fluoxetine has been researched along with desipramine in 461 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (12.80) | 18.7374 |
| 1990's | 151 (32.75) | 18.2507 |
| 2000's | 162 (35.14) | 29.6817 |
| 2010's | 85 (18.44) | 24.3611 |
| 2020's | 4 (0.87) | 2.80 |
| Authors | Studies |
|---|---|
| Costanzo, MJ; Gardocki, JF; Maryanoff, BE; McComsey, DF; Nortey, SO; Schneider, CR; Setler, PE; Shank, RP | 1 |
| Anderson, VB; Geyer, HM; Kruse, H; Ong, HH; Profitt, JA; Wilker, JC | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Harvey, AL; McKenna, MT; Proctor, GR; Young, LC | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Engel, K; Wang, J | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Goetz, RM; Karpowich, NK; Law, CJ; Reith, ME; Wang, DN; Zhen, J; Zhou, Z | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Buck, LB; Petrascheck, M; Ye, X | 1 |
| Jia, L; Sun, H | 1 |
| Belardi, JK; Bray, JA; Burroughs, KD; Cohn, ST; Cosmi, SA; Deecher, DC; Gavrin, LK; Ho, DM; Johnston, GH; Koury, EJ; Leiter, J; Leventhal, L; Mahaney, PE; Mugford, CA; Platt, B; Rosenzweig-Lipson, SJ; Sabatucci, JP; Santilli, AA; Smith, VA; Stack, GP; Trybulski, EJ; Vu, TA; Ye, F; Zhang, Y | 1 |
| Alfinito, P; Bray, J; Cohn, ST; Deecher, DC; Fensome, A; Johnston, G; Koury, E; Mahaney, PE; Marella, MA; McComas, CC; Nogle, L; Trybulski, EJ; Vu, AT; Ye, F; Zhang, P | 1 |
| Bray, J; Deecher, D; Johnston, G; Koury, E; Mahaney, PE; McComas, CC; Terefenko, EA; Trybulski, E; Vu, A; Zhang, P | 1 |
| Bleich, S; Kornhuber, J; Rupprecht, R; Terfloth, L; Wiltfang, J | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Bray, JA; Cohn, ST; Deecher, DC; Dooley, R; Goljer, I; Johnston, GH; Leiter, J; Mahaney, PE; Moore, WJ; Terefenko, EA; Trybulski, EJ; Vu, AT; Zhang, P | 1 |
| Deecher, DC; Ho, DM; Kim, CY; Mahaney, PE; Manas, E; McConnell, O; Trybulski, EJ; Zhang, Y | 1 |
| Bray, JA; Burroughs, KD; Coghlan, RD; Cohn, ST; Cosmi, SA; Deecher, DC; Heffernan, GD; Huselton, CA; Johnston, GH; Kim, CY; Mahaney, PE; Terefenko, EA; Trybulski, EJ; Vu, AT; Zhang, P | 1 |
| Bray, J; Deecher, D; Fensome, A; Harrison, J; Kim, C; Koury, E; Mahaney, PE; Mark, L; McComas, CC; Mugford, CA; Terefenko, EA; Trybulski, EJ; Vu, AT; Whiteside, GT; Zhang, P | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Bray, JA; Cohn, ST; Cosmi, SA; Deecher, DC; Harrison, JE; Johnston, GH; Kennedy, JD; Kim, CY; Koury, EJ; Leventhal, L; Mahaney, PE; Smith, VA; Trybulski, EJ; Vu, AT; Whiteside, GT; Zhang, P | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Burroughs, K; Cosmi, S; Deecher, DC; Ho, D; Johnston, G; Leiter, J; Mahaney, PE; Sabatucci, JP; Trybulski, E; Zhang, Y | 1 |
| Adedoyin, A; Alfinito, PD; Bray, JA; Cosmi, S; Deecher, DC; Fensome, A; Harrison, J; Leventhal, L; Mann, C; McComas, CC; O'Neill, DJ; Spangler, TB; Sullivan, NR; Trybulski, EJ; Uveges, AJ; Whiteside, GT; Zhang, P | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bush, LR; Campbell, UC; Engel, SR; Hardy, LW; Hewitt, MC; Koch, P; Ma, J; Malcolm, SC; Saraswat, LD; Schreiber, R; Shao, L; Spear, KL; Spicer, NA; Varney, MA; Wang, F | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Adedoyin, A; Bray, JA; Deecher, DC; Fensome, A; Goldberg, JA; Harrison, J; Leventhal, L; Mann, C; Mark, L; Nogle, L; O'Neill, DJ; Spangler, TB; Sullivan, NR; Terefenko, EA; Trybulski, EJ; Uveges, AJ; Vu, A; Whiteside, GT; Zhang, P | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Choi, K; Moon, B; Park, JE; Roh, EJ; Sim, T; Song, C | 1 |
| Alix, K; Dukat, M; Khatri, S; Schulte, MK; Worsham, J | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Wang, J | 1 |
| Schmidt, MJ; Thornberry, JF | 1 |
| Tseng, LF | 2 |
| Janowsky, A; Mishra, R; Sulser, F | 1 |
| Bymaster, FB; Fuller, RW; Perry, KW; Wong, DT | 1 |
| Bymaster, FP; Horng, JS; Wong, DT | 1 |
| Bauer, ME; Tejani-Butt, SM | 1 |
| Brooke, D; Fudala, PJ; Johnson, RE | 1 |
| Blum, B; Bönisch, H; Michael-Hepp, J | 1 |
| Black, B; Uhde, TW | 1 |
| Kriete, M; Rapoport, JL; Ryland, DH | 1 |
| Balon, R; Pohl, R | 1 |
| Altemus, M; Cizza, G; Gold, PW | 1 |
| Baldessarini, RJ; Biederman, J; Flood, JG; McDermott, SP; Puopolo, PR; Wilens, TE | 1 |
| Bergstrom, RF; Lemberger, L; Peyton, AL | 1 |
| Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B | 1 |
| Mancini, C; Van Ameringen, M | 1 |
| Fuller, RW; Snoddy, HD | 1 |
| Cooper, TB; Roose, SP; Suckow, RF | 1 |
| Kapur, S; Mann, JJ | 1 |
| Callahan, PM; Cunningham, KA | 1 |
| Odenheimer, GL | 1 |
| Elie, R; Fontaine, R; Ontiveros, A | 1 |
| Elie, R; Fontaine, R; Ontiveros, A; Vézina, M | 1 |
| Dinan, TG; Lucey, JV; O'Flynn, K; O'Keane, V | 1 |
| Brown, BS; Haertzen, CA; Hess, JM; Weddington, WW | 1 |
| Dewan, M; Masand, P | 1 |
| Bäckström, IT; Marcusson, JO | 1 |
| Bowers, MB; Jatlow, PI; Mazure, CM; Nelson, JC | 1 |
| Barrow, NE; Crismon, ML; Michals, M; Stanley, DA | 1 |
| Suh, HH; Tseng, LL | 1 |
| Fedoroff, JP; Morris, PL; Robinson, RG | 1 |
| Bystritsky, A; Pasnau, RO | 1 |
| DeMaso, DR; Hunter, TA | 1 |
| von Ammon Cavanaugh, S | 1 |
| Baron, BM; Dudley, MW; Ogden, AM; Siegel, BW; Stegeman, J; Ursillo, RC | 1 |
| Gonzales, RA; Moerschbaecher, JM; Mosaddeghi, M | 1 |
| Asakura, M; Imafuku, J; Kubota, H; Nakanishi, J; Nishizaki, J; Osada, K; Sato, A; Shibata, M; Shimbo, K; Tsukamoto, T | 1 |
| Gillespie, DD; Manier, DH; Sulser, F | 1 |
| Hammond, DL; Tyce, GM; Yaksh, TL | 1 |
| Fuller, RW; Perry, KW | 2 |
| Eisen, A | 1 |
| Bäckström, IT; Marcusson, JO; Ross, SB | 1 |
| Eckert, ED; Hatsukami, D; Mitchell, JE; Pomeroy, C; Pyle, RL; Zimmerman, R | 1 |
| Goodnick, PJ | 1 |
| Downs, AD; Downs, JM | 1 |
| Asakura, M; Hasegawa, K; Imafuku, J; Ino, M; Kubota, H; Nishizaki, J; Sato, A; Shinbo, K; Tsukamoto, T | 1 |
| Goldstein, FJ; Kellstein, DE; Malseed, RT; Ossipov, MH | 1 |
| Moyer, JA; Sigg, EB; Silver, PJ | 1 |
| Lloyd, KG; Pilc, A; Thuret, F | 1 |
| Foley, AJ; Leedham, JA; Pennefather, JN | 1 |
| Raleigh, MJ | 1 |
| Durcan, MJ; Eckardt, MJ; Linnoila, M; Lister, RG | 2 |
| Richardson, KD; Urban, JH; Van de Kar, LD | 1 |
| Abrahamsson, T; Carlsson, L | 1 |
| Davidson, RK; Dilsauer, SC; Hariharen, M | 1 |
| Li, TK; Lumeng, L; McBride, WJ; Murphy, JM | 1 |
| Bell, IR; Cole, JO | 1 |
| Azmitia, EC | 1 |
| Hwang, SA; Wilcox, GL | 1 |
| Marsden, CA; Routledge, C | 1 |
| Cohen, BS; Dillon, D; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR | 1 |
| Hicks, PE; Langer, SZ; Raisman, R; Schoemaker, H; Segonzac, A; Tateishi, T | 1 |
| Jones, DJ; Stauderman, KA | 1 |
| Chuang, DM; Costa, E; Nakaki, T; Roth, BL | 1 |
| Cohen, O; Globus, M; Melamed, E; Rosenthal, J; Uzzan, A | 1 |
| Monroe, PJ; Smith, DJ | 1 |
| Jackson, DM; Jenkins, OF | 2 |
| Jenner, P; Kelly, E; Marsden, CD | 1 |
| Engber, TM; Knight, PB; Manaker, S; Winokur, A | 1 |
| Costa, M; Cuello, AC; Elde, RP; Furness, JB; Steinbusch, HW; Verhofstad, AA | 1 |
| Harms, HH | 1 |
| Bernasconi, S; Kostowski, W; Kozak, W; Valzelli, L | 1 |
| Enna, SJ | 1 |
| Descarries, L; Ferron, A; Reader, TA | 1 |
| Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 1 |
| Carter, RB; Leander, JD | 1 |
| Azmitia, EC; Marovitz, WF | 1 |
| Aghajanian, GK; De Montigny, C; Reader, TA; Wang, RY | 1 |
| Jobe, PC; Ray, TB | 1 |
| Sugrue, MF | 1 |
| Glusman, S; Haber, B; Ritchie, T | 1 |
| Gladfelter, WE; Heym, J | 1 |
| Mogilnicka, E | 1 |
| Bartolini, F; Benazzi, F; Mazzoli, M | 1 |
| Low, G | 1 |
| Baker, GB; McManus, DJ; Todd, KG | 1 |
| Nelson, JC; Price, LH | 1 |
| Freilicher, J; Miller, FT | 1 |
| Hrdina, PD; Mann, CD; Vu, TB | 1 |
| Burt, AM; Gillespie, DD; Huang, M; Nalepa, I; Perrin, C; Rossby, SP; Schmidt, DE; Sulser, F | 1 |
| Friedman, E; Tilakaratne, N; Yang, Z | 1 |
| Goodwin, WB; Guyenet, PG; Huangfu, D | 1 |
| Tella, SR | 1 |
| Di Chiara, G; Frau, R; Tanda, G | 2 |
| Gard, PR; Mandy, A; Meakin, AJ; Nickels, DP; Whiting, JM | 1 |
| Blier, P; De Montigny, C; Mongeau, R | 1 |
| Gackenheimer, SL; Gehlert, DR; Schober, DA | 1 |
| Blackburn, TP; de Biasi, V; Kennett, GA; Lightowler, S; Stevens, NC; Tulloch, IF; Wood, MD | 1 |
| Cass, WA; Gerhardt, GA | 1 |
| Klemfuss, H; Kripke, DF | 1 |
| Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A | 1 |
| Goldberg, SR; Tella, SR | 1 |
| Simon, G; Vonkorff, M; Wagner, E | 1 |
| Chen, NH; Reith, ME | 1 |
| Battaglia, G; Brownfield, MS; Cabrera, TM; Levy, AD; Li, Q; Van de Kar, LD | 2 |
| Asai, K; Mori, H; Nankai, M; Toru, M; Watanabe, A; Yamada, S; Yoshimoto, S | 1 |
| Amsterdam, JD; Fava, M; McGrath, PJ; Quitkin, FM; Rosenbaum, JF; Stewart, JW | 1 |
| Baker, G; McGregor, A; Roberts, DC | 1 |
| Coplan, JD; Gorman, JM; Papp, LA; Tiffon, L | 1 |
| Bayer, BM; Berkeley, MB; Daussin, S; Hernandez, MC | 1 |
| Coutaux, AF; Mooney, JJ; Wirth, DF | 1 |
| Andrews, AM; Murphy, DL | 2 |
| Baschirotto, A; Borsini, F; Ceci, A | 1 |
| Fawcett, JP; Menkes, DB; Patel, PP | 1 |
| Baker, GB; Goodnough, DB | 1 |
| Alderman, J; Chung, M; Harris, S; Harrison, W; Messig, M; Preskorn, SH | 1 |
| Aspeslet, LJ; Baker, GB; Coutts, RT; Torok-Both, GA | 1 |
| Boja, JW; Brouard, A; Carroll, FI; Kuhar, MJ; Pelaprat, D; Rostene, W; Vial, M | 1 |
| Cheng, CH; Costall, B; Naylor, RJ; Rudd, JA | 1 |
| Bowden, CL; Contreras, SA; Dessain, E; Rosenbaum, A; Samson, JA; Sayler, M; Schatzberg, AF | 1 |
| Calabrese, JR; Rapport, DJ | 1 |
| Brandt, DM; Szarek, BL | 1 |
| Goldberg, SR; Schindler, CW; Tella, SR | 1 |
| Gackenheimer, SL; Gehlert, DR; Robertson, DW | 1 |
| el-Yazigi, A; Raines, DA | 1 |
| Joffe, RT; Schuller, DR | 1 |
| Nishikawa, T; Shirayama, Y; Takahashi, K; Umino, A | 1 |
| Goodman, WK; McDougle, CJ; Price, LH | 1 |
| Battaglia, G; Brownfield, MS; Cabrera, TM; Levy, AD; Li, Q; Rittenhouse, PA; van de Kar, LD | 1 |
| Alhaider, AA; Mustafa, AA | 1 |
| Ekhatore, N; Loosen, PT; Shelton, RC; Winn, S | 1 |
| Horgan, D | 1 |
| Ghetti, B; Simon, JR | 1 |
| Cohen, LS; Dimmock, JA; Rosenbaum, JF; Sichel, DA | 1 |
| Baker, GB; Coutts, RT; Goodnough, DB | 1 |
| Burke, MJ; Harvey, AT; Preskorn, SH | 1 |
| Duman, RS; Nestler, EJ; Nibuya, M | 1 |
| Preskorn, SH | 1 |
| Berman, R; Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Miller, HL; Salomon, RM | 1 |
| Grothaus, L; Heiligenstein, JH; Katon, W; Revicki, DA; Simon, GE; VonKorff, M; Wagner, EH | 1 |
| Kurz, T; Offner, B; Richardt, G; Schömig, A; Schreieck, J; Tölg, R | 1 |
| Leroi, I; Walentynowicz, MA | 1 |
| Artigas, F; Bel, N | 1 |
| Afkhami-Dastjerdian, S; Carli, M; Reader, TA | 1 |
| Hashimoto, K; Minabe, Y; Narita, N; Tomitaka, S | 1 |
| Bushell, I; Newton, W | 1 |
| Clarke, AS; Coe, CL; Hou, FY | 1 |
| Bores, GM; Corbett, R; Klein, JT; Kongsamut, S; Roehr, JE; Smith, CP; Szewczak, MR; Woods-Kettelberger, AT | 1 |
| Bekavac, I; Gould, EM; Waterhouse, BD | 1 |
| Aulakh, CS; Mazzola-Pomietto, P; Murphy, DL | 1 |
| Ordway, GA; Zhu, MY | 1 |
| Hughes, ZA; Stanford, SC | 2 |
| Hunter, JC; Jett, MF; McGuirk, J; Waligora, D | 1 |
| Cao, Y; Lester, HA; Mager, S | 1 |
| Devlin, MJ; Fleiss, J; Loeb, KL; Pike, KM; Roose, SP; Walsh, BT; Waternaux, C; Wilson, GT | 1 |
| Bourin, M; Redrobe, JP | 1 |
| Francis, R; Kuhn, C | 1 |
| Hrdina, PD; Li, Q | 1 |
| Hatsuda, S; Matsubara, M; Miura, K; Murakami, H; Nakazawa, K; Ohara, M; Sugita, S; Suzuki, S; Terashima, M | 1 |
| Ahern, D; Ball, SE; Kao, J; Scatina, J | 1 |
| Benazzi, F | 1 |
| Detke, MJ; Johnson, J; Lucki, I | 1 |
| Budney, AJ; Higgins, ST | 1 |
| Anand, A; Barr, LC; Goodman, WK; McDougle, CJ; Price, LH | 1 |
| Rowe, PM | 1 |
| Kleven, MS; Koek, W | 1 |
| Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS | 1 |
| Apparsundaram, S; Blakely, RD; Ordway, GA; Zhu, MY | 1 |
| Lucki, I; Rénéric, JP | 1 |
| Nelson, JC | 1 |
| Daya, S; Walsh, HA | 1 |
| Allikmets, L; Matto, V; Skrebuhhova, T | 1 |
| Chen, N; Justice, JB; Trowbridge, CG | 1 |
| Clarke, AS; Kraemer, GW; Kupfer, DJ | 1 |
| Daws, LC; Frazer, A; Lopez, R | 1 |
| Del Río, J; Frechilla, D; Otano, A | 1 |
| Chen, JX; Gershon, MD; Pan, H; Rothman, TP; Wade, PR | 1 |
| Kameyama, T; Maeda, H; Matsuno, K; Nanya, Y; Ukai, M | 1 |
| Heal, DJ; Kilpatrick, IC; Needham, PL; Rowley, HL | 1 |
| Schatzberg, AF | 1 |
| Ainsworth, K; Franklin, M; Pei, Q; Sharp, T; Smith, SE; Zetterström, TS | 1 |
| Bustos, SG; Lacerra, C; Martijena, ID; Molina, VA | 1 |
| McDaniel, JS; Schwartz, JA | 1 |
| Gard, PR; Mandy, A; Sutcliffe, MA | 1 |
| Kristensen, AS; Mortensen, OV; Rudnick, G; Wiborg, O | 1 |
| Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Licinio, J; Miller, HL; Moreno, FA; Salomon, RM | 1 |
| Clarke, AS; Ebert, MH; Kraemer, GW; McKinney, WT; Schmidt, DE | 1 |
| Ferrel, A; Figlewicz, DP; Schaefer, J; Zavosh, A | 1 |
| Labouvie, E; Liu, X; Loeb, KL; Petkova, E; Walsh, BT; Waternaux, C; Wilson, GT | 1 |
| De Oliveira, K; Hennings, EC; Kiss, JP; Toth, PT; Vizi, ES | 1 |
| Esser, MJ; Reid, AR; Sawynok, J | 1 |
| Esteban, S; García-Sevilla, JA; Lladó, J; Sastre-Coll, A | 1 |
| Joffe, RT; Kamil, R; Levitt, AJ; McIntyre, R | 1 |
| Dalvi, A; Detke, MJ; Kirby, LG; Lucki, I; Page, ME | 1 |
| Borda, E; Busch, L; Sterin-Borda, L; Wald, M | 1 |
| Cousins, MS; Overstreet, DH; Seiden, LS; Vosmer, G | 1 |
| López-Rubalcava, C; Lucki, I | 1 |
| Harkin, A; Nowak, G; Paul, IA | 1 |
| Kask, A; Pähkla, R; Rägo, L | 1 |
| McCleane, G | 1 |
| Marshall, M; Roth, JD; Rowland, NE | 1 |
| Duman, RS; Impey, S; Sakai, N; Shin, K; Steffen, C; Storm, D; Thome, J; Zhang, YJ | 1 |
| Diaz, J; Lammers, CH; Schwartz, JC; Sokoloff, P | 1 |
| Clarke, AS; Laudenslager, ML | 1 |
| Greenawald, MH; Tyra, JM | 1 |
| Elie, R; Habimana, A; Hébert, C; Reader, TA | 1 |
| Ainsworth, K; Sharp, T; Smith, SE | 1 |
| Aguerre, S; Chaouloff, F; Combourieu, I; Durand, M; Edno, L; Fernandez, F; Mormède, P | 1 |
| Hatsuda, S; Hayashi, T; Kimura, H; Matsubara, M; Miura, K; Mori, T; Murakami, H; Ohara, M; Ohta, T; Sugita, S; Suzuki, S; Terashima, M | 1 |
| Norrholm, SD; Ouimet, CC | 1 |
| Brodde, OE; Leineweber, K; Seyfarth, T | 1 |
| Manev, H; Manev, R; Smalheiser, NR; Uz, T | 1 |
| Bouvard, M; Rénéric, JP; Stinus, L | 2 |
| Lamont, SR; Paulls, A; Stewart, CA | 1 |
| Bayer, BM; Pellegrino, TC | 1 |
| Gong, ZH; Luo, ZP; Zhang, FQ | 1 |
| Baba, J; Fujishiro, J; Imanishi, T; Kosaka, K | 1 |
| Donati, RJ; Rasenick, MM; Thukral, C | 1 |
| Baek, D; Bergstrom, DA; Freeman, LE; Ruskin, DN; Walters, JR | 1 |
| Dalvi, A; Lucki, I; Mayorga, AJ | 1 |
| Guralnik, O; Schmeidler, J; Simeon, D | 1 |
| Dalvi, A; Hen, R; Lucki, I; Mayorga, AJ; Page, ME; Zimov-Levinson, S | 1 |
| Ferris, CF; Koppel, G; Messenger, T; Rasmussen, MF | 1 |
| Bryan-Lluka, LJ; Paczkowski, FA | 1 |
| Jain, NK; Kulkarni, SK; Singh, A | 1 |
| Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA | 1 |
| Blendy, JA; Conti, AC; Cryan, JF; Dalvi, A; Lucki, I | 1 |
| Cecil, A; Crites, G; Goldenberg, R; Knapp, RJ; Malatynska, E; Miller, C; Shuck, C; Watkins, J | 1 |
| Ferris, CF; King, JA; Messenger, T | 1 |
| Bartholomä, P; Baumann, B; Erlandsson, N; Giehl, KM; Kaufmann, K; Rössler, OG; Thiel, G; Wirth, T | 1 |
| Budygin, EA; John, CE; Jones, SR; Mateo, Y | 1 |
| Bethus, I; Goodall, G; Muscat, R; Sammut, S | 1 |
| Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA; Runkel, F; Sucic, S | 1 |
| Alpert, J; Baer, L; Fava, M; Lagomasino, I; Nierenberg, A; Rosenbaum, JF; Sonawalla, S; Tedlow, J; Worthington, J | 1 |
| Avital, A; Caftori, R; Levkovitz, Y; Richter-Levin, G | 1 |
| Maurice, T; Roman, FJ; Romieu, P; Urani, A | 1 |
| Finkelstein, FO; Finkelstein, SH; Watnick, S; Wuerth, D | 1 |
| Bryan-Lluka, LJ; Sucic, S | 1 |
| Beyer, CE; Boikess, S; Dawson, LA; Luo, B | 1 |
| Asensio, VJ; García-Sevilla, JA; Miralles, A | 1 |
| Keating, E; Martel, F | 1 |
| Knoll, J; Miklya, I | 1 |
| Dawson, LA; Li, P | 1 |
| Kamei, J; Miyata, S; Morita, K; Saitoh, A; Takeda, H | 1 |
| Fujiwara, H; Iida, Y; Kanegawa, N; Kawashima, H; Kiyono, Y; Nishimura, H; Saji, H | 1 |
| Huang, WC; Li, YF; Liu, YQ; Luo, ZP | 1 |
| Murray, K; Murray, M | 1 |
| Bianchi, M; Cavanni, P; Crespi, F; Faedo, S; Heidbreder, CA; Lacroix, LP; Perdona, E; Remelli, R | 1 |
| Alpert, J; Fava, M; Mischoulon, D; Nierenberg, AA; Perlis, RH; Rosenbaum, JF; Yeung, A | 1 |
| Bowers, MB; Jatlow, PI; Mazure, CM; Nelson, JC; Price, LH | 1 |
| Altamirano, AV; Benmansour, S; Frazer, A; Gould, GG; Jones, DJ; Morilak, DA; Pardon, MC; Sanchez, TA | 1 |
| Fink, H; Rex, A; Schickert, R | 1 |
| Feighner, JP; Freed, JS; Hlavka, J; Nicolau, G; Overstreet, DH | 1 |
| Hume, AS; Kyle, PB; Ordway, GA; Zhu, MY | 1 |
| Cohen, LH; Hollembaek, J; Li, W; Penn, LD; Yu, C | 1 |
| Caboche, J; Girault, JA; Hervé, D; Pagès, C; Valjent, E | 1 |
| Cryan, JF; Dalvi, A; Friedland, JC; Hirsch, BR; Jin, SH; Lucki, I; O'Leary, OF; Ouyang, M; Page, ME; Thomas, SA | 1 |
| Alvarado, I; Flockhart, D; Flores, DL; Licinio, J; Wong, ML | 1 |
| Chen, CC; Chen, JC; Fu, YK; Hwang, JJ; Lee, JS; Liu, RS; Ting, G; Wey, SP; Ye, XX | 1 |
| Fernández-Guasti, A; Martínez-Mota, L | 1 |
| Griebel, G; Overstreet, DH | 1 |
| Alpert, JE; Bottiglieri, T; Fava, M; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Petersen, T; Rosenbaum, JF; Ryan, JL | 1 |
| Cryan, JF; Desrayaud, S; Slattery, DA | 1 |
| Alpert, JE; Denninger, JW; Fava, M; Nierenberg, AA; Papakostas, GI; Pava, JA; Petersen, T; Tossani, E | 1 |
| Alpert, JE; Burns, AM; Fava, M; Iosifescu, DV; Nierenberg, AA; Papakostas, GI; Petersen, T; Rosenbaum, JF | 1 |
| Carey, GJ; Gold, LH; Nielsen, DM | 1 |
| Irizarry, K; Jepson, R; Lake, S; Licinio, J; Merriman, B; O'Kirwan, F; Tantisira, KG; Thakur, S; Weiss, ST; Wong, ML | 1 |
| Crawley, JN; Dreiling, J; Gold, E; Holmes, A; Koenig, EA; Li, Q; Stephenson, D; Sullivan, T; Yang, RJ | 1 |
| Barden, N; Blom, JM; Brunello, N; Carra, S; Tascedda, F; Vinet, J | 1 |
| Bertotto, ME; Bustos, SG; Martijena, ID; Molina, VA | 1 |
| Banks, ML; Budygin, EA; John, CE; Jones, SR; Mateo, Y | 1 |
| Matuszewich, L; Yamamoto, BK | 1 |
| Carlezon, WA; Cayetano, K; Cohen, BM; Mague, SD; Meloni, EG; Parsegian, A; Renshaw, PF; Rohan, ML; Rouse, ED; Tomasiewicz, HC | 1 |
| Biba, A; Christodoulou, A; Chrysikakou, S; Giannou, H; Kontis, D; Maillis, A; Pallidi, S; Rabavilas, A; Tsaltas, E | 1 |
| Cai, W; Khaoustov, VI; Le, W; Pan, T; Xie, Q; Yoffe, B | 1 |
| Dow, AL; Duman, RS; Russell, DS | 1 |
| Ben-Shachar, D; Grauer, E; Karry, R; Klein, E; Laifenfeld, D | 1 |
| Gebicke-Haerter, PJ; Henn, FA; Rapp, S; Thome, J; Zink, M | 1 |
| Pei, Q; Sharp, T; Tordera, RM | 1 |
| Swant, J; Thompson, AM; Wagner, JJ | 1 |
| Abdel-Razaq, W; Bates, TE; Kendall, DA; Richards, JK | 1 |
| Folk, JE; Rice, KC; Torregrossa, MM; Watson, SJ; Woods, JH | 1 |
| Hutson, PH; Ivarsson, M; Paterson, LM | 1 |
| Davies, PS; Fields, HL; Reisner, LA; Rowbotham, MC | 1 |
| Huang, KX; Kecojevic, A; Koliatsos, VE; Welsh, AM; Zhou, L | 1 |
| Ikeda, K; Kobayashi, T; Ogai, Y; Ohta, M; Ozaki, M; Takahashi, T; Takamatsu, Y; Yamamoto, H | 1 |
| Cao, JB; Guan, TT; Li, YF; Liu, YQ; Luo, ZP; Wang, HL; Zhang, YZ | 1 |
| Dwivedi, Y; Pandey, GN; Rizavi, HS | 1 |
| Blaha, CD; Cooper, S; Harris, BT; Hitti, FL; Kim, U; Lee, KH; Leiter, JC; Roberts, DW | 1 |
| Chen, H; Dwivedi, Y; Pandey, GN | 1 |
| Brandão, ML; Martinez, RC; Santos, JM | 1 |
| Khundakar, AA; Zetterström, TSC | 1 |
| Crabbe, JC; Kliethermes, CL | 1 |
| Karoly, R; Kiss, JP; Lenkey, N; Mike, A; Szasz, BK; Vizi, ES | 1 |
| Bechtholt, AJ; Crowley, JJ; Lucki, I; O'Leary, OF; Valentino, RJ | 1 |
| Cantor, RM; Delgado, M; Deloukas, P; Licinio, J; McCann, SM; Whelan, F; Whittaker, P; Wong, ML | 1 |
| Eastwood, BJ; Jones, CK; Need, AB; Shannon, HE | 1 |
| Allain, H; Bentué-Ferrer, D; Bourin, M; Drapier, D; Laviolle, B; Millet, B; Reymann, JM | 1 |
| Ben-Shabat, S; Fride, E; Gobshtis, N | 1 |
| Crozatier, C; Dumas, S; Farley, S; Giros, B; Mansuy, IM; Tzavara, ET | 1 |
| Buddenberg, T; Huston, JP; Schulz, D | 1 |
| Busnello, JV; Elashoff, RM; Licinio, J; Ribeiro, L; Sharma, A; Thakur, S; Whelan, F; Wong, ML | 1 |
| Bechtholt, AJ; Crowley, JJ; Hill, TE; Lucki, I; O'Leary, OF; Page, ME | 1 |
| Abdel-Razaq, W; Bates, TE; Kendall, DA | 2 |
| Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S | 1 |
| Bichon, F; Detoc, M; Henriquet, C; Jaffuel, D; Mathieu, M; Michel, A; Portet, K; Roumestan, C | 1 |
| Popik, P; Schneider, T | 1 |
| Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM | 1 |
| Gerevich, Z; Illes, P; Karoly, R; Kiss, JP; Mike, A; Szasz, BK; Vizi, ES | 1 |
| Aiso, S; Ito, M; Katada, M; Kawasaki, A; Matsuoka, M; Nishizawa, K; Terashita, K; Torii, K | 1 |
| Rosenzweig-Lipson, S; Schechter, LE; Sukoff Rizzo, SJ | 1 |
| Harvey, BH; Korff, S; Stein, DJ | 1 |
| Cruz-Martínez, JJ; Fernández-Guasti, A; Márquez-Baltazar, S; Martínez-Mota, L | 1 |
| Bylund, DB; Happe, HK; Petty, F; Reed, AL | 1 |
| Borah, M; Radhakrishnan, M; Ramamoorthy, R | 1 |
| Mahesh, R; Minasri, B; Rajkumar, R; Venkatesha Perumal, R | 1 |
| Lolait, SJ; O'Carroll, AM; Roper, JA; Stewart, LQ; Young, WS | 1 |
| Fujibayashi, Y; Kanegawa, N; Kawashima, H; Kiyono, Y; Kuge, Y; Saji, H; Sugita, T; Ueda, M | 1 |
| Baros, AM; Bondi, CO; Lapiz, MD; Morilak, DA; O'Donnell, JM; Zhang, HT; Zhao, Z | 1 |
| Fernandes, C; Lanças, FM; Sandra, P; Van Hoeck, E | 1 |
| Balu, DT; Hoshaw, BA; Lucki, I; Malberg, JE; Rosenzweig-Lipson, S; Schechter, LE | 1 |
| Akil, H; Calvo, N; Cecchi, M; Jama, A; Watson, SJ | 1 |
| Benekareddy, M; Dias, BG; Kulkarni, VA; Mehrotra, P; Ramakrishnan, P; Vaidya, VA | 1 |
| Belzung, C; Surget, A; Yalcin, I | 1 |
| Donnici, L; Musazzi, L; Popoli, M; Racagni, G; Tardito, D; Tiraboschi, E | 1 |
| Banasr, M; Dow, A; Duman, R; Pittman, B; Valentine, G | 1 |
| Hirano, K; Hotta, Y; Kajiwara, Y; Kobayashi, Y; Sugimoto, Y; Tagawa, N; Yamada, J; Yamada, S | 1 |
| Caron, M; Hall, FS; Lesch, KP; Murphy, DL; Perona, MT; Sora, I; Uhl, GR; Waters, S | 1 |
| Lin, Y; Quartermain, D; Stone, EA | 1 |
| Baraka, AM; El Din, NM; El Said Darwish, I; Guemei, AA | 1 |
| Berlanga, C; Estrada-Camarena, E; Fernández-Guasti, A; Rivera, NM | 1 |
| Ipser, JC; Sander, C; Stein, DJ | 1 |
| Anderson, BT; Balu, DT; Hodes, GE; Lucki, I | 1 |
| Kiss, JP; Mayer, A; Szasz, BK | 1 |
| Dong, C; Licinio, J; Wong, ML | 1 |
| Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T | 1 |
| He, XJ; Nakayama, H; Shibui, Y; Uchida, K | 1 |
| Breese, G; Fredericks, K; Knapp, D; McMichael, J; Overstreet, DH | 1 |
| Bliziotes, MM; Bogenschutz, ED; Bond, JL; Fuchs, RK; Grogg, JD; Hassett, SM; Hilles, EL; Rydberg, J; Smith, HD; Turner, CH; Warden, SJ | 1 |
| Kompagne, H; Kuki, Z; Lévay, G; Markó, B; Nagy, KM; Sziray, N | 1 |
| Allen, KE; Babu, KN; Hanson, KL; Kunze, KL; Nelson, WL; VandenBrink, BM | 1 |
| Di Benedetto, B; Ganal, V; Holsboer, F; Kessler, JS; Kirmeier, T; Nothdurfter, C; Rammes, G; Rein, T; Rupprecht, R; Tanasic, S; Wagner, EM | 1 |
| Akagawa, K; Fujiwara, T; Kofuji, T; Snada, M; Yoshikawa, T | 1 |
| Andrews, AM; Earnheart, JC; Lal, R; Luellen, BA; Luscher, B; Shen, Q | 1 |
| Nikiforuk, A; Popik, P | 1 |
| Corda, MG; Giorgi, O; Piras, G | 1 |
| Drugan, RC; Macomber, H; Warner, TA | 1 |
| Iijima, M; Matsuki, N; Miyamoto, D; Nomura, H; Yamamoto, H | 1 |
| Fisar, Z; Hroudová, J; Raboch, J | 1 |
| Bult-Ito, A; Burrow, T; Castillo, MR; Foltz, H; Greene-Schloesser, DM; Gregg, KA; Sheppard, DK; Slater, M; Van der Zee, EA | 1 |
| Alaux-Cantin, S; André, E; Houchi, H; Legastelois, R; Naassila, M; Pierrefiche, O; Simon O'Brien, E; Vilpoux, C | 1 |
| Branco-de-Almeida, LS; Cardoso, CR; Franco, GC; Han, X; Kajiya, M; Kawai, T; Ohta, K; Rosalen, PL; Silva, MJ; Taubman, MA | 1 |
| Estrada-Camarena, E; Hernández-Aragón, A; López-Rubalcava, C; Mejía-Mauries, S; Picazo, O | 1 |
| Basta-Kaim, A; Budziszewska, B; Grygier, B; Jantas, D; Kubera, M; Lason, W; Leskiewicz, M; Maes, M; Nowak, W; Rogóż, Z; Roman, A; Wrona, D | 1 |
| Isoherranen, N; Lutz, JD | 1 |
| Calhau, C; Faria, A; Lemos, C; Martel, F; Meireles, M; Monteiro, R | 1 |
| Fujii, H; Hashikawa-Hobara, N; Kawasaki, H; Mio, M; Miyake, N; Takatori, S; Tangsucharit, P; Zamami, Y | 1 |
| Carreno, FR; Frazer, A; Furmaga, H | 1 |
| Basta-Kaim, A; Budziszewska, B; Curzytek, K; Detka, J; Duda, W; Kubera, M; Lasoń, W; Leśkiewicz, M; Maes, M; Majewska-Szczepanik, M; Marcińska, K; Ptak, W; Szczepanik, M | 1 |
| Altimus, CM; Hattar, S; Kirkwood, A; Lee, HK; LeGates, TA; Wang, H; Weber, ET; Yang, S; Zhao, H | 1 |
| Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J | 1 |
| Huang, BR; Lai, CH; Lin, C; Lin, H; Lin, HY; Lu, DY; Yeh, WL | 1 |
| Di Benedetto, B; Radecke, J; Rupprecht, R; Schmidt, MV | 1 |
| Chen, P; Fan, Y; Li, Y; Zhu, MY | 1 |
| Bohner, LO; Costa, AP; De Lima, TC; Lino-de-Oliveira, C; Santos, EC; Silva, CF; Vieira, C | 1 |
| Corda, MG; Giorgi, O; Piludu, MA; Piras, G | 1 |
| Arteta, B; Basta-Kaim, A; Budziszewska, B; Curzytek, K; Duda, W; Grygier, B; Kubera, M; Lasoń, W; Leśkiewicz, M; Maes, M | 1 |
| Cadeddu, R; Carboni, E; Ibba, M; Sadile, A | 1 |
| Basta-Kaim, A; Budziszewska, B; Curzytek, K; Duda, W; Kubera, M; Lasoń, W; Leśkiewicz, M; Maes, M; Majewska-Szczepanik, M; Marcińska, K; Ptak, W; Szczepanik, M | 1 |
| Der-Avakian, A; Kesby, JP; Markou, A; Mazei-Robison, MS; Nestler, EJ | 1 |
| Liu, A; Liu, W; Qin, L; Wei, J; Yan, Z; Yuen, EY | 1 |
| Arcos-Burgos, M; Bornstein, S; Dong, C; Ehrhart-Bornstein, M; Flores, DL; Licinio, J; Wong, ML | 2 |
| Derry, S; Hearn, L; Moore, RA; Phillips, T; Wiffen, PJ | 1 |
| Altimimi, HF; Duseja, R; Heir, R; Lewitus, GM; Stellwagen, D | 1 |
| Guo, M; Lu, XY | 1 |
| Lewis, CM; Müller-Myhsok, B; Perlis, RH; Ripke, S; Uher, R | 1 |
| Grater, DM; Morgan, C; Shannonhouse, JL; Wellman, PJ; York, D | 1 |
| Collins, SL; Contreras-Mora, HM; Correa, M; Errante, EL; Rowland, MA; Salamone, JD; Yohn, SE | 1 |
| Fernández-Guasti, A; Martínez-Mota, L; Olivares-Nazario, M | 1 |
| Basta-Kaim, A; Budziszewska, B; Curzytek, K; Duda, W; Głombik, K; Korzeniak, B; Kubera, M; Lasoń, W; Leśkiewicz, M; Maes, M; Majewska-Szczepanik, M; Ptak, W; Regulska, M; Szczepanik, M | 1 |
| Dulawa, SC; Ho, EV; Katzka, WR; Knowles, JA; Sharifi, MF; Thompson, SL | 1 |
| García-Fuster, MJ; García-Sevilla, JA | 1 |
| Brunello, N; Ferrari, F; Gorini, A; Tascedda, F; Villa, RF | 1 |
| Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X | 1 |
| Jiang, CL; Liu, WZ; Shang, ZL; Wang, W; Xiang, ZH | 1 |
| Barygin, OI; Belinskaya, DA; Nagaeva, EI; Shestakova, NN; Tikhonov, DB; Vanchakova, NP | 1 |
| Barski, JJ; Bielecka-Wajdman, AM; Kasprowska, D; Małecki, A; Nowacka-Chmielewska, MM; Obuchowicz, E; Paul-Samojedny, M | 1 |
| Bagini, L; Brunello, N; Ferrari, F; Gorini, A; Tascedda, F; Villa, RF | 1 |
| Benham, RS; Engin, E; Hewage, NB; Rudolph, U; Suckow, RF | 1 |
| Carvalho, MC; Padovan, CM; Pereira, AC | 1 |
| Daws, LC; Koek, W; Sandoval, TL | 1 |
| Domingues, K; Lino de Oliveira, C; Suman, PR; Theindl, LC; Zerbinatti, N | 1 |
| Fernández-Guasti, A; Hernández, A | 1 |
| Crestani, CC; Guimarães, FS; Joca, SRL; Sales, AJ | 1 |
| Gmeiner, P; Gulbins, E; Kornhuber, J; Löber, S; Rhein, C; Tripal, P | 1 |
| Bessa, JM; Dulawa, SC; Ho, EV; Knowles, JA; Morais, M; Portugal-Nunes, C; Thompson, SL; Welch, AC; Young, JW | 1 |
| Chmielarz, P; Chorązka, K; Kowalska, M; Kuśmierczyk, J; Nalepa, I; Rafa-Zabłocka, K; Satała, G | 1 |
| Börger, V; Bromkamp, C; Doeppner, TR; Giebel, B; Gulbins, E; Gunzer, M; Hagemann, N; Hasenberg, M; Hermann, DM; Hussner, T; Kleinschnitz, C; Kleuser, B; Kolesnick, R; Martiny, C; Mohamud Yusuf, A; Schumacher, F; Sickmann, A; Solari, FA; Tertel, T; Zafar, M; Zhang, X | 1 |
| Arteta, B; Curzytek, K; Grygier, B; Kubera, M; Maes, M; Malicki, S | 1 |
| Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A | 1 |
18 review(s) available for fluoxetine and desipramine
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Topics: Animals; Biogenic Amines; Humans; Plasma Membrane Neurotransmitter Transport Proteins; Xenobiotics | 2016 |
The emergence of suicidal ideation and behavior during antidepressant pharmacotherapy.
Topics: Antidepressive Agents; Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Fluvoxamine; Humans; Imipramine; Mianserin; Suicide | 1991 |
Management of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents; Causality; Desipramine; Electroconvulsive Therapy; Evaluation Studies as Topic; Fluoxetine; Humans | 1991 |
Depression and cerebrovascular disease.
Topics: Cerebrovascular Disorders; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Male; Nortriptyline | 1990 |
Hypothesis: bromocriptine lacks intrinsic dopamine receptor stimulating properties.
Topics: Adenylyl Cyclases; alpha-Methyltyrosine; Animals; Bromocriptine; Desipramine; Dextroamphetamine; Drug Interactions; Fluoxetine; Humans; Methyltyrosines; Mice; Motor Activity; Nialamide; Nomifensine; Nucleus Accumbens; Rats; Receptors, Dopamine; Reserpine; Stereotyped Behavior | 1985 |
The pharmacotherapy of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Buspirone; Clomipramine; Desipramine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Sertraline | 1993 |
