Page last updated: 2024-09-27

De Lange Syndrome

A syndrome characterized by growth retardation, severe MENTAL RETARDATION, short stature, a low-pitched growling cry, brachycephaly, low-set ears, webbed neck, carp mouth, depressed nasal bridge, bushy eyebrows meeting at the midline, hirsutism, and malformations of the hands. The condition may occur sporadically or be associated with an autosomal dominant pattern of inheritance or duplication of the long arm of chromosome 3. (Menkes, Textbook of Child Neurology, 5th ed, p231)

Synonyms(1)

Synonym
De Lange Syndrome

Research Excerpts

Overview

ExcerptReference
"Cornelia de Lange syndrome is a collection of congenital anomalies."( Schuster, DI, 1988)
"The Cornelia de Lange syndrome is a multiple congenital anomaly syndrome characterised by dysmorphic facial features, hirsutism, severe growth and developmental delays, and malformed upper limbs."( Bhuiyan, ZA; Hennekam, RC; Zilfalil, BA, 2006)

Research

Studies (58)

TimeframeStudies, This Condition (%)All Conditions %
pre-199026 (44.83)23.3326
1990's3 (5.17)12.5806
2000's8 (13.79)18.1394
2010's15 (25.86)28.8240
2020's6 (10.34)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
salicylic acid0low10
nitrous oxide0low20
urea0low10
hydroxyindoleacetic acid0low10
baclofen0low10
bupivacaine0low20
carbamazepine0low10
chlorpromazine0low10
diazepam0low20
valproic acid0low10
fluphenazine0low10
fluoxetine0low10
halothane0low10
imipramine0low10
ketamine0low10
mesalamine0low10
midazolam0low20
apnea0low10
pemoline0low10
phenobarbital0low10
sevoflurane0low30
thalidomide0low20
trazodone0low10
mitomycin0low10
prednisolone0low10
estriol0low20
thyroxine0low10
triiodothyronine0low10
aspartic acid0low10
uridine0low10
galactose0low10
leucine0low10
lactose0low10
tryptophan0low10
s,n,n'-tripropylthiocarbamate0low10
barium sulfate0low10
trolamine salicylate0low10
triamcinolone0low10
oxcarbazepine0low10
voriconazole0low10
inositol 3-phosphate0low20
tretinoin0low10
squalene0low10
phenylthiourea0low10
thiourea0low10
17-ketosteroids0low10
amphotericin b0low10
phenylephrine hydrochloride0low20
levetiracetam0low10
morphine0low10
dexmedetomidine0low10
pituitrin0low10
acid phosphatase0low10
glutaminase0low10
cyclin d10low10
exudates0low20
eye0low10

Protein Targets (745)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, Cruzipain3003
interleukin 82002
phosphopantetheinyl transferase100010
GLS protein6006
glucocorticoid receptor [Homo sapiens]160016
farnesoid X nuclear receptor8008
peroxisome proliferator-activated receptor delta8008
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA7007
nuclear factor erythroid 2-related factor 2 isoform 1150015
peripheral myelin protein 22110011
lamin isoform A-delta10190019
Cytochrome P450 1A20124
Cytochrome P450 3A40528
Cytochrome P450 2D60426
Cytochrome P450 2C9 0819
Cytochrome P450 2C190315
Nuclear receptor ROR-gamma4116
Potassium voltage-gated channel subfamily H member 2012012
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
thioredoxin reductase120012
ATAD5 protein, partial4004
TDP1 protein160016
Microtubule-associated protein tau7007
estrogen-related nuclear receptor alpha190019
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2210021
Bloom syndrome protein isoform 19009
D(1A) dopamine receptor7007
neuropeptide S receptor isoform A3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Ferritin light chain2002
aldehyde dehydrogenase 1 family, member A1130013
cytochrome P450 2C19 precursor3003
lethal factor (plasmid)5005
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
Carbonic anhydrase 10305
Carbonic anhydrase 20305
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0506
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0506
Glutamate receptor ionotropic, NMDA 2B0506
Glutamate receptor ionotropic, NMDA 2C0506
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0506
Glutamate receptor ionotropic, NMDA 3B0506
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0506
NFKB1 protein, partial5005
GLI family zinc finger 3170017
AR protein180018
regulator of G-protein signaling 46006
67.9K protein3003
activating transcription factor 64004
cytochrome P450 3A4 isoform 18008
histone acetyltransferase KAT2A isoform 17007
Gamma-aminobutyric acid receptor subunit pi83213
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015015
Gamma-aminobutyric acid type B receptor subunit 20213
Gamma-aminobutyric acid type B receptor subunit 20202
Bile salt export pump025025
Gamma-aminobutyric acid receptor subunit beta-183213
Gamma-aminobutyric acid receptor subunit delta83213
Gamma-aminobutyric acid receptor subunit gamma-283314
Gamma-aminobutyric acid receptor subunit alpha-583213
Gamma-aminobutyric acid receptor subunit alpha-383213
Gamma-aminobutyric acid receptor subunit gamma-183213
Gamma-aminobutyric acid receptor subunit alpha-283213
Gamma-aminobutyric acid receptor subunit alpha-483213
Gamma-aminobutyric acid receptor subunit gamma-383213
Gamma-aminobutyric acid receptor subunit alpha-683213
Gamma-aminobutyric acid receptor subunit alpha-183314
Gamma-aminobutyric acid receptor subunit beta-383213
Gamma-aminobutyric acid receptor subunit beta-283314
GABA theta subunit83213
Canalicular multispecific organic anion transporter 1013013
Gamma-aminobutyric acid receptor subunit epsilon83213
Gamma-aminobutyric acid type B receptor subunit 10213
Gamma-aminobutyric acid type B receptor subunit 10101
ATP-dependent phosphofructokinase6006
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20325
Potassium channel subfamily K member 90101
Chain A, Beta-lactamase2002
acetylcholinesterase3003
RAR-related orphan receptor gamma150015
USP1 protein, partial120012
thyroid stimulating hormone receptor7007
retinoic acid nuclear receptor alpha variant 1130013
pregnane X nuclear receptor140014
estrogen nuclear receptor alpha240024
IDH15005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid hormone receptor beta isoform a9009
nuclear factor erythroid 2-related factor 2 isoform 25005
mitogen-activated protein kinase 16006
geminin190019
Vpr2002
Bile salt export pump0404
Albumin0055
Major prion protein0033
Cellular tumor antigen p53160016
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70205
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0405
Cytochrome P450 2J20606
Sodium channel protein type 9 subunit alpha0404
Frizzled-80011
P2X purinoceptor 40202
Carbonic anhydrase 40203
Carbonic anhydrase0102
Carbonic anhydrase 150203
Proteasome subunit beta type-110001
Fumarate hydratase4004
Thrombopoietin2002
Smad33003
caspase 7, apoptosis-related cysteine protease5005
estrogen receptor 2 (ER beta)8008
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor9009
NADPH oxidase 10202
cytochrome P450 family 3 subfamily A polypeptide 4120012
retinoid X nuclear receptor alpha110011
G7007
cytochrome P450 2D66006
polyprotein4004
peroxisome proliferator activated receptor gamma120012
Snq2p0003
caspase-35005
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)9009
Histone H2A.x6006
Caspase-74004
Spike glycoprotein0224
Replicase polyprotein 1ab0224
cytochrome P450 2D6 isoform 15005
cellular tumor antigen p53 isoform a4004
chromobox protein homolog 1110011
potassium voltage-gated channel subfamily H member 2 isoform d5005
caspase-34004
thyroid hormone receptor beta isoform 2120012
histone deacetylase 9 isoform 31001
heat shock protein beta-13003
atrial natriuretic peptide receptor 2 precursor3003
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 14004
DNA polymerase kappa isoform 16006
survival motor neuron protein isoform d3003
M-phase phosphoprotein 85005
muscarinic acetylcholine receptor M14004
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0505
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transmembrane protease serine 20224
Glutamate receptor ionotropic, NMDA 2D0202
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0202
Voltage-dependent L-type calcium channel subunit alpha-1F0505
5-hydroxytryptamine receptor 40808
Epidermal growth factor receptor0202
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 7007
Albumin0225
