) |
"We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5." | 1.37 | [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats]. ( Akulova, VK; Fedotova, YO; Ordian, NÉ; Pivina, SG, 2011) |
" Dam dosing was adjusted to reflect the 50th and 85th percentiles of serum concentrations observed in pregnant women." | 1.37 | Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk. ( Bourke, CH; Capello, CF; Nemeroff, A; Newport, DJ; Owens, MJ; Ritchie, JC; Stowe, ZN, 2011) |
"Fluoxetine is an antidepressant drug, only recently discovered to be a QT interval prolonging agent." | 1.33 | Prolonged QT interval in an infant of a fluoxetine treated mother. ( Dubnov, G; Fogelman, R; Merlob, P, 2005) |
"Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 1.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
"Fluoxetine is a widely used serotonin reuptake inhibitor effective in the treatment of depression." | 1.29 | A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats. ( Acuff-Smith, KD; Buelke-Sam, J; Fisher, JE; Moran, MS; Schilling, MA; Vorhees, CV, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 9 (7.20) | 18.2507 |
2000's | 20 (16.00) | 29.6817 |
2010's | 66 (52.80) | 24.3611 |
2020's | 30 (24.00) | 2.80 |
Authors | Studies |
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Sylte, OC | 1 |
Johansen, JS | 1 |
Heinla, I | 3 |
Houwing, DJ | 6 |
Olivier, JDA | 5 |
Heijkoop, R | 3 |
Snoeren, EMS | 3 |
Marks, C | 1 |
Silvola, R | 1 |
Teal, E | 1 |
Quinney, SK | 1 |
Haas, DM | 1 |
Leussis, MP | 1 |
Thanos, JM | 1 |
Powers, A | 1 |
Peterson, E | 1 |
Head, JP | 1 |
McGovern, NJ | 1 |
Malarkey, FJ | 1 |
Drake, A | 1 |
Ramsteijn, AS | 2 |
Verkaik-Schakel, RN | 1 |
Plösch, T | 1 |
Linhares, SSG | 2 |
Meurer, YDSR | 2 |
Aquino, A | 1 |
Câmara, DA | 2 |
Brandão, LEM | 2 |
Dierschnabel, AL | 1 |
Fiuza, FP | 2 |
Lima, RH | 2 |
Engelberth, RC | 1 |
Cavalcante, JS | 2 |
Biancardi, V | 1 |
Patrone, LGA | 1 |
Vicente, MC | 1 |
Marques, DA | 1 |
Bícego, KC | 1 |
Funk, GD | 1 |
Gargaglioni, LH | 1 |
Ascencio Gutierrez, V | 1 |
Carrillo, AA | 1 |
Boersma, GJ | 1 |
Tamashiro, KLK | 1 |
Moran, TH | 1 |
Iñiguez, SD | 1 |
Treesukosol, Y | 1 |
Arzuaga, AL | 1 |
Edmison, DD | 1 |
Mroczek, J | 1 |
Larson, J | 1 |
Ragozzino, ME | 1 |
de Aquino, ACQ | 1 |
Engelberth, RCJG | 1 |
Zaidan, H | 2 |
Wnuk, A | 1 |
Aderka, IM | 1 |
Kajta, M | 1 |
Gaisler-Salomon, I | 2 |
Pawluski, JL | 11 |
Murail, P | 1 |
Grudet, F | 1 |
Bys, L | 1 |
Golubeva, AV | 1 |
Bastiaanssen, T | 1 |
Oberlander, TF | 1 |
Cryan, JF | 1 |
O'Mahony, SM | 1 |
Charlier, TD | 6 |
Lan, Z | 1 |
Tachibana, RO | 1 |
Kanno, K | 1 |
Gallo, MT | 1 |
Brivio, P | 1 |
Dolci, B | 1 |
Fumagalli, F | 1 |
Calabrese, F | 1 |
Prowse, KL | 1 |
Law, H | 1 |
Raez-Villanueva, S | 1 |