From the initial clinic contact to aftercare: a brief review of effective strategies for retaining cocaine abusers in treatment.
Topics: Antidepressive Agents; Appointments and Schedules; Clinical Trials as Topic; Cocaine; Desipramine; Fluoxetine; Humans; Patient Compliance; Psychotherapy; Social Support; Substance-Related Disorders; Treatment Outcome | 1997 |
Augmentation strategies with serotonergic-noradrenergic combinations.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bupropion; Clinical Trials as Topic; Depressive Disorder; Desipramine; Drug Synergism; Drug Therapy, Combination; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1998 |
Noradrenergic versus serotonergic antidepressants: predictors of treatment response.
Topics: Adrenergic Uptake Inhibitors; Catecholamines; Clinical Trials as Topic; Depressive Disorder; Desipramine; Fluoxetine; GTP-Binding Proteins; Humans; Norepinephrine; Probability; Receptor Cross-Talk; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment Outcome | 1998 |
The treatment of depression in patients maintained on dialysis.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Fluoxetine; Humans; Kidney Failure, Chronic; Practice Guidelines as Topic; Psychiatric Status Rating Scales; Renal Dialysis; Selective Serotonin Reuptake Inhibitors | 2002 |
Pharmacotherapy and psychotherapy for body dysmorphic disorder.
Topics: Adrenergic Uptake Inhibitors; Body Image; Clomipramine; Cognitive Behavioral Therapy; Desipramine; Fluoxetine; Humans; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Somatoform Disorders | 2009 |
In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors.
Topics: Algorithms; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Area Under Curve; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Fluoxetine; Forecasting; Humans; Kinetics; Models, Statistical | 2012 |
Desipramine for neuropathic pain in adults.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Pain; Clomipramine; Desipramine; Diabetic Neuropathies; Fluoxetine; Humans; Middle Aged; Neuralgia, Postherpetic; Randomized Controlled Trials as Topic | 2014 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 2016 |
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride | 2023 |
34 trial(s) available for fluoxetine and desipramine
| Article | Year |
|---|---|
Weighing up the pros and cons: help-seeking by drug misusers in Baltimore, USA.
Topics: Adult; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Fear; Female; Fluoxetine; Humans; Male; Methadone; Middle Aged; Motivation; Opioid-Related Disorders; Patient Acceptance of Health Care; Phencyclidine Abuse; Substance Abuse Treatment Centers; Substance-Related Disorders; Urban Population | 1992 |
Elective mutism as a variant of social phobia.
Topics: Child; Desipramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Mutism; Phobic Disorders; Single-Blind Method; Social Behavior; Social Environment; Verbal Behavior | 1992 |
Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Animals; Clomipramine; Dermatitis; Desipramine; Disease Models, Animal; Dog Diseases; Dogs; Double-Blind Method; Fenfluramine; Fluoxetine; Follow-Up Studies; Grooming; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Serotonin; Sertraline; Ulcer | 1992 |
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Depression; Desipramine; Diabetic Neuropathies; Double-Blind Method; Female; Fluoxetine; Humans; Infant, Newborn; Male; Middle Aged; Pain | 1992 |
Effect of fluoxetine on noradrenergic mediated growth hormone release: a double blind, placebo-controlled study.
Topics: Adult; Analysis of Variance; Depressive Disorder; Desipramine; Double-Blind Method; Female; Fluoxetine; Growth Hormone; Humans; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales | 1991 |
Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study.
Topics: Adaptation, Psychological; Adult; Affect; AIDS Serodiagnosis; Amantadine; Baltimore; Cocaine; Combined Modality Therapy; Desipramine; Female; Fluoxetine; HIV Seropositivity; Humans; Male; Patient Dropouts; Psychotherapy; Sick Role; Substance-Related Disorders | 1991 |
Initial reaction and subsequent response to antidepressants in panic patients.
Topics: Anxiety Disorders; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Humans; Panic; Psychiatric Status Rating Scales | 1990 |
Response to alternative antidepressants in imipramine nonresponders with bulimia nervosa.
Topics: Adolescent; Adult; Antidepressive Agents; Bulimia; Clinical Trials as Topic; Desipramine; Feeding Behavior; Female; Fluoxetine; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nortriptyline; Random Allocation | 1989 |
Cost-effectiveness comparisons using "real world" randomized trials: the case of new antidepressant drugs.
Topics: Antidepressive Agents; Cost-Benefit Analysis; Desipramine; Drug Costs; Fluoxetine; Humans; Imipramine; Patient Compliance; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; United States | 1995 |
Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Lithium; Male; Pilot Projects; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 1994 |
Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine.
Topics: 1-Naphthylamine; Antidepressive Agents; Chromatography, High Pressure Liquid; Desipramine; Dextromethorphan; Drug Interactions; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Sertraline | 1994 |
Fluoxetine and desipramine in major depressive disorder.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Middle Aged; Personality Inventory | 1993 |
An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression.
Topics: Adult; Ambulatory Care; Buspirone; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors | 1993 |
Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression.
Topics: 1-Naphthylamine; Adrenergic Uptake Inhibitors; Antidepressive Agents; Brain; Brain Chemistry; Depressive Disorder; Desipramine; Diphenhydramine; Dopamine; Fluoxetine; Humans; Mazindol; Methyltyrosines; Norepinephrine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Initial antidepressant choice in primary care. Effectiveness and cost of fluoxetine vs tricyclic antidepressants.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Desipramine; Drug Costs; Drug Utilization; Drug Utilization Review; Family Practice; Female; Fluoxetine; Health Maintenance Organizations; Humans; Imipramine; Male; Middle Aged; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Quality of Life; Washington | 1996 |
Medication and psychotherapy in the treatment of bulimia nervosa.
Topics: Adolescent; Adult; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Personality Inventory; Placebos; Psychiatric Status Rating Scales; Psychotherapy; Treatment Outcome | 1997 |
Addition of desipramine to serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Adrenergic Uptake Inhibitors; Adult; Clomipramine; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Fluvoxamine; Humans; Male; Obsessive-Compulsive Disorder; Placebos; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 1997 |
Double-blind comparison of fluoxetine and desipramine in the treatment of depressed women with advanced HIV disease: a pilot study.
Topics: Adult; Depressive Disorder; Desipramine; Double-Blind Method; Female; Fluoxetine; HIV Infections; Humans; Pilot Projects; Psychiatric Status Rating Scales | 1999 |
Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action.
Topics: Adult; Aged; Amino Acids; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Depressive Disorder, Major; Desipramine; Female; Fluoxetine; Humans; Male; Middle Aged; Norepinephrine; Recurrence; Serotonin; Time Factors; Tryptophan | 1999 |
Psychological versus pharmacological treatments of bulimia nervosa: predictors and processes of change.
Topics: Adolescent; Adult; Antidepressive Agents; Bulimia; Cognitive Behavioral Therapy; Desipramine; Female; Fluoxetine; Humans; Middle Aged; Professional-Patient Relations; Prognosis; Psychotherapy, Brief; Treatment Outcome | 1999 |
Do depressed subjects who have failed both fluoxetine and a tricyclic antidepressant respond to the combination?
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Humans; Imipramine; Middle Aged; Personality Inventory; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1999 |
Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antimanic Agents; Chi-Square Distribution; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Lithium Chloride; Male; Middle Aged | 2002 |
The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression.
Topics: Acute Disease; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; Female; Fluoxetine; Humans; Male; Memory; Middle Aged; Selective Serotonin Reuptake Inhibitors; Statistics, Nonparametric | 2002 |
Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day.
Topics: Adult; Antidepressive Agents, Tricyclic; Demography; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Lithium; Male; Selective Serotonin Reuptake Inhibitors; Socioeconomic Factors; Treatment Outcome | 2003 |
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Depressive Disorder; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment Outcome | 2004 |
Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Lithium; Male; Probability; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Vitamin B 12 | 2004 |
Psychosocial functioning during the treatment of major depressive disorder with fluoxetine.
Topics: Activities of Daily Living; Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Antimanic Agents; Depressive Disorder, Major; Desipramine; Disability Evaluation; Double-Blind Method; Drug Therapy; Drug Therapy, Combination; Female; Fluoxetine; Follow-Up Studies; Humans; Lithium Carbonate; Male; Middle Aged; Personality Inventory; Psychometrics; Reproducibility of Results; Social Adjustment; Treatment Outcome | 2004 |
Obesity among outpatients with major depressive disorder.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Body Mass Index; Body Weight; Depressive Disorder, Major; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Follow-Up Studies; Humans; Lithium Carbonate; Male; Middle Aged; Obesity; Personality Inventory; Risk Factors; Sex Factors; Statistics as Topic; Treatment Outcome | 2005 |
Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.
Topics: Adult; Antidepressive Agents; Anxiety; Depressive Disorder; Desipramine; Double-Blind Method; Female; Fluoxetine; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Matched-Pair Analysis; Mexican Americans; Prospective Studies; Receptors, Corticotropin-Releasing Hormone; Reference Values; Treatment Outcome | 2004 |
Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Patient Dropouts; Treatment Outcome | 2005 |
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Aged; Antidepressive Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Fluoxetine; Genetic Predisposition to Disease; Humans; Male; Mexican Americans; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Prospective Studies; Single-Blind Method | 2006 |
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Fluoxetine; Humans; Middle Aged; Pain Measurement; Patient Dropouts; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Time Factors; Treatment Outcome; Xerostomia | 2007 |
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.
Topics: Adult; Aged; Alleles; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Case-Control Studies; Depressive Disorder, Major; Desipramine; Double-Blind Method; Female; Fluoxetine; Gene Frequency; Genetic Markers; Genetic Variation; Haplotypes; Humans; Introns; Los Angeles; Male; Mexican Americans; Middle Aged; Open Reading Frames; Pharmacogenetics; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Treatment Outcome; Untranslated Regions; White People; Young Adult | 2009 |
Clinical outcomes and genome-wide association for a brain methylation site in an antidepressant pharmacogenetics study in Mexican Americans.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Epigenesis, Genetic; Female; Fluoxetine; Genome-Wide Association Study; Genotype; Humans; Male; Mexican Americans; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Psychiatric Status Rating Scales; Research Design; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2014 |
409 other study(ies) available for fluoxetine and desipramine
| Article | Year |
|---|---|
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Catecholamines; Chemical Phenomena; Chemistry; Dopamine; Isoquinolines; Male; Molecular Conformation; Motor Activity; Norepinephrine; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Synaptosomes; Tetrabenazine | 1987 |
Novel tetracyclic spiropiperidines. 1. 3-Aryl-1,3-dihydrospiro[benzo[c]thiophene-1,4'-piperidines] as potential antidepressants.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Blepharoptosis; Chemical Phenomena; Chemistry; Drug Synergism; Male; Mice; Physostigmine; Piperidines; Spiro Compounds; Tetrabenazine | 1981 |
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Selective Serotonin Reuptake Inhibitors; Tacrine | 1997 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Cation Transport Proteins; Tyramine | 2005 |
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Topics: Amino Acid Sequence; Animals; Antidepressive Agents, Tricyclic; Bacterial Proteins; Binding Sites; Caenorhabditis elegans Proteins; Cell Line; Conserved Sequence; Crystallography, X-Ray; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Drosophila Proteins; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Plasma Membrane Neurotransmitter Transport Proteins; Protein Binding; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Sequence Homology, Amino Acid; Serotonin | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation | 2007 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Topics: Animals; Cell Line; Cyclohexanols; Ethylamines; Female; Humans; Male; Mice; Models, Molecular; Molecular Structure; Norepinephrine; Pain; Rats; Structure-Activity Relationship; Symporters | 2008 |
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
Topics: Humans; Indoles; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
Topics: Benzimidazoles; Combinatorial Chemistry Techniques; Drug Design; Humans; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Stereoisomerism | 2008 |
Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors.
Topics: Binding Sites; Computer Simulation; Databases, Factual; Models, Chemical; Models, Molecular; Molecular Structure; Molecular Weight; Psychotropic Drugs; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Animals; Chemistry, Pharmaceutical; Dogs; Dopamine Plasma Membrane Transport Proteins; Drug Design; Humans; Inhibitory Concentration 50; Ligands; Models, Chemical; Norepinephrine; Propanolamines; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship | 2009 |
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Cell Line; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Dogs; Dopamine Plasma Membrane Transport Proteins; Drug Discovery; Humans; Molecular Conformation; Norepinephrine; Propanols; Recombinant Proteins; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2009 |
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Animals; Humans; Indoles; Models, Animal; Norepinephrine Plasma Membrane Transport Proteins; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2009 |
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Topics: Administration, Oral; Animals; Behavior, Animal; Benzimidazoles; Biological Transport; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Hyperalgesia; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Propanolamines; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Spinal Nerves; Structure-Activity Relationship; Substrate Specificity | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Topics: Animals; Body Temperature Regulation; Female; Indoles; Magnetic Resonance Spectroscopy; Neurotransmitter Uptake Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Pain; Propanolamines; Rats; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Topics: Animals; Crystallography, X-Ray; Ethylamines; Humans; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Structure-Activity Relationship; Thiophenes | 2010 |
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
Topics: Animals; Cell Line; Cyclic S-Oxides; Drug Discovery; Female; Humans; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Structure-Activity Relationship; Thiadiazoles | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Mice; Naphthalenes; Neurotransmitter Uptake Inhibitors; Norepinephrine; Serotonin | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Topics: Acute Pain; Administration, Oral; Analgesics; Animals; Benzothiazoles; Biological Availability; Cell Line; Chronic Pain; Cricetinae; Cyclic S-Oxides; Dogs; Humans; Inflammation; Injections, Intravenous; Male; Morpholines; Neuralgia; Norepinephrine Plasma Membrane Transport Proteins; Rats; Stereoisomerism; Thiadiazoles | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Lactams; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Pyrrolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2013 |
2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character.
Topics: Amination; Animals; Antidepressive Agents; Anura; Halogenation; Hindlimb Suspension; Mice; Quinazolines; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists | 2013 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Norepinephrine-stimulated cyclic AMP accumulation in brain slices in vitro after serotonin depletion or chronic administration of selective amine reuptake inhibitors.
Topics: Animals; Brain; Cyclic AMP; Desipramine; Fluoxetine; In Vitro Techniques; Male; Norepinephrine; p-Chloroamphetamine; Phenyl Ethers; Propylamines; Rats; Serotonin | 1977 |
Blockade of para-methoxyamphetamine induced serotonin release by serotonin uptake inhibitors.
Topics: Amphetamines; Animals; Brain; Clomipramine; Desipramine; Fluoxetine; Hydroxyindoleacetic Acid; Male; Muscle Contraction; Rats; Serotonin; Serotonin Antagonists | 1978 |
Hydroxytryptamine uptake inhibitors block para- methoxyamphetamine-induced 5-HT release.
Topics: Amphetamines; Animals; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male; Methysergide; Muscle Contraction; Pargyline; Rats; Serotonin | 1979 |
Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine.
Topics: Adenylyl Cyclases; Animals; Brain; Desipramine; Dihydroalprenolol; Fluoxetine; Male; Norepinephrine; Propylamines; Rats; Receptors, Adrenergic | 1979 |
Nisoxetine prevents the 6-hydroxydopamine induced decrease in post-decapitation convulsions.
Topics: Animals; Brain Stem; Cerebral Cortex; Decerebrate State; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hydroxydopamines; Male; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Seizures; Spinal Cord | 1977 |
dl-N-methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart.
Topics: Animals; Biological Transport; Brain; Depression, Chemical; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Heart; Male; Myocardium; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Synaptosomes | 1975 |
Effects of repeated administration of desipramine or electroconvulsive shock on norepinephrine uptake sites measured by [3H]nisoxetine autoradiography.
Topics: Animals; Autoradiography; Desipramine; Electroshock; Fluoxetine; Male; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tritium | 1992 |
Characterization of the [3H]-desipramine binding site of the bovine adrenomedullary plasma membrane.
Topics: Adrenal Medulla; Animals; Binding Sites; Carrier Proteins; Cattle; Cell Membrane; Chlorides; Desipramine; Fluoxetine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; Receptors, Drug; Receptors, Neurotransmitter; Sensitivity and Specificity; Sodium; Solubility; Symporters; Tritium | 1992 |
Antidepressants, panic disorder, and PTSD.
Topics: Adult; Desipramine; Female; Fluoxetine; Humans; Panic Disorder; Stress Disorders, Post-Traumatic | 1992 |
Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro.
Topics: Animals; Arginine Vasopressin; Desipramine; Fluoxetine; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Reference Values; Trazodone | 1992 |
Fluoxetine inhibits desipramine metabolism.
Topics: Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Retrospective Studies | 1992 |
Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction.
Topics: Adult; Desipramine; Drug Evaluation; Drug Interactions; Fluoxetine; Humans; Imipramine; Male; Middle Aged | 1992 |
Adverse effects of switching from fluoxetine to desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Metabolic Clearance Rate; Middle Aged; Risk Factors; Substance Withdrawal Syndrome | 1992 |
Role of norfluoxetine in the inhibition of desipramine metabolism and in the inhibition of serotonin uptake after fluoxetine administration to rats.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Depression, Chemical; Desipramine; Fluoxetine; Hydroxyindoleacetic Acid; Liver; Male; Rats; Rats, Inbred Strains | 1991 |
Effect of fluoxetine on plasma desipramine and 2-hydroxydesipramine.
Topics: Aged; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans | 1992 |
Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat.
Topics: Animals; Cocaine; Desipramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluoxetine; Male; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains | 1991 |
Refractory depression: the addition of lithium to fluoxetine or desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Drug Therapy, Combination; Drug Tolerance; Female; Fluoxetine; Humans; Lithium; Lithium Carbonate; Male; Middle Aged; Personality Tests; Psychiatric Status Rating Scales | 1991 |
Lithium carbonate augmentation of desipramine and fluoxetine in refractory depression.
Topics: Adult; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Lithium; Lithium Carbonate; Male; Middle Aged; Psychiatric Status Rating Scales | 1991 |
Association of fluoxetine with suicidal ideation.
Topics: Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Humans; Imipramine; Suicide | 1991 |
High- and low-affinity [3H]desipramine-binding sites in human postmortem brain tissue.
Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Carrier Proteins; Citalopram; Cricetinae; Desipramine; Female; Fluoxetine; Humans; Male; Middle Aged; Norepinephrine; Radioligand Assay; Receptors, Drug; Receptors, Neurotransmitter | 1990 |
A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression.
Topics: Adult; Aged; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Hospitalization; Humans; Male; Middle Aged; Psychiatric Status Rating Scales | 1991 |
Elevated tricyclic antidepressant plasma concentrations associated with fluoxetine: two case reports.
Topics: Adult; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metabolic Clearance Rate; Nortriptyline | 1990 |
Intrathecal administration of thiorphan, bestatin, desipramine and fluoxetine differentially potentiate the antinociceptive effects induced by beta-endorphin and morphine, administered intracerebroventricularly.
Topics: Analgesics; Animals; beta-Endorphin; Desipramine; Fluoxetine; Injections, Intraventricular; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred ICR; Morphine; Reaction Time; Thiorphan | 1990 |
Combining fluoxetine with desipramine.
Topics: Adolescent; Desipramine; Drug Interactions; Female; Fluoxetine; Humans; Obsessive-Compulsive Disorder | 1990 |
Drug-drug interactions of fluoxetine with tricyclics.
Topics: Depressive Disorder; Desipramine; Drug Synergism; Drug Therapy, Combination; Fluoxetine; Humans; Metabolic Clearance Rate; Nortriptyline | 1990 |
Rapid down regulation of beta-adrenoceptors by co-administration of desipramine and fluoxetine.
Topics: Adenosine Triphosphate; Animals; Cerebral Cortex; Cyclic AMP; Desipramine; Dihydroalprenolol; Fluoxetine; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin | 1988 |
Effect of monoamine uptake inhibitors on norepinephrine-stimulated phosphatidylinositol hydrolysis in rat cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Desipramine; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Receptors, Adrenergic, alpha | 1989 |
Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Bucladesine; Cerebral Cortex; Desipramine; Fluoxetine; Injections, Intraventricular; Male; Maprotiline; Mianserin; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Time Factors | 1989 |
Dual aminergic regulation of central beta adrenoceptors. Effect of "atypical" antidepressants and 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adrenergic beta-Agonists; Animals; Antidepressive Agents; Binding, Competitive; Desipramine; Dihydroalprenolol; Fluoxetine; Male; Mianserin; Models, Biological; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Regression Analysis; Reserpine; Serotonin; Serotonin Antagonists; Tritium | 1989 |
Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla.
Topics: Animals; Blood; Desipramine; Electric Stimulation; Fluoxetine; Hydroxyindoleacetic Acid; Male; Medulla Oblongata; Norepinephrine; Raphe Nuclei; Rats; Rats, Inbred Strains; Secretory Rate; Serotonin; Specimen Handling; Spinal Cord | 1985 |
Effect of fluoxetine pretreatment on plasma and tissue concentrations of desipramine in rats.
Topics: Animals; Biotransformation; Brain; Chromatography, Liquid; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Half-Life; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1989 |
Fluoxetine and desipramine: a strategy for augmenting anti-depressant response.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Lithium; Male; Middle Aged | 1989 |
[3H]desipramine binding to rat brain tissue: binding to both noradrenaline uptake sites and sites not related to noradrenaline neurons.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Desipramine; Endopeptidases; Fluoxetine; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1989 |
Influence of fluoxetine on plasma levels of desipramine.
Topics: Adult; Desipramine; Drug Interactions; Fluoxetine; Humans; Male | 1989 |
Effect of fluoxetine on metabolism of tricyclic antidepressants in the lungs.
Topics: Desipramine; Female; Fluoxetine; Humans; Liver; Lung | 1989 |
Role of serotonin in the regulation of beta-adrenoceptors by antidepressants.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Fenclonine; Fluoxetine; In Vitro Techniques; Male; Maprotiline; Membranes; Mianserin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin | 1987 |
Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines.
Topics: Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Drug Interactions; Fluoxetine; Male; Morphine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Time Factors | 1988 |
Antidepressants and protein kinases: desipramine treatment affects pineal gland cAMP-dependent protein kinase activity.
Topics: Animals; Antidepressive Agents; Desipramine; Fluoxetine; Iprindole; Isoproterenol; Male; Pineal Gland; Protein Kinases; Rats; Rats, Inbred Strains; Zimeldine | 1986 |
Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Electroshock; Fluoxetine; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin Antagonists; Time Factors; Viloxazine | 1985 |
Some pharmacological actions of nisoxetine, a bicyclic inhibitor of noradrenaline uptake.
Topics: Animals; Bradykinin; Carbachol; Desipramine; Fluoxetine; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Propylamines; Rats; Receptors, Adrenergic, alpha; Reserpine; Vas Deferens; Xylazine | 1985 |
Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Arousal; Behavior, Animal; Brain; Chlorocebus aethiops; Desipramine; Dominance-Subordination; Dose-Response Relationship, Drug; Fluoxetine; Male; Motor Activity; Receptors, Cholinergic; Receptors, Serotonin; Tryptophan | 1987 |
Interactions of 5HT reuptake inhibitors and ethanol in tests of exploration and anxiety.
Topics: Animals; Anxiety; Citalopram; Desipramine; Drug Interactions; Ethanol; Exploratory Behavior; Fluoxetine; Fluvoxamine; Mice; Mice, Inbred Strains; Motor Activity; Oximes; Serotonin Antagonists | 1988 |
Behavioral interactions of fluoxetine and other 5-hydroxytryptamine uptake inhibitors with ethanol in tests of anxiety, locomotion and exploration.
Topics: Animals; Anxiety; Citalopram; Desipramine; Ethanol; Exploratory Behavior; Fluoxetine; Fluvoxamine; Male; Mice; Motor Activity; Oximes; Serotonin Antagonists | 1988 |
Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats.
Topics: Animals; Blood Pressure; Desipramine; Dose-Response Relationship, Drug; Fenclonine; Fenfluramine; Fluoxetine; Heart Rate; Male; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Renin; Serotonin; Serotonin Antagonists; Time Factors; Tryptophan | 1985 |
Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium.
Topics: Animals; Antidepressive Agents; Biological Transport, Active; Chromatography, High Pressure Liquid; Clonidine; Coronary Disease; Desipramine; Fluoxetine; Heart; Isomerism; Lidocaine; Male; Maprotiline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1988 |
Desipramine subsensitizes nicotinic mechanism involved in regulating core temperature.
Topics: Amitriptyline; Animals; Body Temperature Regulation; Brain; Desipramine; Fluoxetine; Light; Lithium; Male; Nicotine; Phenelzine; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1988 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feeding Behavior; Fluoxetine; Male; Rats; Reference Values; Species Specificity | 1988 |
Fluoxetine induces elevation of desipramine level and exacerbation of geriatric nonpsychotic depression.
Topics: Adult; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans | 1988 |
Reengineering the brain serotonin system: localized application of specific neurotoxins and fetal serotonergic neurons into the adult CNS.
Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Animals; Brain; Desipramine; Fluoxetine; Injections, Intraventricular; Iontophoresis; Methods; Microsurgery; Nerve Tissue; Neurons; Neurotoxins; Norepinephrine; Raphe Nuclei; Serotonin; Tryptophan | 1986 |
Analgesic properties of intrathecally administered heterocyclic antidepressants.
Topics: Analgesics; Animals; Antidepressive Agents; Citalopram; Desipramine; Dibenzocycloheptenes; Fluoxetine; Injections, Spinal; Male; Mice; Propylamines; Protriptyline | 1987 |
Lack of selectivity between the uptake of [3H]adrenaline and [3H]noradrenaline into rat hypothalamic slices.
Topics: Animals; Benztropine; Desipramine; Epinephrine; Fluoxetine; Hypothalamus; Male; Maprotiline; Norepinephrine; Rats; Rats, Inbred Strains; Tissue Distribution | 1987 |
Antipanic drug effects during lactate infusion in lactate-refractory panic patients.
Topics: Adult; Agoraphobia; Alprazolam; Clonidine; Desipramine; Fear; Female; Fluoxetine; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic; Phobic Disorders; Psychological Tests; Psychotropic Drugs | 1987 |
Tryptamine, a substrate for the serotonin transporter in human platelets, modifies the dissociation kinetics of [3H]imipramine binding: possible allosteric interaction.
Topics: Allosteric Regulation; Antidepressive Agents, Tricyclic; Blood Platelets; Carrier Proteins; Desipramine; Fluoxetine; Humans; Imipramine; Serotonin; Serotonin Antagonists; Tryptamines | 1985 |
Characterization of sodium-dependent, high-affinity serotonin uptake in rat spinal cord synaptosomes.
Topics: Animals; Desipramine; Fluoxetine; Kinetics; Male; Nomifensine; Rats; Rats, Inbred Strains; Serotonin; Sodium; Spinal Cord; Synaptosomes; Temperature | 1985 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid Cells; Imipramine; Iprindole; Kinetics; Mianserin; Neuroblastoma; Opipramol; Rats; Serotonin | 1985 |
Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clomipramine; Corpus Striatum; Desipramine; Dopamine; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Nomifensine; Norepinephrine; Pyridines; Serotonin Antagonists | 1985 |
Demonstration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation.
Topics: Animals; Cocaine; Desipramine; Fluoxetine; Lysergic Acid Diethylamide; Male; Norepinephrine; Pargyline; Potassium; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Synaptosomes | 1985 |
Bromocriptine potentiates the behavioural effects of directly and indirectly acting dopamine receptor agonists in mice.
Topics: alpha-Methyltyrosine; Animals; Bromocriptine; Desipramine; Drug Synergism; Fluoxetine; Haloperidol; Levodopa; Male; Methyltyrosines; Mice; Motor Activity; Nomifensine; Receptors, Dopamine; Reserpine | 1985 |
Evidence that [3H]dopamine is taken up and released from nondopaminergic nerve terminals in the rat substantia nigra in vitro.
Topics: Amphetamine; Animals; Catecholamines; Corpus Striatum; Desipramine; Dopamine; Female; Fluoxetine; Hydroxydopamines; Medial Forebrain Bundle; Nerve Endings; Nomifensine; Oxidopamine; Potassium Chloride; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Substantia Nigra; Synaptosomes | 1985 |
Intraventricular 5,7-dihydroxytryptamine increases thyrotropin-releasing hormone content in regions of rat brain.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Desipramine; Dihydroxytryptamines; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Time Factors; Tissue Distribution | 1985 |
Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their visualization and reactions to drug treatment.
Topics: 5,7-Dihydroxytryptamine; Animals; Desipramine; Digestive System; Fenclonine; Fluorescent Antibody Technique; Fluoxetine; Guinea Pigs; Hydroxydopamines; Mice; Myenteric Plexus; Oxidopamine; Rabbits; Rats; Reserpine; Serotonin; Submucous Plexus | 1982 |
The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue.
Topics: Absorption; Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Fluoxetine; Fluvoxamine; Humans; In Vitro Techniques; Male; Norepinephrine; Oximes; Rats; Serotonin; Zimeldine | 1983 |
Activity of desipramine, fluoxetine and nomifensine on spontaneous and p-CPA-induced muricidal aggression.
Topics: Aggression; Animals; Antidepressive Agents; Desipramine; Fenclonine; Fluoxetine; Humans; Male; Nomifensine; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Brain serotonin receptors and neuropsychiatric disorders.
Topics: Animals; Brain; Desipramine; Fluoxetine; Humans; Imipramine; Kinetics; Lysergic Acid Diethylamide; Mental Disorders; Organ Specificity; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Serotonin; Schizophrenia; Serotonin | 1981 |
Responsiveness of cortical neurons to serotonin after 5,7-DHT denervation or PCPA depletion.
