fluoxetine and clozapine

fluoxetine has been researched along with clozapine in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.19)	18.7374
1990's	22 (26.19)	18.2507
2000's	22 (26.19)	29.6817
2010's	37 (44.05)	24.3611
2020's	2 (2.38)	2.80

Authors

Authors	Studies
Hamblin, MW; Monsma, FJ; Shen, Y; Sibley, DR; Ward, RP	1
Dukat, M; Glennon, RA; Hufeisen, S; Lee, DK; Lee, M; McBride, A; Rangisetty, JB; Rauser, L; Roth, BL; Savage, JE	1
Topliss, JG; Yoshida, F	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Morphy, R; Rankovic, Z	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Ahman, M; Holmén, AG; Wan, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Sen, S; Sinha, N	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Peters, JU	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Cassady, SL; Thaker, GK	1
Brewerton, TD; Shannon, M	1
Dahms, JL; Seiden, LS; Shaughnessy, RA	1
Leonsegui, I; Salvador-Carulla, L	1
Campbell, M; Cueva, JE	1
Kingsbury, SJ; Puckett, KM	1
Eales, MJ; Layeni, AO	1
Goldberg, HL	1
Crismon, ML; Dorson, PG; Eggert, AE	1
Baldessarini, RJ; Centorrino, F; Cohen, BM; Flood, JG; Huston-Lyons, D; Volpicelli, SA	1
Baldessarini, RJ; Centorrino, F; Flood, JG; Frankenburg, FR; Kando, J; Puopolo, PR; Volpicelli, SA	1
Hollander, E; Hwang, MY; Simeon, D; Stein, D	1
Baker, RW; Chengappa, KN; Schooler, NR; Steingard, S	1
Patel, B; Tandon, R	1
Baldessarini, RJ; Centorrino, F; Flood, JG; Frankenburg, FR; Kando, J; Volpicelli, SA	1
Ball, P; Breier, A; Bryant, N; Buchanan, RW; Kirkpatrick, B	1
Purdon, SE; Snaterse, M	1
Avenoso, A; Caputi, AP; Fabrazzo, M; Facciolà, G; Maj, M; Monteleone, P; Perucca, E; Spina, E	1
Ferslew, KE; Hagardorn, AN; Harlan, GC; McCormick, WF	1
Aymard, N; Baldacci, C; Caroli, F; Smagghe, PO; Vacheron, MN; Viala, A	1
Chang, WH; Lane, HY; Lu, ML	1
Pallanti, S; Pazzagli, A; Quercioli, L; Rossi, A	1
Lund, BC; Miller, DD; Perry, PJ	1
Kaur, G; Kulkarni, SK	1
Ferris, CF; King, JA; Messenger, T	1
Rehavi, M; Roz, N; Weizman, A	1
Jiang, A; LoGrasso, PV; Stearns, BA; Trauger, JW	1
Conca, A; Hubmann, MR; König, P; Moll, W; Waschgler, R	1
Howpage, P; Varambally, S	1
Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM	1
Adachi, YU; Higuchi, H; Kazama, T; Mimuro, S; Sato, S; Satomoto, M; Watanabe, K; Yamada, S	1
Fontenelle, LF; Leite, MA	1
Ibi, D; Koike, H; Mizoguchi, H; Nabeshima, T; Nagai, T; Nitta, A; Takuma, K; Yamada, K; Yoneda, Y	1
Crisp, KM; Grupe, RE; Lobsang, TT; Yang, X	1
Barros, S; de Carvalho, J	1
Akagi, T; Aruga, J; Hashikawa, T; Morimura, N; Odaka, YS; Sakoori, K; Takashima, N; Yamada, K	1
Rushlow, WJ; Sutton, LP	1
Andrade, C	1
Bai, YY; Li, CQ; Li, F; Ruan, CS; Shen, LJ; Yang, CR; Zhang, ZG; Zheng, HY; Zhou, HF; Zhou, L; Zhou, XF	1
Bernardi, RE; Bošković, M; Djordjević, S; Djurdjević, A; Filipović, D; Lazarević-Pašti, T; Todorović, N; Tomanović, N; Zlatković, J	1
Bai, YY; Liu, D; Ruan, CS; Shen, LJ; Wang, XF; Yang, CR; Zheng, HY; Zhou, HF; Zhou, XF	1
De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S	1
Chang, CH; Chang, YC; Chen, YW; Cheng, YS; Chung, W; Tseng, PT; Wang, HY; Wu, CK	1
Agrawal, T; Dhamija, E; Kar, M; Kumar, R; Medigeshi, GR	1
Filipović, D; Todorović, N	2
Bernardi, RE; Filipović, D; Gass, P; Inta, D; Jasnić, N; Perić, I; Stanisavljević, A	1
Filipović, D; Mićić, B; Schwirtlich, M; Stevanović, M; Todorović, N	1
Ahsan, MI; Jaffery, A; Jaffery, FA; Khan, RA; Masood, SM	1
Du, JY; Li, F; Liang, R; Liu, Y; Meng, FJ; Ming, D; Mu, XF; Wang, S; Yang, CR; Yu, M; Zhang, FQ; Zhang, XY; Zhou, FH; Zhou, L; Zhou, XF	1
Alli-Balogun, O; Bidkhanian, P; Korenis, P; Singh, G	1