Markovic, F | 1 |
Wang, M | 1 |
Borojevic, R | 1 |
Parsons, SP | 1 |
Vincent, AD | 1 |
Holloway, AC | 4 |
Ratcliffe, EM | 1 |
Fricke, HP | 2 |
Krajco, CJ | 2 |
Perry, MJ | 2 |
Reisner, MA | 1 |
Brettingen, LJ | 1 |
Wake, LA | 2 |
Charles, JF | 2 |
Hernandez, LL | 2 |
Desorcy-Scherer, KM | 1 |
Yang, C | 1 |
Si, J | 1 |
Suo, L | 1 |
Zhang, Y | 1 |
Li, J | 1 |
Schuttel, K | 1 |
Struik, EL | 1 |
Arling, C | 1 |
Christodoulos, IN | 1 |
Chyou, TY | 1 |
Nishtala, PS | 1 |
Visco, DB | 1 |
Manhães-de-Castro, R | 2 |
da Silva, MM | 1 |
Dantas-Alves, JS | 1 |
Costa-de-Santana, BJR | 1 |
Braz, GRF | 1 |
da Silva, AI | 1 |
Lagranha, CJ | 1 |
Toscano, AE | 1 |
Si, Y | 1 |
Xue, X | 1 |
Liu, S | 1 |
Feng, C | 1 |
Zhang, H | 1 |
Zhang, S | 1 |
Ren, Y | 1 |
Ma, H | 1 |
Dong, Y | 1 |
Li, H | 1 |
Xie, L | 1 |
Zhu, Z | 1 |
Van der Knaap, N | 1 |
Wiedermann, D | 1 |
Schubert, D | 2 |
Hoehn, M | 1 |
Homberg, JR | 6 |
Cavalcanti, CCL | 1 |
Da Silva Aragão, R | 1 |
Cadena-Burbano, EV | 1 |
Oliveira, TRDP | 1 |
Silva, JM | 1 |
Benjamim, RAC | 1 |
Lago, AB | 1 |
Silva, EHM | 1 |
Costa, TL | 1 |
Galiani, D | 1 |
Vuong, HE | 1 |
Coley, EJL | 1 |
Kazantsev, M | 1 |
Cooke, ME | 1 |
Rendon, TK | 1 |
Paramo, J | 1 |
Hsiao, EY | 1 |
Scarborough, J | 1 |
Mueller, FS | 1 |
Weber-Stadlbauer, U | 1 |
Mattei, D | 1 |
Opitz, L | 1 |
Cattaneo, A | 1 |
Richetto, J | 1 |
Qiu, W | 1 |
Go, KA | 1 |
Wen, Y | 1 |
Duarte-Guterman, P | 1 |
Eid, RS | 1 |
Galea, LAM | 1 |
Amani, M | 1 |
Salari, AA | 2 |
Moraga-Amaro, R | 1 |
Díaz-Galarce, R | 1 |
Donoso-Ramos, JP | 1 |
Ugalde, V | 1 |
Linsambarth, S | 1 |
Doorduin, J | 1 |
de Vries, EF | 1 |
Ampuero, E | 1 |
Peña, F | 1 |
Pacheco, R | 1 |
Wyneken, U | 1 |
Stehberg, J | 1 |
Kus, K | 2 |
Ratajczak, P | 1 |
Czaja, N | 1 |
Zaprutko, T | 2 |
Nowakowska, E | 2 |
Avitsur, R | 5 |
Kiryanova, V | 7 |
Meunier, SJ | 2 |
Dyck, RH | 7 |
Głombik, K | 3 |
Stachowicz, A | 2 |
Trojan, E | 3 |
Olszanecki, R | 2 |
Ślusarczyk, J | 3 |
Suski, M | 2 |
Chamera, K | 3 |
Budziszewska, B | 2 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226] | 1,431 participants (Actual) | Observational | 2007-09-30 | Completed | |||
Antidepressant Use During Pregnancy[NCT00279370] | 283 participants (Actual) | Observational | 1999-09-30 | Completed | |||
Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127] | 20 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for fluoxetine and Delayed Effects, Prenatal Exposure
Article | Year |
---|---|
Long-lasting neurotoxic effects of exposure to methylmercury during development.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Proliferation; Cellular Senescence; Depressi | 2013 |
Long-term outcomes of developmental exposure to fluoxetine: a review of the animal literature.
