fluoxetine has been researched along with norfluoxetine in 266 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.38) | 18.7374 |
| 1990's | 89 (33.46) | 18.2507 |
| 2000's | 94 (35.34) | 29.6817 |
| 2010's | 63 (23.68) | 24.3611 |
| 2020's | 11 (4.14) | 2.80 |
| Authors | Studies |
|---|---|
| Baumann, MH; Hufeisen, SJ; McBride, A; Rauser, L; Roth, BL; Rothman, RB; Savage, JE | 1 |
| Choi, BH; Choi, JS; Hahn, SJ; Jo, YH; Kim, MS; Min, DS; Rhie, DJ; Yoon, SH | 1 |
| Dormann, SM; Haefeli, WE; Kerpen, CJ; Ketabi-Kiyanvash, N; Martin-Facklam, M; Weiss, J | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Sen, S; Sinha, N | 1 |
| Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA | 1 |
| Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
| Choi, Y; Raymer, BK | 1 |
| Fuller, RW; Krushinski, JH; Robertson, DW; Snoddy, HD | 1 |
| Bizzi, A; Caccia, S; Coltro, G; Fracasso, C; Frittoli, E; Garattini, S; Mennini, T | 1 |
| Anelli, M; Bizzi, A; Caccia, S; Codegoni, AM; Fracasso, C; Garattini, S | 1 |
| Fuller, RW; Perry, KW | 1 |
| Clancy, K; Fava, M; Flood, JG; Gonzalez, RG; Guimaraes, AR; Pearlman, JD; Puopolo, PR; Renshaw, PF; Rosenbaum, JF | 1 |
| Aspeslet, LJ; Baker, GB; Coutts, RT; McKenna, KF; Torok-Both, GA | 1 |
| Diquet, B; Thomare, P; Van Der Meersch-Mougeot, V; Wang, K | 1 |
| Cooper, TB; Suckow, RF; Zhang, MF | 1 |
| Bergstrom, RF; Lemberger, L; Peyton, AL | 1 |
| Burch, KJ; Wells, BG | 1 |
| Keck, PE; McElroy, SL | 1 |
| Lasher-Sisson, TA; Steenwyk, RC; Swanson, CN; Wright, CE | 1 |
| Fuller, RW; Snoddy, HD | 2 |
| Burger, RL; Dailey, JW; Jobe, PC; Mishra, PK; Yan, QS | 1 |
| DeVane, CL; Murphy, DL; Pato, MT | 1 |
| Carpenter, R; Peyton, AL; Rutkowski, K | 1 |
| Brøsen, K; Skjelbo, E | 1 |
| Antal, EJ; Fleishaker, JC; Lasher, TA; Steenwyk, RC | 1 |
| Griffiths, HW; Marshall, EF; Tyrer, SP | 1 |
| Dixit, V; Dixit, VM; Nguyen, H | 1 |
| Asberg, M; Mårtensson, B; Montero, D; Siwers, B; Wgner, A | 1 |
| Caccia, S; Cappi, M; Fracasso, C; Garattini, S | 1 |
| Isenberg, KE | 1 |
| Dellafera, SS; Fernandes, R; Kranzler, H; Wong, SH | 1 |
| Bertilsson, L; Brodin, E; Mårtensson, B; Nyberg, S; Toresson, G | 1 |
| Byrd, TK; Hamilton, M; Koons, JR; Pohland, RC | 1 |
| Garvey, MJ; Holstad, SG; Kelly, MW; Perry, PJ | 1 |
| Downs, AD; Downs, JM | 1 |
| Crowley, G; Debus, JR; Kenney, JT; Orsulak, PJ; Wittman, PD | 1 |
| Bergstrom, RF; Lemberger, L; Schenker, S; Wolen, RL | 1 |
| Bemis, KG; Bymaster, FP; Holland, DR; Smallwood, JK; Steinberg, MI | 1 |
| Aronoff, GR; Bergstrom, RF; Lemberger, L; Pottratz, ST; Sloan, RS; Wolen, RL | 1 |
| Bopp, RJ; Carmichael, RH; Farid, KZ; Lemberger, L; Nash, JF | 1 |
| Bushnell, WD; Kreider, MS; Oakes, R; Wheadon, DE | 1 |
| Chaleby, K; el-Yazigi, A; Gad, A; Raines, DA | 1 |
| Barbadoro, S; Fairman, M; Steiner, M; Stewart, DE; Zownir, P | 1 |
| Charlson, JR; Lawson, GM; Nichols, JH | 1 |
| Armitage, R; Battaglia, J; Cain, JW; Debus, JR; Grannemann, BD; Hendrickse, WA; Orsulak, PJ; Roffwarg, HP; Rush, AJ | 1 |
| Castro-Silva, O; Curti, C; Polizello, AC; Souza, ME; Uyemura, SA | 1 |
| Coutaux, AF; Mooney, JJ; Wirth, DF | 1 |
| Cardwell, D; Karson, CN; Komoroski, RA; Newton, JE; Pearce, J; Sprigg, J | 1 |
| Baker, GB; Goodnough, DB | 1 |
| Markovitz, PJ; Schwartz, EM | 1 |
| el-Yazigi, A; Raines, DA | 1 |
| Anderson, GD; Gidal, BE; Miyoshi, HR; Seaton, TL; Wilenksy, AJ | 1 |
| Beasley, CM; Bergstrom, RF; Blumenfield, M; Lemberger, L; Levy, NB | 1 |
| Ceccherini-Nelli, A; Guidi, L | 1 |
| Chanut, E; Dessalles, MC; Gardier, AM; Jacquot, C; Lepoul, E; Trouvin, JH | 1 |
| Braun, BG; Fichtner, CG; Jobe, TH | 1 |
| Koponen, H; Leinonen, E; Lepola, U | 1 |
| Bonini, M; Combourieu, I; Creppy, EE; el Maanni, A | 1 |
| Stevens, JC; Wrighton, SA | 1 |
| Amitai, Y; DeSandre, P; Fawcett, J; Frischer, H; Kennedy, E | 1 |
| Burrows, GD; Gupta, RK; Judd, FK; Norman, TR; Parker, G | 1 |
| Cheung, SW; Joffe, RT; Otton, SV; Sellers, EM; Wu, D | 1 |
| Coplan, JD; Gorman, JM | 1 |
| Grey, P | 1 |
| Bopp, RJ; Farid, KZ; Koons, J; Lantz, RJ; Tenbarge, JB | 1 |
| Bymaster, FP; Krushinski, JH; Mayle, DA; Reid, LR; Robertson, DW; Wong, DT | 1 |
| Binkley, SN; Ring, BJ; Roskos, L; Wrighton, SA | 1 |
| Baker, GB; Coutts, RT; Goodnough, DB | 1 |
| Hashimoto, K; Minabe, Y; Narita, N; Tomitaka, S | 1 |
| Baker, GB; Holt, A | 1 |
| Cua, W; Dominguez, RA; Kumar, AM | 1 |
| Baumann, P; Eap, CB; Gaillard, N; Powell, K | 1 |
| Allard, S; Johnson, M; Piergies, AA; Roth-Schechter, BF; Sweet, J | 1 |
| Hietala, J; Kuoppamäki, M; Laakso, A; Majasuo, H; Pälvimäki, EP; Roth, BL; Syvälahti, E | 1 |
| Duan, SX; Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; von Moltke, LL; Wright, CE | 2 |
| Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; von Moltke, LL | 1 |
| Cain, JW; Dominguez, RA; Koran, LM; Rush, AJ; Thiemann, S | 1 |
| Burke, WJ; Hendricks, SE; Jacques, D; McArthur-Campbell, D; Stull, T | 1 |
| Lauterbach, EC; Shillcutt, SD | 1 |
| Karnes, HT; March, C; Ramaiya, A | 1 |
| Bessard, G; Fontanille, P; Jourdil, N; Villier, C | 1 |
| Amsterdam, JD; Beasley, CM; Fawcett, J; Hornig-Rohan, M; Michelson, D; Quitkin, FM; Reimherr, FW; Rosenbaum, JF | 1 |
| Ito, S; Koren, G | 1 |
| Anelli, M; Bergami, A; Caccia, S; Confalonieri, S; Fracasso, C; Garattini, S | 1 |
| Bernhard, NR; Pohland, RC | 1 |
| Crifasi, JA; Le, NX; Long, C | 1 |
| Coccaro, EF; Kavoussi, RJ | 1 |
| Dewey, MJ; Holladay, JW; Yoo, SD | 2 |
| Gundert-Remy, U; Kress, I; Meineke, I; Schreeb, K | 1 |
| Altieri, I; Avenoso, A; Pacifici, R; Pellegrini, M; Perucca, E; Pichini, S; Spina, E; Zuccaro, P | 1 |
| Advenier, C; Alvarez, JC; Bothua, D; Collignon, I; Spreux-Varoquaux, O | 1 |
| Belpaire, FM; Brøsen, K; Rasmussen, BB; Temmerman, A; Wijnant, P | 1 |
| Mattes, JA | 1 |
| Addison, RS; Franklin, ME; Hooper, WD | 1 |
| Bugamelli, F; Casamenti, G; Mandrioli, R; Raggi, MA; Volterra, V | 1 |
| Battaglia, G; Garcia, F; Muma, NA; Raap, DK; van de Kar, LD; Wolf, WA | 1 |
| Mukherjee, J; Yang, ZY | 1 |
| Bourdeaux, R; Capolaghi, B; Desor, D; Lehr, PR; Younos, C | 1 |
| Choi, JS; Hahn, SJ; Jo, YH; Kim, MS; Rhie, DJ; Yoon, SH | 1 |
| Bezerra, FA; Corso, G; De Nucci, G; Lerner, FE; Moraes, ME; Moraes, MO | 1 |
| Begg, EJ; Hackett, LP; Ilett, KF; Kristensen, JH; Paech, M; Yapp, P | 1 |
| Desiderio, C; Fanali, S; Raggi, MA; Rudaz, S | 1 |
| Dremencov, E; Gur, E; Lerer, B; Newman, ME | 1 |
| Czachura, JF; Rasmussen, K | 1 |
| Court, MH; Duan, SX; Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL | 1 |
| Bruhwyler, J; Decamp, E; Dresse, A; Géczy, J; Lejeune, C; Liégeois, JF; Masset, H; Scuvée-Moreau, J; Seutin, V; Szejtli, J; Szente, L; Van Heugen, JC | 1 |
| Skrinska, VA; Wong, SH; Yee, L | 1 |
| Birnbaum, AK; Nelson, MH; Remmel, RP | 1 |
| Harvey, AT; Preskorn, SH | 1 |
| Bengtsson, F; Lundmark, J; Reis, M | 1 |
| Albano, D; Amchin, J; Ereshefsky, L; Klockowski, PM; Taylor, K; Zarycranski, W | 1 |
| D'Souza, DL; Dimmitt, DC; Koch, KM; Nezamis, J; Robbins, DK; Simms, L | 1 |
| Binkley, SN; Eckstein, JA; Gillespie, JS; Ring, BJ; VandenBranden, M; Wrighton, SA | 1 |
| Badenhorst, D; de Jager, AD; Hundt, AF; Hundt, HK; Scanes, T; Sutherland, FC; Swart, KJ | 1 |
| Baumann, P; Bondolfi, G; Eap, CB; Kosel, M; Powell-Golay, K; Savary-Cosendai, L; Zullino, D | 1 |
| Chen, XP; Cheng, ZN; Huang, SL; Jiang, CH; Liu, ZQ; Ou-Yang, DS; Zhou, HH | 1 |
| Cheng, ZN; Liu, ZQ; Ou-Yang, DS; Tan, ZR; Wang, W; Zhou, HH | 1 |
| Altshuler, LL; Fukuchi, A; Hendrick, V; Hostetter, A; Hwang, S; Leight, K; Mintz, J; Stowe, ZN; Suri, R | 1 |
| He, N; Huang, SL; Liu, ZQ; Shu, Y; Wang, LS; Zhou, HH | 1 |
| Amsterdam, JD; Beasley, CM; Brunswick, DJ; Fawcett, J; Quitkin, FM; Reimherr, FW; Rosenbaum, JF | 2 |