Reviews

8 review(s) available for fluoxetine and clozapine

Article	Year
Designed multiple ligands. An emerging drug discovery paradigm. Journal of medicinal chemistry, 2005, Oct-20, Volume: 48, Issue:21 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chemistry, Pharmaceutical; Dopamine D2 Receptor Antagonists; Drug Design; Humans; Ligands; Metabolic Diseases; Peroxisome Proliferator-Activated Receptors; Receptors, Histamine H1; Selective Serotonin Reuptake Inhibitors	2005
Polypharmacology - foe or friend? Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22 Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety	2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Psychosocial effects in pharmacology: something more than an anecdote?]. Medicina clinica, 1995, Oct-14, Volume: 105, Issue:12 Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Clozapine; Fluoxetine; Humans; Hypnotics and Sedatives; Psychology, Social; Psychopharmacology; Triazolam	1995
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II. Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:10 Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonidine; Clozapine; Depressive Disorder; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Fluoxetine; Humans; Imipramine; Lithium; Mutism; Obsessive-Compulsive Disorder; Phenobarbital; Phenytoin; Phobic Disorders; Schizophrenia; Sleep Wake Disorders; Tranquilizing Agents	1995
Psychotropic drugs in pregnancy and lactation. International journal of psychiatry in medicine, 1994, Volume: 24, Issue:2 Topics: Clozapine; Embryonic and Fetal Development; Female; Fluoxetine; Humans; Lactation; Lithium; Mental Disorders; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Psychotropic Drugs; Puerperal Disorders	1994
Pathological gambling and primary antiphospholipid (Hughes) syndrome: a unique neuropsychiatric association. Lupus, 2011, Volume: 20, Issue:10 Topics: Antidepressive Agents; Antiphospholipid Syndrome; Antipsychotic Agents; Clomipramine; Clozapine; Fluoxetine; Fructose; Gambling; Humans; Male; Middle Aged; Topiramate	2011
Atypical neuroleptic malignant syndrome in patients treated with aripiprazole and clozapine: a case-series study and short review. International journal of psychiatry in medicine, 2015, Volume: 49, Issue:1 Topics: Adult; Aripiprazole; Clozapine; Creatine Kinase; Dose-Response Relationship, Drug; Drug Substitution; Drug Therapy, Combination; Female; Fluoxetine; Hospitalization; Humans; Injections, Intramuscular; Male; Middle Aged; Neuroleptic Malignant Syndrome; Piperazines; Psychotic Disorders; Quinolones; Schizophrenia; Schizophrenic Psychology	2015

Trials

4 trial(s) available for fluoxetine and clozapine

Article	Year
Serum concentrations of clozapine and its major metabolites: effects of cotreatment with fluoxetine or valproate. The American journal of psychiatry, 1994, Volume: 151, Issue:1 Topics: Adult; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Psychotic Disorders; Schizophrenia; Stimulation, Chemical; Valproic Acid	1994
Fluoxetine augmentation of clozapine treatment in patients with schizophrenia. The American journal of psychiatry, 1996, Volume: 153, Issue:12 Topics: Adult; Ambulatory Care; Clozapine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Placebos; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome	1996
Pharmacoclinical strategy in neuroleptic resistant schizophrenic patients treated by clozapine: clinical evolution, concentration of plasma and red blood cell clozapine and desmethylclozapine, whole blood serotonin and tryptophan. Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Depressive Disorder; Drug Monitoring; Female; Fluoxetine; Humans; Male; Middle Aged; Schizophrenia; Serotonin; Tryptophan	1999
The emergence of social phobia during clozapine treatment and its response to fluoxetine augmentation. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:12 Topics: Adult; Ambulatory Care; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Fluoxetine; Follow-Up Studies; Humans; Male; Phobic Disorders; Psychiatric Status Rating Scales; Schizophrenia, Paranoid; Selective Serotonin Reuptake Inhibitors; Treatment Outcome	1999

Other Studies

72 other study(ies) available for fluoxetine and clozapine

Article	Year
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology, 1993, Volume: 43, Issue:3 Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain Chemistry; Cell Line; Cloning, Molecular; DNA; GTP-Binding Proteins; Lysergic Acid Diethylamide; Molecular Sequence Data; Polymerase Chain Reaction; Psychotropic Drugs; Rats; Receptors, Serotonin; RNA; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection	1993
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of medicinal chemistry, 2000, Mar-09, Volume: 43, Issue:5 Topics: Adenylyl Cyclases; Cell Line; Enzyme Activation; Humans; Methoxydimethyltryptamines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Tryptamines	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19 Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Addition of fluoxetine to clozapine. The American journal of psychiatry, 1992, Volume: 149, Issue:9 Topics: Adult; Clozapine; Drug Therapy, Combination; Fluoxetine; Humans; Male; Schizophrenia; Schizophrenic Psychology	1992
Possible clozapine exacerbation of bulimia nervosa. The American journal of psychiatry, 1992, Volume: 149, Issue:10 Topics: Acute Disease; Adult; Bulimia; Clozapine; Dyskinesia, Drug-Induced; Female; Fluoxetine; Humans; Recurrence; Schizophrenia; Thiothixene	1992
Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule. Psychopharmacology, 1985, Volume: 86, Issue:1-2 Topics: Animals; Antidepressive Agents; Bupropion; Clozapine; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Haloperidol; Male; Propiophenones; Rats; Rats, Inbred Strains; Reinforcement Schedule; Trazodone; Zimeldine	1985
Effects of fluoxetine on serum clozapine levels. The American journal of psychiatry, 1995, Volume: 152, Issue:3 Topics: Adult; Clonazepam; Clozapine; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Fluoxetine; Humans; Lorazepam; Male; Schizophrenia, Paranoid	1995
Exacerbation of obsessive-compulsive symptoms associated with clozapine. The British journal of psychiatry : the journal of mental science, 1994, Volume: 164, Issue:5 Topics: Adult; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Schizophrenia; Schizophrenic Psychology	1994
Lack of effect of fluoxetine on plasma clozapine concentrations. The Journal of clinical psychiatry, 1994, Volume: 55, Issue:10 Topics: Adult; Clozapine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Male; Schizophrenia; Stimulation, Chemical	1994
Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 9, Issue:2 Topics: Animals; Brain; Clozapine; Fluoxetine; Half-Life; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Valproic Acid	1993
Clozapine, obsessive symptoms, and serotonergic mechanisms. The American journal of psychiatry, 1993, Volume: 150, Issue:9 Topics: Clozapine; Drug Therapy, Combination; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Schizophrenia; Schizophrenic Psychology	1993
Clozapine, obsessive symptoms, and serotonergic mechanisms. The American journal of psychiatry, 1993, Volume: 150, Issue:9 Topics: Clozapine; Drug Therapy, Combination; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Receptors, Serotonin	1993
Development of obsessive-compulsive symptoms during clozapine treatment. The American journal of psychiatry, 1993, Volume: 150, Issue:5 Topics: Adult; Clozapine; Female; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Schizophrenia	1993
Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors. The American journal of psychiatry, 1996, Volume: 153, Issue:6 Topics: 1-Naphthylamine; Adult; Affective Disorders, Psychotic; Aged; Ambulatory Care; Clozapine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Middle Aged; Paroxetine; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Sertraline; Stimulation, Chemical	1996
Selective serotonin reuptake inhibitor modulation of clozapine effects on cognition in schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:1 Topics: 1-Naphthylamine; Adult; Antipsychotic Agents; Clozapine; Cognition; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Fluoxetine; Humans; Male; Neuropsychological Tests; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Selective Serotonin Reuptake Inhibitors; Sertraline	1998
Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia. International clinical psychopharmacology, 1998, Volume: 13, Issue:3 Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Biotransformation; Chronic Disease; Clozapine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2D6 Inhibitors; Depression; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Schizophrenia	1998
A fatal drug interaction between clozapine and fluoxetine. Journal of forensic sciences, 1998, Volume: 43, Issue:5 Topics: Antipsychotic Agents; Clozapine; Drug Interactions; Drug Overdose; Fatal Outcome; Fluoxetine; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors	1998
Selective serotonin reuptake inhibitor syndrome: precipitated by concomitant clozapine? Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:4 Topics: Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluoxetine; Humans; Male; Middle Aged; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Substance Withdrawal Syndrome	1999
