| Assay ID | Title | Year | Journal | Article |
|---|
| AID107563 | Inhibition of 2-[125I]iodomelatonin binding to melatonin receptor in quail brain | 1993 | Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
| 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. |
| AID108040 | Relative Intrinsic activity evaluated on [35S]GTP-gamma-S, binding in NIH3T3 cells stably transfected with human Melatonin receptor type 1B | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. |
| AID107400 | Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to N-acetyl-5-methoxytryptamine (aMT)) | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
| Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. |
| AID107876 | Relative Intrinsic activity evaluated on [35S]GTP-gamma-S, binding in NIH3T3 cells stably transfected with human Melatonin receptor type 1A | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. |
| AID227176 | Activity considered from GTP-gamma-S and cAMP index values;A-PA= agonist-partial agonist | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID107536 | Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines. |
| AID107381 | Pigment aggregation response in Xenopus laevis Melanophores at 10e-8 M of concentration; Agonist response | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines. |
| AID227388 | GTPgammaS index is the ratio of the IC50 of compound with GTP and without GTP to the IC50 of melatonin with GTP and without GTP | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID1527849 | Displacement of 2-[1251]-iodomelatonin from whole quail brain membrane melatonin receptor | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Indole-based melatonin analogues: Synthetic approaches and biological activity. |
| AID107567 | Inhibition of 2-[125I]iodomelatonin binding to melatonin receptor in quail brain as 1/Ka | 1993 | Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
| 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. |
| AID230718 | Relative binding to melatonin receptor compared to melatonin, ratio of IC50 | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID227181 | Activity considered from GTP-gamma-S index and cAMP index; AN = Antagonist | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID108056 | Relative Binding Affinity (pRA1) to cloned human Melatonin receptor type 1B, stably expressed in NIH3T3 rat fibroblast cells, determined using 2-[125I]iodomelatonin | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. |
| AID1858345 | Agonist activity at human MT1 Q181A mutant receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as shift in concentration response curve i | 2022 | RSC medicinal chemistry, Oct-19, Volume: 13, Issue:10
| Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. |
| AID107559 | Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligand | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID230719 | Ratio of the IC50 of compound to the IC50 of melatonin | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID1858344 | Agonist activity at human MT1 N162A mutant receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as shift in concentration response curve i | 2022 | RSC medicinal chemistry, Oct-19, Volume: 13, Issue:10
| Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. |
| AID227390 | Inhibition of forskolin stimulated cAMP accumulation and represented as cAMP index which is the ratio of percent inhibition to percent inhibition of melatonin | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID107558 | Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID107549 | Compound was tested in vivo for its activity against melatonin receptor in Syrian hamster gonadal regression model; Antagonist | 1993 | Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
| 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. |
| AID1858339 | Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by T | 2022 | RSC medicinal chemistry, Oct-19, Volume: 13, Issue:10
| Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. |
| AID1858340 | Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by T | 2022 | RSC medicinal chemistry, Oct-19, Volume: 13, Issue:10
| Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. |
| AID108023 | Relative Binding Affinity (pRA1) to cloned human Melatonin receptor type 1A, stably expressed in NIH3T3 rat fibroblast cells, determined using 2-[125I]iodomelatonin | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8
| Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. |
| AID227389 | GTPgammaS index is the ratio of the IC50 of compound with GTP and without GTP to the IC50 of melatonin with GTP and without GTP | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID107565 | Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. |
| AID107569 | Compound was tested in vivo for its activity against melatonin receptor in rabbit parietal cortex model; Mixed activity | 1993 | Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
| 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. |
| AID107564 | Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin (100 pM) as labelled ligand | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID227391 | Inhibition of forskolin stimulated cAMP accumulation and represented as cAMP index which is the ratio of percent inhibition to percent inhibition of melatonin | 1997 | Journal of medicinal chemistry, Jun-20, Volume: 40, Issue:13
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. |
| AID1858343 | Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by T | 2022 | RSC medicinal chemistry, Oct-19, Volume: 13, Issue:10
| Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |