fluoxetine has been researched along with Sensitivity and Specificity in 71 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Weight gain during olanzapine/fluoxetine combination (OFC) therapy is very common." | 7.77 | Early weight gain as a predictor of substantial weight gain with olanzapine/fluoxetine combination: an analysis of 2 adult studies in treatment-resistant depression. ( Case, M; Degenhardt, EK; Jamal, HH; Tormey, S, 2011) |
| " The sensitivity and specificity of 4-[(18)F]-ADAM binding to SERT were evaluated in one monkey challenged with different doses of fluoxetine and one monkey treated with 3,4-methylendioxymethamphetamine (MDMA)." | 3.78 | Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study. ( Chen, CY; Chen, YA; Cheng, CY; Huang, SY; Huang, WS; Li, IH; Lin, YS; Liu, RS; Ma, KH; Shiue, CY; Wang, SJ, 2012) |
| "Weight gain during olanzapine/fluoxetine combination (OFC) therapy is very common." | 3.77 | Early weight gain as a predictor of substantial weight gain with olanzapine/fluoxetine combination: an analysis of 2 adult studies in treatment-resistant depression. ( Case, M; Degenhardt, EK; Jamal, HH; Tormey, S, 2011) |
| "A selective, sensitive, simple, and rapid method for the simultaneous determination of fluoxetine (FL) and norfluoxetine (nor-FL) was developed and validated, and further applied to analyze plasma samples obtained from FL-treated patients with Parkinson disease (n = 18)." | 3.73 | Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study. ( Djordjevic, S; Kovacevic, I; Miljkovic, B; Pokrajac, M; Vuksanovic, J, 2005) |
| "Fluoxetine, citalopram, paroxetine and venlafaxine have been widely used in the treatment of depression." | 3.73 | Simultaneous determination of fluoxetine, citalopram, paroxetine, venlafaxine in plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI). ( Huande, L; Juan, H; Zhiling, Z, 2005) |
| "We studied the sensitivity in detecting changes of the 6-item version of the original 17-item Hamilton Depression Rating Scale (HAM-D) and compared it with the more widely used versions among 164 depressed outpatients with and without atypical features before and after treatment with fluoxetine." | 3.69 | Sensitivity of the six-item Hamilton Depression Rating Scale. ( Agustin, C; Baer, L; Fava, M; O'Sullivan, RL; Rosenbaum, JF, 1997) |
| "The aim of this study was to estimate the cost effectiveness of nefazodone compared with imipramine or fluoxetine in treating women with major depressive disorder." | 3.69 | Modelling the cost effectiveness of antidepressant treatment in primary care. ( Anton, SF; Bakish, D; Brown, RE; Feeny, D; Palmer, W; Revicki, DA; Rosser, WW, 1995) |
| " The method was successfully applied to a pharmacokinetic study of fixed dose combination of Olanzapine/Fluoxetine in healthy male volunteers." | 2.79 | Simultaneous determination of Olanzapine and Fluoxetine in human plasma by LC-MS/MS: its pharmacokinetic application. ( Bhadane, RP; Bonde, SL; Gaikwad, A; Gavali, SR; Katale, DU; Narendiran, AS, 2014) |