| Berzas Nevado, JJ; Contento Salcedo, AM; Villaseñor Llerena, MJ | 1 |
| Altshuler, LL; Hendrick, V; Hostetter, A; Stowe, ZN; Suri, R; Widawski, M | 1 |
| Ekblad, U; Heikkine, T; Laine, K | 1 |
| Cui, J; Dai, J; Huang, B; Ji, Z; Li, C; Liu, P; Nan, F; Shao, Q; Xu, F; Yu, C; Yuan, H; Zhang, M; Zhen, J | 1 |
| Gatti, G; Guarneri, L; Jannuzzi, G; Magni, P; Pacifici, R; Perucca, E; Spina, E; Torta, R; Zuccaro, P | 1 |
| Jiang, A; LoGrasso, PV; Stearns, BA; Trauger, JW | 1 |
| Berecz, R; Cáceres, M; de la Rubia, A; Dorado, P; González, A; Jesús Norberto, M; LLerena, A | 1 |
| Abrams, A; Biederman, J; Cohen, L; Faird, N; Neft, D; Sinha, V; Wilens, TE | 1 |
| Ginovart, N; Houle, S; Hussey, D; Meyer, JH; Wilson, AA | 1 |
| Ulrich, S | 1 |
| Conca, A; Hubmann, MR; König, P; Moll, W; Waschgler, R | 1 |
| Bonomi, I; Fattore, C; Gatti, G; Marchiselli, R; Pacifici, R; Perucca, E; Scordo, G; Spina, E | 1 |
| Fukushima, T; Guo, X; Imai, K; Li, F | 1 |
| Drafts, BC; Fisher, JL; Robinson, RT | 1 |
| Ekblad, U; Heikkinen, T; Laine, K; Palo, P | 1 |
| Ciribassi, J; Kaloostian-Whittymore, L; Luescher, A; Pasloske, KS; Robertson-Plouch, C; Zimmerman, A | 1 |
| Cherkaoui, S; Mottaz, M; Souverain, S; Veuthey, JL | 1 |
| Anderson, GM; Czarkowski, K; Epperson, CN; Jatlow, PI | 1 |
| Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Thompson, MR | 1 |
| Berecz, R; Dorado, P; González, AP; LLerena, A; Peñas-LLedó, EM | 1 |
| Borrelli, B; Cook, JW; Hitsman, B; Keuthen, NJ; Kristeller, J; McChargue, DE; Niaura, R; Spring, B | 1 |
| Kim, J; Riggs, KW; Rurak, DW | 1 |
| Costa, E; Guidotti, A; Pinna, G | 4 |
| Li, KM; McGregor, IS; Thompson, MR | 1 |
| Aalto, S; Hietala, J; Hirvonen, J; Ilonen, T; Kajander, J; Någren, K; Penttilä, J; Syvälahti, E | 1 |
| Bányász, T; Kecskeméti, V; Magyar, J; Nánási, PP; Szentandrássy, N | 1 |
| Bugamelli, F; Fanali, S; Mercolini, L; Musenga, A; Raggi, MA; Sabbioni, C; Saracino, MA; Varani, G | 1 |
| Banfield, C; Flannery, B; Gupta, S; Herron, J; Kantesaria, B | 1 |
| Cameron, OG; Guthrie, SK; Phan, KL; Teter, CJ | 1 |
| Armstrong, SJ; Chumbley, JR; Kennard, LE; Mathie, A; Ranatunga, KM; Veale, EL | 1 |
| Banks, KE; Brooks, BW; Chambliss, CK; Johnson, RD; Lewis, RJ; Ramirez, A; Stanley, JK | 1 |
| Djordjevic, S; Kovacevic, I; Miljkovic, B; Pokrajac, M; Vuksanovic, J | 1 |
| Abdel-Razaq, W; Bates, TE; Kendall, DA; Richards, JK | 1 |
| Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R | 1 |
| Cambon, N; Crivelli, F; Crivelli, M; Dal, BL; Genevray, M; Ismaili, S; Keller, T; Marzo, A; Mazzucchelli, P | 1 |
| Dahl, ML; Gatti, G; Perucca, E; Scordo, MG; Spina, E | 1 |
| Chen, L; Guo, B; Li, C; Wang, G | 1 |
| Lambert, WE; Maudens, KE; Van Peteghem, CH; Wille, SM | 1 |
| Jovanovic, D; Kovacevic, I; Miljkovic, B; Pokrajac, M; Prostran, M | 1 |
| Fitzgerald, C; Grunau, RE; Kent, N; Kim, J; Misri, S; Oberlander, TF; Riggs, KW; Rurak, DW | 1 |
| Chemin, J; Kupfer, E; Lory, P; Nargeot, J; Traboulsie, A | 1 |
| Chassard, D; Hermann, P; Puozzo, C | 1 |
| Carboni, G; Nelson, M; Pibiri, F; Pinna, G | 1 |
| Anderson, CL; Anson, BD; Delisle, BP; Eckhardt, LL; Gillman, BM; Holzem, KM; January, CT; Klemens, CA; Makielski, JC; Rajamani, S; Valdivia, CR | 1 |
| Marchi, I; Rudaz, S; Selman, M; Veuthey, JL | 1 |
| Alves, C; Fernandes, C; Lanças, FM; Neto, AJ; Rodrigues, JC | 1 |
| Barrio, RJ; Barrondo, S; Goicolea, MA; Gómez-Caballero, A; Ruiz de Azúa, I; Sallés, J; Unceta, N | 1 |
| Abdel-Razaq, W; Bates, TE; Kendall, DA | 2 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
| Chu, S; Metcalfe, CD | 1 |
| Cameron, MD; Gulati, A; Miller, BH; Pletcher, MT; Schultz, LE | 1 |
| Ferrance, J; Jong, YJ; Ko, WK; Lu, CC; Wu, SM | 1 |
| Angier, MK; Johnson, RD; Lewis, RJ | 1 |
| Mårtensson, L; Mathiasson, L; Zorita, S | 1 |
| Hirai, N; Kondo, T; Nakamura, Y; Sekizawa, J; Tatarazako, N; Yamamoto, H | 1 |
| Alves, C; Fernandes, C; Lanças, FM; Rodrigues, JC; Santos-Neto, AJ | 1 |
| Barrio, RJ; Goicolea, MA; Gómez-Caballero, A; Millán, S; Sallés, J; Sampedro, MC; Sánchez, A; Unceta, N | 1 |
| Costa, E; Guidotti, A; Nelson, M; Pibiri, F; Pinna, G | 1 |
| Agis-Balboa, RC; Costa, E; Guidotti, A; Nelson, M; Pibiri, F; Pinna, G | 1 |
| Bévalot, F; Fanton, L; Gaillard, Y; Grait, H; Le Meur, C; Malicier, D | 1 |
| Cheng, XP; Lu, YG; Sun, H; Xu, TL; Ye, ZY; Zhou, JN | 1 |
| Fong, PP; Molnar, N | 1 |
| Metcalfe, CD; Paterson, G | 1 |
| Agis-Balboa, RC; Nelson, M; Pibiri, F; Pinna, G | 1 |
| Gross, S; Oh, JE; Toth, M; Zupan, B | 1 |
| Aluisio, L; Boggs, J; Hoey, K; Lord, B; Lovenberg, T; Mazur, C; Qu, Y | 1 |
| de Freitas, DF; de Siqueira, ME; Porto, CE; Vieira, EP | 1 |
| Borges, F; Calheiros, R; Garrido, EM; Garrido, J; Marques, MP | 1 |
| Lanças, FM; Queiroz, ME; Silva, BJ | 1 |
| Kamath, N; Kandasamy, M; Kristjansson, F; Pai, B; Ravi, S; Srinivas, NR; Thangam, S; Tripathy, K | 1 |
| Allen, KE; Babu, KN; Hanson, KL; Kunze, KL; Nelson, WL; VandenBrink, BM | 1 |
| Helsel, JC; Luther, JF; Perel, JM; Sit, D; Wisner, KL; Wisniewski, SR | 1 |
| Able, JA; Jandacek, R; McNamara, RK; Rider, T; Tso, P | 1 |
| Nelson, M; Pinna, G | 1 |
| Escher, BI; Neuwoehner, J | 1 |
| Li, Z; Liu, Y; Shi, S; Wu, J; Zeng, F; Zhao, Y; Zhong, D | 1 |
| Chow, TW; Riggs, KW; Rurak, DW; Szeitz, A | 1 |
| Emm, T; Li, Y; Yeleswaram, S | 1 |
| Barclay, VK; Johansson, IM; Pettersson, CE; Tyrefors, NL | 2 |
| Howell, LL; Sawyer, EK | 1 |
| Burger, R; Egberts, K; Fegert, JM; Gerlach, M; Kliegl, K; Koelch, M; Ludolph, AG; Mehler-Wex, C; Pfalzer, AK; Rothenhöfer, S; Stingl, J; Taurines, R | 1 |
| Jiang, H; Wang, S; Yu, L; Zeng, S; Zhou, H | 1 |
| de Figueiredo, EC; Dos Santos-Neto, AJ; Oliveira, AF | 1 |
| Johansen, SS; Nielsen, MK | 1 |
| Cooper, P; Damoiseaux, R; Krogstad, P; Kye, S; Quinn, KK; Zuo, J | 1 |
| Abts, F; Charlier, TD; Fillet, M; Houbart, V; Pawluski, JL; Servais, AC | 1 |
| Corbett, A; Flannery, T; McGowin, A; Sibbitt, B; Sieber, S | 1 |
| Babu, KN; Isoherranen, N; Kunze, KL; Lutz, JD; Nelson, WL; VandenBrink, BM | 1 |
| Asensi-Bernardi, L; Escuder-Gilabert, L; Martín-Biosca, Y; Medina-Hernández, MJ; Sagrado, S | 1 |
| Afonso, CM; Castro, PM; Maia, AS; Moreira, IS; Ribeiro, AR; Tiritan, ME | 1 |
| Able, JA; Jandacek, R; Liu, Y; McNamara, RK; Rider, T; Tso, P | 1 |
| Hu, H; Huang, M; Wang, S; Wang, Z; Yu, L; Zeng, S | 1 |
| Davis, C; Foti, RS; Isoherranen, N; Kunze, KL; Lutz, JD; Sager, JE | 1 |
| Elbe, D; Wicholas, L | 1 |
| Abrams, Z; Charlier, TD; Fillet, M; Houbart, V; Pawluski, JL; Steinbusch, HW; van Donkelaar, E | 1 |
| Begg, EJ; Bournissen, FG; Ilett, KF; Ito, S; Kristensen, JH; Taddio, A; Tanigawara, Y; Tanoshima, R; Wallach, I | 1 |
| Afonso, CM; Castro, PM; Moreira, IS; Ribeiro, AR; Tiritan, ME | 1 |
| Garcia, P; Höcht, C; Laino, CH; Podestá, MF; Reinés, A; Slobodianik, N | 1 |
| Cumming, RI; de Polo, A; Margiotta-Casaluci, L; Owen, SF; Panter, GH; Rand-Weaver, M; Sumpter, JP; Winter, MJ | 1 |
| Garland, M; Shoulson, RL; Stark, RL | 1 |
| Aryal, P; Brennan, PE; Burgess-Brown, NA; Cao, L; Carpenter, EP; Clausen, MV; Dong, L; Dong, YY; Goubin, S; Grieben, M; Mackenzie, A; McClenaghan, C; Mukhopadhyay, S; Pike, AC; Quigley, A; Ruda, GF; Sansom, MS; Tucker, SJ | 1 |
| Caris, JA; Chaves, AR; Moura, BH; Queiroz, ME; Rabelo, D | 1 |
| Huang, S; Jiang, R; Liu, Y; Ouyang, G; Wu, R; Xu, J; Yang, M; Zhu, F | 1 |
| Bebianno, MJ; Gonzalez-Rey, M; Lino, CM; Martins, MC; Meisel, LM; Pena, A; Pereira, AMPT; Silva, LJG | 1 |
| Barden, R; Kasprzyk-Hordern, B; Petrie, B; Youdan, J | 1 |
| Manoharan, A; Muthuramalingam, A; Paul, A; Rajkumar, RP; Shewade, DG; Sundaram, R | 1 |
| Alvim, J; Cass, QB; Lopes, BR | 1 |
| Caron, P; Guillemette, C; Hudon Thibeault, AA; Laurent, L; Sanderson, JT; Sauvé, S; Vaillancourt, C; Vo Duy, S | 1 |
