Page last updated: 2024-09-28

Cast Syndrome

DUODENAL OBSTRUCTION by the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) which travels in the root of the MESENTERY and crosses over the DUODENUM. The syndrome is characterized by the dilated proximal duodenum and STOMACH, bloating, ABDOMINAL CRAMPS, and VOMITING. Often it is observed in patient with body casts after spinal surgery.

Synonyms(5)

Synonym
Wilkie Syndrome
Mesenteric Duodenal Compression Syndrome
Cast Syndrome
Duodenal Compression Syndrome, Mesenteric
Superior Mesenteric Artery Syndrome

Research Excerpts

Overview

ExcerptReference
"Superior mesenteric artery syndrome is a rare complication in patients immobilized in a body cast or hip spica."( Chen, SH; Chen, WS; Chuang, JH, 1992)

Research

Studies (36)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (19.44)23.3326
1990's4 (11.11)12.5806
2000's9 (25.00)18.1394
2010's11 (30.56)28.8240
2020's5 (13.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carnitine0low10
thiamine0low10
1-anilino-8-naphthalenesulfonate0low10
domperidone0low10
fentanyl0low10
fluoxetine0low10
lansoprazole0low10
prazosin0low10
thiabendazole0low10
prednisolone0low10
methylprednisolone0low10
diatrizoate meglumine0low10
barium sulfate0low130
pica0low10
oxycodone0low10
barium0low30
folic acid0low10

