Page last updated: 2024-10-27

fluoxetine and Diabetes Mellitus

fluoxetine has been researched along with Diabetes Mellitus in 14 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"To study the effect of fluoxetine, a specific serotonin reuptake inhibitor, on insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) independently of its action on body weight."9.08Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss. ( Bourque, J; Chiasson, JL; Ducros, F; Garon, J; Maheux, P, 1997)
"Treatment with olanzapine may impact a patient's weight; thus, long-term weight gain and potential predictors (e."6.71Long-term weight gain in patients treated with open-label olanzapine in combination with fluoxetine for major depressive disorder. ( Andersen, SW; Clemow, DB; Corya, SA, 2005)
"To study the effect of fluoxetine, a specific serotonin reuptake inhibitor, on insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) independently of its action on body weight."5.08Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss. ( Bourque, J; Chiasson, JL; Ducros, F; Garon, J; Maheux, P, 1997)
"In comorbid diabetes mellitus and depression, most evidence supports the use of fluoxetine in control of glucose handling."4.81Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. ( Goodnick, PJ, 2001)
"Treatment with olanzapine may impact a patient's weight; thus, long-term weight gain and potential predictors (e."2.71Long-term weight gain in patients treated with open-label olanzapine in combination with fluoxetine for major depressive disorder. ( Andersen, SW; Clemow, DB; Corya, SA, 2005)
"Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain."2.68Usefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study. ( Daubresse, JC; Kolanowski, J; Krzentowski, G; Kutnowski, M; Scheen, A; Van Gaal, L, 1996)
"Body weight was kept constant."2.67Fluoxetine increases insulin action in obese type II (non-insulin dependent) diabetic patients. ( Frölich, M; Krans, HM; Meinders, AE; Potter van Loon, BJ; Radder, JK; Zwinderman, AH, 1992)
"Fluoxetine is an inhibitor of serotonin re-uptake which has been found to produce weight loss in humans and animals."2.67A randomized double-blind clinical trial of fluoxetine in obese diabetics. ( Bray, GA; Devine, W; Fujioka, K; Gray, DS, 1992)
"Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved."2.67Fluoxetine therapy in obese diabetic and glucose intolerant patients. ( Daubresse, JC; Friedman, H; Kolanowski, J; Krzentowski, G; Kutnowski, M; Scheen, A; Van Gaal, L, 1992)
"Treating leptin-deficient ob/ob and leptin receptor-deficient db/db mice with fluoxetine did not normalize body weight or rescue fertility, perhaps due to altered serotonergic tone in these animals."1.31Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction? ( Clayton, AH; Howard, LC; Moenter, SM; Sullivan, SD, 2002)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (42.86)18.2507
2000's5 (35.71)29.6817
2010's2 (14.29)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Bez, Y1
Coffey, BJ1
Aswar, U1
Chepurwar, S1
Shintre, S1
Aswar, M1
Isaac, R1
Boura-Halfon, S1
Gurevitch, D1
Shainskaya, A1
Levkovitz, Y1
Zick, Y1
Lustman, PJ1
Clouse, RE1
Andersen, SW1
Clemow, DB1
Corya, SA1
Theleritis, CG1
Papadimitriou, GN1
Papageorgiou, CC1
Dikeos, DG1
Masdrakis, V1
Kostoulas, C1
Psarros, C1
Soldatos, CR1
Connolly, VM1
Gallagher, A1
Kesson, CM1
Daubresse, JC2
Kolanowski, J2
Krzentowski, G2
Kutnowski, M2
Scheen, A2
Van Gaal, L2
Maheux, P1
Ducros, F1
Bourque, J1
Garon, J1
Chiasson, JL1
Goodnick, PJ1
Sullivan, SD1
Howard, LC1
Clayton, AH1
Moenter, SM1
Potter van Loon, BJ1
Radder, JK1
Frölich, M1
Krans, HM1
Zwinderman, AH1
Meinders, AE1
Gray, DS1
Fujioka, K1
Devine, W1
Bray, GA1
Friedman, H1

Reviews

2 reviews available for fluoxetine and Diabetes Mellitus

ArticleYear
Treatment of depression in diabetes: impact on mood and medical outcome.
    Journal of psychosomatic research, 2002, Volume: 53, Issue:4

    Topics: Behavior Therapy; Clinical Trials as Topic; Comorbidity; Depressive Disorder; Diabetes Mellitus; Flu

2002
Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2001, Volume: 13, Issue:1

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Blood Glucose; Clinical Trials as T

2001

Trials

7 trials available for fluoxetine and Diabetes Mellitus

ArticleYear
Long-term weight gain in patients treated with open-label olanzapine in combination with fluoxetine for major depressive disorder.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:11

    Topics: Adult; Ambulatory Care; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Depressive Disorder,

2005
A study of fluoxetine in obese elderly patients with type 2 diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:5

    Topics: Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Evaluation S

1995
Usefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
    Obesity research, 1996, Volume: 4, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dou

1996
Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:2

    Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fluoxetine

1997
Fluoxetine increases insulin action in obese type II (non-insulin dependent) diabetic patients.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 4

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Double-Blind Method; Female; Fluoxetine; Glucose; Glu

1992
A randomized double-blind clinical trial of fluoxetine in obese diabetics.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 4

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Femal

1992
Fluoxetine therapy in obese diabetic and glucose intolerant patients.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 4

    Topics: Blood Glucose; Diabetes Mellitus; Double-Blind Method; Female; Fluoxetine; Glucose Tolerance Test; G

1992

Other Studies

5 other studies available for fluoxetine and Diabetes Mellitus

ArticleYear
Fluoxetine-Induced Serum Sickness-Like Reaction in an Adolescent with Obsessive Compulsive Disorder and Diabetes.
    Journal of child and adolescent psychopharmacology, 2021, Volume: 31, Issue:9

    Topics: Adolescent; Diabetes Mellitus; Fluoxetine; Humans; Obsessive-Compulsive Disorder; Selective Serotoni

2021
Telmisartan attenuates diabetes induced depression in rats.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depress

2017
Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.
    The Journal of biological chemistry, 2013, Feb-22, Volume: 288, Issue:8

    Topics: Animals; Apoptosis; Cell Death; Cell Line; Diabetes Mellitus; Fluoxetine; Humans; Insulin; Insulin R

2013
Excessive weight gain after remission of depression in a schizophrenic patient treated with risperidone: case report.
    BMC psychiatry, 2006, Sep-05, Volume: 6

    Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bulimia; Depression; Diabetes

2006
Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction?
    Biology of reproduction, 2002, Volume: 66, Issue:6

    Topics: Animals; Body Weight; Diabetes Mellitus; Eating; Estrous Cycle; Fasting; Female; Fertility; Fluoxeti

2002