Craniofacial Microsomia

Mandibulofacial dysostosis with congenital eyelid dermoids.

Synonyms(21)

Synonym
OAVS with Radial Defect
Microsomia Hemifacial Radial Defects
Oculoauriculovertebral Dysplasia
Goldenhar Disease
Oculoauriculovertebral Spectrum
Oculoauriculovertebral Spectrum with Radial Defect
Goldenhar Syndrome
Oculoauriculovertebral Syndrome
Goldenhar-Gorlin Syndrome
Moeschler Clarren Syndrome
Lateral Facial Dysplasia
Facioauriculovertebral Dysplasia
Hemifacial Microsomia
Otomandibular Dysostosis
Facioauriculovertebral Sequence
Hemifacial Microsomia with Radial Defects
First and Second Branchial Arch Syndrome
Oral-Mandibular-Auricular Syndrome
Craniofacial Microsomia
Goldenhar Syndrome with Ipsilateral Radial Defect
First and Second Pharyngeal Arch Syndromes

Research Excerpts

Overview

Excerpt	Reference
"Oculoauriculovertebral dysplasia is a developmental disorder characterized by a triad of anomalies; epibulbar dermoids with or without lipodermoids, preauricular appendages or blind preauricular fistulae, and vertebral anomalies."	( Hendricks, WM; Kallor, AD, 1979)
"Goldenhar syndrome is a well-known developmental anomaly of maxillofacial skeleton and hemi-facial soft tissue, was later included to a broader classification called oculo-ariculo-vertebral spectrum."	( Canter, HI; Konaş, E; Mavili, ME, 2006)
"Children with Goldenhar syndrome are known to present airway management challenges for the anesthesiologist."	( Rosenblatt, WH; Sukhupragarn, W, 2008)
"Goldenhar syndrome is characterized by the typical features of craniofacial microsomia (CFM) with the addition of epibulbar dermoids and vertebral anomalies."	( Bartlett, SP; Paliga, JT; Tahiri, Y; Taylor, JA; Tuin, J, 2015)

Research

Studies (63)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	13 (20.63)	23.3326
1990's	14 (22.22)	12.5806
2000's	9 (14.29)	18.1394
2010's	18 (28.57)	28.8240
2020's	9 (14.29)	9.53

Drug	Relationship Strength	Studies
nitrous oxide	low	3
aspirin	low	1
bupivacaine	low	1
valproic acid	low	1
fluoxetine	low	1
gentamicin	low	1
halothane	low	2
2-propanol	low	1
apnea	low	1
primidone	low	1
propofol	low	1
sevoflurane	low	4
thalidomide	low	1
alanine	low	1
kanamycin a	low	1
medroxyprogesterone acetate	low	1
medroxyprogesterone	low	1
glycopyrrolate	low	1
cladribine	low	1
titanium	low	2
trolamine salicylate	low	2
propiconazole	low	5
fomesafen	low	1
cephalosporin c	low	1
atropine	low	1
inositol 3-phosphate	low	4
trichostatin a	low	1
tretinoin	low	3
cocaine	low	2
mercaptopurine	low	1
pica	low	1
quinine	low	1
misoprostol	low	1
phenylephrine hydrochloride	low	6
fluorapatite	low	1
beta-sitosterol oleate	low	2
jaw	low	1
cardiovascular agents	low	1
transforming growth factor beta	low	1
eye	low	6