| "Fluoxetine was used as an internal standard for agomelatine." | 2.77 | Validated LC-MS/MS method for quantification of agomelatine in human plasma and its application in a pharmacokinetic study. ( Kalamkar, AM; Mangaonkar, KV; Nerurkar, KK; Patil, SR; Pingale, SG; Pukale, V, 2012) |
| "Fluoxetine was found to be enriched with S(+)-enantiomer, which is more toxic to P." | 1.39 | Multi-residue enantiomeric analysis of pharmaceuticals and their active metabolites in the Guadalquivir River basin (South Spain) by chiral liquid chromatography coupled with tandem mass spectrometry. ( Barceló, D; Kasprzyk-Hordern, B; López-Serna, R; Petrović, M, 2013) |
| "Fluoxetine (Prozac) was more potent at blocking hERG 1a/1b than 1a channels, yielding a corresponding reduction in the safety margin." | 1.37 | hERG subunit composition determines differential drug sensitivity. ( Abi-Gerges, N; Holkham, H; Jones, EM; Pollard, CE; Robertson, GA; Valentin, JP, 2011) |
| " Because of its sensitivity, this HPLC/MS/MS method is suitable both for routine therapeutic drug monitoring and for pharmacokinetic studies, due to its low limits of quantification." | 1.35 | A simple method to monitor serum concentrations of fluoxetine and its major metabolite for pharmacokinetic studies. ( Faggiani, A; Franceschi, L; Furlanut, M, 2009) |
| "Ethyl chloroformate was employed as derivatizing agent producing symmetrical peaks." | 1.35 | Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction. ( Fernandes, C; Lanças, FM; Sandra, P; Van Hoeck, E, 2008) |
| "D-Fenfluramine is a drug that acutely releases 5-HT into the synaptic cleft and blocks its reuptake." | 1.30 | Sensitive measurement of agonist-stimulated [3H]inositol monophosphate accumulation in rat cortical miniprisms. ( Erfurth, A; Wurtman, RJ, 1997) |
| "A sensitive, robust gas chromatographic-mass spectrometric assay suitable for use in pharmacokinetic or bioequivalence studies is presented for the selective serotonin reuptake inhibitor, fluoxetine, and its major metabolite, norfluoxetine (N-desmethylfluoxetine)." | 1.30 | Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies. ( Addison, RS; Franklin, ME; Hooper, WD, 1998) |
| "Fluoxetine is an atypical antidepressant drug, which selectively inhibits the neuronal reuptake of serotonin, and is widely used in the treatment of depressive disorders." | 1.30 | Determination of fluoxetine and norfluoxetine in human plasma by high-pressure liquid chromatography with fluorescence detection. ( Bugamelli, F; Casamenti, G; Mandrioli, R; Raggi, MA; Volterra, V, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (30.99) | 18.2507 |
| 2000's | 30 (42.25) | 29.6817 |
| 2010's | 18 (25.35) | 24.3611 |
