Page last updated: 2024-10-27

fluoxetine and Weight Reduction

fluoxetine has been researched along with Weight Reduction in 60 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
"This open-label pilot study of combination therapy of metformin and fluoxetine gave encouraging weight reduction, and these results suggest the need for a randomized double-blind clinical trial comparing the two components and the combination to placebo."9.12An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction. ( Amini, M; Aminorroaya, A; Dastjerdi, MS; Kazemi, F; Mohammady, M; Najafian, A, 2007)
"To evaluate the weight reducing effect of fluoxetine on steroid-induced obesity, we conducted an open, clinical intervention study of 20-40 mg/day fluoxetine, 24 weeks duration."9.09Fluoxetine treatment for weight reduction in steroid-induced obesity: a pilot study in myasthenia gravis patients. ( Achiron, A; Barak, Y; Noy, S; Pinhas-Hamiel, O, 1999)
"This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke."9.09Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000)
"To study the effect of fluoxetine, a specific serotonin reuptake inhibitor, on insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) independently of its action on body weight."9.08Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss. ( Bourque, J; Chiasson, JL; Ducros, F; Garon, J; Maheux, P, 1997)
"Our study aims at assessing the efficacy and safety of fluoxetine as compared with placebo in the treatment of obesity using a double-blind crossover design."9.08Comparison of fluoxetine and placebo in the treatment of obesity. ( Barredo-Acedo, F; Escobar-Jiménez, F; Fernández-Soto, ML; González-Jiménez, A; Luna del Castillo, JD, 1995)
"Fluoxetine hydrochloride (Lovan, Eli Lilly and Company, Indianapolis, Indiana, USA), a specific serotonin uptake inhibitor, was compared with placebo in 458 obese outpatients in a 52-week double-blind randomized ten-site trial to study its effect on weight reduction."9.07Fluoxetine: a randomized clinical trial in the treatment of obesity. ( Enas, GG; Fludzinski, LA; Goldstein, DJ; Levine, LR; Potvin, JH; Rampey, AH, 1994)
" To demonstrate the use of this methodology, we applied the criteria in an analysis of eight randomized, double-blind controlled trials comparing fluoxetine (n = 522) with placebo (n = 504) for weight loss."9.07Evaluating success of weight loss programs, with an application to fluoxetine weight reduction clinical trial data. ( Atkinson, RL; Goldstein, DJ; Roback, PJ; Sayler, ME, 1994)
" Fluoxetine, an inhibitor of serotonin reuptake, decreases food intake in animals and is associated with weight loss in depressed and otherwise healthy obese patients."9.06Use of fluoxetine, a selective serotonin-uptake inhibitor, in the treatment of obesity: a dose-response study (with a commentary by Michael Weintraub). ( Byyny, RL; Dauer, AD; Enas, GG; Kirby, RW; Kreindler, TG; Levine, LR; Levy, B; Lucas, CP; McIlwain, HH; Thompson, WL, 1989)
"Eleven healthy male subjects of normal body weight received either 60 mg of the 5-HT re-uptake inhibitor fluoxetine (FXT) or matching placebo daily for two weeks, with a minimum one month wash-out period between treatments."9.06The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. ( McGuirk, J; Silverstone, T, 1990)
"The rising popularity of herbal medicine as a weight loss remedy, fueled by misleading propaganda, raises concerns about the manufacturing processes and potential inclusion of controlled substances such as fluoxetine (FLU)."8.31Determination of Fluoxetine in Weight Loss Herbal Medicine Using an Electrochemical Sensor Based on rGO-CuNPs. ( Barreto, FC; Cesarino, I; Melaré, AG; Silva, MKL; Simões, RP, 2023)
"Fluoxetine is a highly specific serotonin reuptake inhibitor."7.77Clinical studies with fluoxetine in obesity. ( Wise, SD, 1992)
"These data suggest that fluoxetine and olanzapine treatment decreases weight gain in rats; a pharmacodynamic event-related effect that differs considerably from what is observed in the clinical condition."7.72Weight loss dynamics during combined fluoxetine and olanzapine treatment. ( Chabla, JM; Hallas, BH; Horowitz, JM; Perrone, JA; Torres, G, 2004)
"Fluoxetine, a serotonin re-uptake inhibitor with antidepressive and appetite reduction effects, could improve insulin sensitivity."7.69[The effect of fluoxetine on insulin resistance in non diabetic obese patients]. ( Aguirre, C; Araya, V; Contreras, P; Depix, MS; Zura, ML, 1995)
"A 27-year-old woman experienced a modest weight loss during treatment for depression with fluoxetine."7.69Hyperphagia and weight loss during fluoxetine treatment. ( Braun, BG; Fichtner, CG, 1994)
" To examine whether weight loss produced by serotoninergic drugs involves a selective reduction in CHO intake, obese females who consumed at least 30% of their daily calories from CHO-rich snacks were treated with dexfenfluramine ([DF] 15 mg b."7.68Dexfenfluramine, fluoxetine, and weight loss among female carbohydrate cravers. ( Berry, E; Gleason, R; Goldberg, H; Kahne, M; McDermott, J; Tsay, R; Wurtman, J; Wurtman, R, 1993)
"Fluoxetine treatment was associated with greater reduction in depressive symptoms (p<0."6.71Cognitive behavioral therapy and fluoxetine as adjuncts to group behavioral therapy for binge eating disorder. ( Bellace, D; Carino, J; Devlin, MJ; Dobrow, I; Goldfein, JA; Jiang, H; Kamenetz, C; Mayer, L; Petkova, E; Raizman, PS; Walsh, BT; Wolk, S, 2005)
"Obesity is a major health care concern because of its associated medical complications and increased mortality."6.68Efficacy and safety of long-term fluoxetine treatment of obesity--maximizing success. ( Goldstein, DJ; Hamilton, SH; Rampey, AH; Roback, PJ; Sayler, ME; Tollefson, GD; Wilson, MG, 1995)
"Fluoxetine 60 mg/day was effective for a longer period than fluoxetine 20 mg/day or placebo in maintaining weight loss."6.67Fluoxetine: a randomized clinical trial in the maintenance of weight loss. ( Dornseif, BE; Fludzinski, LA; Goldstein, DJ; Levine, LR; Potvin, JH; Rampey, AH, 1993)
"To compare the efficacy and safety of diethylpropion (DEP), fenproporex (FEN), mazindol (MZD), fluoxetine (FXT) and sibutramine (SIB) in promoting weight loss."5.19A comparative study of five centrally acting drugs on the pharmacological treatment of obesity. ( Boguszewski, CL; Cunha, DR; do Desterro de Figueiredo, M; dos Santos, CM; Radominski, R; Suplicy, H, 2014)
"This open-label pilot study of combination therapy of metformin and fluoxetine gave encouraging weight reduction, and these results suggest the need for a randomized double-blind clinical trial comparing the two components and the combination to placebo."5.12An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction. ( Amini, M; Aminorroaya, A; Dastjerdi, MS; Kazemi, F; Mohammady, M; Najafian, A, 2007)
"This study compared nortriptyline and fluoxetine with placebo in the treatment of depression and in recovery from physical and cognitive impairments after stroke."5.09Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. ( Castillo, C; Curdue, K; Kopel, T; Kosier, JT; Newman, RM; Petracca, G; Robinson, RG; Schultz, SK; Starkstein, SE, 2000)
"To evaluate the weight reducing effect of fluoxetine on steroid-induced obesity, we conducted an open, clinical intervention study of 20-40 mg/day fluoxetine, 24 weeks duration."5.09Fluoxetine treatment for weight reduction in steroid-induced obesity: a pilot study in myasthenia gravis patients. ( Achiron, A; Barak, Y; Noy, S; Pinhas-Hamiel, O, 1999)
"Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported."5.09Changes in weight during a 1-year trial of fluoxetine. ( Amsterdam, JD; Beasley, CM; Kim, Y; Michelson, D; Quitkin, FM; Reimherr, FW; Rosenbaum, JF; Sundell, KL; Zajecka, J, 1999)
"This study assessed the effect of fluoxetine 20 mg/day on weight loss in older patients treated for major depression in a multicenter, double-blind placebo-controlled, 6-week clinical trial."5.08Fluoxetine in medically stable, depressed geriatric patients: effects on weight. ( Beasley, CM; Goldstein, DJ; Hamilton, SH; Masica, DN, 1997)
"To study the effect of fluoxetine, a specific serotonin reuptake inhibitor, on insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) independently of its action on body weight."5.08Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss. ( Bourque, J; Chiasson, JL; Ducros, F; Garon, J; Maheux, P, 1997)
" We have evaluated the weight loss of a selective inhibitor of serotonin uptake, fluoxetine, alone as compared with combined therapeutic trial with another serotoninergic drug, dexfenfluramine."5.08The addition of dexfenfluramine to fluoxetine in the treatment of obesity: a randomized clinical trial. ( Halpern, A; Lima, N; Medeiros-Neto, G; Pedrinola, F; Sztejnsznajd, C, 1996)
"Our study aims at assessing the efficacy and safety of fluoxetine as compared with placebo in the treatment of obesity using a double-blind crossover design."5.08Comparison of fluoxetine and placebo in the treatment of obesity. ( Barredo-Acedo, F; Escobar-Jiménez, F; Fernández-Soto, ML; González-Jiménez, A; Luna del Castillo, JD, 1995)