Topics: Animals; Anxiety; Brain; Depression; Female; Fluoxetine; Humans; Pregnancy; Prenatal Exposure Delaye | 2013 |
Risks associated with in utero and lactation exposure to selective serotonin reuptake inhibitors (SSRIs).
Topics: Adult; Breast Feeding; Cardiovascular Abnormalities; Congenital Abnormalities; Female; Fluoxetine; H | 2010 |
Fluoxetine during pregnancy: impact on fetal development.
Topics: Animals; Antidepressive Agents, Second-Generation; Circadian Rhythm; Depression; Disease Models, Ani | 2005 |
Psychotropic drugs in pregnancy and lactation.
Topics: Clozapine; Embryonic and Fetal Development; Female; Fluoxetine; Humans; Lactation; Lithium; Mental D | 1994 |
120 other studies available for fluoxetine and Delayed Effects, Prenatal Exposure
Article | Year |
---|---|
Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment.
Topics: Animals; Behavior, Animal; Female; Fluoxetine; Male; Pregnancy; Prenatal Exposure Delayed Effects; R | 2021 |
Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study.
Topics: Antidepressive Agents; Bupropion; Citalopram; Duloxetine Hydrochloride; Escitalopram; Female; Fluoxe | 2021 |
Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Communication; Depression; Female; Flu | 2021 |
Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats.
Topics: Animals; Epigenesis, Genetic; Female; Fluoxetine; Gene Expression; Hippocampus; Humans; Male; Myelin | 2022 |
Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5-HT expression in male and female adult Wistar rats.
Topics: Animals; Antidepressive Agents; Circadian Rhythm; Female; Fluoxetine; Locomotion; Male; Neuropeptide | 2022 |
Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats.
Topics: Animals; Carbon Dioxide; Female; Fluoxetine; Humans; Hypercapnia; Hyperventilation; Male; Placenta; | 2022 |
Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats.
Topics: Animals; Avoidance Learning; Body Weight; Female; Fluoxetine; Lithium Chloride; Male; Prenatal Expos | 2022 |
Prenatal stress and fluoxetine exposure in mice differentially affect repetitive behaviors and synaptic plasticity in adult male and female offspring.
Topics: Animals; Autism Spectrum Disorder; Female; Fluoxetine; Humans; Male; Mice; Mice, Inbred C57BL; Neuro | 2023 |
Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring.
Topics: Animals; Anxiety; Female; Fluoxetine; Humans; Male; Placenta; Pregnancy; Prenatal Exposure Delayed E | 2022 |
Pre-reproductive stress in adolescent female rats alters maternal care and DNA methylation patterns across generations.
Topics: Animals; DNA Methylation; Epigenesis, Genetic; Female; Fluoxetine; Humans; Male; Prenatal Exposure D | 2023 |
Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome-gut-brain axis.
Topics: Animals; Antidepressive Agents; Brain-Gut Axis; Female; Fluoxetine; Humans; Pregnancy; Prenatal Expo | 2023 |
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring.
Topics: Animals; Female; Fluoxetine; Humans; Lactation; Maternal Exposure; Mice; Pregnancy; Prenatal Exposur | 2023 |
Perinatal serotonergic manipulation shapes anhedonic and cognitive behaviors in a sex- and age-dependent manner: Identification of related biological functions at central and peripheral level.