| 2020's | 1 (1.41) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Q | 1 |
| Chen, Z | 1 |
| Chen, D | 1 |
| Luo, S | 1 |
| Xie, L | 1 |
| López-Serna, R | 1 |
| Kasprzyk-Hordern, B | 1 |
| Petrović, M | 1 |
| Barceló, D | 1 |
| Lin, CH | 1 |
| Chen, CC | 1 |
| Wang, FC | 1 |
| Lane, HY | 1 |
| Bonde, SL | 1 |
| Bhadane, RP | 1 |
| Gaikwad, A | 1 |
| Gavali, SR | 1 |
| Katale, DU | 1 |
| Narendiran, AS | 1 |
| Wang, R | 1 |
| Schoenfeld, DA | 1 |
| Hoeppner, B | 1 |
| Evins, AE | 1 |
| Patel, BN | 1 |
| Sharma, N | 1 |
| Sanyal, M | 1 |
| Shrivastav, PS | 1 |
| Franceschi, L | 1 |
| Faggiani, A | 1 |
| Furlanut, M | 1 |
| Rodríguez-Flores, J | 1 |
| Contento Salcedo, AM | 3 |
| Muñoz Fernández, L | 1 |
| Castagné, V | 1 |
| Porsolt, RD | 1 |
| Moser, P | 1 |
| Kemp, DE | 1 |
| Ganocy, SJ | 1 |
| Brecher, M | 1 |
| Carlson, BX | 1 |
| Edwards, S | 1 |
| Eudicone, JM | 1 |
| Evoniuk, G | 1 |
| Jansen, W | 1 |
| Leon, AC | 1 |
| Minkwitz, M | 1 |
| Pikalov, A | 1 |
| Stassen, HH | 1 |
| Szegedi, A | 1 |
| Tohen, M | 1 |
| Van Willigenburg, AP | 1 |
| Calabrese, JR | 1 |
| Samanidou, VF | 1 |
| Kourti, PV | 1 |
| Chow, TW | 1 |
| Szeitz, A | 1 |
| Rurak, DW | 1 |
| Riggs, KW | 1 |
| Li, Y | 1 |
| Emm, T | 1 |
| Yeleswaram, S | 1 |
| Abi-Gerges, N | 1 |
| Holkham, H | 1 |
| Jones, EM | 1 |
| Pollard, CE | 1 |
| Valentin, JP | 1 |
| Robertson, GA | 1 |
| Degenhardt, EK | 1 |
| Jamal, HH | 1 |
| Tormey, S | 1 |
| Case, M | 1 |
| Hess, M | 1 |
| Höfner, G | 1 |
| Wanner, KT | 1 |
| Selzman, CH | 1 |
| Hunter, AM | 1 |
| Cook, IA | 1 |
| Greenwald, SD | 1 |
| Tran, ML | 1 |
| Miyamoto, KN | 1 |
| Leuchter, AF | 1 |
| Gopinath, S | 1 |
| Kumar, RS | 1 |
| Alexander, S | 1 |
| Danabal, P | 1 |
| Chen, YA | 1 |
| Huang, WS | 1 |
| Lin, YS | 1 |
| Cheng, CY | 1 |
| Liu, RS | 1 |
| Wang, SJ | 1 |
| Li, IH | 1 |
| Huang, SY | 1 |
| Shiue, CY | 1 |
| Chen, CY | 1 |
| Ma, KH | 1 |
| Patil, SR | 1 |
| Nerurkar, KK | 1 |
| Kalamkar, AM | 1 |
| Pukale, V | 1 |
| Mangaonkar, KV | 1 |
| Pingale, SG | 1 |
| Oliveira, AF | 1 |
| de Figueiredo, EC | 1 |
| Dos Santos-Neto, AJ | 1 |
| Nielsen, MK | 1 |
| Johansen, SS | 1 |
| Houbart, V | 1 |
| Servais, AC | 1 |
| Charlier, TD | 1 |
| Pawluski, JL | 1 |
| Abts, F | 1 |
| Fillet, M | 1 |
| LLerena, A | 1 |
| Dorado, P | 1 |
| Berecz, R | 1 |
| González, A | 1 |
| Jesús Norberto, M | 1 |
| de la Rubia, A | 1 |
| Cáceres, M | 1 |
| Gatti, G | 1 |
| Bonomi, I | 1 |
| Marchiselli, R | 1 |
| Fattore, C | 1 |
| Spina, E | 1 |
| Scordo, G | 1 |
| Pacifici, R | 1 |
| Perucca, E | 1 |
| Guo, X | 1 |
| Fukushima, T | 1 |
| Li, F | 1 |
| Imai, K | 1 |
| Li, KM | 1 |
| Thompson, MR | 1 |
| McGregor, IS | 1 |
| Kung, MP | 1 |
| Choi, SR | 1 |
| Hou, C | 1 |
| Zhuang, ZP | 1 |
| Foulon, C | 1 |
| Kung, HF | 1 |
| Williams, JM | 1 |
| Steketee, JD | 1 |
| Ertürk, S | 1 |
| Cetin, SM | 1 |
| Atmaca, S | 1 |
| Ersoy, L | 1 |