"Fluoxetine hydrochloride (Lovan, Eli Lilly and Company, Indianapolis, Indiana, USA), a specific serotonin uptake inhibitor, was compared with placebo in 458 obese outpatients in a 52-week double-blind randomized ten-site trial to study its effect on weight reduction."5.07Fluoxetine: a randomized clinical trial in the treatment of obesity. ( Enas, GG; Fludzinski, LA; Goldstein, DJ; Levine, LR; Potvin, JH; Rampey, AH, 1994)
"Fluoxetine, an inhibitor of serotonin re-uptake, has been shown to cause weight loss in humans and animals."5.07Fluoxetine treatment of the obese diabetic. ( Bray, GA; Devine, W; Fujioka, K; Gray, DS, 1992)
" To demonstrate the use of this methodology, we applied the criteria in an analysis of eight randomized, double-blind controlled trials comparing fluoxetine (n = 522) with placebo (n = 504) for weight loss."5.07Evaluating success of weight loss programs, with an application to fluoxetine weight reduction clinical trial data. ( Atkinson, RL; Goldstein, DJ; Roback, PJ; Sayler, ME, 1994)
"To determine whether fluoxetine is effective in the long-term treatment of obesity and whether it is particularly useful in the treatment of obese binge-eaters, the authors randomly assigned 45 obese subjects (22 with binge-eating problems and 23 without binge-eating) to fluoxetine (60 mg/day) or placebo in a 52-week double-blind trial."5.06A double-blind, placebo-controlled trial of fluoxetine plus behavior modification in the treatment of obese binge-eaters and non-binge-eaters. ( Ewing, L; Gooding, W; Kern, E; Marcus, MD; McDermott, M; Wing, RR, 1990)
" Fluoxetine, an inhibitor of serotonin reuptake, decreases food intake in animals and is associated with weight loss in depressed and otherwise healthy obese patients."5.06Use of fluoxetine, a selective serotonin-uptake inhibitor, in the treatment of obesity: a dose-response study (with a commentary by Michael Weintraub). ( Byyny, RL; Dauer, AD; Enas, GG; Kirby, RW; Kreindler, TG; Levine, LR; Levy, B; Lucas, CP; McIlwain, HH; Thompson, WL, 1989)
"Eleven healthy male subjects of normal body weight received either 60 mg of the 5-HT re-uptake inhibitor fluoxetine (FXT) or matching placebo daily for two weeks, with a minimum one month wash-out period between treatments."5.06The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. ( McGuirk, J; Silverstone, T, 1990)
"Short period of fluoxetine therapy can lead to weight loss as well as reduction of FPG, HbA1c and TG in T2DM."4.87Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials. ( Chen, L; He, M; Hu, J; Hu, R; Huang, Y; Li, Q; Liu, C; Qu, S; Wang, X; Yang, Z; Ye, Z; Zhang, S; Zhang, Z; Zhao, W, 2011)
"Fluoxetine, orlistat, and sibutramine can achieve statistically significant weight loss over 26 to 52 weeks."4.82Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis. ( Avenell, A; Gregg, E; Kim, C; Lau, J; Norris, SL; Schmid, CH; Zhang, X, 2004)
"Fluoxetine, orlistat, and sibutramine can achieve statistically significant weight loss over 12 to 57 weeks."4.82Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus. ( Avenell, A; Gregg, E; Lau, J; Norris, SL; Schmid, CH; Zhang, X, 2005)
"The rising popularity of herbal medicine as a weight loss remedy, fueled by misleading propaganda, raises concerns about the manufacturing processes and potential inclusion of controlled substances such as fluoxetine (FLU)."4.31Determination of Fluoxetine in Weight Loss Herbal Medicine Using an Electrochemical Sensor Based on rGO-CuNPs. ( Barreto, FC; Cesarino, I; Melaré, AG; Silva, MKL; Simões, RP, 2023)
"Fluoxetine is a highly specific serotonin reuptake inhibitor."3.77Clinical studies with fluoxetine in obesity. ( Wise, SD, 1992)
"Bupropion (BUP) is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor that causes mild weight loss in obese adults."3.74Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis. ( Billes, SK; Cowley, MA, 2008)
"These data suggest that fluoxetine and olanzapine treatment decreases weight gain in rats; a pharmacodynamic event-related effect that differs considerably from what is observed in the clinical condition."3.72Weight loss dynamics during combined fluoxetine and olanzapine treatment. ( Chabla, JM; Hallas, BH; Horowitz, JM; Perrone, JA; Torres, G, 2004)
" To illustrate an application of this method, we used data from 1,026 patients completing at least 6 months of double-blind therapy in clinical trials comparing fluoxetine (N=522) with placebo (N=504) for weight loss."3.69Baseline predictors of success when comparing two treatments. ( Goldstein, DJ; Rampey, AH; Roback, PJ; Wilson, MG, 1994)
