Page last updated: 2024-12-07

mcn 5707

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

McN 5707: structure given in UD [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126059
CHEMBL ID1743803
MeSH IDM0142829

Synonyms (10)

Synonym
pyrrolo(2,1-a)isoquinoline, 6-(2-chlorophenyl)-1,2,3,5,6,10b-hexahydro-, hydrobromide, trans-
mcn 5707-14
6-(2-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo(2,1-a)isoquinoline hbr
mcn-5707
mcn-5707-14
mcn 5707
96795-88-9
CHEMBL1743803 ,
DTXSID20914317
6-(2-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline--hydrogen bromide (1/1)

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"The physical-chemical properties of interest for controlled release (CR) dosage form development presented are based on the author's experience."( Preformulation considerations for controlled release dosage forms. Part I. Selecting candidates.
Chrzanowski, F, 2008
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (11)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Ki0.14030.00020.667710.0000AID5241
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki0.14030.00010.601710.0000AID5241
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.31100.00010.949010.0000AID218673
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki4.52670.00010.739610.0000AID203917
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki0.31100.00000.575110.0000AID218673
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki4.52670.00031.29679.2440AID203917
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)Ki4.52670.00101.67479.2000AID203917
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)Ki4.52670.00101.67479.2000AID203917
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Ki0.14030.00020.590910.0000AID5241
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.31100.00000.965010.0000AID218673
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki0.41500.00000.437510.0000AID65239
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID141943Binding affinity towards Muscarinic acetylcholine receptor at 1.0 uM concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID5241Binding affinity towards 5-hydroxytryptamine 2 receptor1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID123597Gross behavioral effects ascertained in mice; W indicates weak stimulant or depressant activity of little significance.1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196059Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID218673Binding affinity towards alpha-1 adrenergic receptor1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID110188Antagonism of tetrabenazine (TBZ)-induced depression in mice measured for ptosis1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196062Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID110071Antagonism of tetrabenazine (TBZ)-induced depression measured in mice by motor activity1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID65239Binding affinity towards Dopamine receptor D21987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196061Ability to inhibit the uptake of tritiated norepinephrine (NE) 0.1 uM concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196052Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 uM concentration at rat brain synaptosomes1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196063Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID72437Inhibition of GABA uptake at 1 uM concentration.1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID203917Binding affinity towards serotonin S1 receptor1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID196041Ability to inhibit the uptake of [3H]dopamine (DA) 0.1 uM concentration at rat brain synaptosomes1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
AID218805Binding affinity towards alpha-2 adrenergic receptor at 1.0 uM concentration1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]