| Baktr, G | 1 |
| Djordjevic, S | 1 |
| Kovacevic, I | 1 |
| Miljkovic, B | 1 |
| Vuksanovic, J | 1 |
| Pokrajac, M | 1 |
| Juan, H | 1 |
| Zhiling, Z | 1 |
| Huande, L | 1 |
| Vasskog, T | 1 |
| Berger, U | 1 |
| Samuelsen, PJ | 1 |
| Kallenborn, R | 1 |
| Jensen, E | 1 |
| Berzas Nevado, JJ | 3 |
| Villaseñor Llerena, MJ | 3 |
| Guiberteau Cabanillas, C | 1 |
| Rodríguez Robledo, V | 1 |
| Severance, AJ | 1 |
| Milak, MS | 1 |
| Kumar, JSD | 1 |
| Prabhakaran, J | 1 |
| Majo, VJ | 1 |
| Simpson, NR | 1 |
| Van Heertum, RL | 1 |
| Arango, V | 1 |
| Mann, JJ | 1 |
| Parsey, RV | 1 |
| Unceta, N | 1 |
| Barrondo, S | 1 |
| Ruiz de Azúa, I | 1 |
| Gómez-Caballero, A | 1 |
| Goicolea, MA | 1 |
| Sallés, J | 1 |
| Barrio, RJ | 1 |
| Walles, M | 1 |
| Gauvin, C | 1 |
| Morin, PE | 1 |
| Panetta, R | 1 |
| Ducharme, J | 1 |
| Shamsipur, M | 1 |
| Dastjerdi, LS | 1 |
| Haghgoo, S | 1 |
| Armspach, D | 1 |
| Matt, D | 1 |
| Aboul-Enein, HY | 1 |
| Waldinger, MD | 1 |
| Zwinderman, AH | 1 |
| Olivier, B | 1 |
| Schweitzer, DH | 1 |
| Fernandes, C | 1 |
| Van Hoeck, E | 1 |
| Sandra, P | 1 |
| Lanças, FM | 1 |
| Sleight, AJ | 1 |
| Carolo, C | 1 |
| Petit, N | 1 |
| Zwingelstein, C | 1 |
| Bourson, A | 1 |
| Nichols, JH | 1 |
| Charlson, JR | 1 |
| Lawson, GM | 1 |
| Grégoire, J | 1 |
| de Leval, N | 1 |
| Mesters, P | 1 |
| Czarka, M | 1 |
| Eap, CB | 1 |
| Gaillard, N | 1 |
| Powell, K | 1 |
| Baumann, P | 1 |
| Del Boca, FK | 1 |
| Kranzler, HR | 1 |
| Brown, J | 1 |
| Korner, PF | 1 |
| Ramaiya, A | 1 |
| March, C | 1 |
| Karnes, HT | 1 |
| Fontanille, P | 1 |
| Jourdil, N | 1 |
| Villier, C | 1 |
| Bessard, G | 1 |
| O'Sullivan, RL | 1 |
| Fava, M | 1 |
| Agustin, C | 1 |
| Baer, L | 1 |
| Rosenbaum, JF | 1 |
| Urichuk, LJ | 1 |
| Aspeslet, LJ | 1 |
| Holt, A | 1 |
| Silverstone, PH | 1 |
| Coutts, RT | 1 |
| Baker, GB | 1 |
| Erfurth, A | 1 |
| Wurtman, RJ | 1 |
| Aymard, G | 1 |
| Livi, P | 1 |
| Pham, YT | 1 |
| Diquet, B | 1 |
| Holladay, JW | 1 |
| Dewey, MJ | 1 |
| Yoo, SD | 1 |
| Addison, RS | 1 |
| Franklin, ME | 1 |
| Hooper, WD | 1 |
| Raggi, MA | 2 |
| Mandrioli, R | 1 |
| Casamenti, G | 1 |
| Bugamelli, F | 1 |
| Volterra, V | 1 |
| Raap, DK | 1 |
| Garcia, F | 1 |
| Muma, NA | 1 |
| Wolf, WA | 1 |
| Battaglia, G | 1 |
| van de Kar, LD | 1 |
| Revicki, DA | 1 |
| Brown, RE | 1 |
| Palmer, W | 1 |
| Bakish, D | 1 |
| Rosser, WW | 1 |
| Anton, SF | 1 |
| Feeny, D | 1 |
| Maurel, S | 1 |
| De Vry, J | 1 |
| Schreiber, R | 1 |
| Kristoffersen, L | 2 |
| Bugge, A | 1 |
| Lundanes, E | 2 |
| Slørdal, L | 1 |
| Desiderio, C | 1 |
| Rudaz, S | 1 |
| Fanali, S | 1 |
| Prabhakar, AH | 1 |
| Patel, VB | 1 |
| Giridhar, R | 1 |
| Aguas Nuevo, E | 1 |
| Lucca, A | 1 |
| Gentilini, G | 1 |
| Lopez-Silva, S | 1 |
| Soldarini, A | 1 |
| Sutherland, FC | 1 |
| Badenhorst, D | 1 |
| de Jager, AD | 1 |
| Scanes, T | 1 |
| Hundt, HK | 1 |