Topics: Animals; Anxiety; Behavior, Animal; Biomarkers; Brain; Cognition; Female; Fluoxetine; Humans; Male; | 2023 |
Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.
Topics: Animals; Colitis; Female; Fluoxetine; Humans; Inflammation; Male; Pregnancy; Prenatal Exposure Delay | 2023 |
In utero, lactational, or peripartal fluoxetine administration has differential implications on the murine maternal skeleton.
Topics: Animals; Bone and Bones; Bone Development; Female; Fluoxetine; Humans; Lactation; Mice; Pregnancy; P | 2023 |
Developmental fluoxetine exposure affects adolescent and adult bone depending on the dose and period of exposure in mice.
Topics: Animals; Bone and Bones; Depressive Disorder, Major; Female; Fluoxetine; Humans; Mice; Prenatal Expo | 2023 |
Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Depression; Disease Mo | 2019 |
Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.
Topics: Affect; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Anim | 2020 |
Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure.
Topics: Adult; Altruism; Animals; Behavior, Animal; Female; Fluoxetine; Humans; Male; Pregnancy; Prenatal Ex | 2020 |
Safety of fluoxetine use in children and adolescents: a disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Antidepressive Agents, Second-Generation; Anxie | 2020 |
Early life fluoxetine treatment causes long-term lean phenotype in skeletal muscle of rats exposed to maternal lard-based high-fat diet.
Topics: Animals; Animals, Newborn; Body Weight; Citrate (si)-Synthase; Diet, High-Fat; Dietary Fats; Eating; | 2020 |
CRTC1 signaling involvement in depression-like behavior of prenatally stressed offspring rat.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Female; Fluoxetine; Male; | 2021 |
Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.
Topics: Animals; Antidepressive Agents; Brain; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Magn | 2021 |
High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine.
Topics: Animals; Anxiety; Behavior, Animal; Diet, High-Fat; Disease Models, Animal; Energy Intake; Female; F | 2021 |
Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.
Topics: Animals; Female; Fluoxetine; Gene Expression; MicroRNAs; Oocytes; Phenotype; Pregnancy; Prenatal Exp | 2021 |
Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice.
Topics: Animals; Brain; Cell Adhesion Molecules; Disease Models, Animal; Embryo, Mammalian; Female; Fluoxeti | 2021 |
A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Fluoxetine; Mice; Pregna | 2021 |
Maternal fluoxetine reduces hippocampal inflammation and neurogenesis in adult offspring with sex-specific effects of periadolescent oxytocin.
Topics: Adult Children; Animals; Autism Spectrum Disorder; Doublecortin Protein; Female; Fluoxetine; Hippoca | 2021 |
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Female; Fluoxetine; Hippocampus; L | 2021 |
Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Depression; Female; Fluoxetine; Food Pre | 2021 |
Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Avoidance Learning; Central Nervous System Depressants; | 2017 |
Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: role for glucocorticoid insensitivity.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depres | 2017 |
Behavioural outcomes of adult female offspring following maternal stress and perinatal fluoxetine exposure.
Topics: Aging; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Female; Fluoxetine; Ma | 2017 |
Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression.
Topics: 14-3-3 Proteins; Animals; Antidepressive Agents; Cathepsin D; COP9 Signalosome Complex; Depression; | 2017 |
Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis.
Topics: Animals; Animals, Newborn; Epigenesis, Genetic; Female; Fluoxetine; Incidence; Inflammasomes; Lipoge | 2017 |
Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Female; Fluoxetine; Hippocampus; Hypothalamo-Hypophy | 2017 |
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Disease Models, Animal; Female; Fluoxetine; | 2017 |
Intrauterine and lactation exposure to fluoxetine blunted in the offspring the aortic adaptive response induced by acute restraint stress.
Topics: Adaptation, Physiological; Animals; Aorta; Female; Fluoxetine; Lactation; Male; Nitric Oxide; Pregna | 2017 |
Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring.
