Page last updated: 2024-10-27

fluoxetine and Hypochondriacal Neuroses

fluoxetine has been researched along with Hypochondriacal Neuroses in 7 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
"Prior studies of hypochondriasis demonstrated benefits for pharmacotherapy and for cognitive-behavioral therapy (CBT)."2.84A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis. ( Ahern, DK; Barsky, AJ; Fallon, BA; Pavlicova, M; Skritskya, N; Slavov, I, 2017)
"Fluoxetine is a moderately effective and well-tolerated treatment for hypochondriasis."2.73A double-masked, placebo-controlled study of fluoxetine for hypochondriasis. ( Cheng, J; Fallon, BA; Liebowitz, MR; Petkova, E; Sanchez-Lacay, A; Schneier, F; Skritskaya, N; Vermes, D, 2008)
"Given marked similarities between hypochondriasis and obsessive-compulsive disorder, we decided to conduct an open trial of high-dose fluoxetine for patients with DSM-III-R hypochondriasis who did not meet criteria for major depression."2.67Fluoxetine for hypochondriacal patients without major depression. ( Fallon, BA; Hollander, E; Jusino, C; Klein, DF; Liebowitz, MR; Salmán, E; Schneier, FR, 1993)
"Persistence of hypochondriasis was individually predicted by longer duration of prior hypochondriasis (P = 0."1.37Long-term follow-up of hypochondriasis after selective serotonin reuptake inhibitor treatment. ( Fallon, BA; Pavlicova, M; Schweitzer, PJ; Zafar, U, 2011)
"Hypochondriasis is a disorder for which there are no established effective treatments."1.28Hypochondriasis and obsessive compulsive disorder: overlaps in diagnosis and treatment. ( Fallon, BA; Hollander, E; Javitch, JA; Liebowitz, MR, 1991)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fallon, BA5
Ahern, DK1
Pavlicova, M2
Slavov, I1
Skritskya, N1
Barsky, AJ1
Petkova, E1
Skritskaya, N1
Sanchez-Lacay, A1
Schneier, F1
Vermes, D1
Cheng, J1
Liebowitz, MR3
Schweitzer, PJ1
Zafar, U1
Talarowska, M1
Zboralski, K1
Chamielec, M1
Gałecki, P1
Salmán, E1
Schneier, FR1
Jusino, C1
Hollander, E2
Klein, DF1
Javitch, JA1
Viswanathan, R1
Paradis, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Hypochondriasis With CBT and/or SSRI[NCT00339079]Phase 1/Phase 2195 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

25% Improvement on Both Whiteley Index and H-YBOCS-M

Whitley index is a self-report measure of hypochondriasis H-YBOCS-M is an independent evaluator structured assessment of hypochondriasis (NCT00339079)
Timeframe: Measured at Week 24

InterventionParticipants (Count of Participants)
Cognitive Behavioral Therapy (CBT)21
Placebo13
Fluoxetine20
Combined CBT and Fluoxetine25

Trials

3 trials available for fluoxetine and Hypochondriacal Neuroses

ArticleYear
A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.
    The American journal of psychiatry, 2017, 08-01, Volume: 174, Issue:8

    Topics: Adult; Aged; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Fluoxetine; Humans; Hy

2017
A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:6

    Topics: Adult; Aged; Connecticut; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoxetine;

2008
Fluoxetine for hypochondriacal patients without major depression.
    Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:6

    Topics: Adult; Female; Fluoxetine; Humans; Hypochondriasis; Male; Psychiatric Status Rating Scales

1993

Other Studies

4 other studies available for fluoxetine and Hypochondriacal Neuroses

ArticleYear
Long-term follow-up of hypochondriasis after selective serotonin reuptake inhibitor treatment.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Aged; Child Abuse; Clinical Trials as Topic; Diagnostic and Statistical Manual of

2011
The MMPI-2 neurotic triad subscales and depression levels after pharmacological treatment in patients with depressive disorders - clinical study.
    Psychiatria Danubina, 2011, Volume: 23, Issue:4

    Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Female; Fluoxetine; Humans; Hypochond

2011
Hypochondriasis and obsessive compulsive disorder: overlaps in diagnosis and treatment.
    The Journal of clinical psychiatry, 1991, Volume: 52, Issue:11

    Topics: Adult; Aged; Comorbidity; Female; Fluoxetine; Humans; Hypochondriasis; Male; Middle Aged; Obsessive-

1991
Treatment of cancer phobia with fluoxetine.
    The American journal of psychiatry, 1991, Volume: 148, Issue:8

    Topics: Adult; Female; Fluoxetine; Humans; Hypochondriasis; Neoplasms; Obsessive-Compulsive Disorder

1991