fluoxetine has been researched along with Nerve Degeneration in 9 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This fluoxetine-induced increase in GDNF and BDNF protein levels was accompanied by activation of the ERK signaling pathway." | 1.38 | Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy. ( Adame, A; Inglis, C; Mante, M; Masliah, E; May, V; Patrick, C; Rockenstein, E; Spencer, B; Ubhi, K; Winkler, J, 2012) |
| " We trained ADX and control rats in a moving, hidden platform version of the Morris water task before chronic administration (6 weeks) of CORT and either fluoxetine or vehicle." | 1.34 | Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. ( Epp, JR; Keith, JR; Spanswick, SC; Sutherland, RJ, 2007) |
| "Pretreatment with fluoxetine (10 mg kg(-1), x2) failed to alter cerebral MDMA accumulation compared to saline pretreated controls." | 1.31 | The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. ( Camarero, J; Colado, MI; Esteban, B; Green, AR; Peter, MJ; Sanchez, V, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, J | 1 |
| Gao, Y | 1 |
| Jiang, L | 1 |
| Chao, FL | 1 |
| Huang, W | 1 |
| Zhou, CN | 1 |
| Tang, W | 1 |
| Zhang, L | 1 |
| Huang, CX | 1 |
| Zhang, Y | 1 |
| Luo, YM | 1 |
| Xiao, Q | 1 |
| Yu, HR | 1 |
| Jiang, R | 1 |
| Tang, Y | 1 |
| Cambron, M | 1 |
| Mostert, J | 1 |
| Haentjens, P | 1 |
| D'Hooghe, M | 1 |
| Nagels, G | 1 |
| Willekens, B | 1 |
| Heersema, D | 1 |
| Debruyne, J | 1 |
| Van Hecke, W | 1 |
| Algoed, L | 1 |
| De Klippel, N | 1 |
| Fosselle, E | 1 |
| Laureys, G | 1 |
| Merckx, H | 1 |
| Van Wijmeersch, B | 1 |
| Vanopdenbosch, L | 1 |
| Verhagen, W | 1 |
| Hupperts, R | 1 |
| Hengstman, G | 1 |
| Michiels, V | 1 |
| Van Merhaegen-Wieleman, A | 1 |
| De Keyser, J | 1 |
| Capela, JP | 1 |
| Lautenschlager, M | 1 |
| Dirnagl, U | 1 |
| Bastos, ML | 1 |
| Carvalho, F | 1 |
| Meisel, A | 1 |
| Chung, ES | 2 |
| Chung, YC | 2 |
| Bok, E | 2 |
| Baik, HH | 1 |
| Park, ES | 2 |
| Park, JY | 2 |
| Yoon, SH | 2 |
| Jin, BK | 2 |
| Kim, SR | 1 |
| Park, KW | 1 |
| Won, SY | 1 |
| Jin, M | 1 |
| Ko, HW | 1 |
| Kim, YS | 1 |
| Ubhi, K | 1 |
| Inglis, C | 1 |
| Mante, M | 1 |
| Patrick, C | 1 |
| Adame, A | 1 |
| Spencer, B | 1 |
| Rockenstein, E | 1 |
| May, V | 1 |
| Winkler, J | 1 |
| Masliah, E | 1 |
| Spanswick, SC | 1 |
| Epp, JR | 1 |
| Keith, JR | 1 |
| Sutherland, RJ | 1 |
| Hitoshi, S | 1 |
| Maruta, N | 1 |
| Higashi, M | 1 |
| Kumar, A | 1 |
| Kato, N | 1 |
| Ikenaka, K | 1 |
| Sanchez, V | 1 |
| Camarero, J | 1 |
| Esteban, B | 1 |
| Peter, MJ | 1 |
| Green, AR | 1 |
| Colado, MI | 1 |
1 trial available for fluoxetine and Nerve Degeneration
| Article | Year |
|---|---|
Fluoxetine in progressive multiple sclerosis (FLUOX-PMS): study protocol for a randomized controlled trial.
Topics: Adult; Aged; Belgium; Brain; Clinical Protocols; Cognition; Disability Evaluation; Disease Progressi | 2014 |
8 other studies available for fluoxetine and Nerve Degeneration
| Article | Year |
|---|---|
Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; beta Catenin; CA1 | 2017 |
5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures.
Topics: 5,7-Dihydroxytryptamine; Animals; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relation | 2008 |
Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress.
Topics: Animals; Enzyme Activation; Female; Fluoxetine; Lipopolysaccharides; Microglia; NADPH Oxidases; Nerv | 2010 |
Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Cocu | 2011 |
Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Fluoxetine; Glial Cell Line-Derived Neurotrophic | 2012 |
Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine.
Topics: Adrenalectomy; Animals; Biomarkers; Cell Count; Corticosterone; Cytoplasmic Granules; Doublecortin D | 2007 |
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
Topics: Animals; Antidepressive Agents; Biological Assay; Cell Death; Cells, Cultured; Chronic Disease; Cort | 2007 |
The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain.
Topics: Animals; Binding, Competitive; Body Temperature; Brain; Cerebral Cortex; Fluoxetine; Fluvoxamine; In | 2001 |