Treating depression in schizophrenia. The American journal of psychiatry, 2001, Volume: 158, Issue:9 Topics: Antidepressive Agents; Antipsychotic Agents; Clozapine; Comorbidity; Depressive Disorder; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fluoxetine; Humans; Schizophrenia; Schizophrenic Psychology; Secondary Prevention	2001
Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adipose Tissue; Animals; Antipsychotic Agents; Body Weight; Clozapine; Eating; Feeding Behavior; Female; Fluoxetine; Hyperphagia; Mice; Mice, Inbred Strains; Organ Size; Quinpirole; Quipazine; Selective Serotonin Reuptake Inhibitors; Weight Gain	2002
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs. Neuropsychobiology, 2002, Volume: 45, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Appetitive Behavior; Behavior, Animal; Buspirone; Chlordiazepoxide; Clozapine; Cricetinae; Desipramine; Drug Evaluation, Preclinical; Fasting; Fluoxetine; Injections, Intraperitoneal; Male; Mesocricetus; Models, Animal; Stress, Psychological; Yohimbine	2002
Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:3 Topics: Animals; Antipsychotic Agents; Binding Sites; Biological Transport; Brain; Brain Chemistry; Clozapine; Drug Administration Schedule; Fluoxetine; Haloperidol; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Paroxetine; Piperazines; Rats; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins	2002
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). Biochemistry, 2002, Nov-12, Volume: 41, Issue:45 Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Carbamazepine; Catalysis; Clozapine; Enzyme Activation; Enzyme Inhibitors; Fluoxetine; Flurbiprofen; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Oxidation-Reduction; Pregnanediones; Pregnanolone; Recombinant Fusion Proteins; Selective Serotonin Reuptake Inhibitors; Substrate Specificity; Ursodeoxycholic Acid	2002
Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis. International journal of clinical pharmacology and therapeutics, 2002, Volume: 40, Issue:12 Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Chromatography, High Pressure Liquid; Citalopram; Clozapine; Fluoxetine; Humans; Maprotiline; Trazodone	2002
Acute myocarditis associated with clozapine. Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2007, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Antidepressive Agents; Antipsychotic Agents; Clozapine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Lithium Compounds; Male; Myocarditis; Psychotic Disorders; Risk Factors	2007
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants. Psychopharmacology, 2007, Volume: 195, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine	2007
Isoflurane anesthesia inhibits clozapine- and risperidone-induced dopamine release and anesthesia-induced changes in dopamine metabolism was modified by fluoxetine in the rat striatum: an in vivo microdialysis study. Neurochemistry international, 2008, Volume: 52, Issue:3 Topics: Anesthetics, Inhalation; Animals; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Fluid; Fluoxetine; Isoflurane; Male; Microdialysis; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Synaptic Transmission	2008
Treatment-resistant self-mutilation, tics, and obsessive-compulsive disorder in neuroacanthocytosis: a mouth guard as a therapeutic approach. The Journal of clinical psychiatry, 2008, Volume: 69, Issue:7 Topics: Adult; Antipsychotic Agents; Atrophy; Caudate Nucleus; Clonazepam; Clozapine; Dibenzothiazepines; Electromyography; Fluoxetine; Humans; Magnetic Resonance Imaging; Male; Mouth Protectors; Neuroacanthocytosis; Obsessive-Compulsive Disorder; Quetiapine Fumarate; Self-Injurious Behavior	2008
Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behavioural brain research, 2009, Aug-24, Volume: 202, Issue:1 Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Cognition; Emotions; Fluoxetine; Male; Methylphenidate; Mice; Mice, Inbred ICR; Social Behavior; Social Isolation; Stress, Psychological	2009
Biogenic amines modulate pulse rate in the dorsal blood vessel of Lumbriculus variegatus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2010, Volume: 151, Issue:4 Topics: 5-Methoxytryptamine; Animals; Antidepressive Agents, Tricyclic; Biogenic Amines; Blood Vessels; Clozapine; Cyproheptadine; Drug Antagonism; Fluoxetine; Heart Rate; Imines; Octopamine; Oligochaeta; Reserpine; Serotonin; Theophylline	2010
Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia. PloS one, 2011, Volume: 6, Issue:7 Topics: Adaptation, Psychological; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition; Dizocilpine Maleate; Environment; Fluoxetine; Gene Targeting; Genetic Predisposition to Disease; Hippocampus; Membrane Proteins; Memory; Mice; Mice, Knockout; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Synapses	2011
The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling. Neuroscience, 2011, Dec-29, Volume: 199 Topics: Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; beta Catenin; Blotting, Western; Brain; Clozapine; Fluoxetine; Glycogen Synthase Kinase 3; Haloperidol; Imipramine; Immunoprecipitation; Lithium; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Valproic Acid	2011