| Swart, KJ | 1 |
| Hundt, AF | 1 |
| Soini, M | 1 |
| Simeon, D | 1 |
| Guralnik, O | 1 |
| Schmeidler, J | 1 |
| Molander, P | 1 |
| Thomassen, A | 1 |
| Greibrokk, T | 1 |
| Liu, ZQ | 1 |
| Tan, ZR | 1 |
| Wang, D | 1 |
| Huang, SL | 1 |
| Wang, LS | 1 |
| Zhou, HH | 1 |
| Wilson, AA | 1 |
| Ginovart, N | 1 |
| Hussey, D | 1 |
| Meyer, J | 1 |
| Houle, S | 1 |
| Michael-Hepp, J | 1 |
| Blum, B | 1 |
| Bönisch, H | 1 |
5 trials available for fluoxetine and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous determination of Olanzapine and Fluoxetine in human plasma by LC-MS/MS: its pharmacokinetic application.
Topics: Adult; Benzodiazepines; Calibration; Chromatography, Liquid; Cross-Over Studies; Drug Combinations; | 2014 |
Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in 3369 subjects with bipolar I or II depression.
Topics: Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Benz | 2011 |
The antidepressant treatment response index and treatment outcomes in a placebo-controlled trial of fluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Chi-Square Distribution; Depressive Disorder, Major | 2011 |
Validated LC-MS/MS method for quantification of agomelatine in human plasma and its application in a pharmacokinetic study.
Topics: Acetamides; Area Under Curve; Chromatography, Liquid; Fluoxetine; Humans; Least-Squares Analysis; Li | 2012 |
Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer.
Topics: Alcoholism; Anti-Anxiety Agents; Buspirone; Dose-Response Relationship, Drug; Double-Blind Method; F | 1996 |
66 other studies available for fluoxetine and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous quantification of vortioxetine, fluoxetine and their metabolites in rat plasma by UPLC-MS/MS.
Topics: Animals; Chromatography, High Pressure Liquid; Fluoxetine; Linear Models; Male; Rats; Rats, Sprague- | 2020 |
Multi-residue enantiomeric analysis of pharmaceuticals and their active metabolites in the Guadalquivir River basin (South Spain) by chiral liquid chromatography coupled with tandem mass spectrometry.
Topics: Atenolol; Chromatography, Liquid; Environmental Monitoring; Fluoxetine; Metoprolol; Pharmaceutical P | 2013 |
Percentage reduction of depression severity versus absolute severity after initial weeks of treatment to predict final response or remission.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Pr | 2013 |
Detecting treatment-covariate interactions using permutation methods.
Topics: Adolescent; Analysis of Variance; Antidepressive Agents, Second-Generation; Bias; Clinical Decision- | 2015 |
Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.
Topics: Antidepressive Agents, Second-Generation; Chromatography, Liquid; Drug Stability; Fluoxetine; Humans | 2009 |
A simple method to monitor serum concentrations of fluoxetine and its major metabolite for pharmacokinetic studies.