| Brose, SA; Golovko, MY; Henry, LK; Krout, D; Rodriquez, M; Thompson, BJ | 1 |
| Cai, JP; Dai, DP; Fang, P; Han, AX; He, JY; Hu, GX; Lan, T | 1 |
| Ansermot, N; Csajka, C; Eap, CB; Grosjean, D; Hascoët, JM; Nguyen, KA; Panchaud, A; Weisskopf, E | 1 |
| Benham, RS; Engin, E; Hewage, NB; Rudolph, U; Suckow, RF | 1 |
| Lino, CM; Meisel, LM; Pena, A; Pereira, AMPT; Rodrigues, H; Silva, LJG | 1 |
| Hucher, N; Knigge, T; Monsinjon, T; Robert, A; Schultz, IR | 1 |
| Alves, G; Falcão, A; Llerena, A; Magalhães, P | 1 |
| Antunes, MV; da Silva, ACC; Hahn, RZ; Linden, R; Perassolo, MS; Peteffi, GP; Raasch, JR; Vargas, TG | 1 |
| Andrés-Costa, MJ; Gee, AP; Kasprzyk-Hordern, B; Lewis, SE; Pico, Y; Proctor, K; Sabatini, MT | 1 |
| Carvalho, DM; Cass, QB; Cassiano, NM; Lopes, BR; Moisés, ECD | 1 |
| Gu, JG; Ling, J; Viatchenko-Karpinski, V | 1 |
| Carvalho, DM; Cavalli, RC; Duarte, G; Filgueira, GCO; Lanchote, VL; Moisés, ECD; Nardotto, GHB | 1 |
| Clabault, H; Cohen, M; Sanderson, JT; Vaillancourt, C | 1 |
| Baker, GB; Churchward, MA; Dhami, KS; Todd, KG | 1 |
| Chung, YC; Jin, BK; Kim, KI | 1 |
| Bao, X; Ji, Y; Jiang, R; Liu, J; Lu, G; Sun, H; Yan, Z | 1 |
| Doucet, N; Hudon Thibeault, AA; López de Los Santos, Y; Sanderson, JT; Vaillancourt, C | 1 |
| Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB | 1 |
| Hsieh, MM; Wang, ZR | 1 |
| Braunbeck, T; Loerracher, AK; Tisler, S; Zindler, F; Zwiener, C | 1 |
| Cunha, V; Ferreira, M; Guimarães, L; Oliva-Teles, L; Rodrigues, P | 1 |
| Bao, X; Ji, Y; Ling, X; Liu, J; Lu, G; Yan, Z; Yang, H; Zhang, X | 1 |
| Güven, C; Över, SB; Sevgiler, Y; Taskin, E | 1 |
| Baukrowitz, T; Carpenter, EP; Conrad, LJ; Proks, P; Rao, S; Rathje, K; Rödström, KEJ; Schewe, M; Tucker, SJ | 1 |
| Chae, YJ; Jeong, HC; Kang, W; Lee, S; Shin, KH; Yun, HY | 1 |
| Chávez-Castillo, CE; González-Salinas, CG; Medellín-Garibay, SE; Milán-Segovia, RDC; Romano-Moreno, S; Sagahón-Azúa, J | 1 |
| Chen, Y; Lu, G; Yan, Z; Zhang, X | 1 |
| An, H; Fang, J; Ge, Z; He, Z; Hu, B; Lin, H; Sun, Y; Wang, M; Wei, Y | 1 |
8 review(s) available for fluoxetine and norfluoxetine
| Article | Year |
|---|---|
Ion channels as therapeutic targets: a drug discovery perspective.
Topics: Drug Discovery; Humans; Ion Channels; Models, Molecular; Phylogeny | 2013 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
Sleep modulating agents.
Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agents | 2019 |
The effects of renal and hepatic disease on the pharmacokinetics, renal tolerance, and risk-benefit profile of fluoxetine.
Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluoxetine; Humans; Kidney Diseases; Kidney Function Tests; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged | 1993 |
Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Fluoxetine; Humans; Isoenzymes; Oxidoreductases, N-Demethylating; Pharmacokinetics; Selective Serotonin Reuptake Inhibitors | 1996 |
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Fluoxetine; GABA Modulators; Humans; Pregnanes; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereoisomerism | 2006 |
Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aggression; Anabolic Agents; Androstanes; Animals; Behavior, Animal; Down-Regulation; Fear; Female; Fluoxetine; Frontal Lobe; Male; Mice; Muscle, Skeletal; Nandrolone; Organ Size; Pregnanolone; Receptors, GABA-A; RNA, Messenger; Social Isolation; Stanozolol; Stereotyped Behavior; Synaptic Transmission; Testosterone Propionate | 2008 |
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
Topics: Animals; Brain; Fluoxetine; gamma-Aminobutyric Acid; Humans; Mental Disorders; Mood Disorders; Pregnanolone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Social Isolation; Synaptic Transmission | 2009 |
32 trial(s) available for fluoxetine and norfluoxetine
| Article | Year |
|---|---|
Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine.
Topics: Adult; Affect; Alprazolam; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Fluoxetine; Humans; Male; Psychomotor Performance; Spectrophotometry, Ultraviolet | 1991 |
A double-blind, randomized study to provide safety information on switching fluoxetine-treated patients to paroxetine without an intervening washout period.
Topics: Adult; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; Half-Life; Humans; Incidence; Male; Paroxetine; Placebos; Substance Withdrawal Syndrome; Time Factors | 1995 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline | 1995 |
Follicular and late luteal phase serum fluoxetine levels in women suffering from late luteal phase dysphoric disorder.
Topics: Adult; Double-Blind Method; Female; Fluoxetine; Follicular Phase; Humans; Luteal Phase; Middle Aged; Premenstrual Syndrome; Prospective Studies | 1994 |
Fluoxetine: the relationship between response, adverse events, and plasma concentrations in the treatment of bulimia nervosa.
Topics: Adult; Bulimia; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans | 1993 |
Relationship between antidepressant response and plasma concentrations of fluoxetine and norfluoxetine.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales | 1993 |
Lack of change in fluoxetine and norfluoxetine kinetics when switching from fluoxetine to paroxetine.
Topics: Adult; Aged; Cytochrome P-450 CYP2D6 Inhibitors; Depressive Disorder; Double-Blind Method; Drug Interactions; Female; Fluoxetine; Humans; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors | 1996 |
The effect of co-administration of zolpidem with fluoxetine: pharmacokinetics and pharmacodynamics.
Topics: Adult; Analysis of Variance; Area Under Curve; Biological Availability; Drug Administration Schedule; Drug Interactions; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Psychomotor Performance; Pyridines; Selective Serotonin Reuptake Inhibitors; Zolpidem | 1996 |
Are fluoxetine plasma levels related to outcome in obsessive-compulsive disorder?
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Probability; Psychiatric Status Rating Scales; Research Design; Severity of Illness Index; Sex Factors; Stereoisomerism; Treatment Outcome | 1996 |
Fluoxetine and norfluoxetine serum concentrations and clinical response in weekly versus daily dosing.
Topics: Adult; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Psychiatric Status Rating Scales | 1996 |
Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study.
Topics: Adult; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Prospective Studies; Psychiatric Status Rating Scales; Sex Factors; Treatment Outcome | 1997 |
Fluoxetine and impulsive aggressive behavior in personality-disordered subjects.
Topics: Adult; Aggression; Double-Blind Method; Fluoxetine; Humans; Impulsive Behavior; Male; Patient Dropouts; Personality Disorders; Placebos; Psychiatric Status Rating Scales; Serotonin; Treatment Outcome | 1997 |
Fluoxetine bioequivalence study: quantification of fluoxetine and norfluoxetine by liquid chromatography coupled to mass spectrometry.
Topics: Adolescent; Adult; Area Under Curve; Chromatography, Liquid; Cross-Over Studies; Data Interpretation, Statistical; Female; Fluoxetine; Humans; Male; Mass Spectrometry; Selective Serotonin Reuptake Inhibitors; Tablets; Therapeutic Equivalency | 1999 |
Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe.
Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Cyclohexanols; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Female; Fluoxetine; Humans; Male; Metabolic Clearance Rate; Phenotype; Selective Serotonin Reuptake Inhibitors; Time Factors; Urinalysis; Venlafaxine Hydrochloride | 2001 |
Effect of alosetron on the pharmacokinetics of fluoxetine.
Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Biological Availability; Carbolines; Colon; Colonic Diseases, Functional; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluoxetine; Genotype; Half-Life; Humans; Isoenzymes; Male; Metabolic Clearance Rate; Middle Aged; Serotonin Antagonists; Time Factors | 2001 |
Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers.
Topics: Adult; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Psychotic Disorders; Statistics, Nonparametric; Stereoisomerism | 2001 |
Fluoxetine and norfluoxetine plasma concentrations during relapse-prevention treatment.
Topics: Adolescent; Adult; Aged; Depressive Disorder, Major; Double-Blind Method; Drug Administration Schedule; Female; Fluoxetine; Humans; Long-Term Care; Male; Middle Aged; Recurrence; Treatment Outcome | 2002 |
Liquid chromatography/tandem mass spectrometry for the determination of fluoxetine and its main active metabolite norfluoxetine in human plasma with deuterated fluoxetine as internal standard.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Calibration; Chromatography, Liquid; Deuterium; Fluoxetine; Half-Life; Humans; Male; Mass Spectrometry; Quality Control; Reference Standards; Reproducibility of Results; Solvents | 2002 |
Fluoxetine pharmacokinetics in pediatric patients.
Topics: Adolescent; Child; Female; Fluoxetine; Humans; Male; Mental Disorders; Prospective Studies; Selective Serotonin Reuptake Inhibitors | 2002 |
Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation.
Topics: Adult; Child Development; Female; Fluoxetine; Humans; Infant, Newborn; Lactation; Male; Milk, Human; Pregnancy; Prospective Studies | 2003 |
Comparative bioavailability of fluoxetine after transdermal and oral administration to healthy cats.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Biological Availability; Cats; Dose-Response Relationship, Drug; Fluoxetine; Half-Life; Selective Serotonin Reuptake Inhibitors | 2003 |
Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Drug Interactions; Female; Fluoxetine; Genotype; Humans; Male; Mental Disorders; Middle Aged; Phenotype; Selective Serotonin Reuptake Inhibitors | 2004 |
Influence of fluoxetine on positive and negative affect in a clinic-based smoking cessation trial.
Topics: Adult; Affect; Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Combined Modality Therapy; Depression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Models, Psychological; Personality Inventory; Psychiatric Status Rating Scales; Regression Analysis; Smoking Cessation; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2004 |
Effects of fluoxetine on dopamine D2 receptors in the human brain: a positron emission tomography study with [11C]raclopride.
Topics: Adult; Brain Chemistry; Brain Mapping; Fluoxetine; Humans; Male; Neostriatum; Positron-Emission Tomography; Putamen; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Selective Serotonin Reuptake Inhibitors; Thalamus | 2004 |
Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.
Topics: Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Electrocardiography; Female; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors | 2004 |
Relative rectal bioavailability of fluoxetine in normal volunteers.
Topics: Administration, Rectal; Adult; Biological Availability; Biotransformation; Capsules; Cross-Over Studies; Female; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors | 2005 |
Bioequivalence study of fluoxetine hydrochloride in healthy volunteers.
Topics: Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; Fluoxetine; Half-Life; Humans; Male; Mass Spectrometry; Middle Aged; Selective Serotonin Reuptake Inhibitors; Therapeutic Equivalency | 2005 |
Lack of pharmacokinetic interaction when switching from fluoxetine to milnacipran.
Topics: Adult; Area Under Curve; Cyclopropanes; Cytochrome P-450 CYP2D6; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Half-Life; Humans; Male; Metabolic Clearance Rate; Methods; Milnacipran; Nausea; Selective Serotonin Reuptake Inhibitors; Time Factors; Vomiting | 2006 |
Unsuspected poor metabolizer phenotypes of fluoxetine in bioavailability/bioequivalence studies from an indian population perspective. Retrospective pharmacokinetic data evaluation.
Topics: Adult; Antidepressive Agents, Second-Generation; Biological Availability; Biotransformation; Cross-Over Studies; Double-Blind Method; Fluoxetine; Humans; India; Male; Phenotype; Population; Retrospective Studies; Therapeutic Equivalency; Young Adult | 2010 |
Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Humans; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Psychiatric Status Rating Scales; Stereoisomerism | 2010 |
Comparative bioavailability and tolerability of a single 20-mg dose of two fluoxetine hydrochloride dispersible tablet formulations in fasting, healthy Chinese male volunteers: an open-label, randomized-sequence, two-period crossover study.
Topics: Adult; Area Under Curve; Biological Availability; China; Chromatography, Liquid; Cross-Over Studies; Drugs, Generic; Fasting; Fluoxetine; Half-Life; Humans; Male; Selective Serotonin Reuptake Inhibitors; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult | 2010 |
Therapeutic drug monitoring of children and adolescents treated with fluoxetine.
Topics: Adolescent; Age Factors; Child; Cohort Studies; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Monitoring; Feasibility Studies; Female; Fluoxetine; Humans; Male; Selective Serotonin Reuptake Inhibitors; Sex Characteristics; Smoking; Young Adult | 2012 |
226 other study(ies) available for fluoxetine and norfluoxetine
| Article | Year |
|---|---|
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergonovine; Norfenfluramine; Receptors, Serotonin; Serotonin Antagonists | 2000 |
Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1.
Topics: Algorithms; Animals; Brain; Cloning, Molecular; Fluoxetine; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Selective Serotonin Reuptake Inhibitors; Shaw Potassium Channels | 2001 |
Inhibition of P-glycoprotein by newer antidepressants.
Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection | 2003 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Fluoxetine; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred ICR; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereoisomerism | 1992 |
Anorectic activity of fluoxetine and norfluoxetine in rats: relationship between brain concentrations and in-vitro potencies on monoaminergic mechanisms.
Topics: Animals; Appetite Depressants; Biogenic Monoamines; Brain Chemistry; Fluoxetine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Synaptosomes | 1992 |
Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs.
Topics: Animals; Appetite Depressants; Brain; Fluoxetine; Guinea Pigs; Male; Mice; Rats; Species Specificity | 1992 |
Comparison of fluoxetine and norfluoxetine enantiomers as inhibitors of hexobarbitone metabolism in mice.
Topics: Animals; Brain; Drug Interactions; Fluoxetine; Hexobarbital; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Stereoisomerism | 1992 |
Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration.
Topics: Adult; Brain; Confidence Intervals; Depressive Disorder; Female; Fluorine; Fluoxetine; Humans; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder | 1992 |
Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection.
Topics: Animals; Brain Chemistry; Chromatography, Gas; Female; Fluoxetine; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1992 |
Sensitive micromethod for column liquid chromatographic determination of fluoxetine and norfluoxetine in human plasma.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1992 |
Sensitive and selective liquid-chromatographic assay of fluoxetine and norfluoxetine in plasma with fluorescence detection after precolumn derivatization.
Topics: Chromatography, Liquid; Dansyl Compounds; Fluoxetine; Humans; Mass Spectrometry; Reproducibility of Results; Spectrometry, Fluorescence | 1992 |
Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction.
Topics: Adult; Desipramine; Drug Evaluation; Drug Interactions; Fluoxetine; Humans; Imipramine; Male; Middle Aged | 1992 |
Fluoxetine/norfluoxetine concentrations in human milk.
Topics: Adult; Breast Feeding; Depression; Female; Fluoxetine; Humans; Infant; Infant, Newborn; Milk, Human; Puerperal Disorders | 1992 |
Ratio of plasma fluoxetine to norfluoxetine concentrations and associated sedation.
Topics: Adult; Bulimia; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Sleep; Sleep Stages | 1992 |
A pharmacokinetic evaluation of the combined administration of triazolam and fluoxetine.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Interactions; Fluoxetine; Humans; Middle Aged; Tablets; Triazolam | 1992 |
Role of norfluoxetine in the inhibition of desipramine metabolism and in the inhibition of serotonin uptake after fluoxetine administration to rats.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Depression, Chemical; Desipramine; Fluoxetine; Hydroxyindoleacetic Acid; Liver; Male; Rats; Rats, Inbred Strains | 1991 |
Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.
Topics: Animals; Brain; Dialysis; Epilepsy; Female; Fluoxetine; Male; Rats; Seizures; Serotonin; Thalamus | 1992 |
Sustained plasma concentrations of fluoxetine and/or norfluoxetine four and eight weeks after fluoxetine discontinuation.
Topics: Fluoxetine; Humans; Obsessive-Compulsive Disorder; Time Factors | 1991 |
The stereospecific determination of fluoxetine and norfluoxetine enantiomers in human plasma by high-pressure liquid chromatography (HPLC) with fluorescence detection.
Topics: Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyanates; Fluorescence; Fluoxetine; Humans; Isocyanates; Naphthalenes; Reproducibility of Results; Stereoisomerism | 1991 |
Fluoxetine and norfluoxetine are potent inhibitors of P450IID6--the source of the sparteine/debrisoquine oxidation polymorphism.
Topics: Fluoxetine; Humans; Imipramine; Microsomes, Liver; Polymorphism, Genetic | 1991 |
The relationship between response to fluoxetine, plasma drug levels, imipramine binding to platelet membranes and whole-blood 5-HT.
Topics: Biomarkers; Biotransformation; Blood Platelets; Carrier Proteins; Cell Membrane; Depressive Disorder; Dexamethasone; Fluoxetine; Humans; Hydrocortisone; Imipramine; Receptors, Drug; Receptors, Neurotransmitter; Serotonin | 1990 |
Solid-phase extraction of fluoxetine and norfluoxetine from serum with gas chromatography-electron-capture detection.
Topics: Chromatography, Gas; Fluoxetine; Humans | 1991 |
Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder.
Topics: Adult; Aged; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Fluoxetine; Humans; Imipramine; Male; Middle Aged; Receptors, Drug; Receptors, Neurotransmitter; Serotonin | 1990 |
Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat.
Topics: Administration, Oral; Animals; Brain; Fluoxetine; Half-Life; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
Excretion of fluoxetine in human breast milk.
Topics: Adult; Breast Feeding; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newborn; Milk, Human; Puerperal Disorders | 1990 |
Determination of fluoxetine and norfluoxetine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Clomipramine; Depression; Fluoxetine; Humans | 1990 |
Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid.
Topics: Adult; Aged; Depressive Disorder; Female; Fluoxetine; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Peptide Fragments; Substance P | 1989 |
Placental transfer and fetal distribution of fluoxetine in the rat.
Topics: Animals; Autoradiography; Female; Fetus; Fluoxetine; Maternal-Fetal Exchange; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
Serum fluoxetine and norfluoxetine concentrations and antidepressant response.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoxetine; Half-Life; Humans; Male; Middle Aged; Random Allocation | 1989 |
Effect of fluoxetine on metabolism of tricyclic antidepressants in the lungs.
Topics: Desipramine; Female; Fluoxetine; Humans; Liver; Lung | 1989 |
Determination of the antidepressant fluoxetine and its metabolite norfluoxetine in serum by reversed-phase HPLC with ultraviolet detection.
Topics: Antidepressive Agents; Chromatography, High Pressure Liquid; Fluoxetine; Half-Life; Humans; Propylamines; Reference Values | 1988 |
Fluoxetine disposition and elimination in cirrhosis.