Topics: 5,7-Dihydroxytryptamine; Animals; Cerebral Cortex; Desipramine; Dihydroxytryptamines; Fenclonine; Fluoxetine; Male; Neurons; Rats; Serotonin | 1981 |
The effect of selective inhibitors of noradrenaline and serotonin uptake on reserpine- and apomorphine induced hypothermia in mice.
Topics: Animals; Apomorphine; Body Temperature; Citalopram; Desipramine; Fluoxetine; Male; Maprotiline; Mice; Norepinephrine; Propylamines; Reserpine; Serotonin Antagonists | 1983 |
Effects of norepinephrine and serotonin uptake inhibitors on the schedule-controlled behavior of the pigeon.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Columbidae; Conditioning, Operant; Desipramine; Doxepin; Fluoxetine; Iprindole; Male; Norepinephrine; Protriptyline; Reinforcement Schedule; Serotonin Antagonists | 1984 |
In vitro hippocampal uptake of tritiated serotonin (3H-5HT): A morphological, biochemical, and pharmacological approach to specificity.
Topics: 5,7-Dihydroxytryptamine; Animals; Desipramine; Female; Fluoxetine; Hippocampus; In Vitro Techniques; Norepinephrine; Rats; Serotonin | 1980 |
Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin.
Topics: Animals; Denervation; Desipramine; Dihydroxytryptamines; Fluoxetine; gamma-Aminobutyric Acid; Hippocampus; Hydroxydopamines; Isoproterenol; Locus Coeruleus; Male; Norepinephrine; Rats; Serotonin; Synapses | 1980 |
Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
Topics: Animals; Benzofurans; Citalopram; Desipramine; Electric Stimulation; Female; Fluoxetine; Norepinephrine; Propylamines; Rats; Seizures; Serotonin Antagonists; Spinal Cord | 1980 |
Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content.
Topics: Animals; Antidepressive Agents; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Clonidine; Desipramine; Fluoxetine; Glycols; Iprindole; Male; Methoxyhydroxyphenylglycol; Mianserin; Rats | 1981 |
The filum terminale of the frog spinal cord, a nontransformed glial preparation: II. Uptake of serotonin.
Topics: Animals; Biological Transport; Cauda Equina; Clomipramine; Desipramine; Dihydroxytryptamines; Fluoxetine; Kinetics; Neuroglia; Rana pipiens; Serotonin; Sodium | 1981 |
Serotonergic innervation of the lateral hypothalamus: evidence from synaptosomal uptake studies.
Topics: Absorption; Animals; Benztropine; Desipramine; Female; Fluoxetine; Hypothalamus; Kinetics; Mesencephalon; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1982 |
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.
Topics: Albuterol; Animals; Clonidine; Desipramine; Drug Interactions; Exploratory Behavior; Fluoxetine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Yohimbine | 1982 |
Medical complications of polydipsia in nonpsychotic depression.
Topics: Acute Kidney Injury; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Fluoxetine; Humans; Male; Middle Aged; Prostatic Hyperplasia; Tachycardia, Supraventricular; Water Intoxication | 1994 |
New classes of antidepressants that may be lethal in combination.
Topics: Adult; Affective Disorders, Psychotic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatal Outcome; Female; Fluoxetine; Humans; Malignant Hyperthermia | 1995 |
Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Clomipramine; Desipramine; Flunitrazepam; Fluoxetine; Ketanserin; Male; Maprotiline; Phenelzine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, GABA-A; Receptors, Serotonin; Serotonin Antagonists | 1995 |
Lithium or desipramine augmentation of fluoxetine treatment.
Topics: Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fluoxetine; Humans; Lithium; Treatment Outcome | 1995 |
Comparison of TCAs and SSRIs in the treatment of major depression in hospitalized geriatric patients.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Female; Fluoxetine; Heart Diseases; Hospitalization; Humans; Length of Stay; Male; Selective Serotonin Reuptake Inhibitors | 1995 |
Protein kinase C in rat brain cortex and hippocampus: effect of repeated administration of fluoxetine and desipramine.
Topics: Amphetamines; Animals; Antidepressive Agents; Autoradiography; Binding, Competitive; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; Injections, Intraperitoneal; Male; Paraventricular Hypothalamic Nucleus; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Signal Transduction | 1995 |
Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzylamines; Biogenic Monoamines; Desipramine; Fluoxetine; Hippocampus; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Sympathomimetics | 1995 |
Chronic fluoxetine or desmethylimipramine treatment alters 5-HT2 receptor mediated c-fos gene expression.
Topics: Amphetamines; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex; Desipramine; Fluoxetine; Gene Expression; Genes, fos; Hippocampus; Ketanserin; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 1995 |
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors | 1995 |
Effects of monoamine reuptake inhibitors on cocaine self-administration in rats.
Topics: Animals; Biogenic Monoamines; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intravenous; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 1995 |
Local 5HT3 receptors mediate fluoxetine but not desipramine-induced increase of extracellular dopamine in the prefrontal cortex.
Topics: Animals; Desipramine; Dopamine; Fluoxetine; Frontal Lobe; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Time Factors | 1995 |
Reduction of responses to angiotensin II by antidepressant drugs.
Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Animals; Antidepressive Agents; Binding, Competitive; Cocaine; Desipramine; Drinking; Drug Interactions; Female; Fluoxetine; In Vitro Techniques; Isoproterenol; Male; Oxytocin; Rats; Rats, Wistar; Tranylcypromine; Uterine Contraction; Uterus | 1994 |
Effect of long-term administration of antidepressant drugs on the 5-HT3 receptors that enhance the electrically evoked release of [3H]noradrenaline in the rat hippocampus.
Topics: Animals; Antidepressive Agents; Benzamides; Desipramine; Electric Stimulation; Fluoxetine; Hippocampus; In Vitro Techniques; Male; Maprotiline; Moclobemide; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Trimipramine | 1994 |
Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain.
Topics: Animals; Atomoxetine Hydrochloride; Autoradiography; Binding Sites; Brain; Citalopram; Desipramine; Fluoxetine; Male; Norepinephrine; Propylamines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tritium | 1995 |
Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function.
Topics: Animals; Brain; Clomipramine; Desipramine; Fluoxetine; Male; Motor Activity; Norepinephrine; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Time Factors | 1994 |
In vivo assessment of dopamine uptake in rat medial prefrontal cortex: comparison with dorsal striatum and nucleus accumbens.
Topics: Animals; Corpus Striatum; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Electrochemistry; Fluoxetine; Male; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Rats; Rats, Inbred F344 | 1995 |
Antidepressant and depressogenic drugs lack consistent effects on hamster circadian rhythms.
Topics: Animals; Antidepressive Agents; Arousal; Circadian Rhythm; Clonidine; Clorgyline; Cricetinae; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male; Mesocricetus; Motor Activity; Phenelzine; Propranolol | 1994 |
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinking Behavior; Fluoxetine; Haloperidol; Male; Obsessive-Compulsive Disorder; Rats; Rats, Wistar; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors | 1993 |
Monoamine uptake inhibitors alter cocaine pharmacokinetics.
Topics: Animals; Biotransformation; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley | 1993 |
Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships.
Topics: Animals; Biogenic Monoamines; Citalopram; Cocaine; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Lidocaine; Ligands; Male; Microdialysis; Movement; Norepinephrine; Piperazines; Rats; Serotonin; Tetrodotoxin; Ventral Tegmental Area | 1994 |
Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Brain; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hormones; Male; Oxytocin; Prolactin; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Renin; Vasopressins | 1994 |
Platelet 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age.
Topics: Adult; Age Factors; Binding Sites; Blood Platelets; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Infant; Male; Paroxetine; Serotonin | 1994 |
Effect of 6-hydroxydopamine lesions of the amygdala on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Amygdala; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Brain; Chlordiazepoxide; Cocaine; Desipramine; Dopamine; Estrus; Female; Fluoxetine; Ibotenic Acid; Injections, Intravenous; Male; Organ Specificity; Oxidopamine; Rats; Rats, Wistar; Self Administration; Time Factors; Tryptophan | 1994 |
Augmentation strategies with tricyclic or fluoxetine treatment in seven partially responsive panic disorder patients.
Topics: Adult; Alprazolam; Antidepressive Agents, Tricyclic; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Imipramine; Lorazepam; Male; Panic Disorder; Retrospective Studies; Treatment Outcome | 1994 |
In vitro effects of cocaine, lidocaine and monoamine uptake inhibitors on lymphocyte proliferative responses.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Cocaine; Desipramine; Fluoxetine; Lidocaine; Lymphocyte Activation; Male; Mitogens; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes | 1994 |
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
Topics: 1-Naphthylamine; Animals; Chloroquine; Desipramine; Drug Resistance; Drug Synergism; Fluoxetine; Neurotransmitter Uptake Inhibitors; Plasmodium falciparum; Sertraline | 1994 |
Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Carrier Proteins; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1993 |
Effect of fluoxetine on the spontaneous electrical activity of fronto-cortical neurons.
Topics: 5,7-Dihydroxytryptamine; Animals; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Frontal Lobe; Male; Neural Pathways; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Cerebral Cortex; Desipramine; Fluoxetine; Hypothalamus; Male; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1993 |
Antidepressant treatment and chemical sympathectomy fail to modulate alpha 1-adrenoceptor sensitivity in mouse eye.
Topics: Administration, Topical; Amitriptyline; Animals; Antidepressive Agents; Benzamides; Desipramine; Down-Regulation; Fluoxetine; Injections, Intraperitoneal; Male; Methoxamine; Mice; Moclobemide; Oxidopamine; Phentolamine; Phenylephrine; Prazosin; Pupil; Receptors, Adrenergic, alpha-1; Sympathectomy, Chemical; Time Factors | 1993 |
5-Hydroxytryptamine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination.
Topics: Animals; Brain; Cerebral Cortex; Desipramine; Drug Combinations; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Time Factors | 1994 |
The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine.
Topics: Animals; Brain; Chromatography, Gas; Desipramine; Fluoxetine; Iprindole; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1994 |
Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Topics: Animals; Binding Sites; Binding, Competitive; Biological Transport; Cell Membrane; Cells, Cultured; Cocaine; Desipramine; Dopamine; Embryo, Mammalian; Fluoxetine; Iodine Radioisotopes; Kinetics; Mesencephalon; Neurons; Nomifensine; Rats; Rats, Wistar; Stereoisomerism; Tritium | 1993 |
The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Cocaine; Desipramine; Female; Fluoxetine; In Vitro Techniques; Indoles; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptosomes; Tropisetron | 1993 |
Tolerance to fluoxetine.
Topics: 1-Naphthylamine; Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Female; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Sertraline | 1993 |
A comparison of weight changes with fluoxetine, desipramine, and amitriptyline: a retrospective study of psychiatric inpatients.
Topics: Amitriptyline; Body Weight; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluoxetine; Hospitalization; Humans; Male; Mental Disorders; Retrospective Studies; Weight Gain | 1993 |
Cocaine: cardiovascular effects in relation to inhibition of peripheral neuronal monoamine uptake and central stimulation of the sympathoadrenal system.
Topics: Adrenal Medulla; Animals; Biological Transport; Blood Pressure; Catecholamines; Chlorisondamine; Cocaine; Desipramine; Fluoxetine; Heart Rate; Male; Norepinephrine; Oxidopamine; Peripheral Nervous System; Propanolamines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1993 |
Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites.
Topics: Animals; Atomoxetine Hydrochloride; Binding Sites; Desipramine; Fluoxetine; Kinetics; Ligands; Male; Nerve Tissue Proteins; Norepinephrine; Piperazines; Propylamines; Prosencephalon; Rats; Rats, Sprague-Dawley | 1993 |
Concurrent liquid chromatographic measurement of fluoxetine, amitriptyline, imipramine, and their active metabolites norfluoxetine, nortriptyline, and desipramine in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Fluoxetine; Humans; Imipramine; Indicators and Reagents; Nortriptyline; Spectrophotometry, Ultraviolet | 1993 |
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors | 1993 |
p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Desipramine; Fenclonine; Fluoxetine; Guanidines; Hippocampus; Imipramine; Kinetics; Male; Proteins; Rats; Rats, Wistar; Receptors, sigma; Serotonin | 1993 |
Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI).
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Desipramine; Drug Synergism; Fluoxetine; Hormones; Ketanserin; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Vasopressins | 1993 |
Differential effects of fluoxetine on isoprenaline-stimulated water intake in ethanol-treated rats: a role for beta-adrenoceptors.
Topics: Analysis of Variance; Animals; Desipramine; Drinking; Drug Interactions; Ethanol; Fluoxetine; Fluvoxamine; Injections, Intraperitoneal; Isoproterenol; Male; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Zimeldine | 1993 |
The effects of antidepressants on the thyroid axis in depression.
Topics: Ambulatory Care; Antidepressive Agents; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Male; Thyroid Gland; Thyroid Hormones; Thyroxine; Triiodothyronine | 1993 |
Combined fluoxetine and desipramine in resistant depression.
Topics: Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Humans | 1993 |
Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse.
Topics: Animals; Dendrites; Desipramine; Dopamine; Fluoxetine; Mice; Mice, Neurologic Mutants; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Serotonin; Substantia Nigra | 1993 |
Postpartum obsessive compulsive disorder: a case series.
Topics: Adult; Clomipramine; Desipramine; Diagnosis, Differential; Female; Fluoxetine; Follow-Up Studies; Humans; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales; Psychotic Disorders; Puerperal Disorders | 1993 |
Simultaneous quantification of fluoxetine, norfluoxetine, and desipramine using gas chromatography with nitrogen-phosphorus detection.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Chromatography, Gas; Desipramine; Drug Interactions; Fluoxetine; Liver; Male; Mass Spectrometry; Nitrogen; Phosphorus; Rats; Rats, Sprague-Dawley; Reference Standards; Tissue Distribution | 1995 |
Pharmacokinetics of the newer antidepressants.
Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Desipramine; Fluoxetine; Humans; Isoenzymes; Liver; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
Topics: 1-Naphthylamine; Animals; Antidepressive Agents; Base Sequence; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Desipramine; Electric Stimulation; Fluoxetine; Hippocampus; Imipramine; In Situ Hybridization; Male; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Nerve Growth Factor; RNA, Messenger; Rolipram; Sertraline; Time Factors; Tranylcypromine | 1996 |
Drug-drug interactions.
Topics: 1-Naphthylamine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Mixed Function Oxygenases; Paroxetine; Research Design; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Carrier Proteins; Desipramine; Exocytosis; Fluoxetine; In Vitro Techniques; Male; Myocardial Ischemia; Norepinephrine; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Fluoxetine-imipramine interaction.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluoxetine; Humans; Imipramine; Lithium; Suicide Prevention | 1996 |
In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cerebral Cortex; Citalopram; Clonidine; Desipramine; Fluoxetine; Fluvoxamine; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1996 |
[3H]8-OH-DPAT binding and serotonin content in rat cerebral cortex after acute fluoxetine, desipramine, or pargyline.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Desipramine; Dopamine; Fluoxetine; Gyrus Cinguli; Homovanillic Acid; Male; Monoamine Oxidase; Pargyline; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists | 1996 |
Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Fluoxetine; Imipramine; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1996 |
Study addresses question of preferred initial therapy for depression.
Topics: Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Depression; Desipramine; Drug Costs; Fluoxetine; Humans; Imipramine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors | 1996 |
SSRI or tricyclics for depression?
Topics: Adult; Depression; Depressive Disorder; Desipramine; Family Practice; Fluoxetine; Humans; Imipramine; Randomized Controlled Trials as Topic; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1996 |
Fluoxetine treatment alters leukocyte trafficking in the intrathecal compartment of the young primate.
Topics: Adrenergic Uptake Inhibitors; Adrenocorticotropic Hormone; Albumins; Animals; CD4 Lymphocyte Count; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Desipramine; Fluoxetine; Hydrocortisone; Immunoglobulin G; Leukocytes; Macaca mulatta; Maternal Deprivation; Selective Serotonin Reuptake Inhibitors; Social Environment; Spinal Cord | 1996 |
Besipirdine (HP 749) reduces schedule-induced polydipsia in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biogenic Amines; Blepharoptosis; Conditioning, Operant; Desipramine; Drinking Behavior; Female; Fluoxetine; Hippocampus; In Vitro Techniques; Indoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Sympatholytics; Synaptosomes | 1996 |
Chronic desipramine and fluoxetine differentially affect extracellular dopamine in the rat prefrontal cortex.
Topics: Animals; Desipramine; Dopamine; Fluoxetine; Male; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1996 |
Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons.
Topics: Animals; Cocaine; Desipramine; Dopamine; Fluoxetine; Male; Norepinephrine; Piperazines; Rats; Serotonin; Somatosensory Cortex | 1996 |
Long-term antidepressant treatment restores clonidine's effect on growth hormone secretion in a genetic animal model of depression.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clonidine; Clorgyline; Depressive Disorder; Desipramine; Female; Fluoxetine; Growth Hormone; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains | 1996 |
Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors.
Topics: Animals; Antidepressive Agents; Binding Sites; Carrier Proteins; Cell Count; Cell Survival; Desipramine; Down-Regulation; Fluoxetine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; Symporters; Therapeutic Irrigation | 1997 |
Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex.
Topics: Adrenergic Uptake Inhibitors; Animals; Benzylamines; Citalopram; Desipramine; Fluoxetine; Frontal Lobe; In Vitro Techniques; Injections; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptosomes | 1996 |
The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Fluoxetine; Formaldehyde; Hyperalgesia; Male; Mexiletine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Nerves | 1997 |
H+ permeation and pH regulation at a mammalian serotonin transporter.
Topics: Animals; Carrier Proteins; Desipramine; Female; Fluoxetine; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Meglumine; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Nerve Tissue Proteins; Oocytes; Patch-Clamp Techniques; Protons; Rats; Recombinant Proteins; RNA, Complementary; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium; Time Factors; Transcription, Genetic; Xenopus laevis | 1997 |
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
Topics: Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Desipramine; Drug Interactions; Fluoxetine; Fluvoxamine; Imipramine; Ketanserin; Male; Maprotiline; Mice; Ondansetron; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 1997 |
Gender difference in cocaine-induced HPA axis activation.
Topics: Adrenocorticotropic Hormone; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Uptake Inhibitors; Orchiectomy; Ovariectomy; Piperazines; Pituitary-Adrenal System; Rats; Sex Characteristics; Time Factors | 1997 |
GAP-43 phosphorylation by PKC in rat cerebrocortical synaptosomes: effect of antidepressants.