Topics: Antidepressive Agents, Second-Generation; Area Under Curve; Calibration; Chromatography, High Pressu | 2009 |
Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC.
Topics: Chromatography, Micellar Electrokinetic Capillary; Female; Fluoxetine; Humans; Hydrogen-Ion Concentr | 2009 |
Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Fluoxetine; Imip | 2009 |
Rapid HPLC method for the simultaneous monitoring of duloxetine, venlaflaxine, fluoxetine and paroxetine in biofluids.
Topics: Chromatography, High Pressure Liquid; Cyclohexanols; Duloxetine Hydrochloride; Fluoxetine; Humans; L | 2009 |
A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS).
Topics: Animals; Chromatography, Liquid; Fluoxetine; Least-Squares Analysis; Reproducibility of Results; Sen | 2011 |
Simultaneous determination of fluoxetine and its major active metabolite norfluoxetine in human plasma by LC-MS/MS using supported liquid extraction.
Topics: Chromatography, Liquid; Drug Stability; Fluoxetine; Humans; Linear Models; Liquid-Liquid Extraction; | 2011 |
hERG subunit composition determines differential drug sensitivity.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line, Transformed; Drug Evaluation, Preclinical; Ether | 2011 |
Early weight gain as a predictor of substantial weight gain with olanzapine/fluoxetine combination: an analysis of 2 adult studies in treatment-resistant depression.
Topics: Benzodiazepines; Controlled Clinical Trials as Topic; Depression; Drug Combinations; Drug Resistance | 2011 |
Development and validation of a rapid LC-ESI-MS/MS method for quantification of fluoxetine and its application to MS binding assays.
Topics: Diagnostic Techniques, Endocrine; Fluoxetine; Humans; Mass Spectrometry; Radioligand Assay; Selectiv | 2011 |
Invited commentary.
Topics: Animals; Aortic Valve; Biomechanical Phenomena; Fluoxetine; Receptors, Serotonin; Regeneration; Sens | 2011 |
Development of a rapid and sensitive SPE-LC-MS/MS method for the simultaneous estimation of fluoxetine and olanzapine in human plasma.
Topics: Benzodiazepines; Chromatography, High Pressure Liquid; Drug Stability; Fluoxetine; Humans; Linear Mo | 2012 |
Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study.
Topics: Animals; Benzylamines; Brain; Female; Fluorine Radioisotopes; Fluoxetine; Macaca; Male; N-Methyl-3,4 | 2012 |
Analysis of fluoxetine and norfluoxetine in human plasma by liquid-phase microextraction and injection port derivatization GC-MS.
Topics: Drug Monitoring; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Linear Models; | 2013 |
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Analgesics; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chromatography, Hi | 2012 |
A validated microfluidics-based LC-chip-MS/MS method for the quantitation of fluoxetine and norfluoxetine in rat serum.
Topics: Animals; Chromatography, Liquid; Fluoxetine; Linear Models; Microfluidic Analytical Techniques; Mode | 2012 |
Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; | 2003 |
Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography.
Topics: Fluoxetine; Humans; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity | 2003 |
Determination of fluoxetine and norfluoxetine in rat plasma by HPLC with pre-column derivatization and fluorescence detection.
Topics: Animals; Chromatography, High Pressure Liquid; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Reprodu | 2003 |
Rapid quantitation of fluoxetine and norfluoxetine in serum by micro-disc solid-phase extraction with high-performance liquid chromatography-ultraviolet absorbance detection.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Reference Standards; Reproducibility of Re | 2004 |
Selective binding of 2-[125I]iodo-nisoxetine to norepinephrine transporters in the brain.
Topics: Animals; Brain; Fluoxetine; LLC-PK1 Cells; Male; Metabolic Clearance Rate; Norepinephrine Plasma Mem | 2004 |
Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.
Topics: Animals; Biological Transport; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopam | 2004 |
A sensitive HPLC method for the determination of fluoxetine and norfluoxetine in human plasma with fluorescence detection.
