fluoxetine has been researched along with Inadequate Sleep in 11 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine treatment induced a significant decrease in S2 quantities and in the number of sharp waves in S1." | 1.48 | Partial homologies between sleep states in lizards, mammals, and birds suggest a complex evolution of sleep states in amniotes. ( Arthaud, S; Barrillot, B; Beuf, O; Herrel, A; Libourel, PA; Luppi, PH; Massot, B; Morel, AL, 2018) |
| "Using sleep deprivation (SD) as an animal model of mania, this study aimed to examine the possible relationship between PKC and neuroplasticity in mania." | 1.40 | Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania. ( Abrial, E; Bétourné, A; Etiévant, A; Haddjeri, N; Lambás-Señas, L; Lucas, G; Scarna, H, 2014) |
| "Thus, sleep deprivation induced widespread decreases in NET binding, and fewer and well-localized decreases in SERT binding." | 1.33 | Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain. ( Barlow, KB; Hipólide, DC; Moreira, KM; Nobrega, JN; Tufik, S; Wilson, AA, 2005) |
| "In animals, sleep deprivation and pharmacologic treatment with antidepressants exert similar effects on 5-HT neurotransmission, notably functional desensitization of 5-HT1A autoreceptors located on 5-HT neurons in the dorsal raphe nucleus (DRN)." | 1.33 | Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice. ( Adrien, J; Barden, N; Evrard, A; Hamon, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Libourel, PA | 1 |
| Barrillot, B | 1 |
| Arthaud, S | 1 |
| Massot, B | 1 |
| Morel, AL | 1 |
| Beuf, O | 1 |
| Herrel, A | 1 |
| Luppi, PH | 1 |
| Abrial, E | 1 |
| Bétourné, A | 1 |
| Etiévant, A | 1 |
| Lucas, G | 1 |
| Scarna, H | 1 |
| Lambás-Señas, L | 1 |
| Haddjeri, N | 1 |
| Arnedt, JT | 1 |
| Swanson, LM | 1 |
| Dopp, RR | 1 |
| Bertram, HS | 1 |
| Mooney, AJ | 1 |
| Huntley, ED | 1 |
| Hoffmann, RF | 1 |
| Armitage, R | 1 |
| Lu, X | 2 |
| Barr, AM | 2 |
| Kinney, JW | 1 |
| Sanna, P | 1 |
| Conti, B | 2 |
| Behrens, MM | 1 |
| Bartfai, T | 2 |
| Hipólide, DC | 1 |
| Moreira, KM | 1 |
| Barlow, KB | 1 |
| Wilson, AA | 1 |
| Nobrega, JN | 1 |
| Tufik, S | 1 |
| Evrard, A | 1 |
| Barden, N | 1 |
| Hamon, M | 1 |
| Adrien, J | 1 |
| Maier, R | 1 |
| Morale, MC | 1 |
| Sanna, PP | 1 |
| Bilbe, G | 1 |
| Hoyer, D | 1 |
| Carlini, EA | 1 |
| Lindsey, CJ | 1 |
| Ghodhbane, T | 1 |
| Benedetti, F | 1 |
| Barbini, B | 1 |
| Lucca, A | 1 |
| Campori, E | 1 |
| Colombo, C | 1 |
| Smeraldi, E | 1 |
| Leibenluft, E | 1 |
| Noonan, BM | 1 |
| Wehr, TA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression[NCT01545843] | Phase 2 | 68 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total score on a clinician-rated measure of depressive symptoms, minus 3 sleep items Total score range: 0-46. Higher scores represent more severe depression. (NCT01545843)
Timeframe: Post-treatment (8 weeks)
| Intervention | units on a scale (Mean) |
|---|---|
| No Sleep Deprivation | 6.1 |
| Late Bedtime Sleep Deprivation | 8.1 |
| Early Risetime Sleep Deprivation | 6.3 |
Patient-reported depression symptom severity at post-treatment, total score. Total scores range from 0 to 27. Higher scores represent more severe depression. (NCT01545843)
Timeframe: Post-treatment (8 weeks)
| Intervention | units on a scale (Mean) |
|---|---|
| No Sleep Deprivation | 5.3 |
| Late Bedtime Sleep Deprivation | 6.9 |
| Early Risetime Sleep Deprivation | 6.7 |
Measurement of EEG activity during sleep using polysomnography: Total Sleep Time is the length of time from sleep onset to final wake up minus any wakefulness during the night. It reflects the total amount of time asleep during the night. (NCT01545843)
Timeframe: Baseline, 2 weeks, 8 weeks
| Intervention | minutes (Mean) | ||
|---|---|---|---|
| Baseline | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 444.040 | 332.909 | 433.333 |
| Late Bedtime Sleep Deprivation | 439.208 | 337.75 | 428.264 |
| No Sleep Deprivation | 430.132 | 435.382 | 439.6 |
Measurement of EEG activity during sleep using polysomnography: Sleep efficiency [(total sleep time/time in bed)*100] (NCT01545843)
Timeframe: Baseline, 2 weeks, 8 weeks
| Intervention | percent of sleep time (Mean) | ||
|---|---|---|---|
