Inadequate Velopharyngeal Closure

Failure of the SOFT PALATE to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (ADENOIDECTOMY; CLEFT PALATE) or an incompetent PALATOPHARYNGEAL SPHINCTER. It is characterized by hypernasal speech.

Synonyms(4)

Synonym
Inadequate Velopharyngeal Closure
Palatopharyngeal Incompetence
Velopharyngeal Incompetence
Velopharyngeal Insufficiency

Research Excerpts

Overview

Excerpt	Reference
"Velopharyngeal insufficiency is a common problem in the cleft palate population that may require a pharyngeal flap."	( Griner, D; Overmeyer, CL; Sargent, LA, 2013)

Research

Studies (156)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	28 (17.95)	23.3326
1990's	40 (25.64)	12.5806
2000's	45 (28.85)	18.1394
2010's	26 (16.67)	28.8240
2020's	17 (10.90)	9.53

Drug	Relationship Strength	Studies	Trials
glycerol	low	2	0
nitrous oxide	low	1	0
phenytoin	low	1	0
acetaminophen	low	1	0
fluoxetine	low	1	0
methylphenidate	medium	1	1
apnea	low	1	0
phenobarbital	low	1	0
propofol	low	1	0
saccharin	low	2	0
trihexyphenidyl	low	1	0
prednisone	low	3	0
lysine	low	1	0
methionine	low	1	0
valine	low	1	0
methylprednisolone	low	1	0
pyridostigmine bromide	low	1	0
durapatite	low	4	0
tantalum	low	3	0
titanium	low	1	0
barium sulfate	low	7	0
calcium hypochlorite	low	1	0
trolamine salicylate	low	4	0
cortisone	low	1	0
inositol 3-phosphate	low	13	0
cocaine	low	1	0
mycophenolic acid	low	1	0
phenylephrine hydrochloride	medium	97	2
oxycodone	low	1	0
phosphorus	low	1	0
pituitrin	low	1	0
jaw	low	1	0
nad	low	1	0
cellulose	low	1	0

Protein Targets (444)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	8	0	0	8
ATAD5 protein, partial	3	0	0	3
GLS protein	4	0	0	4
Microtubule-associated protein tau	3	0	0	3
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
thyroid stimulating hormone receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	7	0	0	7
EWS/FLI fusion protein	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	12	0	0	12
peroxisome proliferator activated receptor gamma	5	0	0	5
aryl hydrocarbon receptor	3	0	0	3
chromobox protein homolog 1	6	0	0	6
thyroid hormone receptor beta isoform 2	7	0	0	7
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	2	1	7
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	8	0	8
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	4	2	1	7
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	1	7
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	1	7
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	2
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	1	7
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit beta-3	4	2	1	7
Gamma-aminobutyric acid receptor subunit beta-2	4	2	1	7
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	4	2	1	7
Canalicular multispecific organic anion transporter 1	0	5	0	5
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	2	1	7
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
thioredoxin reductase	6	0	0	6
TDP1 protein	8	0	0	8
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Bloom syndrome protein isoform 1	4	0	0	4
D(1A) dopamine receptor	4	0	0	4
lamin isoform A-delta10	10	0	0	10
neuropeptide S receptor isoform A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
GLI family zinc finger 3	10	0	0	10
AR protein	12	0	0	12
glucocorticoid receptor [Homo sapiens]	8	0	0	8
pregnane X nuclear receptor	8	0	0	8
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	6	1	9
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	6	1	10
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	6	1	9
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	6	0	6
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	8	1	9
Sodium-dependent dopamine transporter	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Sodium-dependent serotonin transporter	0	6	2	8
Sodium-dependent serotonin transporter	0	5	0	6
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Sodium-dependent dopamine transporter	0	6	1	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Sodium-dependent dopamine transporter	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	3	0	3
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
endonuclease IV	4	0	0	4
dopamine D1 receptor	1	0	0	1
pregnane X receptor	2	0	0	2
regulator of G-protein signaling 4	4	0	0	4
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
heat shock protein beta-1	2	0	0	2
flap endonuclease 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
geminin	10	0	0	10
survival motor neuron protein isoform d	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
G	4	0	0	4
cytochrome P450 2D6	1	0	0	1
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
Histone H2A.x	3	0	0	3
Caspase-7	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	1	0	0	1
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Albumin	0	0	1	1
Cellular tumor antigen p53	7	0	0	7
Sodium channel protein type 1 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
ATP-dependent translocase ABCB1	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Spike glycoprotein	3	0	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Ataxin-2	4	0	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Histamine H3 receptor	0	1	0	1
cytochrome P450 2C9, partial	4	0	0	4
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
activating transcription factor 6	4	0	0	4
thyroid hormone receptor beta isoform a	3	0	0	3
Chymotrypsinogen A	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
acetylcholinesterase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
glp-1 receptor, partial	2	0	0	2
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
farnesoid X nuclear receptor	2	0	0	2
67.9K protein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	1	0	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
GALC protein	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
USP1 protein, partial	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
alpha-galactosidase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Cholinesterase	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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