| Assay ID | Title | Year | Journal | Article |
|---|
| AID772374 | Agonist activity at human 5HT1A receptor relative to control | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID339892 | Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID772382 | Antagonist activity at human alpha2A AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID772371 | Agonist activity at human alpha2C AR assessed as intrinsic activity | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID536954 | Reduction in morphine tolerance acquisition in CD1 mouse assessed as morphine analgesic effect incidence at 0.05 mg/kg, ip bid administered 15 mins before last morphine dosing by radiant heat tail flick test | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID339889 | Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID536932 | Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID536956 | Reduction in morphine dependence expression in CD1 mouse assessed as decrease in somatic signs at 0.05 mg/kg, ip bid administered 15 mins before last morphine dosing by radiant heat tail flick test | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID683158 | Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID772378 | Binding affinity at human alpha2B AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID536940 | Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID683000 | Agonist activity at human 5HT1A receptor expressed in HeLa cells assessed as [35S]GTPgammaS binding incubated for 20 mins prior to [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting relative to 8-OH-DPAT | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683002 | Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID772380 | Agonist activity at human alpha2C AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID772372 | Binding affinity to I2 imidazoline binding site in rat brain membrane | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID683023 | Antidepressant activity in CD1 mouse assessed as decrease in immobility time at 0.012 mg/kg, ip after 15 mins by forced swim test relative to vehicle-treated control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683153 | Inhibition of human ERG expressed in HEK293 cells after 240 secs by patch clamp assay | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683001 | Agonist activity at human 5HT1A receptor expressed in HeLa cells assessed as [35S]GTPgammaS binding incubated for 20 mins prior to [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID772381 | Agonist activity at human alpha2B AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID339894 | Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID339888 | Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID536942 | Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry relative to (-)noradrenaline | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID772377 | Binding affinity at human alpha2C AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID683022 | Antidepressant activity in CD1 mouse assessed as decrease in immobility time at 0.2 mg/kg, ip after 15 mins by forced swim test relative to vehicle-treated control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID536947 | Reduction in morphine tolerance acquisition in CD1 mouse assessed as morphine analgesic effect incidence at 0.05 mg/kg, ip administered as single dose 15 mins before last morphine dosing on test day post morphine challenge by radiant heat tail flick test | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID339898 | Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID683021 | Antidepressant activity in CD1 mouse assessed as decrease in immobility time at 0.025 mg/kg, ip after 15 mins by forced swim test relative to vehicle-treated control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683160 | Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis relative to control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID682996 | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 mins | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID772379 | Binding affinity at human alpha2A AR | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID536957 | Reduction in morphine dependence expression in CD1 mouse assessed as decrease in frequency of jumping at 0.05 mg/kg, ip bid administered 15 mins before last morphine dosing by radiant heat tail flick test | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID536936 | Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID682997 | Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683004 | Antagonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as reduction in clonidine-induced extracellular acidification after 30 mins by cytosensor microphysiometric analysis | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683024 | Antidepressant activity in CD1 mouse assessed as decrease in immobility time at 0.5 mg/kg, ip after 15 mins by forced swim test relative to vehicle-treated control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID772370 | Antidepressant-like activity in mouse assessed as reduction in immobility time at 0.05 mg/kg, ip by forced swimming test | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID536941 | Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID339899 | Intrinsic activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification relative to (-)-noradrenaline | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID536935 | Antagonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as effect on agonist-induced extracellular acidification by microphysiometry | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID339896 | Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID772375 | Binding affinity at human 5HT1A receptor | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID683003 | Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID536937 | Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID536938 | Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry relative to (-)noradrenaline | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID536955 | Reduction in morphine dependence expression in CD1 mouse assessed as decrease in expression of naloxone-precipitated withdrawal syndrome at 0.05 mg/kg, ip bid administered 15 mins before last morphine dosing by radiant heat tail flick test | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. |
| AID772376 | Agonist activity at human 5HT1A receptor | 2013 | ACS medicinal chemistry letters, Sep-12, Volume: 4, Issue:9
| Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. |
| AID683159 | Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis relative to control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID339890 | Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. |
| AID683019 | Antidepressant activity in CD1 mouse assessed as decrease in immobility time at 0.05 mg/kg, ip after 15 mins by forced swim test relative to vehicle-treated control | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| AID683157 | Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |