fluoxetine has been researched along with Constipation in 7 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of fluoxetine and placebo in the treatment of pain and constipation-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 9.11 | The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. ( Ghoddoosi, A; Malekzadeh, R; Merat, S; Rashidioon, A; Vahedi, H, 2005) |
| " This study investigated the role of AQP3 in the colon in morphine-induced constipation." | 7.81 | Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. ( Fueki, A; Haga, Y; Hayakawa, A; Ikarashi, N; Kon, R; Kusunoki, Y; Machida, Y; Ochiai, W; Sugiyama, K; Tajima, M, 2015) |
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| "To compare the effects of fluoxetine and placebo in the treatment of pain and constipation-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 5.11 | The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. ( Ghoddoosi, A; Malekzadeh, R; Merat, S; Rashidioon, A; Vahedi, H, 2005) |
| " This study investigated the role of AQP3 in the colon in morphine-induced constipation." | 3.81 | Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. ( Fueki, A; Haga, Y; Hayakawa, A; Ikarashi, N; Kon, R; Kusunoki, Y; Machida, Y; Ochiai, W; Sugiyama, K; Tajima, M, 2015) |
| "Amitriptyline was dosed as follows: 8 mg/day for 6 days, 8 mg twice a day for 6 days, 20 mg/day for 6 days, and 20 mg twice a day for 45 days." | 2.70 | Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study. ( Alves, LA; Barbosa, JS; Krymchantowski, AV; Silva, MT, 2002) |
| "Fluoxetine was used to block the 5-HT reuptake transporter (SERT), and the levels of mRNA for tryptophan hydroxylase 1 and SERT were determined by quantitative PCR, and SERT protein was determined by Western blot." | 1.38 | Serotonin availability in rat colon is reduced during a Western diet model of obesity. ( Bertrand, PP; Bertrand, RL; Chen, H; Howitt, L; Liu, L; Murphy, TV; Sandow, SL; Senadheera, S; Tan, KL; Tanoto, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kon, R | 1 |
| Ikarashi, N | 1 |
| Hayakawa, A | 1 |
| Haga, Y | 1 |
| Fueki, A | 1 |
| Kusunoki, Y | 1 |
| Tajima, M | 1 |
| Ochiai, W | 1 |
| Machida, Y | 1 |
| Sugiyama, K | 1 |
| Sheehan, DV | 1 |
| Nemeroff, CB | 1 |
| Thase, ME | 1 |
| Entsuah, R | 1 |
| Bertrand, RL | 1 |
| Senadheera, S | 1 |
| Tanoto, A | 1 |
| Tan, KL | 1 |
| Howitt, L | 1 |
| Chen, H | 1 |
| Murphy, TV | 1 |
| Sandow, SL | 1 |
| Liu, L | 1 |
| Bertrand, PP | 1 |
| Krymchantowski, AV | 1 |
| Silva, MT | 1 |
| Barbosa, JS | 1 |
| Alves, LA | 1 |
| Vahedi, H | 1 |
| Merat, S | 1 |
| Rashidioon, A | 1 |
| Ghoddoosi, A | 1 |
| Malekzadeh, R | 1 |
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Capparelli, EV | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Tasci, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for fluoxetine and Constipation
| Article | Year |
|---|---|
Placebo-controlled inpatient comparison of venlafaxine and fluoxetine for the treatment of major depression with melancholic features.
Topics: Adult; Antidepressive Agents; Blood Pressure; Constipation; Cyclohexanols; Depressive Disorder, Majo | 2009 |
Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Constipation; Double-Blind Method; Drug Therapy, | 2002 |
The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study.
Topics: Abdominal Pain; Adult; Constipation; Double-Blind Method; Female; Fluoxetine; Humans; Irritable Bowe | 2005 |
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
3 other studies available for fluoxetine and Constipation
| Article | Year |
|---|---|
Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion.
Topics: Analgesics, Opioid; Animals; Aquaporin 3; Colon; Constipation; Defecation; Disease Models, Animal; F | 2015 |
Serotonin availability in rat colon is reduced during a Western diet model of obesity.
Topics: Animals; Colon; Constipation; Diet; Diet, High-Fat; Enterochromaffin Cells; Fluoxetine; Gastrointest | 2012 |
Tegaserod-related possible drug interactions.
Topics: Constipation; Drug Interactions; Female; Fluoxetine; Humans; Indoles; Panic Disorder; Serotonin Rece | 2007 |