Topics: Adult; Aged; Fluoxetine; Humans; Indocyanine Green; Liver; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Propylamines | 1988 |
Hemodynamic and electrocardiographic effects of fluoxetine and its major metabolite, norfluoxetine, in anesthetized dogs.
Topics: Amitriptyline; Animals; Cardiac Output; Dogs; Electrocardiography; Female; Fluoxetine; Heart Rate; Hemodynamics; Male; Propylamines; Serotonin; Stroke Volume; Vascular Resistance | 1986 |
Fluoxetine kinetics and protein binding in normal and impaired renal function.
Topics: Administration, Oral; Blood Proteins; Fluoxetine; Half-Life; Humans; Kidney Diseases; Kinetics; Male; Propylamines; Protein Binding | 1984 |
Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.
Topics: Chromatography, Gas; Electrons; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Propylamines | 1982 |
Automated HPLC assay of fluoxetine and norfluoxetine in serum.
Topics: Autoanalysis; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Quality Control; Sensitivity and Specificity | 1994 |
The effects of fluoxetine on the polysomnogram of depressed outpatients: a pilot study.
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Pilot Projects; Polysomnography; Reaction Time; Sleep | 1994 |
Effect of fluoxetine on rat liver mitochondria.
Topics: Animals; Dose-Response Relationship, Drug; Energy Metabolism; Fluoxetine; Ketoglutaric Acids; Male; Mitochondria, Liver; Proton-Translocating ATPases; Rats; Rats, Wistar; Succinates; Succinic Acid | 1994 |
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
Topics: 1-Naphthylamine; Animals; Chloroquine; Desipramine; Drug Resistance; Drug Synergism; Fluoxetine; Neurotransmitter Uptake Inhibitors; Plasmodium falciparum; Sertraline | 1994 |
In vivo 19F spin relaxation and localized spectroscopy of fluoxetine in human brain.
Topics: Adolescent; Adult; Aged; Brain; Brain Chemistry; Electron Spin Resonance Spectroscopy; Equipment Design; Female; Fluorine; Fluoxetine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Structural | 1994 |
5-Hydroxytryptamine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination.
Topics: Animals; Brain; Cerebral Cortex; Desipramine; Drug Combinations; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Time Factors | 1994 |
Fluoxetine responsivity mediated by serum levels, not dose.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluoxetine; Humans; Middle Aged | 1993 |
Concurrent liquid chromatographic measurement of fluoxetine, amitriptyline, imipramine, and their active metabolites norfluoxetine, nortriptyline, and desipramine in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Fluoxetine; Humans; Imipramine; Indicators and Reagents; Nortriptyline; Spectrophotometry, Ultraviolet | 1993 |
Evaluation of the effect of fluoxetine on the formation of carbamazepine epoxide.
Topics: Animals; Carbamazepine; Drug Evaluation, Preclinical; Drug Interactions; Fluoxetine; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Perfusion; Rats; Rats, Sprague-Dawley | 1993 |
Changes in dopamine metabolism in rat forebrain regions after cessation of long-term fluoxetine treatment: relationship with brain concentrations of fluoxetine and norfluoxetine.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Male; Nucleus Accumbens; Prosencephalon; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1994 |
Possible therapeutic window for serotonin reuptake inhibitors.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Humans; Suicide | 1994 |
Delirium during fluoxetine treatment. A case report.
Topics: Aged; Delirium; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluoxetine; Humans; Metabolic Clearance Rate; Risk Factors | 1993 |
Fluoxetine, an antidepressant, and norfluoxetine, its metabolite, determined by HPLC with a C8 column and ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans | 1993 |
Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Fluoxetine; Humans; Kinetics; Liver; Male; Mixed Function Oxygenases; Quinidine; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1993 |
Red cell and plasma concentrations of fluoxetine and norfluoxetine.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Fluoxetine; Humans; In Vitro Techniques; Plasma | 1993 |
Inhibition by fluoxetine of cytochrome P450 2D6 activity.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Fluoxetine; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Multiple Sclerosis; Oxidation-Reduction; Oxycodone; Phenotype; Selective Serotonin Reuptake Inhibitors | 1993 |
Detectable levels of fluoxetine metabolites after discontinuation: an unexpected serotonin syndrome.
Topics: Adult; Depressive Disorder; Drug Interactions; Female; Fluoxetine; Half-Life; Humans; Monoamine Oxidase Inhibitors; Serotonin | 1993 |
Fluoxetine and onset of its therapeutic effect.
Topics: Affect; Depressive Disorder; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans | 1993 |
Determination of fluoxetine and norfluoxetine in human plasma by capillary gas chromatography with electron-capture detection.
Topics: Calibration; Chromatography, Gas; Drug Stability; Electrons; Fluorocarbons; Fluoxetine; Humans; Indicators and Reagents; Reproducibility of Results; Toluene | 1993 |
Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain.
Topics: Animals; Antidepressive Agents; Atomoxetine Hydrochloride; Brain; Dose-Response Relationship, Drug; Fluoxetine; Male; Paroxetine; Propylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1993 |
Drug concentrations in mouse brain at pharmacologically active doses of fluoxetine enantiomers.
Topics: Animals; Brain Chemistry; Fluoxetine; Male; Mice; Mice, Inbred ICR; p-Chloroamphetamine; Serotonin; Stereoisomerism | 1993 |
Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.
Topics: 1-Naphthylamine; Catalysis; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors; Sertraline | 1995 |
Simultaneous quantification of fluoxetine, norfluoxetine, and desipramine using gas chromatography with nitrogen-phosphorus detection.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Chromatography, Gas; Desipramine; Drug Interactions; Fluoxetine; Liver; Male; Mass Spectrometry; Nitrogen; Phosphorus; Rats; Rats, Sprague-Dawley; Reference Standards; Tissue Distribution | 1995 |
Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Fluoxetine; Imipramine; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1996 |
Inhibition of rat brain monoamine oxidase enzymes by fluoxetine and norfluoxetine.
Topics: Animals; Binding, Competitive; Brain; Dialysis; Fluoxetine; Hydroxyindoleacetic Acid; Kinetics; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley | 1996 |
Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry.
Topics: Fluoxetine; Fluvoxamine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 1996 |
Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.
Topics: Animals; Antidepressive Agents, Tricyclic; Choroid Plexus; Citalopram; Fluoxetine; Imipramine; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors | 1996 |
Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.
Topics: Anesthetics, Intravenous; Anti-Anxiety Agents; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluoxetine; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors | 1996 |
Dyskinesia with fluoxetine: tardive or late-onset persistent, acute norfluoxetine dyskinesia?
Topics: Acute Disease; Animals; Diagnosis, Differential; Dyskinesia, Drug-Induced; Fluoxetine; Humans; Movement Disorders; Rats; Terminology as Topic | 1997 |
Single pump column switching technique employing a flow gradient and wavelength programmed fluorescence for simultaneous monitoring of serotonin, fluoxetine and norfluoxetine in rat brain microdialysate.
Topics: Animals; Calibration; Drug Monitoring; Fluoxetine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Serotonin | 1997 |
Direct analysis of fluoxetine and norfluoxetine in plasma by gas chromatography with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Fluoxetine; Humans; Nitrogen; Phosphorus; Reproducibility of Results; Sensitivity and Specificity | 1997 |
Antidepressants and breast-feeding.
Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Female; Fluoxetine; Humans; Infant, Newborn; Milk, Human | 1997 |
Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine.
Topics: Administration, Oral; Animals; Appetite Depressants; Body Weight; Brain Chemistry; Catecholamines; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hippocampus; Indoles; Male; Norfenfluramine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereoisomerism; Time Factors | 1997 |
Human cytochromes mediating N-demethylation of fluoxetine in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Microsomes, Liver; Selective Serotonin Reuptake Inhibitors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1997 |
Postmortem serum and tissue redistribution of fluoxetine and norfluoxetine in dogs following oral administration of fluoxetine hydrochloride (Prozac).
Topics: Administration, Oral; Animals; Dogs; Fluoxetine; Liver; Lung; Male; Myocardium; Postmortem Changes; Tissue Distribution | 1997 |
Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS.
Topics: Antidepressive Agents, Second-Generation; Calibration; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Quality Control; Reference Standards | 1997 |
Pharmacokinetics and antidepressant activity of fluoxetine in transgenic mice with elevated serum alpha-1-acid glycoprotein levels.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Brain Chemistry; Female; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Orosomucoid; Swimming; Time Factors | 1998 |
Routine measurement of fluoxetine and norfluoxetine by high-performance liquid chromatography with ultraviolet detection in patients under concomitant treatment with tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Drug Monitoring; Fluoxetine; Humans; Polypharmacy; Selective Serotonin Reuptake Inhibitors; Stereoisomerism; Ultraviolet Rays | 1998 |
Issues in methodology and applications for therapeutic drug monitoring of fluoxetine and norfluoxetine enantiomers.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1998 |
Quantification of fluoxetine and norfluoxetine serum levels by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Fluoxetine; Hydrogen-Ion Concentration; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Quality Control; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity | 1997 |
Determination of fluoxetine and its metabolite norfluoxetine in serum and brain areas using high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Calibration; Caudate Nucleus; Chromatography, High Pressure Liquid; Fluoxetine; Mice; Prefrontal Cortex; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1998 |
The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.
Topics: 1-Naphthylamine; Adult; Anti-Arrhythmia Agents; Child; Citalopram; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Kinetics; Male; Methylation; Metoprolol; Microsomes, Liver; Oxidation-Reduction; Paroxetine; Quinidine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1998 |
Fluoxetine and norfluoxetine.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1998 |
Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies.
Topics: Adult; Antidepressive Agents, Second-Generation; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity | 1998 |
Determination of fluoxetine and norfluoxetine in human plasma by high-pressure liquid chromatography with fluorescence detection.
Topics: Calibration; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Molecular Structure; Sensitivity and Specificity; Spectrometry, Fluorescence | 1998 |
Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Brain; Drug Interactions; Fluoxetine; GTP-Binding Protein alpha Subunits, Gi-Go; Hypothalamus; Male; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Serotonin Receptor Agonists; Substance Withdrawal Syndrome | 1999 |
Monoamine oxidase A inhibition by fluoxetine: an in vitro and in vivo study.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Clorgyline; Fluoxetine; In Vitro Techniques; Ligands; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley | 1999 |
Effects of fluoxetine and norfluoxetine on 5-hydroxytryptamine metabolism in blood platelets and brain after administration to rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Blood Platelets; Brain; Fluoxetine; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin | 1998 |
Mechanism of fluoxetine block of cloned voltage-activated potassium channel Kv1.3.
Topics: Animals; Antidepressive Agents, Second-Generation; CHO Cells; Cricetinae; Electrophysiology; Fluoxetine; Humans; Kv1.3 Potassium Channel; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Recombinant Proteins; T-Lymphocytes | 1999 |
Distribution and excretion of fluoxetine and norfluoxetine in human milk.