Topics: Administration, Oral; Area Under Curve; Benzofurans; Chromatography, High Pressure Liquid; Drug Admi | 2005 |
Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study.
Topics: Adult; Aged; Chromatography, Liquid; Clinical Trials as Topic; Female; Fluoxetine; Humans; Male; Mas | 2005 |
Simultaneous determination of fluoxetine, citalopram, paroxetine, venlafaxine in plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI).
Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Citalopram; Cyclohexanols; D | 2005 |
Selective serotonin reuptake inhibitors in sewage influents and effluents from Tromsø, Norway.
Topics: Calibration; Chemical Fractionation; Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; F | 2006 |
Screening of citalopram, fluoxetine and their metabolites in human urine samples by gas chromatography-mass spectrometry. A global robustness/ruggedness study.
Topics: Citalopram; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Se | 2006 |
In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter.
Topics: Adrenergic Uptake Inhibitors; Animals; Carbon Radioisotopes; Diagnostic Imaging; Fluoxetine; Image P | 2007 |
Determination of fluoxetine, norfluoxetine and their enantiomers in rat plasma and brain samples by liquid chromatography with fluorescence detection.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluoxetine; Rats; Reproducibility of Results; | 2007 |
Comparison of sub-2-microm particle columns for fast metabolite ID.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structur | 2007 |
Chiral selectors for enantioresolution and quantitation of the antidepressant drug fluoxetine in pharmaceutical formulations by (19)F NMR spectroscopic method.
Topics: Antidepressive Agents; Chemistry, Pharmaceutical; Cyclodextrins; Dosage Forms; Fluorine; Fluoxetine; | 2007 |
Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy.
Topics: Antidepressive Agents; Coitus; Data Interpretation, Statistical; Ejaculation; Fluoxetine; Fluvoxamin | 2008 |
Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction.
Topics: Adsorption; Antidepressive Agents; Desipramine; Fluoxetine; Formic Acid Esters; Gas Chromatography-M | 2008 |
Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment.
Topics: Animals; Binding Sites; Down-Regulation; Fluoxetine; Hypothalamus; Kinetics; Male; Membranes; Pindol | 1995 |
Automated HPLC assay of fluoxetine and norfluoxetine in serum.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Quality Control; Sensitivity | 1994 |
Validation of the Quality of Life in Depression Scale in a population of adult depressive patients aged 60 and above.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Depression; Female; Fluoxetine; Humans; Male; Middle | 1994 |
Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry.
Topics: Fluoxetine; Fluvoxamine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; S | 1996 |
Single pump column switching technique employing a flow gradient and wavelength programmed fluorescence for simultaneous monitoring of serotonin, fluoxetine and norfluoxetine in rat brain microdialysate.
Topics: Animals; Calibration; Drug Monitoring; Fluoxetine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; | 1997 |
Direct analysis of fluoxetine and norfluoxetine in plasma by gas chromatography with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Fluoxetine; Humans; Nitrogen; Phosphorus; Reproducibility of Results; Sensitivi | 1997 |
Sensitivity of the six-item Hamilton Depression Rating Scale.
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Depression; Female; Fluoxetine; Humans; | 1997 |
Determination of p-trifluoromethylphenol, a metabolite of fluoxetine, in tissues and body fluids using an electron-capture gas chromatographic procedure.
Topics: Animals; Brain; Chromatography, Gas; Fluoxetine; Humans; Liver; Male; Phenols; Rats; Rats, Sprague-D | 1997 |
Sensitive measurement of agonist-stimulated [3H]inositol monophosphate accumulation in rat cortical miniprisms.
Topics: Animals; Carbachol; Cerebral Cortex; Fenfluramine; Fluoxetine; Histological Techniques; Inositol Pho | 1997 |
Sensitive and rapid method for the simultaneous quantification of five antidepressants with their respective metabolites in plasma using high-performance liquid chromatography with diode-array detection.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatog | 1997 |
Quantification of fluoxetine and norfluoxetine serum levels by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Fluoxetine; Hydrogen-Ion Concentration; Kinet | 1997 |
Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies.
