| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| sb 206553 | [no description available] | medium | 3 | 0 | pyrroloindole | |
| sb 242084 | [no description available] | medium | 4 | 0 | | |
| diazepam | [no description available] | medium | 1 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic |
| sb 228357 | [no description available] | medium | 1 | 0 | indolyl carboxylic acid | |
| sb 243213 | [no description available] | medium | 1 | 0 | indolyl carboxylic acid | |
| tryptamine | [no description available] | medium | 1 | 0 | aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines | human metabolite;
mouse metabolite;
plant metabolite |
| 8-hydroxy-2-(di-n-propylamino)tetralin | [no description available] | medium | 1 | 0 | phenols;
tertiary amino compound;
tetralins | serotonergic antagonist |
| 1-(3-chlorophenyl)piperazine | [no description available] | medium | 2 | 0 | monochlorobenzenes;
N-arylpiperazine | drug metabolite;
environmental contaminant;
serotonergic agonist;
xenobiotic |
| 5-carboxamidotryptamine | [no description available] | medium | 1 | 0 | tryptamines | |
| alpha-methylserotonin | [no description available] | medium | 1 | 0 | tryptamines | serotonergic agonist |
| cgs 12066 | [no description available] | medium | 1 | 0 | N-arylpiperazine;
organofluorine compound;
pyrroloquinoxaline | serotonergic agonist |
| ketanserin | [no description available] | medium | 1 | 0 | aromatic ketone;
organofluorine compound;
piperidines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist |
| methiothepin | [no description available] | medium | 1 | 0 | aryl sulfide;
dibenzothiepine;
N-alkylpiperazine;
tertiary amino compound | antipsychotic agent;
dopaminergic antagonist;
geroprotector;
serotonergic antagonist |
| mianserin | [no description available] | medium | 1 | 0 | dibenzoazepine | adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
H1-receptor antagonist;
histamine agonist;
sedative;
serotonergic antagonist |
| 1-(3-trifluoromethylphenyl)piperazine | [no description available] | medium | 1 | 0 | (trifluoromethyl)benzenes;
N-arylpiperazine | environmental contaminant;
psychotropic drug;
serotonergic agonist;
xenobiotic |
| pindolol | [no description available] | medium | 1 | 0 | indoles;
secondary amine | antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent |
| quipazine | [no description available] | medium | 1 | 0 | piperazines;
pyridines | |
| ritanserin | [no description available] | medium | 2 | 0 | organofluorine compound;
piperidines;
thiazolopyrimidine | antidepressant;
antipsychotic agent;
anxiolytic drug;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist |
| spiperone | [no description available] | medium | 1 | 0 | aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound | alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist |
| trazodone | [no description available] | medium | 1 | 0 | monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
triazolopyridine | adrenergic antagonist;
antidepressant;
anxiolytic drug;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor |
| ergotamine | [no description available] | medium | 1 | 0 | peptide ergot alkaloid | alpha-adrenergic agonist;
mycotoxin;
non-narcotic analgesic;
oxytocic;
serotonergic agonist;
vasoconstrictor agent |
| methylergonovine | [no description available] | medium | 1 | 0 | ergoline alkaloid | |
| methysergide | [no description available] | medium | 1 | 0 | ergoline alkaloid | |
| metergoline | [no description available] | medium | 1 | 0 | carbamate ester;
ergoline alkaloid | dopamine agonist;
geroprotector;
serotonergic antagonist |
| quinpirole | [no description available] | medium | 1 | 0 | pyrazoloquinoline | dopamine agonist |
| 2,5-dimethoxy-4-bromoamphetamine | [no description available] | medium | 1 | 0 | | |
| spiramide | [no description available] | medium | 1 | 0 | aromatic ether;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound | dopaminergic antagonist;
serotonergic antagonist |
| mesulergine | [no description available] | medium | 1 | 0 | ergot alkaloid;
sulfamides | antiparkinson drug;
dopamine agonist;
serotonergic antagonist |
| mdl 11939 | [no description available] | medium | 1 | 0 | primary amine | |
| 6-chloro-2-(1-piperazinyl)pyrazine | [no description available] | medium | 1 | 0 | N-arylpiperazine | |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | [no description available] | medium | 1 | 0 | indoles | |
| rs 127445 | [no description available] | medium | 2 | 0 | | |
| ro 60-0175 | [no description available] | medium | 1 | 0 | 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine | 5-hydroxytryptamine 2B receptor agonist;
5-hydroxytryptamine 2C receptor agonist |
| n-(1-methyl-5-indolyl)-n'-(3-methyl-5-isothiazolyl)urea | [no description available] | medium | 1 | 0 | 1,2-thiazoles;
indoles;
ureas | receptor modulator;
serotonergic antagonist |
| sb-224289 | [no description available] | medium | 1 | 0 | 1,2,4-oxadiazole;
azaspiro compound;
benzamides;
organic heterotetracyclic compound | serotonergic antagonist |
| rs 102221 | [no description available] | medium | 1 | 0 | aromatic ketone | |
| bw 723c86 | [no description available] | medium | 1 | 0 | tryptamines | |
| mdl 100907 | [no description available] | medium | 2 | 0 | | |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | [no description available] | medium | 1 | 0 | | |
| clozapine | [no description available] | medium | 1 | 0 | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound | adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic |
| piperidines | [no description available] | medium | 1 | 0 | | |
| amitriptyline | [no description available] | medium | 1 | 0 | carbotricyclic compound;
tertiary amine | adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic |
| citalopram | [no description available] | medium | 1 | 0 | 2-benzofurans;
cyclic ether;
nitrile;
organofluorine compound;
tertiary amino compound | |
| imipramine | [no description available] | medium | 1 | 0 | dibenzoazepine | adrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor |
| fluorobenzenes | [no description available] | medium | 1 | 0 | monofluorobenzenes | NMR chemical shift reference compound |