Topics: Adult; Animals; Breast Feeding; Chromatography, High Pressure Liquid; Female; Fluoxetine; Humans; Infant; Infant, Newborn; Male; Milk; Selective Serotonin Reuptake Inhibitors; Time Factors | 1999 |
Enantiomeric separation of fluoxetine and norfluoxetine in plasma and serum samples with high detection sensitivity capillary electrophoresis.
Topics: Antidepressive Agents, Second-Generation; Electrophoresis, Capillary; Fluoxetine; Humans; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 1999 |
Subchronic fluoxetine administration to rats: effects on 5-HT autoreceptor activity as measured by in vivo microdialysis.
Topics: Animals; Antidepressive Agents; Cyclic AMP; Fluoxetine; Hippocampus; Hypothalamus; Microdialysis; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin | 2000 |
Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Fluoxetine; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Neurons; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2000 |
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
Topics: Antibodies; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Paroxetine; Piperazines; Sertraline; Triazoles | 2000 |
The inclusion of fluoxetine into gamma-cyclodextrin increases its bioavailability: behavioral, electrophysiological and pharmacokinetic studies.
Topics: Adolescent; Adult; Animals; Biological Availability; Cyclodextrins; Fluoxetine; gamma-Cyclodextrins; Humans; Male; Mice; Middle Aged; Prospective Studies; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Swimming | 2000 |
Chiral high-performance liquid chromatographic analysis of fluoxetine and norfluoxetine in rabbit plasma, urine, and vitreous humor using an acetylated beta-cyclodextrin column.
Topics: Animals; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Fluoxetine; Male; Rabbits; Stereoisomerism; Vitreous Body | 2000 |
Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors.
Topics: Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Child, Preschool; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluoxetine; Humans; Hydroxylation; Male; Microsomes, Liver; Middle Aged; Paroxetine; Phenytoin; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2001 |
Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Male; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors | 2001 |
Serum concentrations of fluoxetine in the clinical treatment setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Child; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Models, Biological | 2001 |
Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Catalysis; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2001 |
Sensitive liquid chromatographic-tandem mass spectrometric method for the determination of fluoxetine and its primary active metabolite norfluoxetine in human plasma.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Mass Spectrometry; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity | 2001 |
Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Biotransformation; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Fluoxetine; Gene Dosage; Genotype; Humans; Liver; Male; Mixed Function Oxygenases; Mutation; Oxidation-Reduction; Polymorphism, Genetic; Selective Serotonin Reuptake Inhibitors | 2001 |
Determination of fluoxetine and its metabolite norfluoxetine in human liver microsomes by reversed-phase HPLC in vitro.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; In Vitro Techniques; Microsomes, Liver | 2000 |
Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk.
Topics: Breast Feeding; Depression, Postpartum; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate; Milk, Human; Pregnancy | 2001 |
Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Fluoxetine; Humans; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic; Selective Serotonin Reuptake Inhibitors; Sulfaphenazole | 2001 |
Fluoxetine and norfluoxetine plasma levels after discontinuing fluoxetine therapy.
Topics: Depression; Fluoxetine; Humans; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome | 2001 |
Micellar electrokinetic capillary chromatography for the determination of fluoxetine and its metabolite norfluoxetine in biological fluids.
Topics: Chromatography, Micellar Electrokinetic Capillary; Fluoxetine; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity | 2002 |
Estimates of nursing infant daily dose of fluoxetine through breast milk.
Topics: Adult; Antidepressive Agents, Second-Generation; Breast Feeding; Depression, Postpartum; Female; Fluoxetine; Humans; Infant; Infant, Newborn; Lactation; Milk, Human; Models, Biological | 2002 |
Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.
Topics: Citalopram; Female; Fluoxetine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Prospective Studies; Protein Binding; Selective Serotonin Reuptake Inhibitors | 2002 |
Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Depression; Female; Fluoxetine; Humans; Male; Mental Disorders; Middle Aged; Statistics, Nonparametric; Stereoisomerism | 2002 |
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Carbamazepine; Catalysis; Clozapine; Enzyme Activation; Enzyme Inhibitors; Fluoxetine; Flurbiprofen; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Oxidation-Reduction; Pregnanediones; Pregnanolone; Recombinant Fusion Proteins; Selective Serotonin Reuptake Inhibitors; Substrate Specificity; Ursodeoxycholic Acid | 2002 |
Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Male; Mental Disorders; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2003 |
[11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats.
Topics: Adrenergic Uptake Inhibitors; Animals; Benzylamines; Brain; Carrier Proteins; Cats; Citalopram; Dopamine Antagonists; Fluoxetine; Haloperidol; Maprotiline; Membrane Glycoproteins; Membrane Transport Proteins; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Tranylcypromine | 2003 |
Direct stereoselective assay of fluoxetine and norfluoxetine enantiomers in human plasma or serum by two-dimensional gas-liquid chromatography with nitrogen-phosphorus selective detection.
Topics: Antidepressive Agents, Second-Generation; Chromatography, Gas; Fluoxetine; Humans; Nitrogen; Phosphorus; Reproducibility of Results; Stereoisomerism | 2003 |
Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Chromatography, High Pressure Liquid; Citalopram; Clozapine; Fluoxetine; Humans; Maprotiline; Trazodone | 2002 |
Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography.
Topics: Fluoxetine; Humans; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Stereoisomerism | 2003 |
Determination of fluoxetine and norfluoxetine in rat plasma by HPLC with pre-column derivatization and fluorescence detection.
Topics: Animals; Chromatography, High Pressure Liquid; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Fluoxetine increases GABA(A) receptor activity through a novel modulatory site.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminobutyric Acid; Mammals; Receptors, GABA-A; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors | 2003 |
Rapid analysis of fluoxetine and its metabolite in plasma by LC-MS with column-switching approach.
Topics: Administration, Oral; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2003 |
Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs.
Topics: Adult; Blood Platelets; Depressive Disorder; Female; Fluoxetine; Half-Life; Humans; Infant; Infant, Newborn; Milk, Human; Puerperal Disorders; Selective Serotonin Reuptake Inhibitors; Serotonin | 2003 |
Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Body Fluids; Body Temperature; Body Weight; Brain; Carrier Proteins; Chromatography, High Pressure Liquid; Depression; Drinking; Drug Interactions; Fluoxetine; Immobilization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurotransmitter Agents; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Serotonin Plasma Membrane Transport Proteins; Swimming | 2004 |
Stereoselective pharmacokinetics of fluoxetine and norfluoxetine enantiomers in pregnant sheep.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Female; Fetus; Fluoxetine; Half-Life; In Vitro Techniques; Maternal-Fetal Exchange; Microsomes, Liver; Pregnancy; Pregnancy, Animal; Selective Serotonin Reuptake Inhibitors; Sheep; Stereoisomerism; Time Factors | 2004 |
Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids.
Topics: Animals; Brain; Drug Synergism; Fluoxetine; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereoisomerism | 2004 |
Rapid quantitation of fluoxetine and norfluoxetine in serum by micro-disc solid-phase extraction with high-performance liquid chromatography-ultraviolet absorbance detection.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Reference Standards; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2004 |
Effects of norfluoxetine on the action potential and transmembrane ion currents in canine ventricular cardiomyocytes.
Topics: Action Potentials; Animals; Dogs; Fluoxetine; Ion Channels; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Selective Serotonin Reuptake Inhibitors | 2004 |
A rapid HPLC-DAD method for the analysis of fluoxetine and norfluoxetine in plasma from overdose patients.
Topics: Antidepressive Agents, Second-Generation; Calibration; Chromatography, High Pressure Liquid; Drug Overdose; Fluoxetine; Humans; Indicators and Reagents; Reproducibility of Results; Solutions | 2004 |
Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aggression; Animals; Behavior; Brain; Estrogens; Female; Fluoxetine; Humans; Male; Mice; Motor Activity; Orchiectomy; Ovariectomy; Pregnanolone; Progesterone; Receptors, GABA-A; Testosterone | 2005 |
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine.
Topics: Cell Line; Dose-Response Relationship, Drug; Fluoxetine; Humans; Inhibitory Concentration 50; Mutation; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Tandem Pore Domain; Selective Serotonin Reuptake Inhibitors; Transfection | 2005 |
Determination of select antidepressants in fish from an effluent-dominated stream.
Topics: Animals; Antidepressive Agents; Brain; Fishes; Fluoxetine; Liver; Muscles; Rivers; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors; Water Pollutants, Chemical | 2005 |
Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study.
Topics: Adult; Aged; Chromatography, Liquid; Clinical Trials as Topic; Female; Fluoxetine; Humans; Male; Mass Spectrometry; Middle Aged; Parkinson Disease; Reproducibility of Results; Sensitivity and Specificity | 2005 |
The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system.
Topics: Alkaline Phosphatase; Animals; Antidepressive Agents, Tricyclic; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; GPI-Linked Proteins; Isoenzymes; Phosphorylation; Transcription, Genetic | 2005 |
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cells, Cultured; Clonazepam; Cochlear Nucleus; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Fluoxetine; Male; Membrane Potentials; Mice; Neurons, Afferent; Patch-Clamp Techniques; Phenytoin; Selective Serotonin Reuptake Inhibitors | 2005 |
Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine.
Topics: Adolescent; Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; DNA; Female; Fluoxetine; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 2005 |
Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma.
Topics: Animals; Dogs; Fluoxetine; Male; Protein Binding; Time Factors | 2006 |
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Mianserin; Microchemistry; Mirtazapine; Piperazines; Reproducibility of Results; Sertraline | 2005 |
Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Fluoxetine; Humans; Linear Models; Mass Spectrometry; Spectrometry, Fluorescence | 2006 |
Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding.
Topics: Adult; Aging; Antidepressive Agents, Second-Generation; Breast Feeding; Depressive Disorder, Major; Female; Fetal Blood; Fluoxetine; Humans; Infant, Newborn; Maternal-Fetal Exchange; Milk, Human; Postpartum Period; Pregnancy; Pregnancy Complications; Prospective Studies; Stereoisomerism | 2006 |
T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine.
Topics: Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Fluoxetine; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Recombinant Proteins | 2006 |
Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids.
Topics: Aggression; Androgens; Anesthetics; Animals; Behavior, Animal; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluoxetine; Gene Expression Regulation; Male; Mice; Motor Activity; Pregnanolone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Sex Factors; Social Isolation; Testosterone; Time Factors | 2006 |
Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Blotting, Western; Cell Line; Cell Membrane; Cisapride; Dose-Response Relationship, Drug; Drug Overdose; Ether-A-Go-Go Potassium Channels; Female; Fluoxetine; Humans; Long QT Syndrome; Membrane Potentials; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Protein Transport; Pyridines; Sodium Channels; Time Factors; Transfection | 2006 |
Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis.
Topics: Alanine; Blood Proteins; Chemical Precipitation; Cholecalciferol; Chromatography, Liquid; Flunitrazepam; Fluoxetine; Mass Spectrometry; Methadone; Multivariate Analysis; Online Systems; Pyrrolidines; Solid Phase Extraction | 2007 |
Solid-phase microextraction-liquid chromatography (SPME-LC) determination of fluoxetine and norfluoxetine in plasma using a heated liquid flow through interface.