Topics: Animals; Antidepressive Agents; Blotting, Western; Cerebral Cortex; Desipramine; Electrophoresis, Polyacrylamide Gel; Fluoxetine; GAP-43 Protein; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes | 1997 |
[A study of the effects of antidepressants on the GABAA receptor and its complex based on the drug actions on the power-spectral changes of rat hippocampal EEG induced by GABA antagonists and inverse agonists].
Topics: Animals; Antidepressive Agents; Carbolines; Depression, Chemical; Desipramine; Electroencephalography; Fluoxetine; GABA Antagonists; Hippocampus; Imipramine; Male; Norepinephrine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Trazodone | 1997 |
Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.
Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cyclohexanols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Fluoxetine; Fluvoxamine; Frozen Sections; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Lethal Dose 50; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Venlafaxine Hydrochloride | 1997 |
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy.
Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypotension; Panic Disorder; Piperazines; Substance Withdrawal Syndrome; Triazoles; Venlafaxine Hydrochloride | 1997 |
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
Topics: Acute Disease; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Desipramine; Fluoxetine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Swimming | 1997 |
How do antidepressants work?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Brain; Desipramine; Fluoxetine; Humans; Mianserin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin | 1995 |
Fluoxetine increases norepinephrine release in rat hypothalamus as measured by tissue levels of MHPG-SO4 and microdialysis in conscious rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Desipramine; Dialysis Solutions; Dopamine; Extracellular Space; Fluoxetine; Hydroxyindoleacetic Acid; Hypothalamus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin | 1997 |
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
Topics: Animals; Cocaine; Desipramine; Discrimination Learning; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1998 |
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Desipramine; Drug Interactions; Epilepsy; Female; Fluoxetine; Idazoxan; Methoxamine; Microinjections; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Superior Colliculi; Synaptic Transmission | 1998 |
Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine.
Topics: Adrenergic Uptake Inhibitors; Blotting, Western; Carrier Proteins; Cell Line; Desipramine; Embryo, Mammalian; Fluoxetine; Humans; Kidney; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; RNA, Messenger; Symporters | 1998 |
Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Cyclopropanes; Desipramine; Duloxetine Hydrochloride; Fluoxetine; Male; Milnacipran; Motor Activity; Rats; Rats, Sprague-Dawley; Thiophenes | 1998 |
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Fluoxetine; Liver; Male; Melatonin; Rats; Rats, Wistar; Tryptophan Oxygenase | 1998 |
The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms.
Topics: Aggression; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Apomorphine; Citalopram; Desipramine; Dopamine Agents; Electroshock; Fluoxetine; Levodopa; Male; Pain Measurement; Rats; Rats, Wistar; Tryptophan | 1998 |
Voltammetric studies on mechanisms of dopamine efflux in the presence of substrates and cocaine from cells expressing human norepinephrine transporter.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Carrier Proteins; Cocaine; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Fluoxetine; Humans; Ionophores; Kinetics; LLC-PK1 Cells; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ouabain; Phenethylamines; Psychotropic Drugs; Swine; Symporters; Time Factors; Tyramine; Valinomycin; Veratridine | 1998 |
Effects of rearing condition on HPA axis response to fluoxetine and desipramine treatment over repeated social separations in young rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Anxiety, Separation; Corticotropin-Releasing Hormone; Desipramine; Dexamethasone; Disease Models, Animal; Female; Fluoxetine; Glucocorticoids; Hydrocortisone; Hypothalamo-Hypophyseal System; Macaca mulatta; Male; Maternal Deprivation; Object Attachment; Peer Group; Pituitary-Adrenal System; Social Environment; Social Isolation | 1998 |
Effects of antidepressant treatment on inhibitory avoidance behavior and amygdaloid beta-adrenoceptors in rats.
Topics: Adrenergic beta-Antagonists; Amygdala; Animals; Antidepressive Agents; Avoidance Learning; Desipramine; Fluoxetine; Injections, Intraventricular; Male; Muscarinic Antagonists; Phenelzine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Scopolamine | 1998 |
Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents, Tricyclic; Benzylamines; Citalopram; Desipramine; Fluoxetine; Frontal Lobe; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptosomes | 1998 |
Effect of chronic antidepressant treatment on transcription factor binding activity in rat hippocampus and frontal cortex.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Autoradiography; Desipramine; Electrophoresis, Polyacrylamide Gel; Fluoxetine; Hippocampus; Male; Nuclear Proteins; Prefrontal Cortex; Rats; Rats, Wistar; Transcription Factors | 1998 |
Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Brain Stem; Carrier Proteins; Clomipramine; Cloning, Molecular; Desipramine; DNA, Complementary; Fluoxetine; Guinea Pigs; HeLa Cells; Humans; Imipramine; Intestinal Mucosa; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peristalsis; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transcription, Genetic; Zimeldine | 1998 |
Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioral despair in mice exposed to tail suspension.
Topics: Animals; Anisoles; Antidepressive Agents; Body Weight; Desipramine; Drug Interactions; Fluoxetine; Hindlimb Suspension; Male; Mice; Motor Activity; Narcotics; Nootropic Agents; Pentazocine; Piperazines; Propylamines; Receptors, sigma | 1998 |
Elevation of extracellular cortical noradrenaline may contribute to the antidepressant activity of zotepine: an in vivo microdialysis study in freely moving rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Calcium; Desipramine; Dibenzothiepins; Extracellular Space; Fluoxetine; Frontal Lobe; Kinetics; Male; Microdialysis; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley | 1998 |
Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Autoradiography; Desipramine; Dopamine; Extracellular Space; Fluoxetine; In Situ Hybridization; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors | 1998 |
Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Avoidance Learning; Conditioning, Classical; Cues; Desipramine; Diazepam; Electroshock; Escape Reaction; Fluoxetine; Male; Odorants; Phenelzine; Rats; Sexual Behavior, Animal; Substance Withdrawal Syndrome; Time Factors | 1999 |
Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Cell Culture Techniques; Depression, Postpartum; Desipramine; Disease Models, Animal; Female; Fluoxetine; Humans; Losartan; Male; Mice; Receptors, Angiotensin; Tranylcypromine | 1999 |
Molecular cloning, expression and characterization of a bovine serotonin transporter.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1999 |
Biogenic amine activity in response to fluoxetine and desipramine in differentially reared rhesus monkeys.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animal Husbandry; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety, Separation; Behavior, Animal; Binding, Competitive; Biogenic Amines; Desipramine; Fluoxetine; Homovanillic Acid; Hydroxyindoleacetic Acid; Macaca mulatta; Methoxyhydroxyphenylglycol; Random Allocation; Social Environment; Time Factors | 1999 |
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters; Tumor Cells, Cultured | 1999 |
Nicotinic acetylcholine receptor antagonistic activity of monoamine uptake blockers in rat hippocampal slices.
Topics: Animals; Culture Techniques; Desipramine; Electric Stimulation; Electrophysiology; Fluoxetine; Hippocampus; Male; Neurons; Neurotransmitter Uptake Inhibitors; Nicotinic Antagonists; Nomifensine; Norepinephrine; Rats; Rats, Wistar; Receptors, Nicotinic; Sodium Channels; Superior Cervical Ganglion; Tetrodotoxin | 1999 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Preclinical; Fluoxetine; Male; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Spinal Nerves | 1999 |
Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo.
Topics: 5-Hydroxytryptophan; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Autoreceptors; Brain; Carboxy-Lyases; Cerebral Cortex; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Hippocampus; Male; Norepinephrine; Protriptyline; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Tryptophan; Tyrosine; Zimeldine | 1999 |
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test.
Topics: Animals; Antidepressive Agents; Desipramine; Fenclonine; Fluoxetine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Stress, Physiological; Swimming | 1999 |
Fluoxetine modulates norepinephrine contractile effect on rat vas deferens.
Topics: Animals; Calcium; Cocaine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sodium Chloride; Vas Deferens | 2000 |
Rats selectively bred for responsiveness to 5-hydroxytryptamine(1A) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Age Factors; Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Conditioning, Operant; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Hypothermia; Ketanserin; Male; Rats; Receptors, Serotonin; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2000 |
Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents; Desipramine; Fluoxetine; Male; Motor Activity; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Restraint, Physical; Species Specificity; Stress, Psychological; Swimming | 2000 |
Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents, Tricyclic; Benzylamines; Cerebral Cortex; Desipramine; Fluoxetine; Glycine; Kynurenic Acid; Male; Mice; Norepinephrine; Receptors, N-Methyl-D-Aspartate | 2000 |
Differential effects of beta-carbolines and antidepressants on rat exploratory activity in the elevated zero-maze.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Carbolines; Convulsants; Desipramine; Exploratory Behavior; Fluoxetine; Male; Motor Activity; Rats; Rats, Wistar | 2000 |
Peripheral antinociceptive actions of desimipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Fluoxetine; Inflammation; Pain; Pain Measurement; Peripheral Nerve Injuries; Rats | 2000 |
Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Desipramine; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Fluoxetine; Norepinephrine; Phentermine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Receptor Agonists; Time Factors | 2000 |
cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; beta-Galactosidase; Brain Chemistry; Cocaine; Coloring Agents; Cyclic AMP Response Element-Binding Protein; Desipramine; Dopamine Uptake Inhibitors; Fluoxetine; Haloperidol; Lac Operon; Mice; Mice, Transgenic; Monoamine Oxidase Inhibitors; Phosphorylation; Transcription, Genetic; Tranylcypromine; Up-Regulation | 2000 |
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments.
Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Dopamine; Dynorphins; Electroshock; Fluoxetine; Gene Expression; Imipramine; Islands of Calleja; Limbic System; Male; Monoamine Oxidase Inhibitors; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Substance P; Tranylcypromine | 2000 |
Antidepressant treatment during social challenge prior to 1 year of age affects immune and endocrine responses in adult macaques.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Aging; Animals; Antibody Formation; Antidepressive Agents, Second-Generation; Arousal; Child; Desipramine; Fluoxetine; Humans; Hydrocortisone; Macaca mulatta; Norepinephrine; Social Isolation | 2000 |
TCAs or SSRIs as initial therapy for depression?
Topics: Adult; Antidepressive Agents, Tricyclic; Costs and Cost Analysis; Depression; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Male; Randomized Controlled Trials as Topic; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1999 |
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.
Topics: Animals; Antidepressive Agents; Autoradiography; Brain Chemistry; Carrier Proteins; Citalopram; Cyclohexanols; Desipramine; Fluoxetine; Gene Expression Regulation; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques; Symporters; Trimipramine; Venlafaxine Hydrochloride | 2001 |
Repeated administration of fluoxetine, desipramine and tranylcypromine increases dopamine D2-like but not D1-like receptor function in the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Apomorphine; Behavior, Animal; Benzazepines; Desipramine; Dopamine Agonists; Fluoxetine; Male; Phenethylamines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Tranylcypromine | 1998 |
Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain Chemistry; Desipramine; Fluoxetine; Imipramine; Male; Mesencephalon; Neurosecretory Systems; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, beta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Species Specificity | 2000 |
Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes.
Topics: Animals; Antidepressive Agents; Desipramine; Electroencephalography; Fluoxetine; Fourier Analysis; GABA Antagonists; Hippocampus; Imipramine; Male; Nortriptyline; Pentylenetetrazole; Rats; Rats, Wistar; Trazodone | 2000 |
Chronic fluoxetine administration to juvenile rats prevents age-associated dendritic spine proliferation in hippocampus.
Topics: Adrenergic Uptake Inhibitors; Animals; Cell Count; Dendrites; Desipramine; Fluoxetine; Fluvoxamine; Hippocampus; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2000 |
Chamber-specific alterations of noradrenaline uptake (uptake(1)) in right ventricles of monocrotaline-treated rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Heart Failure; Heart Ventricles; Hypertrophy; In Vitro Techniques; Male; Membranes; Monocrotaline; Norepinephrine; Piperazines; Rats; Rats, Wistar; Tritium | 2000 |
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.
Topics: Animals; Antidepressive Agents; Brain; Cell Division; Cells, Cultured; Cerebellum; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Nervous System; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Thymidine | 2001 |
Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Cyclopropanes; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Idazoxan; Male; Milnacipran; Motor Activity; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 2001 |
Repeated electroconvulsive stimulation, but not antidepressant drugs, induces mossy fibre sprouting in the rat hippocampus.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Coloring Agents; Dentate Gyrus; Desipramine; Drug Administration Schedule; Electroshock; Fluoxetine; Hippocampus; Histocytochemistry; Male; Mossy Fibers, Hippocampal; Rats; Rats, Inbred Strains; Selective Serotonin Reuptake Inhibitors | 2001 |
Specific serotonin reuptake inhibitor-induced decreases in lymphocyte activity require endogenous serotonin release.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Cell Division; Desipramine; Dopamine Uptake Inhibitors; Fenclonine; Fluoxetine; Lymphocyte Activation; Lymphocytes; Male; Mitogens; Neurons; p-Chloroamphetamine; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Sertraline | 2000 |
Desipramine and fluoxetine antagonized 5,7-dihydroxytryptamine-induced lesion on rat hippocampal and cortical neurons.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Antidepressive Agents; Cells, Cultured; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; Neurons; Neuroprotective Agents; Rats; Rats, Wistar | 1999 |
Comparison of noradrenergic and serotonergic antidepressants in reducing immobility time in the tail suspension test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Fluoxetine; Fluvoxamine; Male; Models, Animal; Nortriptyline; Rats; Rats, Inbred Strains; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Tail | 2001 |
Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha.
Topics: Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Fluoxetine; Glioma; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Rats; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Biogenic Monoamines; Biological Clocks; Carrier Proteins; Cocaine; Desipramine; Dizocilpine Maleate; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Globus Pallidus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Periodicity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 2001 |
Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male; Mice; Motor Activity; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2001 |
Development of a depersonalization severity scale.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Depersonalization; Desipramine; Discriminant Analysis; Female; Fluoxetine; Humans; Interview, Psychological; Male; Observer Variation; Psychiatric Status Rating Scales; Psychometrics; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2001 |
Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; Fenclonine; Fluoxetine; Mice; Motor Activity; Mutation; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents | 2001 |
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder.
Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; Clomipramine; Cricetinae; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Grooming; Hair; Hypothalamus; Male; Microinjections; Obsessive-Compulsive Disorder; Pigmentation; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 2001 |
Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology.
Topics: Amino Acid Substitution; Animals; Biological Transport; Chlorocebus aethiops; Cocaine; Codon; COS Cells; Desipramine; Dopamine; Fluoxetine; Humans; Kinetics; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship; Symporters; Transfection; Tyrosine | 2001 |
Lipopolysaccharide-mediated immobility in mice: reversal by cyclooxygenase enzyme inhibitors.
Topics: Animals; Antidepressive Agents, Tricyclic; Cyclooxygenase Inhibitors; Desipramine; Enterotoxins; Female; Fluoxetine; Lactones; Lipopolysaccharides; Male; Mice; Motor Activity; Naproxen; Reserpine; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Swimming | 2001 |
Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter.
Topics: Adrenergic Uptake Inhibitors; Amino Acid Substitution; Animals; Binding Sites; Cocaine; COS Cells; Desipramine; Dopamine Uptake Inhibitors; Fluoxetine; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Symporters; Transfection | 2002 |
cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Crosses, Genetic; Cyclic AMP Response Element-Binding Protein; Desipramine; Endocrine System; Exercise Test; Fluoxetine; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Motor Activity; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Transcription, Genetic; Up-Regulation | 2002 |
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model.
Topics: Animals; Antidepressive Agents; Competitive Behavior; Desipramine; Diazepam; Dioxoles; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Maze Learning; Models, Animal; Nootropic Agents; Piperidines; Piracetam; Pyrrolidinones; Rats; Rats, Sprague-Dawley | 2002 |
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Appetitive Behavior; Behavior, Animal; Buspirone; Chlordiazepoxide; Clozapine; Cricetinae; Desipramine; Drug Evaluation, Preclinical; Fasting; Fluoxetine; Injections, Intraperitoneal; Male; Mesocricetus; Models, Animal; Stress, Psychological; Yohimbine | 2002 |
Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Death; Cyclic AMP; Desipramine; DNA-Binding Proteins; Early Growth Response Protein 1; Fluoxetine; I-kappa B Proteins; Immediate-Early Proteins; Lysophospholipids; Mitochondria; Mitogen-Activated Protein Kinases; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; PC12 Cells; Phosphorylation; Rats; Sphingosine; Transcription Factors | 2002 |
Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cocaine; Desipramine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electric Stimulation; Electrochemistry; Extracellular Space; Fluoxetine; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters | 2002 |
Antidepressant reversal of interferon-alpha-induced anhedonia.
Topics: Animals; Antidepressive Agents; Antiviral Agents; Depression; Desipramine; Drinking Behavior; Drug Administration Schedule; Fluoxetine; Humans; Interferon Type I; Male; Rats; Recombinant Proteins; Time | 2002 |
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cell Line; Cocaine; Conserved Sequence; COS Cells; Desipramine; Dopamine Agents; Female; Fluoxetine; Gene Expression; Glutamic Acid; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ovary; Sequence Homology, Amino Acid; Sodium; Structure-Activity Relationship; Symporters; Transfection | 2002 |
Enhanced antidepressant effect of sigma(1) (sigma(1)) receptor agonists in beta(25-35)-amyloid peptide-treated mice.
Topics: Amyloid beta-Peptides; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Avoidance Learning; Cinnamates; Cyclopropanes; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Male; Memory; Mice; Morpholines; Peptide Fragments; Progesterone; Receptors, sigma; Sigma-1 Receptor; Stress, Psychological; Swimming | 2002 |
In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Clonidine; Cyclopropanes; Depression; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Male; Mianserin; Milnacipran; Mirtazapine; Motor Activity; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Swimming | 2002 |
The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Binding Sites; Cell Line; Cocaine; Conserved Sequence; Desipramine; Enzyme Inhibitors; Fluoxetine; Glycine; Humans; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Sequence Alignment; Symporters; Vasoconstrictor Agents | 2002 |
Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Fluoxetine; Male; Microdialysis; Norepinephrine; Paroxetine; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Venlafaxine Hydrochloride | 2002 |
Acute treatment with the cyclic antidepressant desipramine, but not fluoxetine, increases membrane-associated G protein-coupled receptor kinases 2/3 in rat brain.
Topics: Animals; Antidepressive Agents, Tricyclic; beta-Adrenergic Receptor Kinases; Brain; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Desipramine; Fluoxetine; G-Protein-Coupled Receptor Kinase 3; Gene Expression Regulation, Enzymologic; Male; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley | 2002 |
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine.