| fluoxetine | [no description available] | medium | 1 | 0 | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | |
| urea | [no description available] | medium | 1 | 0 | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
| sb 200646 | [no description available] | medium | 1 | 0 | indoles | |
| dizocilpine maleate | [no description available] | medium | 1 | 0 | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist |
| phencyclidine | [no description available] | medium | 1 | 0 | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug |
| alpha-aminopyridine | [no description available] | medium | 1 | 0 | | |
| 5-fluoroindole-2-carboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| ics 205-930 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| indole-2-carboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-chloroindole-2-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| tert-butyloxycarbonyltryptophan | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| indole-1-acetic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid;
monocarboxylic acid | |
| 6-fluorotryptophan | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| sr 27897 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| umifenovir | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3H-benzo[e]indole-2-carboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-methoxy-3-methyl-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5,6,7-trimethoxy-1-methyl-2-indolecarboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[1-oxo-2-(1-piperidinyl)ethyl]amino]-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| tropisetron | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-(4-morpholinylsulfonyl)-1H-indole-3-carboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-bromo-3-[[2-(4-cyclohexyl-1-piperazinyl)-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-chloro-3-[[2-(4-ethoxycarbonyl-1-piperazinyl)-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5,6-dimethoxy-3-[[(3-methoxyphenyl)-oxomethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-bromo-3-ethyl-1H-indole-2-carboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 7-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-1-oxoethyl]amino]-5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 4-chloro-3-[[2-[4-(2-hydroxyethyl)-1-piperazinyl]-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1-oxoethyl]amino]-6-methyl-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[2-[1,3-benzodioxol-5-yl(ethyl)amino]-1-oxoethyl]amino]-5-chloro-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1-oxoethyl]amino]-5-ethoxy-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 1-methyltryptophan | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 6-bromo-5-hydroxy-2-methyl-1H-indole-3-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| rg108 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| N-cyclohexyl-2,3-dihydroindole-1-carboxamide | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 2,3-dihydroindol-1-yl-(1-methyl-4-pyrazolyl)methanone | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| (4-bromo-2,5-dimethyl-3-pyrazolyl)-(2,3-dihydroindol-1-yl)methanone | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| N-(1,3-benzodioxol-5-ylmethyl)-2-[3-[oxo(thiophen-2-yl)methyl]-1-indolyl]acetamide | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-hydroxy-1-methyl-4-(4-morpholinylmethyl)-2-[(phenylthio)methyl]-3-indolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-hydroxy-1,2-dimethyl-4,6-dinitro-3-indolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 6-(1,3-dioxo-2-isoindolyl)hexanoic acid (4-methyl-2-oxo-1-benzopyran-7-yl) ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-bromo-3-[[3-(3,3-dimethyl-1-piperidinyl)-1-oxopropyl]amino]-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-fluoro-3-[(4-methoxyphenyl)sulfonylamino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[(2,3-dimethylanilino)-sulfanylidenemethyl]amino]-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[[2-furanyl(oxo)methyl]amino]-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[(3,3-dimethyl-1-oxobutyl)amino]-1H-indole-2-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 1-[2-furanyl(oxo)methyl]-2-benzo[cd]indolone | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-(1H-indol-3-yl)propanoic acid [2-[tert-butyl-(phenylmethyl)amino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| Methyl indole-5-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 2-[3-[2-furanyl(oxo)methyl]-1-indolyl]-N-(2-methoxyphenyl)acetamide | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| dolasetron | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 3-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-methyl-2-indolecarboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| sb 203186 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-[3-(3,5-dimethyl-1,2,4-triazol-1-yl)-2-hydroxypropoxy]-2-methyl-1-(phenylmethyl)-3-indolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-acetyloxy-6-bromo-2-[[(6-but-3-enyl-3-cyano-2-pyridinyl)thio]methyl]-1-methyl-3-indolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 5-[5-(2,3-dihydroindol-1-ylsulfonyl)-2,3-dihydroindol-1-yl]-5-oxopentanoic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| d-64406 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| 1-[2-(2,5-dimethylphenoxy)ethyl]-3-indolecarboxylic acid | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| mk-0524 | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |
| lapidilectine b | [no description available] | low | 0 | 0 | indolyl carboxylic acid | metabolite |
| Benzotriazol-1-yl 1H-indole-5-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | anticoronaviral agent |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | anticoronaviral agent |
| 5-Chloropyridin-3-yl 1H-indole-2-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | anticoronaviral agent |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | [no description available] | low | 0 | 0 | indolyl carboxylic acid | anticoronaviral agent |
| 1H-indole-4-carboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | [no description available] | low | 0 | 0 | indolyl carboxylic acid | |