Topics: Chromatography, High Pressure Liquid; Fluoxetine; Humans; Reproducibility of Results; Solid Phase Microextraction | 2007 |
Determination of fluoxetine, norfluoxetine and their enantiomers in rat plasma and brain samples by liquid chromatography with fluorescence detection.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluoxetine; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2007 |
The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system.
Topics: Alkaline Phosphatase; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; CHO Cells; Clomipramine; Cricetinae; Cricetulus; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Genes, Reporter; Humans; Receptors, Adrenergic, beta-2; Thiazepines; Time Factors; Transcription, Genetic | 2007 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |
Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Fishes; Fluoxetine; Molecular Structure; Paroxetine; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2007 |
Genetic regulation of behavioral and neuronal responses to fluoxetine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bromodeoxyuridine; Cell Differentiation; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluoxetine; Gene Expression Regulation; Hippocampus; Immobility Response, Tonic; Male; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Selective Serotonin Reuptake Inhibitors; Time Factors | 2008 |
On-line sample stacking and short-end injection CE for the determination of fluoxetine and norfluoxetine in plasma: Method development and validation using experimental designs.
Topics: Electrophoresis, Capillary; Fluoxetine; Humans; Reference Standards; Selective Serotonin Reuptake Inhibitors | 2007 |
The distribution of fluoxetine in human fluids and tissues.
Topics: Accidents, Aviation; Body Fluids; Fluoxetine; Forensic Medicine; Humans; Selective Serotonin Reuptake Inhibitors; Tissue Distribution | 2007 |
Hollow-fibre supported liquid membrane extraction for determination of fluoxetine and norfluoxetine concentration at ultra trace level in sewage samples.
Topics: Chemistry; Chemistry, Organic; Chromatography; Fluoxetine; Humic Substances; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Organic Chemicals; Reproducibility of Results; Salts; Sewage; Sodium Chloride; Water Pollutants, Chemical; Water Purification | 2007 |
The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): acute toxicity in fish larvae and bioaccumulation in juvenile fish.
Topics: Animals; Environmental Monitoring; Fishes; Fluoxetine; Hydrogen-Ion Concentration; Larva; Oryzias; Risk Assessment; Tissue Distribution; Water Pollutants, Chemical | 2008 |
Fluoxetine and norfluoxetine analysis by direct injection of human plasma in a column switching liquid chromatographic system.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Molecular Structure; Plasma | 2008 |
Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Humans; Hydrogen-Ion Concentration; Osmolar Concentration; Solid Phase Extraction; Temperature | 2008 |
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain Chemistry; Cerebral Cortex; Fear; Fluoxetine; Gene Expression Regulation; Limbic System; Mice; Models, Animal; Pregnanolone; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress Disorders, Post-Traumatic | 2008 |
Fatal intoxication with milnacipran.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Chromatography, High Pressure Liquid; Cyclopropanes; Female; Fluoxetine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Milnacipran; Nordazepam; Oxazepam; Phenothiazines; Selective Serotonin Reuptake Inhibitors; Sertraline; Suicide | 2008 |
Fluoxetine inhibition of glycine receptor activity in rat hippocampal neurons.
Topics: Animals; Cell Line; Cells, Cultured; Central Nervous System Agents; Dose-Response Relationship, Drug; Fluoxetine; Glycine; Hippocampus; Humans; Membrane Potentials; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Glycine; Selective Serotonin Reuptake Inhibitors | 2008 |
Norfluoxetine induces spawning and parturition in estuarine and freshwater bivalves.
Topics: Animals; Bivalvia; Dreissena; Female; Fluoxetine; Male; Sewage; Sexual Behavior, Animal; Water Pollutants, Chemical | 2008 |
Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes).
Topics: Animals; Antidepressive Agents; Biological Transport; Environmental Exposure; Fluoxetine; Oryzias; Selective Serotonin Reuptake Inhibitors | 2008 |
Enhanced fear responses in mice treated with anabolic androgenic steroids.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Amygdala; Anabolic Agents; Androgens; Animals; Conditioning, Psychological; Fear; Female; Fluoxetine; Gene Expression; Glutamic Acid; Hippocampus; Mice; Neurons; Prefrontal Cortex; Pregnanolone; RNA, Messenger; Steroids; Testosterone Propionate | 2009 |
Paradoxical anxiogenic response of juvenile mice to fluoxetine.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Drug Administration Schedule; Exploratory Behavior; Fluoxetine; Infusion Pumps, Implantable; Male; Maze Learning; Mice; Mice, Inbred Strains; Reaction Time; Selective Serotonin Reuptake Inhibitors; Swimming | 2009 |
Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex.
Topics: Animals; Chromatography, Liquid; Fluoxetine; Frontal Lobe; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Tandem Mass Spectrometry | 2009 |
Three-phase, liquid-phase microextraction combined with high performance liquid chromatography-fluorescence detection for the simultaneous determination of fluoxetine and norfluoxetine in human plasma.
Topics: Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence; Fluoxetine; Humans; Solvents | 2010 |
Fluoxetine and norfluoxetine revisited: new insights into the electrochemical and spectroscopic properties.
Topics: Antidepressive Agents; Electrochemistry; Fluoxetine; Hydrogen-Ion Concentration; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Quantum Theory; Spectrum Analysis, Raman | 2009 |
Determination of fluoxetine and norfluoxetine enantiomers in human plasma by polypyrrole-coated capillary in-tube solid-phase microextraction coupled with liquid chromatography-fluorescence detection.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Polymers; Pyrroles; Solid Phase Microextraction; Spectrometry, Fluorescence; Stereoisomerism | 2009 |
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase | 2010 |
Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition.
Topics: Animals; Antidepressive Agents, Second-Generation; Body Weight; Chromatography, Gas; Chromatography, High Pressure Liquid; Erythrocytes; Fatty Acids; Female; Fluoxetine; Male; Prefrontal Cortex; Random Allocation; Rats; Rats, Long-Evans; Serotonin | 2010 |
S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Corpus Striatum; Fluoxetine; Locomotion; Male; Mice; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Social Isolation | 2011 |
The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model.
Topics: Amines; Fluoxetine; Hydrogen-Ion Concentration; Kinetics; Lidocaine; Liposomes; Models, Chemical; Propranolol; Quantitative Structure-Activity Relationship; Scenedesmus; Trimipramine; Water | 2011 |
The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria.
Topics: Animals; Antidepressive Agents; CHO Cells; Clomipramine; Cricetinae; Cricetulus; Desipramine; Electron Transport Chain Complex Proteins; Fluoxetine; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Oxygen Consumption; Rats; Rats, Wistar; Thiazepines | 2011 |
A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS).
Topics: Animals; Chromatography, Liquid; Fluoxetine; Least-Squares Analysis; Reproducibility of Results; Sensitivity and Specificity; Sheep; Stereoisomerism; Tandem Mass Spectrometry | 2011 |
Simultaneous determination of fluoxetine and its major active metabolite norfluoxetine in human plasma by LC-MS/MS using supported liquid extraction.
Topics: Chromatography, Liquid; Drug Stability; Fluoxetine; Humans; Linear Models; Liquid-Liquid Extraction; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Trace analysis of fluoxetine and its metabolite norfluoxetine. Part I: development of a chiral liquid chromatography-tandem mass spectrometry method for wastewater samples.
Topics: Antidepressive Agents; Chromatography, Liquid; Fluoxetine; Sewage; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2011 |
Pharmacokinetics of fluoxetine in rhesus macaques following multiple routes of administration.
Topics: Administration, Oral; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Evaluation, Preclinical; Female; Fluoxetine; Humans; Injections, Subcutaneous; Macaca mulatta; Mice; Models, Animal; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity; Time Factors | 2011 |
Trace analysis of fluoxetine and its metabolite norfluoxetine. Part II: Enantioselective quantification and studies of matrix effects in raw and treated wastewater by solid phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Deuterium; Fluoxetine; Reproducibility of Results; Sewage; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2012 |
Simultaneous determination of fluoxetine and norfluoxetine enantiomers using isotope discrimination mass spectroscopy solution method and its application in the CYP2C9-mediated stereoselective interactions.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Drug Stability; Fluoxetine; Humans; Isotope Labeling; Linear Models; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry | 2012 |
Analysis of fluoxetine and norfluoxetine in human plasma by liquid-phase microextraction and injection port derivatization GC-MS.
Topics: Drug Monitoring; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Linear Models; Liquid Phase Microextraction; Reference Standards; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Time Factors | 2013 |
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Analgesics; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clopenthixol; Fluoxetine; Histamine Antagonists; Humans; Limit of Detection; Linear Models; Methotrimeprazine; Methylphenidate; Mianserin; Mirtazapine; Pharmaceutical Preparations; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Fluoxetine is a potent inhibitor of coxsackievirus replication.
Topics: Antidepressive Agents; Antiviral Agents; Enterovirus; Fluoxetine; Genes, Reporter; Green Fluorescent Proteins; HeLa Cells; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; RNA, Viral; Small Molecule Libraries; Transfection; Virus Replication | 2012 |
A validated microfluidics-based LC-chip-MS/MS method for the quantitation of fluoxetine and norfluoxetine in rat serum.
Topics: Animals; Chromatography, Liquid; Fluoxetine; Linear Models; Microfluidic Analytical Techniques; Models, Theoretical; Rats; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2012 |
A method for reliable voluntary oral administration of a fixed dosage (mg/kg) of chronic daily medication to rats.
Topics: Administration, Oral; Animal Feed; Animals; Animals, Outbred Strains; Chromatography, High Pressure Liquid; Drug Combinations; Drug Delivery Systems; Female; Fluoxetine; Male; Pharmaceutical Preparations; Pilot Projects; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity; Time Factors | 2012 |
Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluoxetine; Humans; Microsomes, Liver; Risk Assessment; Stereoisomerism | 2013 |
Fast evaluation of enantioselective drug metabolism by electrophoretically mediated microanalysis: application to fluoxetine metabolism by CYP2D6.
Topics: Cytochrome P-450 CYP2D6; Electrophoresis, Capillary; Fluoxetine; Humans; Kinetics; Recombinant Proteins; Stereoisomerism | 2013 |
Enantioselective quantification of fluoxetine and norfluoxetine by HPLC in wastewater effluents.
Topics: Chromatography, High Pressure Liquid; Environmental Monitoring; Fluoxetine; Stereoisomerism; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2014 |
Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression.
Topics: alpha-Linolenic Acid; Animals; Body Weight; Brain; Diet; Fatty Acids, Omega-3; Fluoxetine; Male; Motor Activity; Random Allocation; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming | 2014 |
Characterizing the effect of cytochrome P450 (CYP) 2C8, CYP2C9, and CYP2D6 genetic polymorphisms on stereoselective N-demethylation of fluoxetine.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Fluoxetine; Humans; Kinetics; Methylation; Polymorphism, Genetic; Recombinant Proteins; Stereoisomerism | 2014 |
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Drug Interactions; Female; Fluoxetine; Half-Life; Hepatocytes; Humans; Lovastatin; Male; Midazolam; Models, Statistical; Omeprazole; Stereoisomerism | 2014 |
Lack of detectable serum levels following topical fluoxetine administration in a child.