"Fluoxetine, a serotonin re-uptake inhibitor with antidepressive and appetite reduction effects, could improve insulin sensitivity."3.69[The effect of fluoxetine on insulin resistance in non diabetic obese patients]. ( Aguirre, C; Araya, V; Contreras, P; Depix, MS; Zura, ML, 1995)
" To investigate this phenomenon as a possible animal model of obsessive-compulsive disorder (OCD), rats were treated for 5 weeks with fluoxetine, an antidepressant that relieves OCD symptoms in humans (5 mg/kg, 2."3.69Effects of serotonergic agents on food-restriction-induced hyperactivity. ( Altemus, M; Galliven, E; Glowa, JR; Leong, YM; Murphy, DL, 1996)
"A 27-year-old woman experienced a modest weight loss during treatment for depression with fluoxetine."3.69Hyperphagia and weight loss during fluoxetine treatment. ( Braun, BG; Fichtner, CG, 1994)
"The frequency and degree of weight loss noted here in medically ill elderly receiving fluoxetine warrants further investigation."3.68Fluoxetine in elderly patients: is there cause for concern? ( Brymer, C; Winograd, CH, 1992)
" To examine whether weight loss produced by serotoninergic drugs involves a selective reduction in CHO intake, obese females who consumed at least 30% of their daily calories from CHO-rich snacks were treated with dexfenfluramine ([DF] 15 mg b."3.68Dexfenfluramine, fluoxetine, and weight loss among female carbohydrate cravers. ( Berry, E; Gleason, R; Goldberg, H; Kahne, M; McDermott, J; Tsay, R; Wurtman, J; Wurtman, R, 1993)
"Fluoxetine treatment was associated with greater reduction in depressive symptoms (p<0."2.71Cognitive behavioral therapy and fluoxetine as adjuncts to group behavioral therapy for binge eating disorder. ( Bellace, D; Carino, J; Devlin, MJ; Dobrow, I; Goldfein, JA; Jiang, H; Kamenetz, C; Mayer, L; Petkova, E; Raizman, PS; Walsh, BT; Wolk, S, 2005)
" FL did not affect thermic response to oral glucose neither after acute nor chronic administration (p=NS for all groups studied)."2.69Metabolic effects of fluoxetine in obese menopausal women. ( Bertolini, M; Bondi, M; Del Rio, G; Menozzi, R; Venneri, MG, 2000)
"Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain."2.68Usefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study. ( Daubresse, JC; Kolanowski, J; Krzentowski, G; Kutnowski, M; Scheen, A; Van Gaal, L, 1996)
"Obesity is a major health care concern because of its associated medical complications and increased mortality."2.68Efficacy and safety of long-term fluoxetine treatment of obesity--maximizing success. ( Goldstein, DJ; Hamilton, SH; Rampey, AH; Roback, PJ; Sayler, ME; Tollefson, GD; Wilson, MG, 1995)
"Fluoxetine 60 mg/day was effective for a longer period than fluoxetine 20 mg/day or placebo in maintaining weight loss."2.67Fluoxetine: a randomized clinical trial in the maintenance of weight loss. ( Dornseif, BE; Fludzinski, LA; Goldstein, DJ; Levine, LR; Potvin, JH; Rampey, AH, 1993)
"After treatment, weight loss (on average) was observed in both groups: -2."2.67The effect of fluoxetine on body weight, body composition and visceral fat accumulation. ( Koppeschaar, HP; Seidell, JC; Smits, P; Visser, M, 1993)
"Fluoxetine is an antidepressant drug with weight reducing properties."2.67An assessment of the thermogenic effects of fluoxetine in obese subjects. ( Andrews, JF; Murphy, CM; Stinson, JC; Tomkin, GH, 1992)
"Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved."2.67Fluoxetine therapy in obese diabetic and glucose intolerant patients. ( Daubresse, JC; Friedman, H; Kolanowski, J; Krzentowski, G; Kutnowski, M; Scheen, A; Van Gaal, L, 1992)
"Fluoxetine and trazodone were compared in a double-blind, randomized, parallel, 6-week trial in 43 outpatients with major depression after a 1-week single-blind placebo period."2.66Fluoxetine versus trazodone in the treatment of outpatients with major depression. ( Debus, JR; Himmel, C; Polatin, P; Rush, AJ; Tyler, D; Weissenburger, J, 1988)
"The resultant weight loss is variable and there appears to be no way of predicting good responders, nor is there evidence that additional weight loss attributable to drug therapy is sustained once treatment is discontinued, although nonpharmacological strategies for preventing weight regain are worthy of exploration."2.38Appraisal of the clinical value of serotoninergic drugs. ( Hodge, J; Munro, JF; Scott, C, 1992)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.00)18.7374
1990's37 (61.67)18.2507
2000's16 (26.67)29.6817
2010's2 (3.33)24.3611
2020's2 (3.33)2.80