| Baseline | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 92.8248 | 92.9082 | 90.3838 |
| Late Bedtime Sleep Deprivation | 91.6829 | 93.3322 | 88.9224 |
| No Sleep Deprivation | 89.7005 | 90.7824 | 91.6153 |
Reaction Time is measured using a modified Go/No-go test of inhibitory control (NCT01545843)
Timeframe: 0, 2, 8 weeks
| Intervention | milliseconds (Mean) | ||
|---|---|---|---|
| Week 0 (Baseline) | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 470.2942 | 472.7244 | 500.1197 |
| Late Bedtime Sleep Deprivation | 528.3513 | 519.8196 | 557.1635 |
| No Sleep Deprivation | 499.1545 | 493.2579 | 483.7349 |
Change in different aspects of thinking (e.g., memory, attention, executive functioning) (NCT01545843)
Timeframe: Baseline, 2 weeks, 8 weeks
| Intervention | words (Mean) | ||
|---|---|---|---|
| Baseline | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 76.095 | 77.400 | 81.200 |
| Late Bedtime Sleep Deprivation | 74.938 | 81.529 | 79.733 |
| No Sleep Deprivation | 77.118 | 76.647 | 73.923 |
Emotional Perception is measured based on the percent of faces whose emotions are correctly identified using the Facial Emotion Perception Test (FEPT) (NCT01545843)
Timeframe: 0 weeks, 2 weeks, 8 weeks
| Intervention | percentage of emotions accurately ID'ed (Mean) | ||
|---|---|---|---|
| 0 weeks (Baseline) | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 88.83 | 88.75 | 87.74 |
| Late Bedtime Sleep Deprivation | 86.24 | 88.15 | 89.15 |
| No Sleep Deprivation | 83.54 | 83.08 | 85.95 |
Self-report measure of sleep quality. The Pittsburgh Sleep Quality Index is a validated scale which measures self-reported sleep quality based on a wide variety of questions (duration, quality, disturbances, medication, etc.) and converts them to a scale which ranges from 0 to 21 where 6 or higher denotes poor sleep quality. (NCT01545843)
Timeframe: Baseline, 2 weeks and 8 weeks post-treatment
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Baseline | Week 2 | Week 8 | |
| Early Risetime Sleep Deprivation | 6.85 | 5.50 | 6.33 |
| Late Bedtime Sleep Deprivation | 8.67 | 6.07 | 6.23 |
| No Sleep Deprivation | 6.00 | 5.23 | 4.86 |
3 trials available for fluoxetine and Inadequate Sleep
| Article | Year |
|---|---|
Effects of Restricted Time in Bed on Antidepressant Treatment Response: A Randomized Controlled Trial.
Topics: Actigraphy; Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Flu | 2016 |
Sleep deprivation hastens the antidepressant action of fluoxetine.
Topics: Adult; Bipolar Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Sleep Deprivation | 1997 |
Diurnal variation: reliability of measurement and relationship to typical and atypical symptoms of depression.
Topics: Adult; Antidepressive Agents; Circadian Rhythm; Combined Modality Therapy; Depressive Disorder; Fema | 1992 |
8 other studies available for fluoxetine and Inadequate Sleep
| Article | Year |
|---|---|
Partial homologies between sleep states in lizards, mammals, and birds suggest a complex evolution of sleep states in amniotes.
Topics: Animals; Biological Evolution; Birds; Brain; Electroencephalography; Electromyography; Eye Movements | 2018 |
Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania.
Topics: Animals; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Agents; Aripipraz | 2014 |
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Topics: Animals; Antidepressive Agents; Binding Sites; Electroshock; Fluoxetine; Galanin; Male; Raphe Nuclei | 2005 |
Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.
Topics: Animals; Autoradiography; Benzylamines; Brain; Brain Chemistry; Carbon Isotopes; Fluoxetine; Male; M | 2005 |
Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Autoreceptors; Dose-Response | 2006 |
Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain Chemistry; Electroconvulsi | 2007 |
Effect of serotonergic drugs on the aggressiveness induced by delta 9-tetrahydrocannabinol in rem-sleep-deprived rats.
Topics: Aggression; Animals; Cinanserin; Cyproheptadine; Dronabinol; Drug Interactions; Fenclonine; Fluoxeti | 1982 |
["I have been sad from birth"].
Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Psychotherapy; Sleep Deprivation | 1994 |