Compounds > fluoxetine

fluoxetine and 4-aminopyridine

fluoxetine has been researched along with 4-aminopyridine in 8 studies

*4-Aminopyridine: One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes. [MeSH]

*4-Aminopyridine: One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes. [MeSH]

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN1
Sen, S; Sinha, N1
Kuo, YH; Su, CF; Wang, SJ1
Hong, Z; Kelly, RF; Lang, IM; Murar, J; Nelson, DP; Rezaie-Majd, S; Varghese, A; Weir, EK1
Alfonsi, E; Bergamaschi, R; Callieco, R; Candeloro, E; Cosi, V; Romani, A1
Wang, SJ1
de la Rosa, RF; Delgado, M; García-García, L; Pozo, MA; Shiha, AA1
Khin, PP; Sohn, UD; Zaw, TS1

Trials

1 trial(s) available for fluoxetine and 4-aminopyridine

ArticleYear
Fatigue in multiple sclerosis: multidimensional assessment and response to symptomatic treatment.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2004, Volume: 10, Issue:4

    Topics: 4-Aminopyridine; Adult; Antidepressive Agents, Second-Generation; Cognition; Depression; Disability Evaluation; Evoked Potentials, Motor; Evoked Potentials, Somatosensory; Fatigue; Female; Fluoxetine; Humans; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Neuropsychological Tests; Potassium Channel Blockers; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors

2004

Other Studies

7 other study(ies) available for fluoxetine and 4-aminopyridine

ArticleYear
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
    Chemical biology & drug design, 2016, Volume: 88, Issue:6

    Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain

2016
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Fluoxetine depresses glutamate exocytosis in the rat cerebrocortical nerve terminals (synaptosomes) via inhibition of P/Q-type Ca2+ channels.
    Synapse (New York, N.Y.), 2003, Jun-15, Volume: 48, Issue:4

    Topics: 4-Aminopyridine; Animals; Antidepressive Agents, Second-Generation; Calcium; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cerebral Cortex; Exocytosis; Fluoxetine; Glutamic Acid; Male; Membrane Potentials; Neurotransmitter Agents; Potassium Channel Blockers; Protein Kinase C; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptosomes

2003
Increased release of serotonin from rat ileum due to dexfenfluramine.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:5

    Topics: 4-Aminopyridine; Animals; Caffeine; Calcium; Chromatography, High Pressure Liquid; Cytosol; Dexfenfluramine; Fluoxetine; Hypertension, Pulmonary; Ileum; Male; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists

2004
Potential antidepressant LY 367265 presynaptically inhibits the release of glutamate in rat cerebral cortex.
    Synapse (New York, N.Y.), 2005, Mar-01, Volume: 55, Issue:3

    Topics: 4-Aminopyridine; Animals; Antidepressive Agents; Calcium Channels; Calcium Signaling; Cerebral Cortex; Cyclic S-Oxides; Dose-Response Relationship, Drug; Fluoxetine; Glutamic Acid; Ionomycin; Male; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Nerve Tissue Proteins; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Synaptosomes; Thiadiazoles

2005
Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats.
    CNS & neurological disorders drug targets, 2017, Volume: 16, Issue:6

    Topics: 4-Aminopyridine; Animals; Brain Injuries; Caspase 9; Cell Death; Convulsants; Disease Models, Animal; Fluoresceins; Fluorodeoxyglucose F18; Fluoxetine; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Phosphopyruvate Hydratase; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors

2017
Signal Transduction Underlying the Inhibitory Mechanism of Fluoxetine on Electrical Field Stimulation Response in Rat Ileal Smooth Muscle.
    Pharmacology, 2017, Volume: 99, Issue:5-6

    Topics: 4-Aminopyridine; Amides; Animals; Atropine; Azepines; Benzophenanthridines; Bicuculline; Calcimycin; Drug Interactions; Electric Stimulation; Estrenes; Fluoxetine; Glyburide; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Ondansetron; Pyridines; Pyrrolidinones; Rats; Signal Transduction; Sulfonamides; Tetraethylammonium

2017