Authors

AuthorsStudies
Melaré, AG1
Barreto, FC1
Silva, MKL1
Simões, RP1
Cesarino, I1
de Souza, JA1
do Amaral Almeida, LC1
Tavares, GA1
Falcão, LAL1
Beltrão, LC1
Costa, FCO1
de Souza, FL1
da Silva, MC1
de Souza, SL1
Suplicy, H1
Boguszewski, CL1
dos Santos, CM1
do Desterro de Figueiredo, M1
Cunha, DR1
Radominski, R1
Yanover, T1
Thompson, JK1
Straub, DM1
Kaplan, AS1
Walsh, BT2
Olmsted, M1
Attia, E1
Carter, JC1
Devlin, MJ2
Pike, KM1
Woodside, B1
Rockert, W1
Roberto, CA1
Parides, M1
Ye, Z1
Chen, L1
Yang, Z1
Li, Q1
Huang, Y1
He, M1
Zhang, S1
Zhang, Z1
Wang, X1
Zhao, W1
Hu, J1
Liu, C1
Qu, S1
Hu, R1
Norris, SL2
Zhang, X2
Avenell, A2
Gregg, E2
Schmid, CH2
Kim, C1
Lau, J2
Weng, CS1
Hung, YL1
Shyu, LY1
Chang, YH1
Perrone, JA1
Chabla, JM1
Hallas, BH1
Horowitz, JM1
Torres, G1
Goldfein, JA1
Petkova, E1
Jiang, H1
Raizman, PS1
Wolk, S1
Mayer, L1
Carino, J1
Bellace, D1
Kamenetz, C1
Dobrow, I1
Dolfing, JG1
Wolffenbuttel, BH1
ten Hoor-Aukema, NM1
Schweitzer, DH1
Goldstein, DJ7
Rampey, AH4
Dornseif, BE1
Levine, LR3
Potvin, JH2
Fludzinski, LA2
Roback, PJ3
Wilson, MG2
Dastjerdi, MS1
Kazemi, F1
Najafian, A1
Mohammady, M1
Aminorroaya, A1
Amini, M1
Whigham, LD1
Dhurandhar, NV1
Rahko, PS1
Atkinson, RL2
Billes, SK1
Cowley, MA1
Toubro, S1
Fernández-Soto, ML1
González-Jiménez, A1
Barredo-Acedo, F1
Luna del Castillo, JD1
Escobar-Jiménez, F1
Barak, Y2
Lampl, Y1
Achiron, A2
Sarova-Pinhas, I1
Elizur, A1
Connolly, VM1
Gallagher, A1
Kesson, CM1
Fichtner, CG1
Braun, BG1
Gray, DS2
Bross, R1
Hoffer, LJ1
Sayler, ME2
Holman, SL1
Enas, GG3
Porterfield, LM1
Wurtman, J1
Wurtman, R1
Berry, E1
Gleason, R1
Goldberg, H1
McDermott, J1
Kahne, M1
Tsay, R1
Visser, M1
Seidell, JC1
Koppeschaar, HP1
Smits, P1
Araya, V1
Contreras, P1
Aguirre, C1
Depix, MS1
Zura, ML1
Hamilton, SH2
Tollefson, GD1
Daubresse, JC2
Kolanowski, J2
Krzentowski, G2
Kutnowski, M2
Scheen, A2
Van Gaal, L2
Altemus, M1
Glowa, JR1
Galliven, E1
Leong, YM1
Murphy, DL1
Foltin, RW1
Haney, M1
Comer, SD1
Fischman, MW1
Pedrinola, F1
Sztejnsznajd, C1
Lima, N1
Halpern, A1
Medeiros-Neto, G1
Maheux, P1
Ducros, F1
Bourque, J1
Garon, J1
Chiasson, JL1
Masica, DN1
Beasley, CM2
Noy, S1
Pinhas-Hamiel, O1
Cowley, G1
Springen, K1
Finkel, SI1
Richter, EM1
Clary, CM1
Batzar, E1
Michelson, D1
Amsterdam, JD1
Quitkin, FM1
Reimherr, FW1
Rosenbaum, JF1
Zajecka, J1
Sundell, KL1
Kim, Y1
Lin, X1
Levitsky, DA1
King, JM1
Campbell, TC1
Robinson, RG1
Schultz, SK1
Castillo, C1
Kopel, T1
Kosier, JT1
Newman, RM1
Curdue, K1
Petracca, G1
Starkstein, SE1
Cash, TF1
Brown, MA1
Bondi, M1
Menozzi, R1
Bertolini, M1
Venneri, MG1
Del Rio, G1
Dursun, SM1
Devarajan, S1
Fujioka, K1
Devine, W1
Bray, GA1
Stinson, JC1
Murphy, CM1
Andrews, JF1
Tomkin, GH1
Friedman, H1
Brymer, C1
Winograd, CH1
Yen, TT1
Fuller, RW1
Wise, SD1
Munro, JF1
Scott, C1
Hodge, J1
Darga, LL1
Carroll-Michals, L1
Botsford, SJ1
Lucas, CP2
Marcus, MD1
Wing, RR1
Ewing, L1
Kern, E1
McDermott, M1
Gooding, W1
McGuirk, J1
Silverstone, T1
Cugurra, F1
Thompson, WL1
Byyny, RL1
Dauer, AD1
Kirby, RW1
Kreindler, TG1
Levy, B1
McIlwain, HH1
Debus, JR1
Rush, AJ1
Himmel, C1
Tyler, D1
Polatin, P1
Weissenburger, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475]Phase 439 participants (Actual)Interventional2015-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for fluoxetine and Weight Reduction