Topics: Adult; Antidepressive Agents, Second-Generation; Fluoxetine; Gas Chromatography-Mass Spectrometry; H | 1998 |
Determination of fluoxetine and norfluoxetine in human plasma by high-pressure liquid chromatography with fluorescence detection.
Topics: Calibration; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Fluoxetine; Hum | 1998 |
Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Brain; Drug Interactio | 1999 |
Modelling the cost effectiveness of antidepressant treatment in primary care.
Topics: Antidepressive Agents; Decision Support Techniques; Depressive Disorder; Female; Fluoxetine; Humans; | 1995 |
5-HT receptor ligands differentially affect operant oral self-administration of ethanol in the rat.
Topics: Administration, Oral; Animals; Behavior, Animal; Ethanol; Fluoxetine; Ligands; Male; Rats; Rats, Wis | 1999 |
Simultaneous determination of citalopram, fluoxetine, paroxetine and their metabolites in plasma and whole blood by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Humans; Hydrogen-Ion Co | 1999 |
Enantiomeric separation of fluoxetine and norfluoxetine in plasma and serum samples with high detection sensitivity capillary electrophoresis.
Topics: Antidepressive Agents, Second-Generation; Electrophoresis, Capillary; Fluoxetine; Humans; Sensitivit | 1999 |
Spectrophotometric determination of fluoxetine hydrochloride in bulk and in pharmaceutical formulations.
Topics: Antidepressive Agents, Second-Generation; Azo Compounds; Buffers; Chemistry, Pharmaceutical; Chlorof | 1999 |
Determination of fluoxetine, fluvoxamine, and clomipramine in pharmaceutical formulations by capillary gas chromatography.
Topics: Chromatography, Gas; Clomipramine; Drug Stability; Fluoxetine; Fluvoxamine; Pharmaceutical Preparati | 2000 |
Simultaneous determination of human plasma levels of four selective serotonin reuptake inhibitors by high-performance liquid chromatography.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Depress | 2000 |
Sensitive liquid chromatographic-tandem mass spectrometric method for the determination of fluoxetine and its primary active metabolite norfluoxetine in human plasma.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Mass Spectrometry; Reproducibility of Resu | 2001 |
[Indications for antidepressive medication].
Topics: Antidepressive Agents; Citalopram; Fluoxetine; Humans; Panic Disorder; Sensitivity and Specificity | 1997 |
Development of a depersonalization severity scale.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Dep | 2001 |
Simultaneous determination of citalopram, fluoxetine, paroxetine and their metabolites in plasma by temperature-programmed packed capillary liquid chromatography with on-column focusing of large injection volumes.
Topics: Chromatography, Liquid; Citalopram; Fluoxetine; Humans; Paroxetine; Reproducibility of Results; Sele | 2002 |
Micellar electrokinetic capillary chromatography for the determination of fluoxetine and its metabolite norfluoxetine in biological fluids.
Topics: Chromatography, Micellar Electrokinetic Capillary; Fluoxetine; Reproducibility of Results; Selective | 2002 |
Simultaneous determination of fluoxetine and its metabolite p-trifluoromethylphenol in human liver microsomes using a gas chromatographic-electron-capture detection procedure.
Topics: Chromatography, Gas; Fluoxetine; Humans; Microsomes, Liver; Phenols; Reference Standards; Selective | 2002 |
In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography.
Topics: Aniline Compounds; Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Female; Fluoxetine; Human | 2002 |
Characterization of the [3H]-desipramine binding site of the bovine adrenomedullary plasma membrane.
Topics: Adrenal Medulla; Animals; Binding Sites; Carrier Proteins; Cattle; Cell Membrane; Chlorides; Desipra | 1992 |