Topics: 1-Methyl-4-phenylpyridinium; Carrier Proteins; Cell Line, Tumor; Choriocarcinoma; Desipramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Placenta; Quinolinium Compounds; Serotonin; Serotonin Plasma Membrane Transport Proteins; Uterine Neoplasms | 2003 |
Analysis of the effect of (-)-BPAP, a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Benzofurans; Brain Chemistry; Brain Stem; Catecholamines; Clorgyline; Desipramine; Dopamine; Fluoxetine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptic Transmission | 2003 |
Effects of 5-HT(6) receptor blockade on the neurochemical outcome of antidepressant treatment in the frontal cortex of the rat.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Desipramine; Drug Synergism; Extracellular Space; Fluoxetine; Glutamic Acid; Male; Microdialysis; Neurons; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Sulfonamides; Synaptic Transmission; Thiophenes; Venlafaxine Hydrochloride | 2003 |
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Blood Glucose; Body Weight; Desipramine; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Hindlimb Suspension; Male; Mice; Mice, Inbred ICR; Motor Activity; Selective Serotonin Reuptake Inhibitors | 2003 |
A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.
Topics: Animals; Cells, Cultured; Desipramine; Fluoxetine; Heart; Heart Ventricles; Humans; Iodine Radioisotopes; Isotope Labeling; Male; Metabolic Clearance Rate; Myocardium; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Symporters; Tissue Distribution | 2003 |
Cytoprotective effect is one of common action pathways for antidepressants.
Topics: Animals; Anticonvulsants; Calcium; Cell Survival; Corticosterone; Desipramine; Fluoxetine; Moclobemide; Nerve Growth Factor; Neuroprotective Agents; PC12 Cells; Rats; RNA, Messenger | 2003 |
Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.
Topics: Adrenergic Uptake Inhibitors; Amines; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P450 Family 2; Desipramine; Diffusion; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Heme; Hydroxylation; Inhibitory Concentration 50; Kinetics; Liver; Male; Microsomes, Liver; Models, Chemical; NADP; Nortriptyline; Oxygen; Protein Binding; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Steroid 16-alpha-Hydroxylase; Steroids; Time Factors | 2003 |
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Amygdala; Animals; Antidepressive Agents, Tricyclic; Binding, Competitive; Desipramine; Electrochemistry; Excitatory Amino Acid Antagonists; Fluoxetine; Humans; Imipramine; In Vitro Techniques; Locus Coeruleus; Male; Microelectrodes; Norepinephrine Plasma Membrane Transport Proteins; Pyridines; Radioligand Assay; Rats; Receptors, Kainic Acid; Symporters; Time Factors | 2003 |
Regulation of the norepinephrine transporter by chronic administration of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; In Situ Hybridization; Locus Coeruleus; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Symporters | 2004 |
Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Motor Activity; NAD; Niacinamide; Rats; Rats, Wistar; Swimming | 2004 |
Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Male; Motor Activity; Oligopeptides; Rats; Selection, Genetic; Species Specificity | 2004 |
The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.
Topics: Adrenergic Uptake Inhibitors; Cell Line; Cell Membrane; Desipramine; Fluoxetine; Humans; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Time Factors | 2004 |
Enzymatic tissue digestion as an alternative sample preparation approach for quantitative analysis using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Antidepressive Agents; Brain; Chromatography, Liquid; Collagenases; Desipramine; Dogs; Dose-Response Relationship, Drug; Endopeptidase K; Esterases; Feasibility Studies; Female; Fluoxetine; Haloperidol; In Vitro Techniques; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzazepines; Brain; Caffeine; Central Nervous System Stimulants; Cocaine; Desipramine; Dopamine Antagonists; Dronabinol; Enzyme Activation; Fluoxetine; Immunohistochemistry; Male; Mice; Mitogen-Activated Protein Kinases; Morphine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Scopolamine; Selective Serotonin Reuptake Inhibitors | 2004 |
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Dopamine beta-Hydroxylase; Droxidopa; Fluoxetine; Gene Deletion; Mice; Morpholines; Norepinephrine; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Tail | 2004 |
Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans.
Topics: Adult; Cytochrome P-450 CYP2D6; Depression; Desipramine; Double-Blind Method; Fluoxetine; Humans; Hypotension, Orthostatic; Mexican Americans; Middle Aged; Polymorphism, Genetic; Prospective Studies; Tachycardia; Vision Disorders | 2004 |
Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Animals; Autoradiography; Brain; Cinanserin; Desipramine; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Clearance Rate; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; p-Chloroamphetamine; Radionuclide Imaging; Radiopharmaceuticals; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tissue Distribution | 2004 |
Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Clomipramine; Desipramine; Female; Fluoxetine; Male; Motor Activity; Norepinephrine; Orchiectomy; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Swimming; Testosterone | 2004 |
Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Desipramine; Fluoxetine; Hydrocarbons, Halogenated; Injections, Intraperitoneal; Rats; Receptors, Corticotropin-Releasing Hormone; Serotonin Antagonists; Social Behavior; Swimming; Thiazines | 2004 |
GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent.
Topics: Animals; Antidepressive Agents; Benzoates; Cyclopentanes; Desipramine; Drug Combinations; Drug Interactions; Fenclonine; Fluoxetine; GABA Antagonists; GABA-B Receptor Antagonists; Male; Motor Activity; Phosphinic Acids; Propanolamines; Pyrimidines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Swimming | 2005 |
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice.
Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hindlimb Suspension; Male; Mice; Morpholines; Motor Activity; Paroxetine; Pyrazoles; Pyrimidines; Pyrroles; Reboxetine; Receptors, Corticotropin-Releasing Hormone; Selegiline; Swimming; Tranylcypromine; Triazines | 2004 |
Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior.
Topics: Animals; Autoradiography; Brain; Depression; Desipramine; DNA Mutational Analysis; Female; Fluoxetine; Galanin; Gene Expression; Genotype; Helplessness, Learned; Injections, Intraventricular; Male; Mice; Mice, Knockout; Mice, Transgenic; Motor Activity; Phenotype; Receptor, Galanin, Type 1; Selective Serotonin Reuptake Inhibitors | 2005 |
Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cyclic AMP Response Element-Binding Protein; Desipramine; Fluoxetine; Hippocampus; In Situ Hybridization; Isoenzymes; Male; Mice; Mice, Transgenic; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; RNA Probes; RNA, Antisense; RNA, Messenger | 2004 |
Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Desipramine; Diazepam; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Drug Interactions; Ethanol; Fluoxetine; Male; Maze Learning; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors | 2005 |
Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens.
Topics: Animals; Biological Assay; Cocaine; Desipramine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extracellular Fluid; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Organ Culture Techniques; Serotonin Plasma Membrane Transport Proteins; Symporters | 2004 |
Effects of chronic stress on methamphetamine-induced dopamine depletions in the striatum.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Male; Methamphetamine; Neostriatum; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stress, Psychological | 2004 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Conditioning, Psychological; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Radiation; Echo-Planar Imaging; Electromagnetic Fields; Fear; Fluoxetine; Freezing Reaction, Cataleptic; Male; Motor Activity; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Swimming; Time Factors | 2005 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Models, Animal; Fluoxetine; Indoles; Male; Maze Learning; Obsessive-Compulsive Disorder; Piperazines; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Tryptamines | 2005 |
Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antiviral Agents; Cell Cycle; Depressive Disorder, Major; Desipramine; Down-Regulation; Fluoxetine; Gene Expression; Hepatoblastoma; Humans; Interferon-alpha; Jurkat Cells; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Receptor, Serotonin, 5-HT1A; Receptors, Glucocorticoid; Taurochenodeoxycholic Acid | 2005 |
Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models.
Topics: Activins; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Blotting, Western; Brain; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Fluoxetine; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Inhibin-beta Subunits; Inhibins; Male; Motor Activity; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smad2 Protein; Time Factors | 2005 |
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Cyclic AMP Response Element-Binding Protein; Desipramine; Disease Models, Animal; Down-Regulation; Fluoxetine; Hippocampus; Laminin; Male; Neural Cell Adhesion Molecule L1; Neuronal Plasticity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Up-Regulation | 2005 |
Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Antidepressive Agents; Brain Mapping; Desipramine; Fluoxetine; Gene Expression; Hippocampus; Injections, Intraperitoneal; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Syntaxin 1; Transcription, Genetic; Tranylcypromine | 2005 |
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Electroshock; Fluoxetine; Male; Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Glutamate Transport Proteins | 2005 |
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin | 2005 |
The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system.
Topics: Alkaline Phosphatase; Animals; Antidepressive Agents, Tricyclic; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; GPI-Linked Proteins; Isoenzymes; Phosphorylation; Transcription, Genetic | 2005 |
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Bupropion; Cerebral Cortex; Desipramine; Drug Tolerance; Fluoxetine; Hippocampus; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Swimming; Time Factors | 2005 |
Antidepressants and REM sleep in Wistar-Kyoto and Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Antidepressive Agents; Body Temperature; Circadian Rhythm; Citalopram; Cross-Over Studies; Desipramine; Electroencephalography; Electromyography; Fluoxetine; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Sleep, REM; Species Specificity | 2005 |
Evidence that serotonin reuptake modulators increase the density of serotonin innervation in the forebrain.
Topics: Adrenergic Uptake Inhibitors; Animals; Axons; Biotin; Desipramine; Dextrans; Fluorescent Dyes; Fluoxetine; Limbic System; Male; Neocortex; Nerve Endings; Nerve Fibers; Prosencephalon; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiazepines | 2006 |
G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Cell Death; Desipramine; Fluoxetine; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; Movement Disorders; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Xenopus | 2006 |
Inhibition of N-methyl-D-aspartate receptor function appears to be one of the common actions for antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Calcium; Calcium Signaling; Cell Survival; Desipramine; Excitatory Amino Acid Antagonists; Fluoxetine; Hippocampus; L-Lactate Dehydrogenase; Moclobemide; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Nitric Oxide Synthase Type I; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tetrazolium Salts; Thiazoles | 2006 |
Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Desipramine; Drug Implants; Exons; Fluoxetine; Gene Expression; Male; Phenelzine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2006 |
Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease.
Topics: Action Potentials; Animals; Behavior, Animal; Corpus Striatum; Desipramine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Female; Fluoxetine; Immunohistochemistry; In Vitro Techniques; Male; Nomifensine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Subthalamic Nucleus; Tyrosine 3-Monooxygenase | 2006 |
Hippocampal cell proliferation regulation by repeated stress and antidepressants.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Proliferation; Corticosterone; Desipramine; Electroshock; Fluoxetine; Helplessness, Learned; Hippocampus; Immunohistochemistry; Male; Neurons; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2006 |
Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents; Conditioning, Psychological; Desipramine; Dose-Response Relationship, Drug; Fear; Fluoxetine; Male; Memory; Rats; Rats, Wistar; Reflex, Startle | 2006 |
Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Depressive Disorder; Desipramine; Drug Administration Schedule; Electroshock; Exons; Fluoxetine; Gene Expression Regulation; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Regulatory Elements, Transcriptional; RNA, Messenger; Transcriptional Activation; Tranylcypromine; Up-Regulation | 2006 |
Pharmacological and genetic influences on hole-board behaviors in mice.
Topics: Animals; Desipramine; Diazepam; Exploratory Behavior; Female; Fluoxetine; Male; Methamphetamine; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piperazines; Selective Serotonin Reuptake Inhibitors | 2006 |
The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine.
Topics: Animals; Antidepressive Agents, Second-Generation; Desipramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Ion Channel Gating; Pregnancy; Rats; Sodium Channel Blockers; Sodium Channels | 2006 |
The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Benzylamines; Cerebral Cortex; Citalopram; Desipramine; Dopamine beta-Hydroxylase; Fluoxetine; Hindlimb Suspension; Immunohistochemistry; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Norepinephrine; Oxidopamine; Presynaptic Terminals; Raphe Nuclei; Selective Serotonin Reuptake Inhibitors | 2007 |
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Carrageenan; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine Hydrochloride; Edema; Fluoxetine; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Paroxetine; Pressure; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Thiophenes; Venlafaxine Hydrochloride | 2006 |
Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze.
Topics: Analysis of Variance; Animals; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Male; Maze Learning; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2007 |
Antidepressant-induced undesirable weight gain: prevention with rimonabant without interference with behavioral effectiveness.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Desipramine; Female; Fluoxetine; Maze Learning; Mice; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Swimming; Time Factors; Weight Gain | 2007 |
Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Calcineurin; Depressive Disorder; Desipramine; Female; Fluoxetine; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphorylation; Receptors, AMPA; Selective Serotonin Reuptake Inhibitors; Up-Regulation | 2007 |
Extinction-induced "despair" in the water maze, exploratory behavior and fear: effects of chronic antidepressant treatment.
Topics: Affect; Animals; Antidepressive Agents; Conditioning, Classical; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Administration Schedule; Escape Reaction; Exploratory Behavior; Extinction, Psychological; Fear; Fluoxetine; Immobility Response, Tonic; Male; Maze Learning; Rats; Rats, Wistar; Statistics, Nonparametric | 2007 |
Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Fluoxetine; Humans; Mexican Americans; Selective Serotonin Reuptake Inhibitors; Suicide | 2007 |
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Brain; Citalopram; Desipramine; Dopamine; Fenclonine; Fluoxetine; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Morpholines; Norepinephrine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin | 2007 |
The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system.
Topics: Alkaline Phosphatase; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; CHO Cells; Clomipramine; Cricetinae; Cricetulus; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Genes, Reporter; Humans; Receptors, Adrenergic, beta-2; Thiazepines; Time Factors; Transcription, Genetic | 2007 |
Anti-inflammatory properties of desipramine and fluoxetine.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Asthma; Cells, Cultured; Cytokines; Desipramine; Disease Models, Animal; Fluoxetine; Humans; Inflammation; Mice; Mice, Inbred BALB C; Monocytes; Prednisolone; Rats; Respiratory Mucosa; Shock, Septic; Treatment Outcome | 2007 |
Attenuation of estrous cycle-dependent marble burying in female rats by acute treatment with progesterone and antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Desipramine; Estrous Cycle; Female; Fluoxetine; Motor Activity; Ovariectomy; Premenstrual Syndrome; Progesterone; Rats; Rats, Wistar | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine | 2007 |
Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system.
Topics: Algorithms; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Cells, Cultured; Central Nervous System; Cerebral Cortex; Desipramine; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Fluoxetine; Magnesium; Neurons; Patch-Clamp Techniques; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Chromatography, Supercritical Fluid; Clorgyline; Cordyceps; Desipramine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Fluoxetine; Head Movements; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Prazosin; Serotonin Antagonists; Sulpiride; Water | 2007 |
A novel approach for predicting antidepressant-induced sexual dysfunction in rats.
Topics: Animals; Antidepressive Agents; Bupropion; Desipramine; Disease Models, Animal; Dopamine Agonists; Fluoxetine; Long-Term Care; Male; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilator Agents; Yohimbine | 2008 |
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Disease Models, Animal; Dopamine Agonists; Drug Evaluation, Preclinical; Female; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Peromyscus; Piperazines; Quinpirole; Receptors, Dopamine D2; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Species Specificity; Stereotyped Behavior | 2008 |
Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats.
Topics: Androstenedione; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aromatase Inhibitors; Brain Chemistry; Desipramine; Estradiol; Estrogens; Female; Fluoxetine; Male; Motor Activity; Orchiectomy; Ovariectomy; Rats; Swimming; Testosterone | 2008 |
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Topics: Adolescent; Age Factors; Animals; Antidepressive Agents; Child; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Escape Reaction; Fluoxetine; Helplessness, Learned; Humans; Imipramine; Injections, Intraperitoneal; Male; Motivation; Rats; Rats, Sprague-Dawley; Swimming; Tranylcypromine | 2008 |
Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Behavior, Animal; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Exploratory Behavior; Fluoxetine; Hindlimb Suspension; Male; Maze Learning; Mice; Motor Activity; Olfactory Bulb; Ondansetron; Paroxetine; Rats; Rats, Wistar; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Stress, Psychological; Venlafaxine Hydrochloride | 2008 |
Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Fluoxetine; Grooming; Hindlimb Suspension; Hyperkinesis; Male; Mice; Motor Activity; Naphthyridines; Nitriles; Olfactory Bulb; Rats; Rats, Wistar; Swimming | 2007 |
The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine Vasopressin; Corticosterone; Corticotropin-Releasing Hormone; Desipramine; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Knockout; Oxytocin; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Receptors, Vasopressin; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Sex Factors | 2008 |
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.
Topics: Animals; Binding, Competitive; Desipramine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Heart; Iodine Radioisotopes; Isotope Labeling; Metabolic Clearance Rate; Morpholines; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Rats; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Tissue Distribution | 2008 |
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competitive; Brain; Depressive Disorder; Desipramine; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Fluoxetine; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stress, Psychological; Synaptic Transmission; Time | 2008 |
Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction.
Topics: Adsorption; Antidepressive Agents; Desipramine; Fluoxetine; Formic Acid Esters; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Time Factors | 2008 |
Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Brain-Derived Neurotrophic Factor; Central Nervous System; Chlordiazepoxide; Desipramine; Electroshock; Fluoxetine; Male; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain Chemistry; Corticosterone; Depressive Disorder; Desipramine; Exploratory Behavior; Fluoxetine; Genes, fos; Image Processing, Computer-Assisted; In Situ Hybridization; Individuality; Male; Motor Activity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swimming | 2008 |
Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
Topics: Animals; Antidepressive Agents; Desipramine; Drug Administration Schedule; Electroconvulsive Therapy; Extracellular Matrix; Fluoxetine; Hippocampus; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinases; Tranylcypromine | 2008 |
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Chronic Disease; Depression; Desipramine; Fluoxetine; Grooming; Imipramine; Injections, Intraperitoneal; Male; Maprotiline; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Selective Serotonin Reuptake Inhibitors; Species Specificity; Stress, Psychological; Time Factors | 2008 |
Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Desipramine; Fluoxetine; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Neuroblastoma; Reboxetine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2008 |
Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Drug Administration Schedule; Escape Reaction; Fluoxetine; Helplessness, Learned; Male; Rats; Rats, Sprague-Dawley; Stress, Psychological; Time Factors | 2008 |
Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Swimming | 2008 |
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.