Protein Targets (411)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase2002
thioredoxin reductase6006
USP1 protein, partial4004
TDP1 protein9009
vitamin D3 receptor isoform VDRA2002
importin subunit beta-1 isoform 11001
flap endonuclease 11001
serine/threonine-protein kinase PLK12002
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin6006
DNA polymerase kappa isoform 11001
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0011
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
cytochrome P450 family 3 subfamily A polypeptide 49009
Spike glycoprotein0011
Replicase polyprotein 1ab0112
potassium voltage-gated channel subfamily H member 2 isoform d4004
thyroid hormone receptor beta isoform 26006
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40606
Bile salt export pump010010
Cellular tumor antigen p536006
Procathepsin L0011
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0708
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10404
Alpha-2B adrenergic receptor0809
Alpha-2C adrenergic receptor0607
Muscarinic acetylcholine receptor M30404
Sodium-dependent noradrenaline transporter 0617
Sodium-dependent dopamine transporter0303
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0619
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0606
Sodium-dependent serotonin transporter0527
Sodium-dependent serotonin transporter0303
Histamine H1 receptor0505
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 2B0606
Histamine H2 receptor4004
5-hydroxytryptamine receptor 60404
Spike glycoprotein4015
Sodium-dependent dopamine transporter 0415
Sigma non-opioid intracellular receptor 10707
Angiotensin-converting enzyme 2 0011
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Hsf1 protein0011
euchromatic histone-lysine N-methyltransferase 26006
chromobox protein homolog 14004
survival motor neuron protein isoform d2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
acetylcholinesterase3003
RAR-related orphan receptor gamma6006
ATAD5 protein, partial4004
Fumarate hydratase2002
NFKB1 protein, partial1001
GALC protein1001
GLI family zinc finger 37007
AR protein9009
Smad31001
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor5005
regulator of G-protein signaling 43003
EWS/FLI fusion protein3003
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha8008
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha9009
cytochrome P450 2D64004
polyprotein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
arylsulfatase A1001
alpha-galactosidase4004
caspase-33003
aryl hydrocarbon receptor5005
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
cytochrome P450 2D6 isoform 13003
peripheral myelin protein 22 isoform 12002
D(1A) dopamine receptor2002
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase mTOR isoform 13003
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi4004
Solute carrier family 22 member 20202
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Voltage-dependent calcium channel gamma-2 subunit5005
D(2) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
D0102
Glutamate receptor 25005
Retinoic acid receptor RXR-alpha0011
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Mu-type opioid receptor0527
5-hydroxytryptamine receptor 3A0101
Kappa-type opioid receptor0415
D(2) dopamine receptor0405
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily H member 20707
Multidrug and toxin extrusion protein 20202
GABA theta subunit4004
Canalicular multispecific organic anion transporter 10505
Multidrug and toxin extrusion protein 10303
ATPase family AAA domain-containing protein 55005
Ataxin-27007
Gamma-aminobutyric acid receptor subunit epsilon4004
5-hydroxytryptamine receptor 3B0101
ATP-dependent phosphofructokinase3003
Luciferase3003
Solute carrier family 22 member 1 0405
Nuclear receptor subfamily 1 group I member 20022
ATP-dependent translocase ABCB10304
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0202
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0404
Mu-type opioid receptor0314
Kappa-type opioid receptor0202
Delta-type opioid receptor0213
Kappa-type opioid receptor0303
Mu-type opioid receptor0112
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10202
estrogen receptor 2 (ER beta)3003
G3003
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor4004
caspase-31001
huntingtin isoform 21001
ras-related protein Rab-9A4004
nuclear factor erythroid 2-related factor 2 isoform 13003
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Sodium-dependent noradrenaline transporter0101
Potassium channel subfamily K member 20101
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0011
Sodium channel protein type 1 subunit alpha0101
Cytochrome P450 3A40101
5-hydroxytryptamine receptor 2C0404
Cytochrome P450 2C80101
Cytochrome P450 2D60202
Cytochrome P450 2C9 0404
Angiotensin-converting enzyme0404
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-10101
Alpha-1B adrenergic receptor0415
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Alpha-2B adrenergic receptor0213
Acetylcholinesterase0101
Alpha-2C adrenergic receptor0213
Acetylcholinesterase0101
Alpha-2A adrenergic receptor0213
Prostaglandin G/H synthase 10101
Alpha-1D adrenergic receptor0415
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 2B0303
Gamma-aminobutyric acid receptor subunit alpha-50101
Cytochrome P450 2C190202
Gamma-aminobutyric acid receptor subunit alpha-30101
Alpha-1A adrenergic receptor0415
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(1A) dopamine receptor2002
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit epsilon0101
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Cytochrome P450 1B10101
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Transporter0101
Nuclear receptor subfamily 3 group C member 3 0404
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0101
Histamine H3 receptor0101
cytochrome P450 2C9, partial3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Ferritin light chain1001
glp-1 receptor, partial1001
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor3003
glucocerebrosidase2002
activating transcription factor 61001
lysosomal alpha-glucosidase preproprotein3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
nuclear factor erythroid 2-related factor 2 isoform 23003
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein2002
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain A, Beta-lactamase1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase1001
GLS protein1001
Microtubule-associated protein tau2002
apical membrane antigen 1, AMA11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
atrial natriuretic peptide receptor 1 precursor1001
phosphoethanolamine/phosphocholine phosphatase isoform 10101
heat shock protein beta-11001
nuclear receptor ROR-gamma isoform 12002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Amyloid-beta precursor protein1001
Neuronal acetylcholine receptor subunit alpha-41001
Microtubule-associated protein tau0101
Neuronal acetylcholine receptor subunit beta-21001
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Indoleamine 2,3-dioxygenase 10101
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha1001
Fatty acid synthase0202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
WD repeat-containing protein 50101
Histone-lysine N-methyltransferase 2A0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Cytosolic endo-beta-N-acetylglucosaminidase0101
Indoleamine 2,3-dioxygenase 20101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
hypoxia-inducible factor 1 alpha subunit2002
PPM1D protein1001
nonstructural protein 11001
IDH11001
muscleblind-like protein 1 isoform 11001
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Androgen receptor0303
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
Acetylcholinesterase0101
Kappa-type opioid receptor0011
farnesoid X nuclear receptor1001
67.9K protein1001
cellular tumor antigen p53 isoform a2002
interferon gamma precursor0001
histone deacetylase 9 isoform 32002
lethal factor (plasmid)1001
Alpha-1A adrenergic receptor0112
Solute carrier family 22 member 30101
Beta-casein0101
Interstitial collagenase0101
Integrin beta-32002
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 1A0101
Matrix metalloproteinase-90101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-1A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-2A adrenergic receptor0101
5-hydroxytryptamine receptor 1A0101
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
Alpha-2B adrenergic receptor0101
5-hydroxytryptamine receptor 1F0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Type-1 angiotensin II receptor0101
Alpha-1A adrenergic receptor0217
Alpha-1B adrenergic receptor0215
5-hydroxytryptamine receptor 70101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2A adrenergic receptor0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Methionine aminopeptidase0101
BRCA11001
pregnane X receptor1001
P531001
pyruvate kinase1001
thyroid hormone receptor beta isoform a1001
Cytochrome P450 1A20101
Methionine aminopeptidase0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Methionine aminopeptidase 20101
Nuclear receptor ROR-gamma1001
Methionine aminopeptidase 10112
Peptidyl-prolyl cis-trans isomerase FKBP1A0011
Fatty-acid amide hydrolase 10101
Reverse transcriptase/RNaseH 0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]