fluoxetine has been researched along with Neuroblastoma in 14 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of fluoxetine (Prozac) on 5-hydroxytryptamine(3) (5-HT(3))-mediated currents in NCB-20 neuroblastoma cells was examined using the whole-cell patch-clamp technique." | 7.72 | Mechanism of block by fluoxetine of 5-hydroxytryptamine3 (5-HT3)-mediated currents in NCB-20 neuroblastoma cells. ( Ahn, HS; Choi, BH; Choi, JS; Hahn, SJ; Jo, YH; Kim, MJ; Kim, MS; Min, DS; Rhie, DJ; Sung, KW; Yoon, SH, 2003) |
| "Fluoxetine (FLX) is an antidepressant drug that belongs to the class of selective serotonin reuptake inhibitors." | 5.46 | Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells. ( Choe, W; Choi, JH; Ha, J; Jeong, YJ; Kang, I; Kim, SS; Yeo, EJ; Yoon, KS; Yu, AR, 2017) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 5.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| " We differentiated and treated human SK-N-SH neuroblastoma cells with a mixture (fluoxetine, carbamazepine and venlafaxine) and valproate (used as a positive control to induce autism-associated profiles), followed by transcriptome analysis with RNA-Seq approach." | 3.83 | Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders. ( Kaushik, G; Thomas, MA; Xia, Y; Yang, L, 2016) |
| "In in vitro studies, the voltage-clamp method was employed to examine whether nisoxetine blocked Na(+) currents in mouse neuroblastoma N2A cells." | 3.79 | Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. ( Chen, YW; Chu, CC; Kuo, CS; Leung, YM; Wang, JJ, 2013) |
| "NCB-20 cells (neuroblastoma X fetal Chinese hamster brain hybrids) are equipped with a [3H]5-hydroxytryptamine [( 3H]5-HT) uptake system and [3H]imipramine recognition sites." | 3.67 | 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. ( Chuang, DM; Costa, E; Nakaki, T; Roth, BL, 1985) |
| "Treatment with genistein (10 nM-10 microM) for 20 min stimulated [(3)H]noradrenaline (NA) uptake by SK-N-SH cells." | 1.36 | Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity. ( Itoh, H; Saito, N; Sakai, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N, 2010) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 1.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stapel, B | 1 |
| Gorinski, N | 1 |
| Gmahl, N | 1 |
| Rhein, M | 1 |
| Preuss, V | 1 |
| Hilfiker-Kleiner, D | 1 |
| Frieling, H | 1 |
| Bleich, S | 1 |
| Ponimaskin, E | 1 |
| Kahl, KG | 1 |
| Choi, JH | 1 |
| Jeong, YJ | 1 |
| Yu, AR | 1 |
| Yoon, KS | 1 |
| Choe, W | 1 |
| Ha, J | 1 |
| Kim, SS | 1 |
| Yeo, EJ | 1 |
| Kang, I | 1 |
| Chen, MK | 1 |
| Peng, CC | 1 |
| Maner, RS | 1 |
| Zulkefli, ND | 1 |
| Huang, SM | 1 |
| Hsieh, CL | 1 |
| Leung, YM | 1 |
| Chu, CC | 1 |
| Kuo, CS | 1 |
| Chen, YW | 1 |
| Wang, JJ | 1 |
| Kaushik, G | 1 |
| Xia, Y | 1 |
| Yang, L | 1 |
| Thomas, MA | 1 |
| Mundalil Vasu, M | 1 |
| Anitha, A | 1 |
| Takahashi, T | 1 |
| Thanseem, I | 1 |
| Iwata, K | 1 |
| Asakawa, T | 1 |
| Suzuki, K | 1 |
| Donnici, L | 1 |
| Tiraboschi, E | 1 |
| Tardito, D | 1 |
| Musazzi, L | 1 |
| Racagni, G | 1 |
| Popoli, M | 1 |
| Toyohira, Y | 1 |
| Ueno, S | 1 |
| Tsutsui, M | 1 |
| Itoh, H | 1 |
| Sakai, N | 1 |
| Saito, N | 1 |
| Takahashi, K | 1 |
| Yanagihara, N | 1 |
| Nothdurfter, C | 1 |
| Tanasic, S | 1 |
| Di Benedetto, B | 1 |
| Rammes, G | 1 |
| Wagner, EM | 1 |
| Kirmeier, T | 1 |
| Ganal, V | 1 |
| Kessler, JS | 1 |
| Rein, T | 1 |
| Holsboer, F | 1 |
| Rupprecht, R | 1 |
| Choi, JS | 1 |
| Choi, BH | 1 |
| Ahn, HS | 1 |
| Kim, MJ | 1 |
| Rhie, DJ | 1 |
| Yoon, SH | 1 |
| Min, DS | 1 |
| Jo, YH | 1 |
| Kim, MS | 1 |
| Sung, KW | 1 |
| Hahn, SJ | 1 |
| Brink, CB | 1 |
| Viljoen, SL | 1 |
| de Kock, SE | 1 |
| Stein, DJ | 1 |
| Harvey, BH | 1 |
| Zavosh, A | 1 |
| Schaefer, J | 1 |
| Ferrel, A | 1 |
| Figlewicz, DP | 1 |
| Hadrich, D | 1 |
| Berthold, F | 1 |
| Steckhan, E | 1 |
| Bönisch, H | 1 |
| Nakaki, T | 1 |
| Roth, BL | 1 |
| Chuang, DM | 1 |
| Costa, E | 1 |
14 other studies available for fluoxetine and Neuroblastoma
| Article | Year |
|---|---|
Fluoxetine induces glucose uptake and modifies glucose transporter palmitoylation in human peripheral blood mononuclear cells.
Topics: Adult; Animals; Energy Metabolism; Fluoxetine; Glucose; Glucose Transport Proteins, Facilitative; Hu | 2019 |
Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Caspases, Initiator; Cell Line, Tumor; Cell | 2017 |
Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; | 2019 |
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; | 2013 |
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders.
Topics: Animals; Autistic Disorder; Carbamazepine; Cell Line, Tumor; Environmental Pollutants; Fluoxetine; G | 2016 |
Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Survival; Fluoxetine; Gene Expression Regulation, Neopl | 2016 |
Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; | 2008 |
Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Estradiol; Fluoxetine | 2010 |
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.
Topics: Animals; Anticholesteremic Agents; Antidepressive Agents; beta-Cyclodextrins; Biophysics; Cholestero | 2010 |
Mechanism of block by fluoxetine of 5-hydroxytryptamine3 (5-HT3)-mediated currents in NCB-20 neuroblastoma cells.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Fluoxetine; Humans; Membrane Potentials; Neurobl | 2003 |
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Topics: Adrenergic Uptake Inhibitors; Androstadienes; Atropine; Cell Line, Tumor; Enzyme Inhibitors; Estrene | 2004 |
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Nore | 1999 |
Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents.
Topics: Carrier Proteins; Cocaine; Dihydropyridines; Fluorescent Dyes; Fluoxetine; Guanidines; Humans; Isoxa | 1999 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid | 1985 |