Topics: Administration, Cutaneous; Child; Fluoxetine; Humans; Male | 2014 |
Fluoxetine dose and administration method differentially affect hippocampal plasticity in adult female rats.
Topics: Animals; Blood Glucose; Body Weight; CA3 Region, Hippocampal; Dose-Response Relationship, Drug; Estradiol; Female; Fluoxetine; Hippocampus; Infusion Pumps, Implantable; Ki-67 Antigen; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptophysin | 2014 |
Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model.
Topics: Adult; Child, Preschool; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Infant; Milk, Human; Models, Biological | 2014 |
Enantioselective biodegradation of fluoxetine by the bacterial strain Labrys portucalensis F11.
Topics: Alphaproteobacteria; Biodegradation, Environmental; Biomass; Carbon; Chromatography, High Pressure Liquid; Fluorides; Fluoxetine; Spectrometry, Fluorescence; Stereoisomerism | 2014 |
Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents.
Topics: Administration, Oral; Animals; Behavior, Animal; Brain; Drug Synergism; Fatty Acids, Omega-3; Fluoxetine; Male; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2014 |
Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Biotransformation; Cyprinidae; Dose-Response Relationship, Drug; Fluoxetine; Humans; Male; Video Recording | 2014 |
Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.).
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fetus; Fluoxetine; Humans; Papio; Pregnancy | 2014 |
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Topics: Amino Acid Sequence; Arachidonic Acid; Binding Sites; Crystallography, X-Ray; Fluoxetine; Humans; Ion Channel Gating; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Potassium; Potassium Channels, Tandem Pore Domain; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary | 2015 |
The development of a new disposable pipette extraction phase based on polyaniline composites for the determination of levels of antidepressants in plasma samples.
Topics: Aniline Compounds; Antidepressive Agents; Blood Chemical Analysis; Chromatography, Liquid; Fluorescence; Fluoxetine; Humans; Solvents | 2015 |
Polyelectrolyte Microcapsules Dispersed in Silicone Rubber for in Vivo Sampling in Fish Brains.
Topics: Animals; Brain; Capsules; Electrolytes; Fluoxetine; Polymers; Silicone Elastomers; Tilapia | 2015 |
Uptake, accumulation and metabolization of the antidepressant fluoxetine by Mytilus galloprovincialis.
Topics: Animals; Antidepressive Agents; Biological Transport; Chromatography, Liquid; Fluoxetine; Mytilus; Portugal; Selective Serotonin Reuptake Inhibitors; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2016 |
New Framework To Diagnose the Direct Disposal of Prescribed Drugs in Wastewater - A Case Study of the Antidepressant Fluoxetine.
Topics: Antidepressive Agents; England; Fluoxetine; Wastewater; Water Pollutants, Chemical | 2016 |
Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine.
Topics: Adolescent; Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, Liquid; Depressive Disorder, Major; Enzyme-Linked Immunosorbent Assay; Female; Fluoxetine; Humans; Interleukin-6; Male; Middle Aged; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Serotonin; Tandem Mass Spectrometry; Treatment Outcome; Young Adult | 2016 |
Simultaneous enantioselective quantification of fluoxetine and norfluoxetine in human milk by direct sample injection using 2-dimensional liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Milk Proteins; Milk, Human; Serum Albumin, Bovine; Stereoisomerism; Tandem Mass Spectrometry | 2016 |
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.
Topics: Aromatase; Cell Line, Tumor; Coculture Techniques; Estradiol; Estrogens; Female; Fluoxetine; Humans; Membrane Transport Proteins; Placenta; Pregnancy; Protein Kinase C; Selective Serotonin Reuptake Inhibitors; Serotonin; Signal Transduction | 2017 |
Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.
Topics: Animals; Citalopram; Fluoxetine; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline; Synaptosomes | 2017 |
Effects of CYP2C19 Variants on Fluoxetine Metabolism in vitro.
Topics: Alleles; Animals; Asian People; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Fluoxetine; Genetic Variation; Humans; Mass Spectrometry; Selective Serotonin Reuptake Inhibitors; Sf9 Cells | 2017 |
Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry.
Topics: Calibration; Chromatography, High Pressure Liquid; Female; Fluoxetine; Humans; Metabolomics; Milk, Human; Selective Serotonin Reuptake Inhibitors; Solid Phase Extraction; Tandem Mass Spectrometry | 2017 |
Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABA
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Anxiety; Depression; Desipramine; Dose-Response Relationship, Drug; Feeding Behavior; Fluoxetine; Male; Mice, 129 Strain; Mice, Knockout; Motor Activity; Phenotype; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2017 |
SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment.
Topics: Animals; Antidepressive Agents; Atlantic Ocean; Environmental Monitoring; Fluoxetine; Humans; Mytilus; Portugal; Risk Assessment; Selective Serotonin Reuptake Inhibitors; Water Pollutants, Chemical | 2017 |
Toxicokinetics, disposition and metabolism of fluoxetine in crabs.
Topics: Animals; Biotransformation; Brachyura; Fluoxetine; Half-Life; Tissue Distribution; Toxicokinetics | 2017 |
Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography.
Topics: Chromatography, Liquid; Drug Monitoring; Fluoxetine; Humans; Paroxetine; Solid Phase Microextraction | 2017 |
Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Dried Blood Spot Testing; Drug Monitoring; Fluoxetine; Hematocrit; Humans; Reproducibility of Results; Tandem Mass Spectrometry | 2018 |
Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance.
Topics: Biodegradation, Environmental; Ecotoxicology; Fluoxetine; Kinetics; Metabolome; Rivers; Sewage; Stereoisomerism; Tetrahymena; Water Pollutants, Chemical | 2017 |
Simultaneous quantification of fluoxetine and norfluoxetine in colostrum and mature human milk using a 2-dimensional liquid chromatography-tandem mass spectrometry system.
Topics: Calibration; Chromatography, Liquid; Colostrum; Female; Fluoxetine; Humans; Limit of Detection; Linear Models; Milk, Human; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Workflow | 2018 |
Characterization of temperature-sensitive leak K
Topics: Animals; Cell Size; Fluoxetine; Ganglia, Spinal; Ion Channel Gating; Male; Neurons; Potassium Channels; Potassium Channels, Tandem Pore Domain; Rats; Riluzole; Temperature | 2018 |
Pharmacokinetics and Transplacental Transfer of Fluoxetine Enantiomers and Their Metabolites in Pregnant Women.
Topics: Adult; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Pregnancy; Stereoisomerism; Young Adult | 2019 |
Effects of selective serotonin-reuptake inhibitors (SSRIs) in JEG-3 and HIPEC cell models of the extravillous trophoblast.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Choriocarcinoma; Female; Fluoxetine; Gene Expression; Humans; Matrix Metalloproteinase 9; Membrane Proteins; Models, Biological; Pregnancy; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Sertraline; Tissue Inhibitor of Metalloproteinase-1; Trophoblasts; Venlafaxine Hydrochloride | 2018 |
Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Cell Survival; Fluoxetine; Microglia; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2019 |
Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopaminergic Neurons; Fluoxetine; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2018 |
Comparison of the accumulation and metabolite of fluoxetine in zebrafish larva under different environmental conditions with or without carbon nanotubes.
Topics: Animals; Fluoxetine; Larva; Nanotubes, Carbon; Water Pollutants, Chemical; Zebrafish | 2019 |
Serotonin and serotonin reuptake inhibitors alter placental aromatase.
Topics: Aromatase; Cells, Cultured; Citalopram; Female; Fluoxetine; Humans; Molecular Docking Simulation; Paroxetine; Placenta; Pregnancy; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Trophoblasts; Venlafaxine Hydrochloride | 2019 |
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabetes Mellitus, Type 1; Drug Repositioning; Enterovirus B, Human; Fluoxetine; Guanidine; Humans; Immunoglobulin G; Lovastatin; Oxadiazoles; Oxazoles; Oximes; Pyrazines; Ribavirin; Sulfonamides | 2020 |
Ultrasound-assisted dispersive liquid-liquid microextraction coupled with field-amplified capillary electrophoresis for sensitive and quantitative determination of fluoxetine and norfluoxetine enantiomers in biological fluids.
Topics: Body Fluids; Electrophoresis, Capillary; Fluoxetine; Humans; Limit of Detection; Liquid Phase Microextraction; Selective Serotonin Reuptake Inhibitors; Sonication; Spectrophotometry, Ultraviolet; Stereoisomerism | 2020 |
Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (
Topics: Animals; Embryo, Nonmammalian; Fluoxetine; Humans; Water Pollutants, Chemical; Zebrafish | 2020 |
Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment.
Topics: Animals; Embryo, Nonmammalian; Fluoxetine; Larva; Pharmaceutical Preparations; Risk Assessment; Venlafaxine Hydrochloride; Water Pollutants, Chemical; Zebrafish | 2020 |
Influence of dissolved organic matter on the accumulation, metabolite production and multi-biological effects of environmentally relevant fluoxetine in crucian carp (Carassius auratus).
Topics: Animals; Bioaccumulation; Fluoxetine; Gills; Goldfish; Humic Substances; Liver; Water Pollutants, Chemical | 2020 |
Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna.
Topics: Animals; Daphnia; Fluoxetine; Oxidation-Reduction; Oxidative Stress | 2020 |
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.
Topics: Binding Sites; Fluoxetine; Ion Channel Gating; Potassium Channels, Tandem Pore Domain | 2021 |
Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling.
Topics: Area Under Curve; Asian People; Cytochrome P-450 Enzyme System; Fluoxetine; Humans; Metabolic Clearance Rate; Models, Biological; Republic of Korea; Selective Serotonin Reuptake Inhibitors | 2021 |
Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders.
Topics: Adult; Antipsychotic Agents; Anxiety; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Depression; Drug Interactions; Female; Fluoxetine; Genotype; Humans; Male; Medication Adherence; Mental Disorders; Mexico; Middle Aged; Olanzapine; Pharmacogenomic Variants; Pharmacokinetics; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2021 |
The metabolites could not be ignored: A comparative study of the metabolite norfluoxetine with its parent fluoxetine on zebrafish (Danio rerio).
Topics: Animals; Early Growth Response Transcription Factors; Ecosystem; Fluoxetine; Humans; Molecular Docking Simulation; Water Pollutants, Chemical; Zebrafish | 2023 |
Stereoselective study of fluoxetine and norfluoxetine across the blood-brain barrier mediated by organic cation transporter 1/3 in rats using an enantioselective UPLC-MS/MS method.
Topics: Animals; Blood-Brain Barrier; Chromatography, Liquid; Fluoxetine; Organic Cation Transporter 1; Rats; Stereoisomerism; Tandem Mass Spectrometry | 2023 |