Page last updated: 2024-09-27

Morgellon's

An unexplained illness which is characterized by skin manifestations including non-healing lesions, itching, and the appearance of fibers.

Synonyms(4)

Synonym
Morgellons
Morgellons Syndrome
Morgellon's
Morgellons Disease

Research Excerpts

Overview

ExcerptReference
"Morgellons disease is a condition, which is widely discussed on the internet and patients often self-diagnose."( Bewley, A; Mohandas, P; Taylor, R, 2018)
"Morgellons disease is a disfiguring and distressing condition."( Aung-Din, D; Feldman, SR; Jorizzo, JL; Sahni, DR, 2018)

Research

Studies (11)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (9.09)18.1394
2010's8 (72.73)28.8240
2020's2 (18.18)9.53
DrugIndicatedRelationship StrengthStudiesTrials
citalopram0low10
fluoxetine0low10
risperidone0low20
trifluoperazine0low20
pimozide0low10
silver0low10
aripiprazole0low10
inositol 3-phosphate0low10
cocaine0low10
quetiapine fumarate0low10

Protein Targets (379)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, JmjC domain-containing histone demethylation protein 3A4004
5-hydroxytryptamine receptor 3E0101
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma3003
SMAD family member 22002
Fumarate hydratase2002
USP1 protein, partial3003
PPM1D protein1001
SMAD family member 32002
TDP1 protein5005
GLI family zinc finger 33003
Microtubule-associated protein tau4004
AR protein4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha4004
G3003
cytochrome P450 2D64004
polyprotein2002
67.9K protein3003
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
euchromatic histone-lysine N-methyltransferase 25005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d5005
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 23003
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 14004
nuclear receptor ROR-gamma isoform 13003
geminin5005
peripheral myelin protein 225005
histone acetyltransferase KAT2A isoform 12002
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A3003
Solute carrier family 22 member 20303
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit4004
5-hydroxytryptamine receptor 3B0101
Bile salt export pump0606
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p533003
ATP-dependent translocase ABCB10506
Cytochrome P450 3A40404
5-hydroxytryptamine receptor 1A0235
5-hydroxytryptamine receptor 2C0718
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
D(2) dopamine receptor0527
5-hydroxytryptamine receptor 2A0718
Alpha-1B adrenergic receptor0505
Alpha-2C adrenergic receptor0303
D0404
5-hydroxytryptamine receptor 1A0505
Glutamate receptor 24004
Muscarinic acetylcholine receptor M30505
D(1A) dopamine receptor0303
D(4) dopamine receptor0202
D(1B) dopamine receptor0101
Alpha-1D adrenergic receptor0505
Alpha-1D adrenergic receptor0505
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0808
D(4) dopamine receptor0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter08311
5-hydroxytryptamine receptor 7 0404
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0404
Histamine H1 receptor0606
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0314
5-hydroxytryptamine receptor 2B0505
Alpha-1A adrenergic receptor0505
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60505
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Spike glycoprotein6006
D(2) dopamine receptor0819
Inositol monophosphatase 13003
Potassium voltage-gated channel subfamily H member 2013013
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20303
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10404
Multidrug and toxin extrusion protein 10303
Histamine H3 receptor0303
cytochrome P450 2C9, partial3003
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, serum paraoxonase0101
DNA polymerase kappa isoform 13003
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 30101
Neutrophil cytosol factor 10101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
Carbonic anhydrase 90101
Carbonic anhydrase 130101
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
thioredoxin reductase4004
aldehyde dehydrogenase 1 family, member A13003
NPC intracellular cholesterol transporter 1 precursor3003
D(1A) dopamine receptor4004
survival motor neuron protein isoform d4004
Solute carrier family 22 member 1 0101
Sodium-dependent noradrenaline transporter0202
5-hydroxytryptamine receptor 40606
Aldo-keto reductase family 1 member B10404
Tryptophan 5-hydroxylase 10202
Angiotensin-converting enzyme0808
Aldo-keto reductase family 1 member B10101
Acetylcholinesterase0202
Aromatase0101
Sodium-dependent noradrenaline transporter 0617
Sodium-dependent dopamine transporter0707
Sodium-dependent serotonin transporter0506
5-hydroxytryptamine receptor 70101