Serotonin reuptake inhibitor treatment of obsessive-compulsive symptoms in clozapine-medicated schizophrenia. The Journal of clinical psychiatry, 2012, Volume: 73, Issue:11 Topics: Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Clomipramine; Clozapine; Comorbidity; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fluoxetine; Fluvoxamine; Humans; Male; Obsessive-Compulsive Disorder; Schizophrenia; Selective Serotonin Reuptake Inhibitors	2012
Foraging activity is reduced in a mouse model of depression. Neurotoxicity research, 2014, Volume: 25, Issue:3 Topics: Animals; Antidepressive Agents; Appetitive Behavior; Body Weight; Cerebral Cortex; Chronic Disease; Clozapine; Depressive Disorder; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; Fluoxetine; Freezing Reaction, Cataleptic; Glial Fibrillary Acidic Protein; Hippocampus; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Stress, Psychological	2014
Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: a histopathological study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Aug-01, Volume: 59 Topics: Alanine Transaminase; Animals; Antidepressive Agents; Antipsychotic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clozapine; Cyclooxygenase 2; Fluoxetine; Glutathione; Glutathione Transferase; Liver; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Oxidative Stress; Rats, Wistar; Superoxide Dismutase	2014
Enhanced aggressive behaviour in a mouse model of depression. Neurotoxicity research, 2015, Volume: 27, Issue:2 Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Clozapine; Depressive Disorder; Disease Models, Animal; Fluoxetine; Hippocampus; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Messenger; Social Dominance; Stress, Psychological	2015
Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. Neuroscience, 2015, Apr-16, Volume: 291 Topics: Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Dietary Sucrose; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Eating; Fluoxetine; Haloperidol; Imipramine; Lithium Compounds; Male; Motivation; Nucleus Accumbens; Phosphorylation; Rats, Sprague-Dawley; Stress, Psychological	2015
N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:11 Topics: A549 Cells; Animals; Antipsychotic Agents; Antiviral Agents; Bronchodilator Agents; Cell Line; Cell Line, Tumor; Clozapine; Cricetinae; Dengue Virus; Drug Repositioning; Epithelial Cells; Fluoxetine; Hepatocytes; Humans; Inhibitory Concentration 50; RNA, Viral; Salmeterol Xinafoate; Virus Replication	2016
Prefrontal cortical glutathione-dependent defense and proinflammatory mediators in chronically isolated rats: Modulation by fluoxetine or clozapine. Neuroscience, 2017, 07-04, Volume: 355 Topics: Animals; Antidepressive Agents; Clozapine; Cytokines; Defense Mechanisms; Disease Models, Animal; Fluoxetine; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Male; Mood Disorders; NADP; NF-kappa B; Nitric Oxide Synthase Type II; Prefrontal Cortex; Rats; Rats, Wistar; Social Isolation	2017
The antidepressant- and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal TNF-α. Pharmacology, biochemistry, and behavior, 2017, Volume: 163 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Clozapine; Fluoxetine; Hippocampus; Male; NF-kappa B; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2017
Chronic Treatment with Fluoxetine or Clozapine of Socially Isolated Rats Prevents Subsector-Specific Reduction of Parvalbumin Immunoreactive Cells in the Hippocampus. Neuroscience, 2018, 02-10, Volume: 371 Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Cell Count; Clozapine; Fluoxetine; Hippocampus; Interneurons; Male; Parvalbumins; Random Allocation; Rats, Wistar; Social Isolation; Stress, Psychological	2018
Subregion-specific Protective Effects of Fluoxetine and Clozapine on Parvalbumin Expression in Medial Prefrontal Cortex of Chronically Isolated Rats. Neuroscience, 2019, 01-01, Volume: 396 Topics: Animals; Caspase 3; Cell Count; Clozapine; Depression; Fluoxetine; Male; Neurons; Neuroprotective Agents; Parvalbumins; Prefrontal Cortex; Rats; Social Isolation	2019
In vivo study to compare the effects of Choline with Fluoxetine and Clozapine for the modulation of cognitive behavior (Learning Memory and Exploratory Behavior). Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:3 (Supplem Topics: Animals; Antipsychotic Agents; Choline; Clozapine; Cognition; Exploratory Behavior; Fluoxetine; Learning; Male; Maze Learning; Memory; Motor Activity; Rats	2019
Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress. Neurotoxicity research, 2020, Volume: 37, Issue:1 Topics: Adaptor Proteins, Vesicular Transport; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Clozapine; Fluoxetine; Hippocampus; Male; Membrane Glycoproteins; Mice; Protein Precursors; Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Signal Transduction; Stress, Psychological	2020
Clozapine Toxicity From Drug-Drug Interaction When Given With Fluoxetine and Diltiazem. The primary care companion for CNS disorders, 2023, 02-09, Volume: 25, Issue:1 Topics: Antipsychotic Agents; Clozapine; Diltiazem; Drug Interactions; Fluoxetine; Humans	2023