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Receptor tyrosine-protein kinase erbB-20202
Major prion protein0011
Integrin beta-33003
Tyrosine-protein kinase Fyn0202
Procathepsin L0224
Aldo-keto reductase family 1 member B10707
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10507
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb3003
5-hydroxytryptamine receptor 1A0314
5-hydroxytryptamine receptor 2C0505
Muscarinic acetylcholine receptor M50303
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor08210
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0224
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10606
Polyunsaturated fatty acid lipoxygenase ALOX150202
Angiotensin-converting enzyme0606
D(2) dopamine receptor0708
5-hydroxytryptamine receptor 2A0707
Alpha-1B adrenergic receptor012012
Sphingomyelin phosphodiesterase0202
Alpha-2B adrenergic receptor0808
Alpha-2C adrenergic receptor0718
D0303
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 1A011112
Alpha-2B adrenergic receptor0606
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30606
Proteasome subunit beta type-10001
Substance-K receptor0404
D(1A) dopamine receptor0405
D(4) dopamine receptor0405
D(1B) dopamine receptor0203
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0606
UDP-glucuronosyltransferase 1A40103
Alpha-2A adrenergic receptor0606
Alpha-1D adrenergic receptor0909
Sodium-dependent noradrenaline transporter 0819
Sodium-dependent dopamine transporter0505
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0707
D(1B) dopamine receptor0303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A010010
5-hydroxytryptamine receptor 2C0909
5-hydroxytryptamine receptor 1B0707
Trypanothione reductase0404
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 2B0505
Histamine H1 receptor0112
Sodium-dependent serotonin transporter012214
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0202
Melanocortin receptor 50404
Pleiotropic ABC efflux transporter of multiple drugs0306
5-hydroxytryptamine receptor 70202
Histamine H1 receptor0808
Mu-type opioid receptor0618
D(3) dopamine receptor0607
Sodium channel protein type 1 subunit alpha0303
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0618
Kappa-type opioid receptor0618
5-hydroxytryptamine receptor 2B0808
Melanocortin receptor 30202
Alpha-1A adrenergic receptor012012
Histamine H2 receptor5106
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor4004
5-hydroxytryptamine receptor 60707
5-hydroxytryptamine receptor 70404
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein92213
Proteasome subunit alpha type-60012
D(2) dopamine receptor0405
Calmodulin 0112
Aldehyde oxidase 10101
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0505
Sodium-dependent dopamine transporter 09110
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10303
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Voltage-dependent L-type calcium channel subunit alpha-1S0505
Voltage-dependent L-type calcium channel subunit alpha-1C0606
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0202
Nuclear receptor subfamily 3 group C member 3 0606
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0202
Inositol hexakisphosphate kinase 17007
D0101
Sodium channel protein type 2 subunit alpha0303
Proteasome subunit beta type-70001
Ataxin-29009
Sigma non-opioid intracellular receptor 10909
Angiotensin-converting enzyme 2 0224
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0303
Sodium channel protein type 10 subunit alpha0202
cytochrome P450 2C9, partial7007
Alpha-1B adrenergic receptor 0011
cytochrome P450 2C9 precursor3003
Alpha-1A adrenergic receptor0112
Gamma-aminobutyric acid 0101
glp-1 receptor, partial4004
Gamma-aminobutyric acid receptor subunit pi0404
Gamma-aminobutyric acid receptor subunit delta0404
Voltage-dependent calcium channel gamma-2 subunit8008
Fatty acid-binding protein, liver0202
Alpha-1-acid glycoprotein 10001
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-10426
Translocator protein0225
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10404
Gamma-aminobutyric acid receptor subunit gamma-20415
Glutamate receptor 28008
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30415
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50426
Gamma-aminobutyric acid receptor subunit alpha-30415
Gamma-aminobutyric acid receptor subunit alpha-20415
Gamma-aminobutyric acid receptor subunit beta-20415
Gamma-aminobutyric acid receptor subunit alpha-40404
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0404
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-60404
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10404
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
ATPase family AAA domain-containing protein 55005
Gamma-aminobutyric acid receptor subunit gamma-30404
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0404
Estrogen receptor0404
Glucocorticoid receptor06112
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10606
Corticosteroid-binding globulin0202
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Alpha-synuclein0202
Solute carrier organic anion transporter family member 1A10101
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20022
UDP-glucuronosyltransferase 1A100001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
NPC intracellular cholesterol transporter 1 precursor1001
huntingtin isoform 21001
Sodium-dependent noradrenaline transporter0202
Cytochrome P450 2C80101
Dipeptidyl peptidase 40101
Acetylcholinesterase0101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10202
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Sodium-dependent serotonin transporter0505
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Cytochrome P450 1B10101
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10213
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0202
Transporter0101