Topics: Animals; Antidepressive Agents; Chromosome Deletion; Depressive Disorder; Desipramine; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; GABA Plasma Membrane Transport Proteins; Helplessness, Learned; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Phenotype; Piperazines; Sucrose; Swimming; Taste | 2008 |
Evaluation of the repeated open-space swim model of depression in the mouse.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Cell Proliferation; Chronic Disease; Depression; Desipramine; Diazepam; Disease Models, Animal; Fluoxetine; Food Preferences; Haloperidol; Hindlimb Suspension; Hypnotics and Sedatives; Male; Mice; Motor Activity; Neurons; Swimming | 2008 |
Do desipramine [10,11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride] and fluoxetine [N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine] ameliorate the extent of colonic damage induced by acetic acid in rats?
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Glutathione; Interleukin-1beta; Male; Peroxidase; Rats; Tumor Necrosis Factor-alpha | 2008 |
Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Cyclohexanols; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Estrogens; Female; Fluoxetine; Injections, Subcutaneous; Motor Activity; Ovariectomy; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Swimming; Venlafaxine Hydrochloride | 2008 |
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Proliferation; Desipramine; Eating; Exploratory Behavior; Flow Cytometry; Fluoxetine; Mice; Mice, Inbred Strains; Neurogenesis; Neuronal Plasticity; Neurons; Reaction Time | 2009 |
Inhibitory effect of antidepressants on the NMDA-evoked [(3)H]noradrenaline release from rat hippocampal slices.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Desipramine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluoxetine; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Neurons; Norepinephrine; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Sodium Channel Blockers; Tritium | 2009 |
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger | 2009 |
MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Uptake Inhibitors; Adult Stem Cells; Animals; Apoptosis; Cerebral Ventricles; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Fluoxetine; Gene Expression Regulation; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurotoxins; Neurotransmitter Transport Proteins; Piperazines; Selective Serotonin Reuptake Inhibitors; Tetrabenazine | 2009 |
Nerve growth factor (NGF) has novel antidepressant-like properties in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Corticosterone; Desipramine; Disease Models, Animal; Drug Interactions; Fluoxetine; Hypothermia; Motor Activity; Nerve Growth Factor; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Agents; Social Behavior; Swimming | 2010 |
Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels.
Topics: Absorptiometry, Photon; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antimanic Agents; Bone Density; Bone Remodeling; Compressive Strength; Desipramine; Enzyme-Linked Immunosorbent Assay; Female; Femur; Fluoxetine; Hindlimb Suspension; Lithium Chloride; Mice; Motor Activity; Random Allocation; Serotonin; Spine | 2010 |
Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models.
Topics: 5,7-Dihydroxytryptamine; Adaptation, Physiological; Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Anxiety; Benzylamines; Chromatography, High Pressure Liquid; Desipramine; Disease Models, Animal; Exploratory Behavior; Fluoxetine; Injections, Intraventricular; Male; Maze Learning; Motor Activity; Norepinephrine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Spatial Behavior | 2010 |
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase | 2010 |
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.
Topics: Animals; Anticholesteremic Agents; Antidepressive Agents; beta-Cyclodextrins; Biophysics; Cholesterol; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fluoxetine; Humans; Imidazoles; Membrane Microdomains; Membrane Potentials; Mice; Neuroblastoma; Patch-Clamp Techniques; Receptors, Serotonin, 5-HT3; Serotonin; Simvastatin; Sulfhydryl Compounds; Time Factors; Transfection | 2010 |
HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Amphetamines; Animals; Behavior, Animal; Desipramine; Dopamine Agonists; Dopamine Antagonists; Fluoxetine; Haloperidol; Hippocampus; Humans; Hypothalamus; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Piperazines; Quinpirole; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Social Behavior; Syntaxin 1 | 2010 |
gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depressive Disorder; Desipramine; Disease Models, Animal; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Mice; Mice, Knockout; Pituitary-Adrenal System; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2010 |
Long-lasting cognitive deficit induced by stress is alleviated by acute administration of antidepressants.
Topics: Animals; Antidepressive Agents; Attention; Behavior, Animal; Citalopram; Cognition Disorders; Desipramine; Drug Administration Schedule; Fluoxetine; Male; Nomifensine; Rats; Rats, Sprague-Dawley; Stress, Psychological; Time Factors | 2011 |
Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Clomipramine; Depression; Desipramine; Disease Models, Animal; Fluoxetine; Genetics, Behavioral; Phenotype; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 2010 |
Intermittent and continuous swim stress-induced behavioral depression: sensitivity to norepinephrine- and serotonin-selective antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Disease Models, Animal; Fluoxetine; Immobilization; Male; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Time Factors | 2010 |
Behavioural effects of antidepressants are dependent and independent on the integrity of the dentate gyrus.
Topics: Animals; Antidepressive Agents; Colchicine; Dentate Gyrus; Desipramine; Drug Administration Schedule; Excitatory Postsynaptic Potentials; Feeding Behavior; Fluoxetine; Immobility Response, Tonic; Male; Maze Learning; Microinjections; Rats; Rats, Sprague-Dawley | 2011 |
The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria.
Topics: Animals; Antidepressive Agents; CHO Cells; Clomipramine; Cricetinae; Cricetulus; Desipramine; Electron Transport Chain Complex Proteins; Fluoxetine; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Oxygen Consumption; Rats; Rats, Wistar; Thiazepines | 2011 |
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride | 2010 |
Predictive validity of a non-induced mouse model of compulsive-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Clomipramine; Compulsive Behavior; Desipramine; Disease Models, Animal; Exploratory Behavior; Fluoxetine; Male; Maze Learning; Mice; Mice, Inbred Strains; Motor Activity; Nesting Behavior | 2011 |
Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats.
Topics: Alcoholism; Analysis of Variance; Animals; Antidepressive Agents; Central Nervous System Depressants; Conditioning, Operant; Cyclopropanes; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Extinction, Psychological; Female; Fluoxetine; Locomotion; Male; Mice; Mice, Inbred DBA; Milnacipran; Rats; Rats, Wistar; Self Administration | 2011 |
Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes.
Topics: Animals; Antigen Presentation; B7-2 Antigen; Cell Proliferation; Coculture Techniques; Cytokines; Dendritic Cells; Desipramine; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Selective Serotonin Reuptake Inhibitors; Serotonin; T-Lymphocytes | 2011 |
Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants.
Topics: Age Factors; Animals; Antidepressive Agents; Body Weight; Desipramine; Estradiol; Estrus; Female; Fluoxetine; Organ Size; Ovariectomy; Rats; Rats, Wistar; Swimming | 2011 |
Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice.
Topics: Animals; Antidepressive Agents; Cell Line, Tumor; Cytokines; Cytotoxicity Tests, Immunologic; Desipramine; Disease Progression; Female; Fluoxetine; Immunity, Cellular; Killer Cells, Natural; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Motor Activity; Spleen | 2011 |
Thiamine is a substrate of organic cation transporters in Caco-2 cells.
Topics: Amiloride; Amprolium; Biological Transport; Caco-2 Cells; Desipramine; Enzyme Inhibitors; Fluoxetine; Humans; Hydrogen-Ion Concentration; Organic Cation Transport Proteins; Oxythiamine; Phosphoric Monoester Hydrolases; Protein Binding; Serotonin; Sodium Chloride; Thiamine | 2012 |
Adrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries.
Topics: Adrenergic Agents; Adrenergic Neurons; Adrenergic Uptake Inhibitors; Animals; Calcitonin Gene-Related Peptide; Desipramine; Fluoxetine; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation | 2012 |
Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Brain; Carbazoles; Desipramine; Enzyme Inhibitors; Fluoxetine; Hippocampus; Indole Alkaloids; Male; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Selective Serotonin Reuptake Inhibitors; Time Factors; Tyrosine; Vagus Nerve; Vagus Nerve Stimulation | 2012 |
Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Dermatitis, Contact; Desipramine; Fluoxetine; Interleukin-10; Lymph Nodes; Mice; Mice, Inbred CBA; Organ Size; Picryl Chloride; Spleen; T-Lymphocytes | 2012 |
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons.
Topics: Affect; Animals; Antidepressive Agents; Body Temperature Regulation; Circadian Rhythm; Cognition; Corticosterone; Depression; Desipramine; Fluoxetine; Learning; Light; Long-Term Potentiation; Male; Memory; Mice; Photoperiod; Retinal Ganglion Cells; Rod Opsins; Sleep; Wakefulness | 2012 |
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Inflammation; Male; Mice; Motor Activity; Phenotype | 2013 |
Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons.
Topics: Animals; Antidepressive Agents; Cell Death; Cell Nucleus; Cell Survival; Desipramine; Dopaminergic Neurons; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fluoxetine; Heme Oxygenase-1; MAP Kinase Kinase 4; Mice; Neurodegenerative Diseases; Neurons; NF-E2-Related Factor 2; Oxidopamine; Rats; Rhodamines; RNA, Small Interfering; Signal Transduction; Transfection; Trypan Blue | 2012 |
Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex.
Topics: Animals; Antidepressive Agents; Astrocytes; Blotting, Western; Corpus Striatum; Desipramine; Fluorescent Antibody Technique; Fluoxetine; Hippocampus; Male; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Prefrontal Cortex | 2013 |
Effects of chronic social defeat on expression of dopamine β-hydroxylase in rat brains.
Topics: Adrenalectomy; Animals; Antidepressive Agents; Brain; Desipramine; Dopamine beta-Hydroxylase; Fluoxetine; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred F344; Rats, Long-Evans; RNA, Messenger; Social Behavior; Spironolactone; Stress, Psychological; Transcription, Genetic; Up-Regulation | 2013 |
A proposal for refining the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramine; Disease Models, Animal; Fluoxetine; Imipramine; Immobility Response, Tonic; Male; Mice; Principal Component Analysis; Swimming; Time Factors | 2013 |
Effects of chronic antidepressant treatments in a putative genetic model of vulnerability (Roman low-avoidance rats) and resistance (Roman high-avoidance rats) to stress-induced depression.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Clomipramine; Data Interpretation, Statistical; Depression; Desipramine; Fluoxetine; Male; Motor Activity; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity; Stress, Psychological; Swimming | 2014 |
Inhibitory effect of antidepressants on B16F10 melanoma tumor growth.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Desipramine; Fluoxetine; Interleukin-10; Male; Melanoma, Experimental; Mianserin; Mice; Mice, Inbred C57BL; Mirtazapine; T-Lymphocytes; Tumor Cells, Cultured | 2013 |
Antidepressants share the ability to increase catecholamine output in the bed nucleus of stria terminalis: a possible role in antidepressant therapy?
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Citalopram; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Male; Morpholines; Norepinephrine; Rats, Sprague-Dawley; Reboxetine; Septal Nuclei; Time Factors | 2014 |
Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Dermatitis, Contact; Desipramine; Dinitrofluorobenzene; Disease Models, Animal; Fluoxetine; Immunity, Cellular; Interferon-gamma; Interleukin-10; Interleukin-6; Lymph Nodes; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Spleen; T-Lymphocytes, Cytotoxic; Thymus Gland | 2013 |
Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Desipramine; Electric Stimulation; Fluoxetine; Hypothalamus; Male; Rats; Rats, Wistar; Reward; Self Stimulation; Signal Transduction; Social Behavior; Stress, Psychological; Swimming; Ventral Tegmental Area | 2014 |
Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons.
Topics: Adrenergic Uptake Inhibitors; Animals; Bicuculline; Blotting, Western; Carrier Proteins; Cells, Cultured; Desipramine; Drug Synergism; Dynamins; Endocytosis; Excitatory Postsynaptic Potentials; Fluoxetine; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; rab5 GTP-Binding Proteins; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; Receptors, AMPA; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Synaptic Transmission | 2014 |
Astrocytic TNFα regulates the behavioral response to antidepressants.
Topics: Animals; Antidepressive Agents; Astrocytes; Behavior, Animal; Desipramine; Fluoxetine; Hindlimb Suspension; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Swimming; Tumor Necrosis Factor-alpha | 2015 |
Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Depressive Disorder, Treatment-Resistant; Desipramine; Fluoxetine; Hippocampus; Hypothalamus; Mice; Mice, Knockout; Prefrontal Cortex; Receptors, Leptin; Selective Serotonin Reuptake Inhibitors; Signal Transduction | 2014 |
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Desipramine; Female; Fluoxetine; Humans; Male; Mexican Americans; Polymorphism, Single Nucleotide | 2015 |
Response to Uher et al.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Desipramine; Female; Fluoxetine; Humans; Male; Mexican Americans; Polymorphism, Single Nucleotide | 2015 |
Sex differences in motivational responses to dietary fat in Syrian hamsters.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Calorimetry; Cohort Studies; Cricetinae; Cyclic AMP Response Element-Binding Protein; Desipramine; Dietary Fats; Disease Models, Animal; Exploratory Behavior; Female; Fluoxetine; Gene Expression Regulation; Male; Mesocricetus; Motivation; Reward; RNA, Messenger; Sex Characteristics; Social Behavior; Social Isolation | 2015 |
Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior.
Topics: Animals; Antidepressive Agents; Benzazepines; Bupropion; Choice Behavior; Desipramine; Dopamine Antagonists; Dose-Response Relationship, Drug; Fluoxetine; Haloperidol; Male; Motivation; Neurotransmitter Uptake Inhibitors; Piperazines; Rats, Sprague-Dawley; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2016 |
Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.
Topics: Aging; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Male; Motor Activity; Random Allocation; Rats, Wistar; Rotarod Performance Test; Swimming | 2016 |
Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction is connected with their suppressive effect on NKT and CD8(+) T cells but not on TCR delta T cells.
Topics: Animals; Antidepressive Agents; Antigens, CD1d; beta 2-Microglobulin; CD8-Positive T-Lymphocytes; Dermatitis, Contact; Desipramine; Fluoxetine; Immunosuppression Therapy; Mice; Mice, Inbred Strains; Mice, Knockout; Natural Killer T-Cells; Picryl Chloride; Receptors, Antigen, T-Cell, gamma-delta | 2015 |
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation.
Topics: Animals; Corpus Striatum; Desipramine; Exploratory Behavior; Female; Fluoxetine; Indoles; Mice; Mice, Inbred C57BL; Obsessive-Compulsive Disorder; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Receptor Agonists; Stereotyped Behavior; Treatment Outcome | 2016 |
Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Apoptosis; Autoreceptors; Blotting, Western; Brain; CASP8 and FADD-Like Apoptosis Regulating Protein; Cerebral Cortex; Clorgyline; Desipramine; Electroshock; Excitatory Amino Acid Antagonists; Fas-Associated Death Domain Protein; Fluoxetine; Idazoxan; Indans; Ketamine; Male; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Phenelzine; Phosphoproteins; Phosphorylation; Rats; RNA-Binding Proteins; Thiazoles | 2016 |
Effect of desipramine and fluoxetine on energy metabolism of cerebral mitochondria.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Energy Metabolism; Fluoxetine; Frontal Lobe; Male; Mitochondria; Proteome; Proteomics; Rats, Sprague-Dawley | 2016 |
Effects of antidepressants on P2X7 receptors.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Paroxetine; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Rats; Receptors, Purinergic P2X7 | 2016 |
Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Atomoxetine Hydrochloride; Brain; Chlorpromazine; Citalopram; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluoxetine; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2017 |
The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF levels induced by chronic social instability stress and inflammation.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Desipramine; Disease Models, Animal; Female; Fluoxetine; Inflammation; Lipopolysaccharides; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological; Thiazepines | 2017 |
Mitochondrial energy metabolism of rat hippocampus after treatment with the antidepressants desipramine and fluoxetine.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Cytochrome Reductases; Desipramine; Electron Transport Complex IV; Energy Metabolism; Fluoxetine; Glutamate Dehydrogenase; Hippocampus; Male; Mitochondria; Rats; Rats, Sprague-Dawley | 2017 |
Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABA
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Anxiety; Depression; Desipramine; Dose-Response Relationship, Drug; Feeding Behavior; Fluoxetine; Male; Mice, 129 Strain; Mice, Knockout; Motor Activity; Phenotype; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2017 |
Both serotonergic and noradrenergic systems modulate the development of tolerance to chronic stress in rats with lesions of the serotonergic neurons of the median raphe nucleus.
Topics: 5,7-Dihydroxytryptamine; Analysis of Variance; Animals; Desipramine; Disease Models, Animal; Dorsal Raphe Nucleus; Drug Tolerance; Fluoxetine; Hippocampus; Male; Maze Learning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Wistar; Serotonergic Neurons; Serotonin; Serotonin Agents; Stress, Psychological | 2019 |
Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J mice.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Fluoxetine; Fluvoxamine; Immobilization; Male; Mice; Mice, Inbred C57BL; Motor Activity; Swimming | 2018 |
Failure to detect the action of antidepressants in the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Butyric Acid; Desipramine; Fluoxetine; Immobility Response, Tonic; Male; Mice; Motor Activity | 2018 |
Male rats with same-sex preference show higher immobility in the forced swim test, but similar effects of fluoxetine and desipramine than males that prefer females.
Topics: Animals; Desipramine; Female; Fluoxetine; Immobility Response, Tonic; Letrozole; Male; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sexual Behavior, Animal | 2018 |
Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels.
Topics: Animals; Antidepressive Agents; Brain; Cannabidiol; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Synergism; Fluoxetine; Male; Mice; Norepinephrine; Random Allocation; Serotonin | 2018 |
Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis.
Topics: Antidepressive Agents; Cell Line, Tumor; Desipramine; Fluoxetine; Humans; Imipramine; Lysosomes; Phospholipids; Sphingomyelin Phosphodiesterase | 2018 |
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Compulsive Behavior; Desipramine; Disease Models, Animal; Exploratory Behavior; Fluoxetine; Mice; Mice, Knockout; Motor Activity; Nerve Net; Nerve Tissue Proteins; Obsessive-Compulsive Disorder | 2019 |
Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Fluoxetine; Gene Expression Regulation; Humans; Imipramine; Mianserin; Mice; PC12 Cells; Rats; Reboxetine; Receptors, Adrenergic, alpha-1; Signal Transduction | 2021 |
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Ceramides; Desipramine; Endothelial Cells; Extracellular Vesicles; Fluoxetine; Ischemia; Mice; Proteomics | 2022 |
Stimulatory effect of fluoxetine and desipramine, but not mirtazapine on C26 colon carcinoma hepatic metastases formation: association with cytokines.
Topics: Animals; Antidepressive Agents; Carcinoma; Colonic Neoplasms; Cytokines; Desipramine; Fluoxetine; Liver Neoplasms; Male; Mice; Mirtazapine | 2023 |