fluoxetine has been researched along with Acute Liver Injury, Drug-Induced in 34 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine was stopped, following which there was improvement in her liver function tests and skin rash, without progression to fulminant hepatic failure." | 5.51 | Fluoxetine-induced Stevens-Johnson syndrome and liver injury. ( Agrawal, R; Almoghrabi, A; Attar, BM; Gandhi, S, 2019) |
| "The fluoxetine-induced rats were concurrently treated with olive oil or leaf extract." | 5.48 | Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis. ( Al Hroob, AM; Allach, M; El-Ghorab, AH; El-Massry, KF; Elgebaly, HA; Mahmoud, AM; Mosa, NM, 2018) |
| "Fluoxetine (FLX) has been widely used as first-line treatment in cases of depression and other neuropsychiatric disorders." | 1.62 | Vinpocetine attenuates fluoxetine-induced liver damage in rats; Role of Nrf2 and PPAR-γ. ( Mohamed Kamel, GA, 2021) |
| "Fluoxetine was stopped, following which there was improvement in her liver function tests and skin rash, without progression to fulminant hepatic failure." | 1.51 | Fluoxetine-induced Stevens-Johnson syndrome and liver injury. ( Agrawal, R; Almoghrabi, A; Attar, BM; Gandhi, S, 2019) |
| "The fluoxetine-induced rats were concurrently treated with olive oil or leaf extract." | 1.48 | Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis. ( Al Hroob, AM; Allach, M; El-Ghorab, AH; El-Massry, KF; Elgebaly, HA; Mahmoud, AM; Mosa, NM, 2018) |
| "The treatment with gallic acid showed significant ameliorations in abnormalities of fluoxetine-induced liver injury as represented by the improvement of hepatic CAT, SOD activities, vitamin C levels, serum biochemical parameters, and histopathological changes, in addition to the recovery of antioxidant defense system status." | 1.46 | Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats. ( Amini, SA; Heidarian, E; Karimi-Khouzani, O, 2017) |
| " We investigated the effects of chronic administration of fluoxetine (15mg/kg/day) or clozapine (20mg/kg/day) on liver injury via the measurement of liver enzymes, oxidative stress and histopathology in rats exposed to chronic social isolation (21days), an animal model of depression, and controls." | 1.40 | Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: a histopathological study. ( Bernardi, RE; Bošković, M; Djordjević, S; Djurdjević, A; Filipović, D; Lazarević-Pašti, T; Todorović, N; Tomanović, N; Zlatković, J, 2014) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Fluoxetine (Flux) is a fluorine-containing drug that selectively inhibits serotonin reuptake." | 1.37 | Impact of fluoxetine on liver damage in rats. ( Inkielewicz-Stępniak, I, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 10 (29.41) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 19 (55.88) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Rana, A | 1 |
| Siddiqui, N | 1 |
| Khan, SA | 1 |
| Ehtaishamul Haque, S | 1 |
| Bhat, MA | 1 |
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Mohamed Kamel, GA | 1 |
| Beigi, T | 1 |
| Safi, A | 1 |
| Satvati, M | 1 |
| Kalantari-Hesari, A | 1 |
| Ahmadi, R | 1 |
| Meshkibaf, MH | 1 |
| Karimi-Khouzani, O | 1 |
| Heidarian, E | 1 |
| Amini, SA | 1 |
| Elgebaly, HA | 1 |
| Mosa, NM | 1 |
| Allach, M | 1 |
| El-Massry, KF | 1 |
| El-Ghorab, AH | 1 |
| Al Hroob, AM | 1 |
| Mahmoud, AM | 1 |
| Jiao, X | 1 |
| Xiao, Y | 1 |
| Li, Y | 1 |
| Liang, M | 1 |
| Xie, X | 1 |
| Wang, X | 1 |
| Tang, B | 1 |
| Agrawal, R | 1 |
| Almoghrabi, A | 1 |
| Attar, BM | 1 |
| Gandhi, S | 1 |
| Zlatković, J | 1 |
| Todorović, N | 1 |
| Tomanović, N | 1 |
| Bošković, M | 1 |
| Djordjević, S | 1 |
| Lazarević-Pašti, T | 1 |
| Bernardi, RE | 1 |
| Djurdjević, A | 1 |
| Filipović, D | 1 |
| Chew, AP | 1 |
| Lim, WS | 1 |
| Tan, KT | 1 |
| De Long, NE | 1 |
| Barry, EJ | 1 |
| Pinelli, C | 1 |
| Wood, GA | 1 |
| Hardy, DB | 1 |
| Morrison, KM | 1 |
| Taylor, VH | 1 |
| Gerstein, HC | 1 |
| Holloway, AC | 1 |
| Yılmaz, A | 1 |
| Elbey, B | 1 |
| Yazgan, ÜC | 1 |
| Dönder, A | 1 |
| Arslan, N | 1 |
| Arslan, S | 1 |
| Alabalık, U | 1 |
| Aslanhan, H | 1 |
| Inkielewicz-Stępniak, I | 1 |
| Condon, J | 1 |
| Hastier, P | 1 |
| Paolini, O | 1 |
| Demarquay, JF | 1 |
| Caroli-Bosc, FX | 1 |
| Chichmanian, RM | 1 |
| Saint-Paul, MC | 1 |
| Delmont, J | 1 |
| Castiella, A | 1 |
| Lopez, P | 1 |
| Arenas, JI | 1 |
| Bobichon, R | 1 |
| Bernard, G | 1 |
| Mion, F | 1 |