Topics: Age Factors; Animals; Animals, Newborn; Disks Large Homolog 4 Protein; Drug Administration Schedule; | 2018 |
Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam.
Topics: Animals; Behavior, Animal; Corticosterone; Female; Fluoxetine; Hippocampus; Maternal Behavior; Neuro | 2018 |
Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Female; Flu | 2018 |
Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Animals, Newborn; Anxiety; Anxiety Disorders; Behavio | 2018 |
Intrauterine and lactational exposure to fluoxetine enhances endothelial modulation of aortic contractile response in adult female rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Aorta, Thoracic; Cyclooxygenase 1; Dose-Response | 2018 |
Male rats with same-sex preference show higher immobility in the forced swim test, but similar effects of fluoxetine and desipramine than males that prefer females.
Topics: Animals; Desipramine; Female; Fluoxetine; Immobility Response, Tonic; Letrozole; Male; Motor Activit | 2018 |
Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight; Cognition; Female; Fluoxetine; Ma | 2018 |
Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring's brain and affects the social interaction of rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; DNA Methylation; Epigenesis, Genetic; Female; Fl | 2018 |
Perinatal fluoxetine has enduring sexually differentiated effects on neurobehavioral outcomes related to social behaviors.
Topics: Animals; Female; Fluoxetine; Hippocampus; Male; Neurogenesis; Neuronal Plasticity; Pregnancy; Pregna | 2019 |
Prenatal Stimulation of 5-HT
Topics: Adaptation, Psychological; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buspirone; Depressi | 2019 |
Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o
Topics: Animals; Anxiety; Depression; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Male; Prefron | 2019 |
Postnatal outcomes in lambs exposed antenatally and acutely postnatally to fluoxetine.
Topics: Animals; Animals, Newborn; Female; Fluoxetine; Heart Rate; Maternal Exposure; Pregnancy; Prenatal Ex | 2019 |
Maternal exposure to fluoxetine during gestation and lactation does not alter plasma concentrations of testosterone, oestrogen or corticosterone in peripubertal offspring.
Topics: Animals; Corticosterone; Estrogens; Female; Fluoxetine; Male; Maternal Exposure; Placenta; Pregnancy | 2019 |
Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.
Topics: Action Potentials; Animals; Behavior, Animal; Female; Fluoxetine; Interneurons; Male; Memory, Short- | 2019 |
Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Environment; Female; Fluoxetine; Pregnancy; Pr | 2019 |
Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats.
Topics: Animals; Antidepressive Agents; Benzylamines; Disease Models, Animal; Drug Administration Schedule; | 2019 |
Perinatal fluoxetine exposure results in social deficits and reduced monoamine oxidase gene expression in mice.
Topics: Animals; Antidepressive Agents; Autism Spectrum Disorder; Behavior, Animal; Brain; Exploratory Behav | 2020 |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats.
Topics: Aging; Amygdala; Animals; Female; Fluoxetine; Lactation; Male; Paraventricular Hypothalamic Nucleus; | 2013 |
Developmental fluoxetine exposure facilitates sexual behavior in female offspring.
Topics: Anal Canal; Analysis of Variance; Animals; Animals, Newborn; Brain; Estradiol; Estrous Cycle; Female | 2014 |
Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Cell Proliferation; Depression; Fema | 2014 |
Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Brain; DNA Methylation; Exp | 2014 |
Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism.
Topics: Animals; Antidepressive Agents, Second-Generation; Arsenic; Depression; Female; Fluoxetine; Helpless | 2014 |
Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Conditioning, Classical; Fear; Female; Fluoxetine; M | 2014 |
Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats.
Topics: Adiposity; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Diabetes | 2015 |
Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; CLOCK Proteins; Estrus; Female; Fluoxetine; Gene | 2015 |
Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Cell Count; Extracellular Matrix Proteins; Female; Fl | 2015 |
Prenatal fluoxetine exposure affects cytokine and behavioral response to an immune challenge.
