Page last updated: 2024-09-27

Agnosia for Faces

The inability to recognize a familiar face or to learn to recognize new faces. This visual agnosia is most often associated with lesions involving the junctional regions between the temporal and occipital lobes. The majority of cases are associated with bilateral lesions, however unilateral damage to the right occipito-temporal cortex has also been associated with this condition. (From Cortex 1995 Jun;31(2):317-29).

Synonyms(5)

Synonym
Facial Recognition Agnosia
Prosopagnosia, Developmental
Agnosia for Faces
Prosopagnosia, Acquired
Prosopagnosia

Research Excerpts

Overview

ExcerptReference
"Prosopagnosia is an inability to recognize familiar faces, in a person who does not have vision impairments or cognitive alterations."( Coelho, F; Santana, I; Tábuas-Pereira, M; Vicente, M, 2016)
"Prosopagnosia is a disorder leading to difficulties in recognizing faces."( Albonico, A; Daini, R; Malaspina, M, 2019)

Research

Studies (33)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's15 (45.45)18.1394
2010's17 (51.52)28.8240
2020's1 (3.03)9.53
DrugIndicatedRelationship StrengthStudiesTrials
uric acid0low10
donepezil0low10
fluoxetine0low10
trimethoprim0low10
galactose0low10
methylprednisolone0low10
sq-117250low10
fluorodeoxyglucose f180low20
deoxyglucose0low10
oxytocin0medium21
arginine vasopressin0low10
phenylephrine hydrochloride0low30
cysteine0low10
ro13-99040low10
piperidines0low10
eye0low70
technetium tc 99m bicisate0low10

Protein Targets (341)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
vitamin D3 receptor isoform VDRA1001
peripheral myelin protein 225005
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0606
Translocator protein0011
Vasopressin V2 receptor0326
Oxytocin receptor0336
Vasopressin V1a receptor0123
Vasopressin V1a receptor0325
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0214
Translocator protein0102
Oxytocin receptor0202
Vasopressin V2 receptor 0213
Canalicular multispecific organic anion transporter 10606
euchromatic histone-lysine N-methyltransferase 24004
geminin5005
Acetylcholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0101
Amyloid-beta precursor protein0101
Cholinesterase0202
ATP-dependent translocase ABCB10203
Cytochrome P450 3A40303
5-hydroxytryptamine receptor 1A0303
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0202
Acetylcholinesterase0325
Liver carboxylesterase 10101
Acetylcholinesterase 0202
Amine oxidase [flavin-containing] B0101
Sodium-dependent serotonin transporter0426
Choline O-acetyltransferase 0101
Acetylcholinesterase0101
Glycogen synthase kinase-3 beta0101
Beta-secretase 10101
Cholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Cholinesterase0101
Acetylcholine receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Potassium voltage-gated channel subfamily H member 20707
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Cytochrome P450 1B10202
Sigma non-opioid intracellular receptor 10202
Acyl-CoA:cholesterol acyltransferase 0101
Sigma non-opioid intracellular receptor 10303
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0202
Histamine H3 receptor0303
thioredoxin reductase3003
RAR-related orphan receptor gamma3003
TDP1 protein3003
GLI family zinc finger 34004
AR protein5005
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor3003
regulator of G-protein signaling 41001
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha5005
G2002
cytochrome P450 2D62002
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma3003
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
chromobox protein homolog 14004
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-31001
thyroid hormone receptor beta isoform 21001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
lamin isoform A-delta102002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40404
Voltage-dependent calcium channel gamma-2 subunit2002
Potassium channel subfamily K member 20101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0022
Cellular tumor antigen p533003
Sodium channel protein type 1 subunit alpha0202
Aldo-keto reductase family 1 member B10202
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Cytochrome P450 2C80101
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10303
Cytochrome P450 2C9 0202
Angiotensin-converting enzyme0404
Dipeptidyl peptidase 40202
5-hydroxytryptamine receptor 2A0505
Gamma-aminobutyric acid receptor subunit alpha-10101
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0404
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Alpha-2B adrenergic receptor0202
Glutamate receptor 22002
Muscarinic acetylcholine receptor M30404
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Prostaglandin G/H synthase 10101
Alpha-1D adrenergic receptor0303
Sodium-dependent noradrenaline transporter 0213
Sodium-dependent dopamine transporter0303
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 2B0505
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0202
Cytochrome P450 2C190101
Gamma-aminobutyric acid receptor subunit alpha-30101
Alpha-1A adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60303
Cytochrome P450 2J20202
Spike glycoprotein3003
D(2) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit epsilon0101
Gastrin/cholecystokinin type B receptor 0101
Sodium-dependent dopamine transporter 0213
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Transporter0202
Nuclear receptor subfamily 3 group C member 3 0404
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Inositol hexakisphosphate kinase 12002
Ataxin-22002
Gamma-aminobutyric acid receptor subunit gamma-30101
Sigma non-opioid intracellular receptor 10101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
cytochrome P450 2C9, partial2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
USP1 protein, partial1001
IDH14004
importin subunit beta-1 isoform 11001
snurportin-11001
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 11001
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
acetylcholinesterase3003
hypoxia-inducible factor 1 alpha subunit1001
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]3003
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
ATPase family AAA domain-containing protein 51001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase1001
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Oxytocin receptor0011
Chain A, 2-oxoglutarate Oxygenase1001
glp-1 receptor, partial1001
GALC protein1001
thyroid stimulating hormone receptor2002
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 12002
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Smad31001
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein1001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor2002
transcriptional regulator ERG isoform 32002
survival motor neuron protein isoform d1001
muscarinic acetylcholine receptor M12002
Solute carrier family 22 member 20101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 1A0123
D(2) dopamine receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Glycine receptor subunit alpha-10011
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 1B0202
Histamine H1 receptor0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
ATAD5 protein, partial2002
activating transcription factor 61001
DNA polymerase iota isoform a (long)1001
Fatty acid-binding protein, liver0101
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0011
Beta-3 adrenergic receptor0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
interleukin 81001
endonuclease IV1001
dopamine D1 receptor1001
NFKB1 protein, partial1001
aldehyde dehydrogenase 1 family, member A11001
67.9K protein1001
cytochrome P450 3A4 isoform 11001
lethal factor (plasmid)1001
Gamma-aminobutyric acid receptor subunit pi1001
Solute carrier family 22 member 1 0101
Dihydrofolate reductase 0102
Dihydrofolate reductase0202
Dihydrofolate reductase0101
Dihydrofolate reductase 0101
Dihydrofolate reductase0202
Dihydrofolate reductase0202
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0101
NH(3)-dependent NAD(+) synthetase0101
Dihydrofolate reductase0202
Thymidylate synthase0101
Dihydrofolate reductase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase type 1 from Tn40030101
Gamma-aminobutyric acid receptor subunit beta-11001
Dihydrofolate reductase0203
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Dihydrofolate reductase0101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Dipeptidyl peptidase 40101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Metabotropic glutamate receptor 50101
5-hydroxytryptamine receptor 70101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Mu-type opioid receptor0101
Dihydrofolate reductase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Trace amine-associated receptor 50011
Dihydrofolate reductase 0202
Dihydrofolate reductase 0101
GABA theta subunit1001
Dihydrofolate reductase0102
Gamma-aminobutyric acid receptor subunit epsilon1001
Protein-arginine deiminase type-40101
Dihydrofolate reductase 0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]