| Friedenberg, FK | 1 |
| Rothstein, KD | 1 |
| Serra-Mestres, J | 1 |
| Shapleske, J | 1 |
| Tym, E | 1 |
| Johnston, DE | 1 |
| Wheeler, DE | 1 |
| Cai, Q | 1 |
| Benson, MA | 1 |
| Talbot, TJ | 1 |
| Devadas, G | 1 |
| Swanson, HJ | 1 |
| Olson, JL | 1 |
| Kirchner, JP | 1 |
| Lin, X | 1 |
| Levitsky, DA | 1 |
| King, JM | 1 |
| Campbell, TC | 1 |
| Capellà, D | 1 |
| Bruguera, M | 1 |
| Figueras, A | 1 |
| Laporte, J | 1 |
| Mars, F | 1 |
| Dumas de la Roque, G | 1 |
| Goissen, P | 1 |
| Montgomery, SA | 1 |
| Gabriel, R | 1 |
| James, D | 1 |
| Hawley, C | 1 |
| Burkitt, P | 1 |
1 review available for fluoxetine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
33 other studies available for fluoxetine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation.
Topics: Animals; Anticonvulsants; Benzamides; Benzothiazoles; Central Nervous System Depressants; Chemical a | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Vinpocetine attenuates fluoxetine-induced liver damage in rats; Role of Nrf2 and PPAR-γ.
Topics: Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Fluoxetine; Gene Expressi | 2021 |
Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Ellagic Acid; Fluoxetine; Male; NF-ka | 2022 |
Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Dose-Response Relationshi | 2017 |
Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Catalase; Chemi | 2018 |
Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and H
Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Duloxetine Hydrochloride; Fluorescent | 2018 |
Fluoxetine-induced Stevens-Johnson syndrome and liver injury.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fluoxetine; Humans; Liver Function Te | 2019 |
Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: a histopathological study.
Topics: Alanine Transaminase; Animals; Antidepressive Agents; Antipsychotic Agents; Aspartate Aminotransfera | 2014 |
Donepezil-induced hepatotoxicity in an elderly adult taking fluoxetine.
Topics: Aged; Alanine Transaminase; Alzheimer Disease; Antidepressive Agents, Second-Generation; Aspartate A | 2014 |
Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats.
Topics: Adiposity; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Diabetes | 2015 |
Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study.
Topics: Animals; Antioxidants; Aryldialkylphosphatase; Caffeic Acids; Chemical and Drug Induced Liver Injury | 2016 |
Impact of fluoxetine on liver damage in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fluorides; Fluoxe | 2011 |
Serotonergic symptoms in neonates exposed to SSRIs during pregnancy.
Topics: Chemical and Drug Induced Liver Injury; Depression; Female; Fluoxetine; Humans; Infant, Newborn; Pre | 2003 |
[Fulminant hepatitis induced by paracetamol at a therapeutic dose favoured by the ingestion of enzyme inducers in a patient with liver cirrhosis].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Depressive D | 1995 |
Fluoxetine.
Topics: Chemical and Drug Induced Liver Injury; Depressive Disorder; Fluoxetine; Humans | 1995 |
[Acute hepatitis during treatment with fluoxetine].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Depressive Disorder; Female; Fluoxetine; Huma | 1993 |
Hepatitis secondary to fluoxetine treatment.
Topics: Adult; Anxiety Disorders; Chemical and Drug Induced Liver Injury; Clonazepam; Drug Therapy, Combinat | 1996 |
Treatment of palilalia with trazodone.
Topics: Adult; Anxiety Disorders; Chemical and Drug Induced Liver Injury; Clonazepam; Drug Therapy, Combinat | 1996 |
Chronic hepatitis related to use of fluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Chronic Dis | 1997 |
Acute hepatitis due to fluoxetine therapy.
Topics: Acute Disease; Adult; Alanine Transaminase; Antidepressive Agents, Second-Generation; Aspartate Amin | 1999 |
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci.
Topics: Adipose Tissue, Brown; Aflatoxin B1; Amphetamine; Animals; Appetite Depressants; Biomarkers; Body Te | 1999 |
Fluoxetine-induced hepatitis: why is postmarketing surveillance needed?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Chemi | 1999 |
[Acute hepatitis during treatment with fluoxetine].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Depression; Female; Fluoxetine; Humans | 1991 |
The specificity of the zimelidine reaction.
Topics: Chemical and Drug Induced Liver Injury; Depressive Disorder; Drug Hypersensitivity; Fluoxetine; Huma | 1989 |