ArticleYear
Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Anti-Obesity Agents; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Fasting; Fluoxetine; Gly

2011
Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis.
    Archives of internal medicine, 2004, Jul-12, Volume: 164, Issue:13

    Topics: Adult; Aged; Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Diabetes Mellitus, Type 2; Dru

2004
Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus.
    The Cochrane database of systematic reviews, 2005, Jan-25, Issue:1

    Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Diabetes Mellitus, Type 2; Fluoxetin

2005
Preclinical pharmacology of fluoxetine, a serotonergic drug for weight loss.
    The American journal of clinical nutrition, 1992, Volume: 55, Issue:1 Suppl

    Topics: Animals; Appetite Depressants; Eating; Fluoxetine; Serotonin; Weight Loss

1992
Clinical studies with fluoxetine in obesity.
    The American journal of clinical nutrition, 1992, Volume: 55, Issue:1 Suppl

    Topics: Adult; Female; Fluoxetine; Humans; Male; Middle Aged; Obesity; Weight Loss

1992
Appraisal of the clinical value of serotoninergic drugs.
    The American journal of clinical nutrition, 1992, Volume: 55, Issue:1 Suppl

    Topics: Appetite Depressants; Fenfluramine; Fluoxetine; Humans; Obesity; Serotonin; Weight Loss

1992

Trials

33 trials available for fluoxetine and Weight Reduction

ArticleYear
A comparative study of five centrally acting drugs on the pharmacological treatment of obesity.
    International journal of obesity (2005), 2014, Volume: 38, Issue:8

    Topics: Adult; Amphetamines; Anti-Obesity Agents; Body Mass Index; Brazil; Cyclobutanes; Diet, Reducing; Die

2014
The slippery slope: prediction of successful weight maintenance in anorexia nervosa.
    Psychological medicine, 2009, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Anorexia Nervosa; Body Image; Body Mass Index; Body Weight; Cognitive Behavioral

2009
Cognitive behavioral therapy and fluoxetine as adjuncts to group behavioral therapy for binge eating disorder.
    Obesity research, 2005, Volume: 13, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Bulimia; Cognitive Behavioral Therapy; Double-Blind

2005
Fluoxetine: a randomized clinical trial in the maintenance of weight loss.
    Obesity research, 1993, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Aged; Body Mass Index; Body Weight; Carbohydrates; Cholesterol; Cholesterol, LDL;

1993
An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction.
    International journal of obesity (2005), 2007, Volume: 31, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Body Mass Index; Drug Therapy, Combination; Female;

2007
Comparison of fluoxetine and placebo in the treatment of obesity.
    Annals of nutrition & metabolism, 1995, Volume: 39, Issue:3

    Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Fluoxetine; Humans; Obesity; Selective Serot

1995
A study of fluoxetine in obese elderly patients with type 2 diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:5

    Topics: Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Evaluation S

1995
Fluoxetine increases resting energy expenditure and basal body temperature in humans.
    The American journal of clinical nutrition, 1995, Volume: 61, Issue:5

    Topics: Adult; Body Temperature; Chemotherapy, Adjuvant; Diet, Reducing; Double-Blind Method; Energy Metabol

1995
Evaluating success of weight loss programs, with an application to fluoxetine weight reduction clinical trial data.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1994, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Diet, Reducing; Double-Blind Method; Female; Flu

1994
Pattern analysis method for assessing successful weight reduction.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1994, Volume: 18, Issue:5

    Topics: Adult; Aged; Blood Pressure; Confidence Intervals; Counseling; Diabetes Mellitus, Type 2; Double-Bli

1994
Fluoxetine: a randomized clinical trial in the treatment of obesity.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1994, Volume: 18, Issue:3

    Topics: Adult; Body Mass Index; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Obesity;

1994
The effect of fluoxetine on body weight, body composition and visceral fat accumulation.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1993, Volume: 17, Issue:5

    Topics: Abdomen; Adipose Tissue; Adult; Body Composition; Double-Blind Method; Fluoxetine; Humans; Magnetic

1993
Efficacy and safety of long-term fluoxetine treatment of obesity--maximizing success.
    Obesity research, 1995, Volume: 3 Suppl 4

    Topics: Double-Blind Method; Fluoxetine; Humans; Obesity; Placebos; Risk Factors; Selective Serotonin Reupta

1995
Usefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
    Obesity research, 1996, Volume: 4, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dou

1996
Effect of fluoxetine on food intake of humans living in a residential laboratory.
    Appetite, 1996, Volume: 27, Issue:2

    Topics: Adult; Dietary Carbohydrates; Dietary Fats; Eating; Energy Intake; Female; Fluoxetine; Humans; Male;

1996
The addition of dexfenfluramine to fluoxetine in the treatment of obesity: a randomized clinical trial.
    Obesity research, 1996, Volume: 4, Issue:6

    Topics: Adult; Aged; Body Mass Index; Drug Therapy, Combination; Female; Fenfluramine; Fluoxetine; Humans; L

1996
Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:2

    Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fluoxetine

1997
Fluoxetine in medically stable, depressed geriatric patients: effects on weight.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:5

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Body Mass Index; Depressive Disor

1997
Fluoxetine treatment for weight reduction in steroid-induced obesity: a pilot study in myasthenia gravis patients.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:1-2

    Topics: Adult; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Body Mass Index; Female;

1999
Comparative efficacy of sertraline vs. fluoxetine in patients age 70 or over with major depression.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1999,Summer, Volume: 7, Issue:3

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Cognition; Depressive Disorder, Major; Double-Blind

1999
Changes in weight during a 1-year trial of fluoxetine.
    The American journal of psychiatry, 1999, Volume: 156, Issue:8

    Topics: Adult; Appetite; Body Mass Index; Body Weight; Depressive Disorder; Female; Fluoxetine; Humans; Male

1999
Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study.
    The American journal of psychiatry, 2000, Volume: 157, Issue:3

    Topics: Activities of Daily Living; Antidepressive Agents, Tricyclic; Cognition Disorders; Depressive Disord

2000
Attitudes about antidepressants: influence of information about weight-related side effects.
    Perceptual and motor skills, 2000, Volume: 90, Issue:2

    Topics: Adolescent; Adult; Antidepressive Agents; Attitude to Health; Body Weight; Drug Information Services

2000
Metabolic effects of fluoxetine in obese menopausal women.
    Journal of endocrinological investigation, 2000, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Second-Generation; Blood Glucose; Body Temperature Regulation; Double-Blind M

2000
Fluoxetine treatment of the obese diabetic.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16, Issue:3

    Topics: Adult; Blood Glucose; Chemotherapy, Adjuvant; Diabetes Mellitus, Type 2; Diet, Reducing; Double-Blin

1992
An assessment of the thermogenic effects of fluoxetine in obese subjects.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16, Issue:5

    Topics: Adult; Basal Metabolism; Body Temperature Regulation; Double-Blind Method; Female; Fluoxetine; Human

1992
Fluoxetine therapy in obese diabetic and glucose intolerant patients.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 4

    Topics: Blood Glucose; Diabetes Mellitus; Double-Blind Method; Female; Fluoxetine; Glucose Tolerance Test; G

1992
Clinical studies with fluoxetine in obesity.
    The American journal of clinical nutrition, 1992, Volume: 55, Issue:1 Suppl

    Topics: Adult; Female; Fluoxetine; Humans; Male; Middle Aged; Obesity; Weight Loss

1992
Fluoxetine's effect on weight loss in obese subjects.
    The American journal of clinical nutrition, 1991, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Double-Blind Method; Fluoxetine; Humans; Middle Aged; Obesity; Time Factors; Weig

1991
A double-blind, placebo-controlled trial of fluoxetine plus behavior modification in the treatment of obese binge-eaters and non-binge-eaters.
    The American journal of psychiatry, 1990, Volume: 147, Issue:7

    Topics: Adolescent; Adult; Attitude to Health; Behavior Therapy; Bulimia; Clinical Trials as Topic; Combined

1990
The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects.
    International journal of obesity, 1990, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Appetite; Body Weight; Double-Blind Method; Energy Intake; Fluoxetine; Humans; Ma

1990
Use of fluoxetine, a selective serotonin-uptake inhibitor, in the treatment of obesity: a dose-response study (with a commentary by Michael Weintraub).
    International journal of obesity, 1989, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Male; Middle

1989
Fluoxetine versus trazodone in the treatment of outpatients with major depression.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:11

    Topics: Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Dizziness; Double-Blind Method; Fluo

1988

Other Studies

22 other studies available for fluoxetine and Weight Reduction

ArticleYear
Determination of Fluoxetine in Weight Loss Herbal Medicine Using an Electrochemical Sensor Based on rGO-CuNPs.
    Molecules (Basel, Switzerland), 2023, Aug-30, Volume: 28, Issue:17

    Topics: Anti-Obesity Agents; Fluoxetine; Graphite; Humans; Plant Extracts; Weight Loss