Beta-2 adrenergic receptor0202
Sigma non-opioid intracellular receptor 10202
Transporter0303
PPM1D protein1001
EWS/FLI fusion protein7007
glucocerebrosidase2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Adenosine receptor A30404
Beta-3 adrenergic receptor0202
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
importin subunit beta-1 isoform 11001
snurportin-11001
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Protein-glutamine gamma-glutamyltransferase 20101
endonuclease IV1001
hypothetical protein, conserved1001
alpha-galactosidase1001
peripheral myelin protein 22 isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Uracil nucleotide/cysteinyl leukotriene receptor0202
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier family 22 member 30101
Prostaglandin G/H synthase 10303
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A0101
D(2) dopamine receptor0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Envelope glycoprotein0011
5-hydroxytryptamine receptor 4 0101
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
5-hydroxytryptamine receptor 3B0101
Solute carrier family 22 member 20101
Acetylcholinesterase0202
Rap guanine nucleotide exchange factor 34004
Cholinesterase0101
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, cellulase0011
Chain A, cellulase0011
Chain A, Galectin-30011
Chain A, Anti-tumor lectin0101
Galectin-30101
Galectin-90011
Galectin-80011
Beta-galactoside-binding lectin0101
Galectin-10113
Galectin-30112
Galectin-30113
Galectin-70011
Alpha 1,4 galactosyltransferase0001
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Large neutral amino acids transporter small subunit 10202
Proton-coupled amino acid transporter 10102
Phospholipase A-2-activating protein0202
chaperonin-containing TCP-1 beta subunit homolog2002
flap endonuclease 12002
Synaptic vesicle glycoprotein 2A0101
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Luciferase4004
15-lipoxygenase, partial1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
aryl hydrocarbon receptor8008
microphthalmia-associated transcription factor isoform 90101
caspase-1 isoform alpha precursor1001
Solute carrier organic anion transporter family member 2B1 0001
Tumor necrosis factor0101
Neuraminidase0101
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Platelet-activating factor receptor1001
Cystathionine gamma-lyase0202
Prostaglandin G/H synthase 20303
Caspase-71001
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Solute carrier organic anion transporter family member 1B30002
Protein-arginine deiminase type-40101
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Solute carrier organic anion transporter family member 1B10003
large T antigen0101
Thioredoxin reductase 0101
muscleblind-like protein 1 isoform 13003
Flavodoxin0001
TAR DNA-binding protein 431001
Lanosterol 14-alpha demethylase0101
ATP-dependent translocase ABCB10202
UDP-glucuronosyltransferase 1-60102
ATP-dependent translocase ABCB10202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 2B10 0101
hypoxia-inducible factor 1 alpha subunit3003
nuclear receptor subfamily 1, group I, member 22002
DNA polymerase iota isoform a (long)4004
Indoleamine 2,3-dioxygenase 10203
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0216
Kappa-type opioid receptor0214
Kappa-type opioid receptor0202
Mu-type opioid receptor0215
Nociceptin receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
GALC protein2002
nonstructural protein 13003
polyadenylate-binding protein 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
bcl-2-related protein A10101
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Chain A, PROTEIN (CATECHOL OXIDASE)0101
pregnane X receptor3003
Polyphenol oxidase 20304
Tyrosinase0101
Tyrosinase0202
Succinyl-diaminopimelate desuccinylase0101
Taste receptor type 2 member 380012
luciferase0001
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0303
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30102
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90102
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130102
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
5'-AMP-activated protein kinase subunit beta-10001
Squalene monooxygenase 0001
Cereblon isoform 40202
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0416
isocitrate dehydrogenase 1, partial1001
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease0203
Urease subunit alpha0202
Urease subunit alpha0101
Urease subunit beta0202
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
apical membrane antigen 1, AMA12002
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0246
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Nuclear Receptor ROR-beta0101
thioredoxin glutathione reductase3003
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
thyrotropin-releasing hormone receptor1001
nuclear receptor ROR-gamma isoform 11001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
Retinoic acid receptor alpha0227
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
SMAD family member 21001
SMAD family member 31001
procathepsin L isoform 1 preproprotein0101
Prothrombin0011
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Plasma kallikrein0001
Myeloperoxidase0101
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0001
SLC16A10 protein0001
Carbonic anhydrase 0001
Tryprostatin B synthase0001
Carbonic anhydrase0001
Carbonic anhydrase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Chain A, Cytidine Deaminase0101
Sodium/nucleoside cotransporter 10202
Sodium/nucleoside cotransporter 20202
Cytidine deaminase0101
Equilibrative nucleoside transporter 20202
Equilibrative nucleoside transporter 10202
Uridine-cytidine kinase 1 0001
Solute carrier family 28 member 30202
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Lanosterol 14-alpha demethylase0011
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]