Sodium-dependent dopamine transporter 0516
Sigma intracellular receptor 20202
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0404
Nuclear receptor subfamily 3 group C member 3 0808
Ataxin-24004
Sigma non-opioid intracellular receptor 10707
Sigma non-opioid intracellular receptor 10202
Transporter0606
ATP-dependent phosphofructokinase1001
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0303
Alpha-2A adrenergic receptor0303
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Gamma-aminobutyric acid receptor subunit beta-30202
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0617
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Glutamate receptor ionotropic, NMDA 3B0101
Gamma-aminobutyric acid receptor subunit gamma-30202
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
endonuclease IV2002
nonstructural protein 11001
glucocerebrosidase2002
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 13003
DNA polymerase beta1001
mitogen-activated protein kinase 13003
DNA polymerase iota isoform a (long)2002
M-phase phosphoprotein 83003
lamin isoform A-delta104004
caspase 7, apoptosis-related cysteine protease2002
regulator of G-protein signaling 42002
cytochrome P450 family 3 subfamily A polypeptide 42002
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
Histone H2A.x1001
Caspase-72002
chromobox protein homolog 13003
caspase-32002
huntingtin isoform 22002
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 13003
Potassium channel subfamily K member 20213
Albumin0033
Sodium channel protein type 1 subunit alpha0101
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Cytochrome P450 2C80101
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10303
Cytochrome P450 2C9 0101
Dipeptidyl peptidase 40101
Alpha-2B adrenergic receptor0404
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Potassium voltage-gated channel subfamily C member 10101
Cytochrome P450 2C190101
D(1A) dopamine receptor2002
Cytochrome P450 2J20101
Gastrin/cholecystokinin type B receptor 0101
Cytochrome P450 1B10101
Sigma non-opioid intracellular receptor 10101
Transporter0202
Beta-2 adrenergic receptor0101
Chain A, Beta-lactamase1001
Chain A, 2-oxoglutarate Oxygenase1001
glp-1 receptor, partial2002
15-lipoxygenase, partial2002
pregnane X receptor1001
phosphopantetheinyl transferase2002
ATAD5 protein, partial2002
NFKB1 protein, partial2002
GALC protein1001
Thrombopoietin2002
apical membrane antigen 1, AMA12002
DNA polymerase III, partial1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor3003
bromodomain adjacent to zinc finger domain 2B1001
arylsulfatase A1001
XBP10101
IDH11001
activating transcription factor 61001
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor3003
atrial natriuretic peptide receptor 1 precursor1001
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
DNA damage-inducible transcript 3 protein0101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Gamma-aminobutyric acid receptor subunit pi2002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent T-type calcium channel subunit alpha-1G0011
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Ubiquitin carboxyl-terminal hydrolase 10202
Sodium channel protein type 2 subunit alpha0101
Integrin beta-32002
ATP-dependent translocase ABCB10101
Integrin alpha-IIb2002
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
D(3) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
ATP-dependent translocase ABCB10101
Glycine receptor subunit alpha-10022
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
D(1B) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Mu-type opioid receptor0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
TAR DNA-binding protein 431001
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
WD repeat-containing protein 480202
GABA theta subunit2002
ATPase family AAA domain-containing protein 51001
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit epsilon2002
Histamine H4 receptor0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Smad32002
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Beta-1 adrenergic receptor0101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 1A0101
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Genome polyprotein 0101
NADPH oxidase 10101
Snq2p0001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
DNA repair protein RAD52 homolog isoform a0001
Lysozyme C-10101
Glycoprotein hormones alpha chain1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Calmodulin-10011
Trypanothione reductase0202
C-8 sterol isomerase0101
Pleiotropic ABC efflux transporter of multiple drugs0102
Calmodulin 0011
Guanine nucleotide-binding protein G1001
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]