Protein Targets (663)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	12	0	0	12
GLI family zinc finger 3	16	0	0	16
AR protein	15	0	0	15
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	13	0	0	13
estrogen nuclear receptor alpha	19	0	0	19
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	7	0	0	7
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
lamin isoform A-delta10	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutamate receptor 2	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	6	0	0	6
GALC protein	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
glucocorticoid receptor [Homo sapiens]	11	0	0	11
estrogen-related nuclear receptor alpha	16	0	0	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	5	0	0	5
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	7	0	0	7
geminin	9	0	0	9
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	5	0	0	5
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	4	2	1	7
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	11
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	1	5
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	14	0	14
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	11
Carbonic anhydrase 2	0	5	1	10
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	1	3
Carbonic anhydrase 3	0	2	1	5
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	4	1	5
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	5	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	5	1	6
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	3	1	4
5-hydroxytryptamine receptor 2A	0	5	0	5
Androgen receptor	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	4	2	1	7
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	1	7
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Carbonic anhydrase 4	0	2	1	4
Carbonic anhydrase 6	0	2	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	1	7
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	1	7
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	1	7
Adenosine receptor A2a	0	2	0	2
5-hydroxytryptamine receptor 2B	0	5	0	5
Sodium-dependent serotonin transporter	0	5	0	6
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	4	1	5
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	1	5
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	2	1	4
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-3	4	2	1	7
Gamma-aminobutyric acid receptor subunit beta-2	4	2	1	7
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	4	2	1	7
Canalicular multispecific organic anion transporter 1	0	11	0	11
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	1	0	2
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	2	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
ATAD5 protein, partial	5	0	0	5
TDP1 protein	13	0	0	13
Microtubule-associated protein tau	6	0	0	6
D(1A) dopamine receptor	4	0	0	4
neuropeptide S receptor isoform A	3	0	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	5	0	0	5
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	3	2	0	5
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	2	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	1	1	6
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	1	1	2
pregnane X nuclear receptor	11	0	0	11
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	3	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	7	1	11
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	1	11
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	8	0	8
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	2	1	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
thyroid stimulating hormone receptor	8	0	0	8
Cellular tumor antigen p53	15	0	0	15
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
glp-1 receptor, partial	3	0	0	3
Fumarate hydratase	3	0	0	3
Smad3	1	0	0	1
farnesoid X nuclear receptor	10	0	0	10
G	8	0	0	8
polyprotein	3	0	0	3
67.9K protein	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
thyroid hormone receptor beta isoform 2	9	0	0	9
huntingtin isoform 2	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	5	0	0	5
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Deoxycytidine kinase	0	0	0	1
Adenosine receptor A3	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Inositol hexakisphosphate kinase 1	8	0	0	8
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent noradrenaline transporter	0	8	1	9
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium-dependent serotonin transporter	0	6	2	8
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	6	1	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sodium-dependent dopamine transporter	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	3	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	8	0	0	8
regulator of G-protein signaling 4	5	0	0	5
peroxisome proliferator activated receptor gamma	10	0	0	10
caspase-3	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Caspase-7	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
chromobox protein homolog 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Albumin	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	7	0	7
ATP-dependent translocase ABCB1	0	5	1	7
Alpha-2A adrenergic receptor	0	3	0	3
Angiotensin-converting enzyme	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
Alpha-1B adrenergic receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	4	0	4
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Alpha-1A adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 6	0	4	0	4
Cytochrome P450 2J2	0	1	0	1
Spike glycoprotein	6	0	1	7
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Beta-2 adrenergic receptor	0	1	0	1
Histamine H3 receptor	0	1	0	1
Luciferase	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
vitamin D3 receptor isoform VDRA	6	0	0	6
Chain A, Cruzipain	4	0	0	4
Albumin	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Chymotrypsinogen A	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
PINK1	2	0	0	2
Parkin	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
pregnane X receptor	5	0	0	5
nonstructural protein 1	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
Estrogen receptor	0	3	2	6
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	3	1	4
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	4	0	4
Alpha-synuclein	2	1	0	3
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	3	2	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
phosphopantetheinyl transferase	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
aryl hydrocarbon receptor	4	0	0	4
hemoglobin subunit beta	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
acetylcholinesterase	2	0	0	2
dopamine D1 receptor	1	0	0	1
USP1 protein, partial	4	0	0	4
flap endonuclease 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Chain A, Ferritin light chain	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Chain A, CES1 protein	0	1	0	1
PPM1D protein	2	0	0	2
DNA polymerase III, partial	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
M-phase phosphoprotein 8	2	0	0	2
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
unnamed protein product	0	0	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 3	0	4	0	6
5-hydroxytryptamine receptor 3A	0	1	0	1
Histone deacetylase 3	0	1	0	1
Plasma kallikrein	0	1	0	1
Coagulation factor VII	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Vitamin D3 receptor	0	1	0	1
Tissue factor	0	2	0	2
Adenosine receptor A1	0	1	0	1
Histone deacetylase 4	0	4	1	8
Histone deacetylase 2	0	1	0	1
Histone deacetylase 1	0	4	2	8
Splicing factor 3B subunit 3	0	1	0	1
Histone deacetylase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	0	2
Histone deacetylase 7	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	1	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 7	0	4	0	6
Histone deacetylase 11	0	1	0	1
Histone deacetylase 2	0	4	1	7
HD2 type histone deacetylase HDA106	0	2	0	2
Polyamine deacetylase HDAC10	0	4	0	6
Histone deacetylase 11	0	4	0	6
Histone deacetylase 9	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 8	0	4	0	6
Histone deacetylase 6	0	4	1	7
Histone deacetylase 9	0	4	0	6
Histone deacetylase 5	0	4	0	6
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Histone deacetylase	0	1	0	1
Cocaine esterase	0	1	0	1
Bile salt export pump	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Craniofacial Microsomia

Synonyms(21)

Research Excerpts

Overview

Research

Studies (63)

Drugs Studied (47)

Protein Targets (663)