2023
Dual exposure to stress in different stages of development affects eating behavior of male Wistar rats.
    Physiology & behavior, 2020, 02-01, Volume: 214

    Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Drug Resistance; Eating; Female; Fluoxetine; Food D

2020
An adolescent male with features of EDNOS and obsessive-compulsive disorder.
    Eating and weight disorders : EWD, 2008, Volume: 13, Issue:2

    Topics: Adolescent; Body Mass Index; Cognitive Behavioral Therapy; Combined Modality Therapy; Comorbidity; D

2008
A study of electrical conductance of meridian in the obese during weight reduction.
    The American journal of Chinese medicine, 2004, Volume: 32, Issue:3

    Topics: Adult; Body Mass Index; Case-Control Studies; Diet, Reducing; Electric Impedance; Exercise; Female;

2004
Weight loss dynamics during combined fluoxetine and olanzapine treatment.
    BMC pharmacology, 2004, Oct-21, Volume: 4

    Topics: Animals; Benzodiazepines; Fluoxetine; Male; Olanzapine; Rats; Rats, Long-Evans; Selective Serotonin

2004
Daily high doses of fluoxetine for weight loss and improvement in lifestyle before bariatric surgery.
    Obesity surgery, 2005, Volume: 15, Issue:8

    Topics: Adult; Appetite Depressants; Bariatric Surgery; Female; Fluoxetine; Health Behavior; Humans; Life St

2005
Baseline predictors of success when comparing two treatments.
    Obesity research, 1994, Volume: 2, Issue:4

    Topics: Anti-Obesity Agents; Fluoxetine; Humans; Obesity; Predictive Value of Tests; Randomized Controlled T

1994
Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.
    International journal of obesity (2005), 2007, Volume: 31, Issue:5

    Topics: Adult; Appetite Depressants; Body Mass Index; Drug Therapy, Combination; Fenfluramine; Fluoxetine; H

2007
Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:6

    Topics: Animals; Area Under Curve; Behavior, Animal; Bupropion; Catecholamines; Dopamine Uptake Inhibitors;

2008
[Pharmacotherapy for weight loss in patients with type 2 diabetes].
    Ugeskrift for laeger, 2007, Aug-13, Volume: 169, Issue:33

    Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Diabetes Mellitus, Type 2; Evidence-Based M

2007
Fluoxetine induced weight loss: a pilot study in postpartum women.
    The Israel journal of psychiatry and related sciences, 1995, Volume: 32, Issue:1

    Topics: Adult; Female; Fluoxetine; Humans; Obesity; Pilot Projects; Puerperal Disorders; Weight Loss

1995
Hyperphagia and weight loss during fluoxetine treatment.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:12

    Topics: Adult; Depression; Eating; Female; Fluoxetine; Humans; Hyperphagia; Weight Loss

1994
Response to Roback et al.
    Obesity research, 1995, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Fluoxetine; Humans; Obesity; Weight Loss

1995
If weight loss persists after other symptoms of depression subside.
    RN, 1994, Volume: 57, Issue:8

    Topics: Anorexia; Depressive Disorder; Female; Fluoxetine; Humans; Middle Aged; Weight Loss

1994
Dexfenfluramine, fluoxetine, and weight loss among female carbohydrate cravers.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 9, Issue:3

    Topics: Adult; Dietary Carbohydrates; Dietary Proteins; Eating; Female; Fenfluramine; Fluoxetine; Humans; Mo

1993
[The effect of fluoxetine on insulin resistance in non diabetic obese patients].
    Revista medica de Chile, 1995, Volume: 123, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Fluoxetine; Glucose Tolerance Test; Humans; Insulin

1995
Effects of serotonergic agents on food-restriction-induced hyperactivity.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Disease Models, Animal; Eating; Female; Fenc

1996
After fen-phen.
    Newsweek, 1997, Sep-29, Volume: 130, Issue:13

    Topics: Antidepressive Agents, Second-Generation; Appetite Depressants; Consumer Product Safety; Fenfluramin

1997
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Adipose Tissue, Brown; Aflatoxin B1; Amphetamine; Animals; Appetite Depressants; Biomarkers; Body Te

1999
Accelerated weight loss after treating refractory depression with fluoxetine plus topiramate: possible mechanisms of action?
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2001, Volume: 46, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Appetite; Depressive Disorder; Drug Therapy, Combin

2001
Fluoxetine in elderly patients: is there cause for concern?
    Journal of the American Geriatrics Society, 1992, Volume: 40, Issue:9

    Topics: Age Factors; Aged; Ambulatory Care; Anorexia; Comorbidity; Depressive Disorder; Female; Fluoxetine;

1992
[XXIV. The future of slimming anorectics].
    La Clinica terapeutica, 1989, Jan-15, Volume: 128, Issue:1

    Topics: Fluoxetine; Forecasting; Humans; Weight Loss

1989