1,2-dianilinoethane profile

1,2-Dianilinoethane, also known as N,N'-bis(phenyl)ethylenediamine, is an organic compound with the formula C₁₄H₁₆N₂. It is a colorless solid that is soluble in organic solvents.

Here's a breakdown of its structure and significance:

**Structure:**

* It consists of a central ethylene bridge (-CH₂-CH₂-) with two aniline groups (-NH-C₆H₅) attached to each end.

**Importance in Research:**

1,2-Dianilinoethane is a versatile compound with potential applications in various research areas:

* **Polymer Chemistry:**
* **Monomer for Polyamides:** It can be used as a monomer in the synthesis of polyamides, which are high-performance polymers with applications in textiles, engineering plastics, and adhesives.
* **Crosslinking Agent:** It can act as a crosslinking agent in the production of polymers, improving their mechanical properties and thermal stability.
* **Materials Science:**
* **Conducting Polymers:** 1,2-Dianilinoethane is a key component in the synthesis of conductive polymers, which are used in electronic devices, sensors, and energy storage applications.
* **Organic Electronics:** It can be incorporated into organic semiconductors, which are materials that conduct electricity. This is important for developing new electronic devices, particularly flexible and transparent displays.
* **Catalysis:**
* **Ligand in Catalysis:** Its nitrogen atoms can coordinate with metal ions, forming complexes that can act as catalysts in various organic reactions.
* **Pharmaceutical Research:**
* **Synthesis of Pharmaceutical Compounds:** It has been investigated as a building block for synthesizing pharmaceutical compounds with potential anti-inflammatory, anti-cancer, and antibacterial properties.

**Note:** The specific applications and research focus on 1,2-dianilinoethane may vary depending on its specific derivatives and modifications.

**Overall:**

1,2-Dianilinoethane is a promising compound with a diverse set of potential applications in various fields, making it a valuable tool for ongoing research and development efforts.

1,2-dianilinoethane: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	67422
SCHEMBL ID	232188
MeSH ID	M0050423

Synonym
AKOS000450419
n,n'-diphenyl-alpha,omega-diaminoethane
brn 0646740
n,n'-diphenyl-1,2-ethylenediamine
nsc 8719
einecs 205-765-6
n,n'-difenylethylendiamin [czech]
ethylenediamine, n,n'-diphenyl-
aniline, n,n'-ethylenedi-
benzenamine, n,n'-1,2-ethanediylbis-
aniline,n'-ethylenedi-
ethylenediamine,n'-diphenyl-
wln: rm2mr
stabilite
150-61-8
n,.omega.-diaminoethane
nsc-8719
n,n'-diphenylethylenediamine
benzenamine,n'-1,2-ethanediylbis-
sym-diphenylethylenediamine
n,n'-ethylenedianiline
1,2-dianilinoethane
nodx
nsc8719
n,n'-diphenylethylenediamine, 98%
n,n'-diphenylethane-1,2-diamine
1,2-ethanediamine, n,n'-diphenyl-
MAYBRIDGE1_002161
SR-01000642436-1
D0887
1,2-bis(phenylamino)ethane
HMS547K05
n1,n2-diphenylethane-1,2-diamine
EN300-85848
2-anilinoethyl-phenyl-amine
pxk7am35l2 ,
unii-pxk7am35l2
n,n'-difenylethylendiamin
1,2-ethanediamine, n1,n2-diphenyl-
CCG-53261
FT-0606337
n,n'-diphenyl-.alpha.,.omega.-diaminoethane
n(sup1),n(sup2)-diphenyl-1,2-ethanediamine
1,2-dianilinoethane [mi]
SCHEMBL232188
1,2 dianilinoethane
DTXSID1059739
STL436405
n1,n2-diphenyl-1,2-ethanediamine
mfcd00003019
Z57493577
AS-60917
D89737
J-008724
Q27286809
CS-W014271
HY-W013555
SY061839

Assay ID	Title	Year	Journal	Article
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (16.67)	18.7374
1990's	2 (8.33)	18.2507
2000's	8 (33.33)	29.6817
2010's	7 (29.17)	24.3611
2020's	3 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.06	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.02	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.06	1	bipyridine	chelator; ferroptosis inhibitor
hydroxyindoleacetic acid (5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.	1.99	1	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.06	1	alkane-alpha,omega-diamine	GABA agonist
fluoxetine Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.	2.02	1	(trifluoromethyl)benzenes; aromatic ether; secondary amino compound
isoproterenol Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.	1.96	1	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.04	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
4-cymene 4-cymene: structure. p-cymene : A monoterpene that is toluene substituted by an isopropyl group at position 4.	2.02	1	monoterpene; toluenes	human urinary metabolite; plant metabolite; volatile oil component
terephthaloyl chloride terephthaloyl chloride: cross-links albumin	2.03	1
benzylamine aminotoluene : Any member of the class of toluenes carrying one or more amino groups.	2.73	3	aralkylamine; primary amine	allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.01	1	catechin	antioxidant; plant metabolite
5-hydroxyindole [no description available]	2.41	2	hydroxyindoles	human metabolite
iridium Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.	2.41	1	cobalt group element atom; platinum group metal atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.44	2	iron group element atom; platinum group metal atom
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.01	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
gallocatechol gallocatechol: structure give in first source; RN given for (trans-(+-))-omer; inhibits DNA-dependent DNA & RNA polymerases. (+)-gallocatechin : A gallocatechin that has (2R,3S)-configuration. It is found in green tea and bananas.. gallocatechin : A catechin that is a flavan substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7 (the trans isomer). It is isolated from Acacia mearnsii.	2.01	1	gallocatechin	antioxidant; metabolite; radical scavenger
cyanates Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).	2.03	1
epicatechin gallate epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea. (-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.	2.01	1	catechin; gallate ester; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite
hexacyanoferrate iii hexacyanoferrate III: RN given refers to parent cpd	2.01	1
tartaric acid tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.	2.05	1	tartaric acid	Escherichia coli metabolite
meso-1,2-diphenylethylenediamine, (r-(r,s))-isomer diphenylethylenediamine: structure in first source	1.93	1
aluminum oxide Aluminum Oxide: An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.	1.96	1
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.6	1	glycoside

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Anemia, Fanconi [description not available]	2.13	1
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.42	2
Leukemia L 1210 [description not available]	1.96	1

1,2-dianilinoethane

Description

Cross-References

Synonyms (58)

Bioassays (3)

Research

Studies (24)

Market Indicators

Research Demand Index: 11.72

Study Types