fluoxetine has been researched along with Genetic Predisposition in 24 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of fluoxetine, which is a selective serotonin reuptake inhibitor antidepressant widely used in clinical practice, to mice of this strain weakened catalepsy and normalized the number of rosette-forming cells in the spleen." | 5.36 | Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. ( Alperina, EL; Bazovkina, DV; Di, VY; Idova, GV; Kulikov, AV; Popova, NK; Tikhonova, MA; Tolstikova, TG, 2010) |
| "Fluoxetine was the first selective serotonin re-uptake inhibitor to be widely available for treatment of depression and numerous other neuropsychiatric disorders." | 4.82 | Safety and side effect profile of fluoxetine. ( Wernicke, JF, 2004) |
| "The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×10(8))." | 3.83 | Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State. ( Al'perina, EL; Gevorgyan, MM; Idova, GV; Kulikov, AV; Tikhonova, MA, 2016) |
| " The present studies tested the possibility that the El mouse model of genetically predisposed/handling-triggered epilepsy would exhibit fewer seizures following SSRI treatment via dietary fluoxetine adulteration." | 3.74 | Seizure prophylaxis in an animal model of epilepsy by dietary fluoxetine supplementation. ( Heinrichs, SC; Richman, A, 2007) |
| "One hundred and twenty-nine children, 2 to 8 years old, with idiopathic autistic spectrum disorder diagnosed by standard instruments (Childhood Austim Ratings Scale and Autism Diagnostic Observation Schedule) were treated with fluoxetine (0." | 3.71 | Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement. ( Burch, S; DeLong, GR; Ritch, CR, 2002) |
| "Risk factors such as borderline personality disorder and childhood abuse experiences were systematically assessed, and patients were genotyped for polymorphisms of GNbeta3." | 2.72 | Genetic, developmental and personality correlates of self-mutilation in depressed patients. ( Joyce, PR; Kennedy, MA; Luty, SE; McKenzie, JM; Miller, AL; Mulder, RT; Sullivan, PF, 2006) |
| "Fluoxetine treatment reversed learned helplessness-induced changes in many long noncoding RNAs and target genes." | 1.48 | Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment. ( Dwivedi, Y; Roy, B; Wang, Q, 2018) |
| " Chronic administration of fluoxetine, which is a selective serotonin reuptake inhibitor antidepressant widely used in clinical practice, to mice of this strain weakened catalepsy and normalized the number of rosette-forming cells in the spleen." | 1.36 | Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. ( Alperina, EL; Bazovkina, DV; Di, VY; Idova, GV; Kulikov, AV; Popova, NK; Tikhonova, MA; Tolstikova, TG, 2010) |
| "Fluoxetine therapy was started and gradually increased over 2 months." | 1.33 | Long-term improvement of slow-channel congenital myasthenic syndrome with fluoxetine. ( Abicht, A; Colomer, J; Gonzalez, V; Lochmüller, H; Müller, JS; Nascimento, A; Pons, M; Vernet, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (62.50) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roy, B | 1 |
| Wang, Q | 1 |
| Dwivedi, Y | 1 |
| Saponara, E | 1 |
| Visentin, M | 1 |
| Baschieri, F | 1 |
| Seleznik, G | 1 |
| Martinelli, P | 1 |
| Esposito, I | 1 |
| Buschmann, J | 1 |
| Chen, R | 1 |
| Parrotta, R | 1 |
| Borgeaud, N | 1 |
| Bombardo, M | 1 |
| Malagola, E | 1 |
| Caflisch, A | 1 |
| Farhan, H | 1 |
| Graf, R | 1 |
| Sonda, S | 1 |
| Urkasemsin, G | 1 |
| Olby, NJ | 1 |
| Gevorgyan, MM | 1 |
| Idova, GV | 2 |
| Al'perina, EL | 1 |
| Tikhonova, MA | 2 |
| Kulikov, AV | 2 |
| Kassa, FA | 1 |
| Van Den Ham, K | 1 |
| Rainone, A | 1 |
| Fournier, S | 1 |
| Boilard, E | 1 |
| Olivier, M | 1 |
| Tsai, SJ | 4 |
| Hong, CJ | 3 |
| Liou, YJ | 2 |
| Yu, YW | 3 |
| Chen, TJ | 3 |
| Hou, SJ | 2 |
| Yen, FC | 2 |
| Chen, ML | 1 |
| Alperina, EL | 1 |
| Tolstikova, TG | 1 |
| Bazovkina, DV | 1 |
| Di, VY | 1 |
| Popova, NK | 1 |
| El Yacoubi, M | 1 |
| Popa, D | 1 |
| Martin, B | 1 |
| Zimmer, L | 1 |
| Hamon, M | 1 |
| Adrien, J | 1 |
| Vaugeois, JM | 1 |
| Takashima, N | 1 |
| Odaka, YS | 1 |
| Sakoori, K | 1 |
| Akagi, T | 1 |
| Hashikawa, T | 1 |
| Morimura, N | 1 |
| Yamada, K | 1 |
| Aruga, J | 1 |
| Sghendo, L | 1 |
| Mifsud, J | 1 |
| DeLong, GR | 1 |
| Ritch, CR | 1 |
| Burch, S | 1 |
| Wernicke, JF | 1 |
| Wang, YC | 1 |
| Lin, WK | 1 |
| Licinio, J | 2 |
| O'Kirwan, F | 1 |
| Irizarry, K | 1 |
| Merriman, B | 1 |
| Thakur, S | 1 |
| Jepson, R | 1 |
| Lake, S | 1 |
| Tantisira, KG | 1 |
| Weiss, ST | 1 |
| Wong, ML | 2 |
| Huang, SC | 1 |
| Chang, JC | 1 |
| Tupal, S | 1 |
| Faingold, CL | 1 |
| Joyce, PR | 1 |
| McKenzie, JM | 1 |
| Mulder, RT | 1 |
| Luty, SE | 1 |
| Sullivan, PF | 1 |
| Miller, AL | 1 |
| Kennedy, MA | 1 |
| Colomer, J | 1 |
| Müller, JS | 1 |
| Vernet, A | 1 |
| Nascimento, A | 1 |
| Pons, M | 1 |
| Gonzalez, V | 1 |
| Abicht, A | 1 |
| Lochmüller, H | 1 |
| Whelan, F | 1 |
| Deloukas, P | 1 |
| Whittaker, P | 1 |
| Delgado, M | 1 |
| Cantor, RM | 1 |
| McCann, SM | 1 |
| Richman, A | 1 |
| Heinrichs, SC | 1 |
| Liu, Z | 1 |
| Zhu, F | 1 |
| Wang, G | 1 |
| Xiao, Z | 1 |
| Tang, J | 1 |
| Liu, W | 1 |
| Wang, H | 1 |
| Liu, H | 1 |
| Wang, X | 1 |
| Wu, Y | 1 |
| Cao, Z | 1 |
| Li, W | 1 |
| Bhansali, P | 1 |
| Dunning, J | 1 |
| Singer, SE | 1 |
| David, L | 1 |
| Schmauss, C | 1 |
| Pletnikov, MV | 1 |
| Rubin, SA | 1 |
| Vogel, MW | 1 |
| Moran, TH | 1 |
| Carbone, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00265291] | Phase 2 | 700 participants (Actual) | Interventional | 1999-11-30 | Completed | ||
| Genetics of Self-injurious Behaviour[NCT05563324] | 234 participants (Actual) | Observational | 2014-05-09 | Completed | |||
| Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents[NCT05765864] | 400 participants (Anticipated) | Observational | 2023-03-23 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluoxetine and Genetic Predisposition
| Article | Year |
|---|---|
Understanding the molecular pharmacology of the serotonergic system: using fluoxetine as a model.
Topics: Brain; Depressive Disorder; Fluoxetine; Genetic Predisposition to Disease; Humans; Models, Biologica | 2012 |
Safety and side effect profile of fluoxetine.
Topics: Adolescent; Adult; Biotransformation; Bipolar Disorder; Cardiovascular Diseases; Child; Comorbidity; | 2004 |
4 trials available for fluoxetine and Genetic Predisposition
| Article | Year |
|---|---|
Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Fluoxetine; Gene Frequ | 2009 |
Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.
Topics: Adult; Antidepressive Agents; Anxiety; Depressive Disorder; Desipramine; Double-Blind Method; Female | 2004 |
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2006 |
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2006 |
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2006 |
Genetic, developmental and personality correlates of self-mutilation in depressed patients.
Topics: Adolescent; Adult; Alleles; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2006 |
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Aged; Antidepressive Agents; Cyclic Nucleotide Phosphodi | 2006 |
18 other studies available for fluoxetine and Genetic Predisposition
| Article | Year |
|---|---|
Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Depression; Disease Models, Ani | 2018 |
Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transdifferentiati | 2018 |
Clinical characteristics of Scottie Cramp in 31 cases.
Topics: Animals; Breeding; Cerebellum; Dog Diseases; Dogs; Female; Fluoxetine; Genetic Predisposition to Dis | 2015 |
Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State.
Topics: Adjuvants, Immunologic; Animals; Antidepressive Agents; Antigen-Presenting Cells; Depression; Drug E | 2016 |
Absence of apolipoprotein E protects mice from cerebral malaria.
Topics: Animals; Apolipoproteins E; Blood-Brain Barrier; Brain; Cytokines; Disease Models, Animal; Disease R | 2016 |
Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Fluoxetine; Gene Frequ | 2009 |
Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes.
Topics: Animals; Antidepressive Agents; Brain; Catalepsy; Fluoxetine; Genetic Predisposition to Disease; Mal | 2010 |
Genetic association between helpless trait and depression-related phenotypes: evidence from crossbreeding studies with H/Rouen and NH/Rouen mice.
Topics: Anhedonia; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Dietary Sucrose; | 2012 |
Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia.
Topics: Adaptation, Psychological; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition; Di | 2011 |
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.
Topics: Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; Cluster Analysis; Depressive Disorder, | 2002 |
Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder.
Topics: Adult; Antidepressive Agents, Second-Generation; Case-Control Studies; Depressive Disorder; Female; | 2004 |
Fluoxetine-induced memory impairment in four family members.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Depressive Disorder, Major; Fe | 2004 |
Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.
Topics: Animals; Cyproheptadine; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Ep | 2006 |
Long-term improvement of slow-channel congenital myasthenic syndrome with fluoxetine.
Topics: Adolescent; Cholinesterase Inhibitors; DNA Mutational Analysis; Dose-Response Relationship, Drug; Dr | 2006 |
Seizure prophylaxis in an animal model of epilepsy by dietary fluoxetine supplementation.
Topics: Animal Feed; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Fluoxet | 2007 |
Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders.
Topics: Adult; Antidepressive Agents; Brain; China; Corticotropin-Releasing Hormone; Depressive Disorder, Ma | 2007 |
Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.
Topics: Age Factors; Animals; Anxiety, Separation; Body Weight; Depressive Disorder; Emotions; Environment; | 2007 |
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Diseases; Animals; Animals, Newborn; Borna Disease; B | 2002 |