Topics: Age Factors; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Body Weight; C | 2015 |
Effects of treatment with fluoxetine on mandibular development: A morphological study in rats.
Topics: Animals; Animals, Newborn; Body Weight; Female; Fluoxetine; Male; Mandible; Pregnancy; Prenatal Expo | 2015 |
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Circadian Rhythm; Corticosteron | 2015 |
Prenatal exposure to selective serotonin reuptake inhibitors (SSRI) increases aggression and modulates maternal behavior in offspring mice.
Topics: Aggression; Animals; Behavior, Animal; Female; Fluoxetine; Male; Maternal Behavior; Mice; Pregnancy; | 2016 |
Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Gene Expression | 2015 |
Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning.
Topics: Animals; Dopamine; Female; Fluoxetine; Hippocampus; Male; Prefrontal Cortex; Pregnancy; Prenatal Exp | 2016 |
Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Femal | 2016 |
Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Epigenesis, | 2016 |
Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring.
Topics: Aggression; Animals; Behavior, Animal; Brain; Disease Models, Animal; Female; Fluoxetine; Male; Mate | 2016 |
Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine?
Topics: Animals; Antidepressive Agents, Second-Generation; Blood Vessels; Female; Fish Oils; Fluoxetine; Fol | 2016 |
Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams.
Topics: Animals; Antidepressive Agents; Brain; Depression; Depressive Disorder; Female; Fluoxetine; Hippocam | 2016 |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Estradiol; Estrous Cycle; Female; Fertility; Fluo | 2016 |
Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring.
Topics: Animals; Animals, Newborn; Anxiety Disorders; Corticosterone; Depressive Disorder; Disease Models, A | 2016 |
Prenatal SSRI alters the hormonal and behavioral responses to stress in female mice: Possible role for glucocorticoid resistance.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Female; Fluoxetine; Hypothalamo-Hypophyseal Syst | 2016 |
Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?
Topics: Age Factors; Analysis of Variance; Animals; Body Weight; Disease Models, Animal; Eating; Female; Flu | 2017 |
Circadian behavior of adult mice exposed to stress and fluoxetine during development.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Circadian Rhythm; Female; Fluoxet | 2017 |
Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Female; Fluoxetine; Gene Expression; Imi | 2017 |
Prolonged neonatal complications after in utero exposure to fluoxetine.
Topics: Adult; Diagnosis, Differential; Female; Fluoxetine; Humans; Infant, Newborn; Neonatal Abstinence Syn | 2008 |
Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Female; Fluoxetine; | 2011 |
[Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
Topics: Age Factors; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Behavi | 2011 |
Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk.
Topics: Aging; Animals; Anxiety; Brain; Central Nervous System; Female; Fetus; Fluoxetine; Image Processing, | 2011 |
Mother-infant antidepressant concentrations, maternal depression, and perinatal events.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Dose-Res | 2011 |
Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour.
Topics: Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Female; Fluoxetine; Mice; Neurons; Pregnancy; P | 2012 |
Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats.
Topics: Animals; Anxiety; Anxiety Disorders; Brain; Corticosterone; Dopamine; Female; Fluoxetine; Hippocampu | 2012 |
Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response.
Topics: Acute-Phase Reaction; Amphetamine; Animals; Antipsychotic Agents; Aripiprazole; Disease Models, Anim | 2012 |
Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone.
Topics: Animals; Behavior, Animal; Dexamethasone; Early Medical Intervention; Female; Fluoxetine; Glucocorti | 2012 |
Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats?
Topics: Animals; Antidepressive Agents; Female; Fluoxetine; Hypericum; Male; Maternal-Fetal Exchange; Pregna | 2013 |
The effects of perinatal fluoxetine treatment on the circadian system of the adult mouse.
Topics: Animals; Behavior, Animal; Circadian Clocks; Darkness; Female; Fluoxetine; Gestational Age; Light; M | 2013 |
Behavioural outcomes of perinatal maternal fluoxetine treatment.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Body Weight; | 2012 |
Developmental fluoxetine exposure and prenatal stress alter sexual differentiation of the brain and reproductive behavior in male rat offspring.
Topics: Anal Canal; Animals; Brain; Ejaculation; Estradiol; Female; Fluoxetine; Genitalia, Male; Male; Midli | 2013 |
Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Child; Child Behavior; Child, Preschool; De | 2002 |
Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats.
Topics: Acetylcholine; Animals; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Pregnancy; Pr | 2002 |
Birth outcomes after prenatal exposure to antidepressant medication.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2003 |
Serotonergic symptoms in neonates exposed to SSRIs during pregnancy.
Topics: Chemical and Drug Induced Liver Injury; Depression; Female; Fluoxetine; Humans; Infant, Newborn; Pre | 2003 |
Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring.
Topics: Animals; Disease Models, Animal; Female; Fluoxetine; Guinea Pigs; Pain Threshold; Pregnancy; Prenata | 2005 |
Prolonged QT interval in an infant of a fluoxetine treated mother.
Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Electrocardiography; Female; Fluoxeti | 2005 |
Neonatal signs after in utero exposure to selective serotonin reuptake inhibitors.
Topics: Female; Fluoxetine; Humans; Infant Behavior; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; | 2005 |
Fluoxetine withdrawal syndrome in the newborn.
Topics: Depressive Disorder; Female; Fluoxetine; Follow-Up Studies; Humans; Infant, Newborn; Neonatal Abstin | 2006 |
Developmental and behavioral consequences of prenatal fluoxetine.
Topics: Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Dose-Response Relat | 2007 |
Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Female; F | 2007 |
Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fetal Diseases; Fluoxetine; Gestational A | 2007 |
Teratogenic effects of maternal antidepressant exposure on neural substrates of drug-seeking behavior in offspring.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Arousal; Brain; Cell | 2008 |
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Chemistry | 2007 |
Poor neonatal adaptation in term infant. Fluoxetine toxicity.
Topics: Depression; Female; Fluoxetine; Humans; Infant, Newborn; Male; Maternal Welfare; Pregnancy; Prenatal | 2008 |
Altered water-maze search behavior in adult guinea pigs following chronic prenatal ethanol exposure: lack of mitigation by postnatal fluoxetine treatment.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Body Weight; Drug Interactions; Eating; Electric | 2008 |
Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice.
Topics: Animals; Body Weight; Copulation; Female; Fluoxetine; Genitalia, Male; Lactation; Male; Mice; Motiva | 2008 |
Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Epigenesis, Genetic; Female; Fluoxetine; Gen | 2008 |
A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Female; Fluoxetine; Litter Size; Male; Motor Activity | 1994 |
Delayed decreases in brain 5-hydroxytryptamine2A/2C receptor density and function in male rat progeny following prenatal fluoxetine.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cerebral Cortex; Female; Fluoxetine; Hypothalamu | 1994 |
Fluoxetine hydrochloride (Prozac) toxicity in a neonate.
Topics: Female; Fluoxetine; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects | 1993 |
Effects of third trimester fluoxetine exposure on the newborn.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; D | 1995 |
Gender-related differences exist in cortical [3H]nisoxetine binding and are not affected by prenatal morphine exposure.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Female; Fluoxetine; Hypothalamus; Kinetics; Male; Morp | 1997 |
Effects of prenatal cocaine exposure on serotonin and norepinephrine transporter density in the rat brain.
Topics: Aging; Animals; Brain; Carrier Proteins; Cocaine; Female; Fluoxetine; Male; Membrane Glycoproteins; | 1998 |
Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Birth Weight; Body Weight; Cycl | 1999 |
Effect of prenatal diazepam, phenobarbital, haloperidol and fluoxetine exposure on foot shock induced aggression in rats.
Topics: Aggression; Animals; Diazepam; Drug Evaluation, Preclinical; Electroshock; Female; Fluoxetine; Halop | 1998 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |