fluoxetine has been researched along with Pregnancy in 327 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare anxiety levels experienced during 4 stressful periods of in vitro fertilization (IVF) and treatment outcomes between women taking fluoxetine and a placebo." | 9.14 | Fluoxetine treatment for anxiety in women undergoing in vitro fertilization. ( Grosman, A; Lobo, DS; Motta, EL; Rocha, AM; Seibel, D; Serafini, P, 2009) |
| "The aim of this prospective clinical trial was to investigate the pharmacokinetics of fluoxetine and its active metabolite, norfluoxetine, during pregnancy, delivery, and lactation in mothers and their infants." | 9.10 | Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation. ( Ekblad, U; Heikkinen, T; Laine, K; Palo, P, 2003) |
| "This study was designed to examine whether there is an increased risk for major malformations following the use of fluoxetine during the first trimester of pregnancy." | 8.80 | Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studies. ( Addis, A; Koren, G, 2000) |
| "Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress." | 8.02 | Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021) |
| "to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 8.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
| "Fluoxetine is commonly prescribed during pregnancy but developmental exposure to the drug, like infection, is associated with sex-specific behavioral changes in the offspring." | 8.02 | Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta. ( Ahmed, S; Arita, Y; Clementelli, C; Jeong Park, H; Levenson, AS; Peltier, MR; Pijush, DB, 2021) |
| "The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 7.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
| " We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD)." | 7.85 | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. ( De Long, NE; Hardy, DB; Holloway, AC; Ma, N, 2017) |
| "Early life stress increases risks of fear and anxiety related disorders in adulthood, which may be alleviated by fluoxetine treatment." | 7.81 | Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors. ( Cao, J; Mao, RR; Xiong, GJ; Xu, L; Yang, Y, 2015) |
| " At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 7.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
| "Several epidemiological studies have reported an association between arsenic exposure and increased rates of psychiatric disorders, including depression, in exposed populations." | 7.80 | Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism. ( Allan, AM; Solomon, BR; Tyler, CR; Ulibarri, AL, 2014) |
| "This study evaluated the reproductive effects of fluoxetine exposure in utero and during lactation on pregnancy outcomes and the sexual development of offspring." | 7.79 | In utero and lactational exposure to fluoxetine in Wistar rats: pregnancy outcomes and sexual development. ( Boareto, AC; Dalsenter, PR; Kienast, MF; Lourenço, EL; Martino-Andrade, AJ; Morais, RN; Müller, JC; Spercoski, KM; Zaia, RM, 2013) |
| "Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation." | 7.74 | Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. ( Costa, LC; Lisboa, SF; Moreira, EG; Oliveira, PE; Venâncio, EJ, 2007) |
| " As compared with controls, fluoxetine exposure resulted in fetal pulmonary hypertension as evidenced by an increase in the weight ratio of the right ventricle to the left ventricle plus septum (P = 0." | 7.74 | Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat. ( Belik, J; Fornaro, E; Li, D; Pan, J, 2007) |
| "Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions." | 7.73 | The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat. ( Elliott, DL; Greenhill, KW; Hofler, VE; Johns, JM; Joyner, PW; Knupp, K; Lomas, LM; McMurray, MS; Middleton, CL; Walker, CH, 2005) |
| "Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery." | 7.73 | Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. ( Fitzgerald, C; Grunau, RE; Kent, N; Kim, J; Misri, S; Oberlander, TF; Riggs, KW; Rurak, DW, 2006) |
| "The aim of the present study was to compare the toxic effects of fluoxetine (F) (8 and 16 mg/kg) and venlafaxine (V) (40 and 80 mg/kg) administered during the third week of pregnancy on early development of rats." | 7.70 | Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy. ( Altenburg, SP; da-Silva, VA; Lindsey, CJ; Malheiros, LR; Thomaz, TG, 1999) |
| "To compare pregnancy outcome following first-trimester fluoxetine (Prozac) exposure with pregnancy outcome in two matched control groups." | 7.68 | Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac) ( Donnenfeld, A; Feldkamp, M; Leen-Mitchell, M; McCormack, M; Pastuszak, A; Pinelli, M; Schick-Boschetto, B; Sihn, S; Woodland, C; Zuber, C, 1993) |
| "SRI use during pregnancy is associated with preterm premature rupture of membranes (PPROM) and subsequent preterm birth." | 5.91 | The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation. ( Abrahams, VM; Fabrizio, VA; Hong, S; Lindsay, CV; Lynn, T; Norwitz, ER; Wilcox, M; Yonkers, KA, 2023) |
| "DOK7 congenital myasthenic syndrome (DOK7-CMS) generally presents early in life and is treated with salbutamol or ephedrine." | 5.48 | DOK7 myasthenic syndrome with subacute adult onset during pregnancy and partial response to fluoxetine. ( Basto, JP; Cruz, S; Peres, J; Salgado, V; Santos, L; Santos, M; Tavares, P; Valverde, AH, 2018) |
| " These provided evidence for a significant increase in the risks for major congenital malformations (selective serotonin reuptake inhibitors, paroxetine, fluoxetine, no evidence for sertraline; eight MAs), congenital heart defects (paroxetine, fluoxetine, sertraline; 11 MAs), preterm birth (eight MAs), neonatal adaptation symptoms (eight MAs), and persistent pulmonary hypertension of the newborn (three MAs)." | 5.41 | Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses. ( Alexandre, C; Alexandre, J; Desaunay, P; Dreyfus, M; Eude, LG; Fedrizzi, S; Guénolé, F; Uguz, F, 2023) |
| "Fluoxetine treatment generated a further increase in muscularisation and did not significantly modify the hyperoxia-induced reductions in alveolar density and increases in the endocrine cells." | 5.38 | Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats. ( Baraldi, M; Chiandetti, L; De Caro, R; Fornaro, E; Grisafi, D; Macchi, V; Masola, V; Onisto, M; Porzionato, A; Salmaso, R; Tassone, E; Zaramella, P, 2012) |
| "Fluoxetine-treated dams gave birth to litters 15% smaller than usual and to pups of reduced weight (until postnatal day 7)." | 5.37 | Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. ( Afrasiab-Middelman, A; Dederen, JP; Homberg, JR; Jonkers, M; Kiliaan, AJ; Korte-Bouws, GA; Martens, GJ; Olivier, JD; Peeters, EJ; Roelofs, JJ; Schubert, D; Vallès, A; van Heesch, F, 2011) |
| "We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5." | 5.37 | [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats]. ( Akulova, VK; Fedotova, YO; Ordian, NÉ; Pivina, SG, 2011) |
| "Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 5.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
| "To compare anxiety levels experienced during 4 stressful periods of in vitro fertilization (IVF) and treatment outcomes between women taking fluoxetine and a placebo." | 5.14 | Fluoxetine treatment for anxiety in women undergoing in vitro fertilization. ( Grosman, A; Lobo, DS; Motta, EL; Rocha, AM; Seibel, D; Serafini, P, 2009) |
| "To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum." | 5.14 | Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing. ( Helsel, JC; Luther, JF; Perel, JM; Sit, D; Wisner, KL; Wisniewski, SR, 2010) |
| "No differences in birth weight and acute neonatal outcome were evident across the two groups, though there was a higher frequency of special care nursery admissions for infants with exposure to fluoxetine late in pregnancy." | 5.09 | Birth outcomes following prenatal exposure to fluoxetine. ( Ablon, JS; Bailey, JW; Bouffard, SM; Cohen, LS; Grush, L; Heller, VL, 2000) |
| "To investigate the safety of fluoxetine use during pregnancy, and to better understand the relationship between maternal fluoxetine use during the first trimester and congenital malformations in infants." | 4.95 | Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies. ( Gao, SY; Ji, C; Liu, CX; Shen, ZQ; Wu, QJ; Xu, X; Zhang, TN; Zhao, YH, 2017) |
| " By chronically exposing pregnant/lactating mice to MeHg, we found persistent behavioural changes in the male offspring, which exhibited depression-like behaviour that could be reversed by chronic treatment with the antidepressant fluoxetine." | 4.89 | Long-lasting neurotoxic effects of exposure to methylmercury during development. ( Bose, R; Ceccatelli, S; Edoff, K; Onishchenko, N; Spulber, S, 2013) |
| "The apparent increased risk of fetal cardiac malformations associated with maternal use of fluoxetine has recently been shown also in depressed women who deferred SSRI therapy in pregnancy, and therefore most probably reflects an ascertainment bias." | 4.89 | The fetal safety of fluoxetine: a systematic review and meta-analysis. ( Frankel, Z; Koren, G; Moretti, M; Pupco, A; Riggin, L, 2013) |
| "During and following pregnancy, women are at high risk of experiencing depression, for which fluoxetine (FLX; brand names Prozac, Sarafem, Rapiflux) is the most commonly prescribed treatment." | 4.89 | Long-term outcomes of developmental exposure to fluoxetine: a review of the animal literature. ( Dyck, RH; Kiryanova, V; McAllister, BB, 2013) |
| "There is no conclusive evidence for increased risk for malformations but paroxetine and possibly fluoxetine use in early pregnancy may be associated with a small increased risk for cardiovascular malformations." | 4.86 | Risks associated with in utero and lactation exposure to selective serotonin reuptake inhibitors (SSRIs). ( Ellfolk, M; Malm, H, 2010) |
| "The recent clinical studies on hypericum extract support the present indications for its use in mild to moderate depression and depressive episodes." | 4.84 | [New developments in hypericum extracts: data on efficacy and interactions]. ( Kraft, K, 2007) |
| "Fluoxetine was the first selective serotonin re-uptake inhibitor to be widely available for treatment of depression and numerous other neuropsychiatric disorders." | 4.82 | Safety and side effect profile of fluoxetine. ( Wernicke, JF, 2004) |
| "The largest number of antidepressant treatment trials in premenstrual syndrome and premenstrual dysphoric disorder (PMDD) have been conducted with fluoxetine." | 4.81 | Review of fluoxetine and its clinical applications in premenstrual dysphoric disorder. ( Pearlstein, T; Yonkers, KA, 2002) |
| "This study was designed to examine whether there is an increased risk for major malformations following the use of fluoxetine during the first trimester of pregnancy." | 4.80 | Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studies. ( Addis, A; Koren, G, 2000) |
| " In particular, we treated female and male rats with fluoxetine (FLX 15 mg/kg dissolved in drinking water) during prenatal or early postnatal life, and we evaluated different pathological-like phenotypes (cognitive deficit, anhedonia, and anxiety) by exposing the rats to a battery of behavioral tests during adolescence and adulthood." | 4.31 | Perinatal serotonergic manipulation shapes anhedonic and cognitive behaviors in a sex- and age-dependent manner: Identification of related biological functions at central and peripheral level. ( Brivio, P; Calabrese, F; Dolci, B; Fumagalli, F; Gallo, MT, 2023) |
| " The selective serotonin reuptake inhibitor fluoxetine (FLX) is the first-line antidepressant drug prescribed during pregnancy." | 4.12 | Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats. ( Biancardi, V; Bícego, KC; Funk, GD; Gargaglioni, LH; Marques, DA; Patrone, LGA; Vicente, MC, 2022) |
| " PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids." | 4.12 | Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. ( Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W, 2022) |
| "During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are usually the first-line treatment." | 4.12 | Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring. ( Brandão, LEM; Câmara, DA; Cavalcante, JS; de Aquino, ACQ; Engelberth, RCJG; Fiuza, FP; Lima, RH; Linhares, SSG; Meurer, YDSR, 2022) |
| "Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress." | 4.02 | Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. ( Butkevich, IP; Mikhailenko, VA; Vershinina, EA, 2021) |
| "Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy." | 4.02 | Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats. ( Hoehn, M; Homberg, JR; Schubert, D; Van der Knaap, N; Wiedermann, D, 2021) |
| "to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 4.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
| "Fluoxetine is commonly prescribed during pregnancy but developmental exposure to the drug, like infection, is associated with sex-specific behavioral changes in the offspring." | 4.02 | Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta. ( Ahmed, S; Arita, Y; Clementelli, C; Jeong Park, H; Levenson, AS; Peltier, MR; Pijush, DB, 2021) |
| " Furthermore, stressed dams were treated with different doses of fluoxetine (FLX; 5, 10and 25 mg/kg) during pregnancy and the postpartum period." | 4.02 | Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring. ( Amani, M; Homberg, JR; Houwing, DJ; Salari, AA, 2021) |
| "Fluoxetine is often prescribed to treat depression during pregnancy." | 4.02 | Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring. ( Ampuero, E; de Vries, EF; Díaz-Galarce, R; Donoso-Ramos, JP; Doorduin, J; Linsambarth, S; Moraga-Amaro, R; Pacheco, R; Peña, F; Stehberg, J; Ugalde, V; Wyneken, U, 2021) |
| "Fluoxetine, antidepressant widely-used during pregnancy, is a selective inhibitor for P-glycoprotein (P-gp)." | 3.96 | Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics. ( Cavalli, RC; Duarte, G; Lanchote, VL; Moisés, ECD; Moreira, FL; Nardotto, GHB; Pinto, L, 2020) |
| "Urinary SSRIs (fluoxetine, sertraline, escitalopram/citalopram) were measured while trying to conceive and, for women who became pregnant, at weeks 0, 4, and 8 of pregnancy." | 3.96 | Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss. ( Flannagan, KS; Kim, K; Mumford, SL; Perkins, NJ; Radoc, JG; Schisterman, EF; Silver, RM; Sjaarda, LA, 2020) |
| " In this regard, we chronically treated normal female mice with different dosages (0, 10, and 20 mg/kg) of fluoxetine (FLU) for 2 weeks before mating them with drug-free male mice and then tested the offspring for anxiety/depression-like behaviors with the elevated plus maze and the tail-suspension test after exposing to acute or chronic stress in adult period." | 3.91 | Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring. ( Li, J; Si, J; Suo, L; Yang, C; Zhang, Y, 2019) |
| "The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 3.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
| " Fluoxetine (a selective serotonin reuptake inhibitor; FLX) is an agent that has been shown to delay the onset of lactogenesis stage II when taken during pregnancy and lactation in women." | 3.88 | Short communication: Effects of fluoxetine on lactation at weaning in sheep. ( Hallford, DM; Harrelson, PL; Ross, TT, 2018) |
| "Our goal was to find out the impact of two antidepressant drugs with various mechanisms of action - imipramine and fluoxetine, on the frontal cortex mitochondria-enriched fraction in an animal model of depression based on the prenatal stress procedure." | 3.88 | Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. ( Basta-Kaim, A; Chamera, K; Głombik, K; Kotarska, K; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2018) |
| "The study aimed to evaluate if maternal exposure to fluoxetine (FLX) during pregnancy and lactation would result in altered aortic reactivity in adult offspring." | 3.88 | Intrauterine and lactational exposure to fluoxetine enhances endothelial modulation of aortic contractile response in adult female rats. ( Akamine, EH; Carvalho, MHC; Ceravolo, GS; Echem, C; Gerardin, DCC; Higashi, CM; Lucchetti, BFC; Moreira, EG; Pelosi, GG; Pinge-Filho, P; Sartoretto, SM, 2018) |
| "We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period." | 3.88 | Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats. ( Butkevich, IP; Mikhailenko, VA, 2018) |
| "Fluoxetine (FLX) is an antidepressant from the selective serotonin reuptake inhibitor class that has largely been used for the treatment of depression in pregnancy." | 3.88 | Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring's brain and affects the social interaction of rat. ( Estrada, VB; Francis-Oliveira, J; Gomes, MV; Moreira, EG; Pelosi, GG; Silva, AS; Toffoli, LV; Veríssimo, LF, 2018) |
| " We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD)." | 3.85 | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. ( De Long, NE; Hardy, DB; Holloway, AC; Ma, N, 2017) |
| " To this end, pregnant female dams were exposed to saline or fluoxetine (FLX) throughout pregnancy, and the behavior of the offspring was examined." | 3.83 | Prenatal exposure to selective serotonin reuptake inhibitors (SSRI) increases aggression and modulates maternal behavior in offspring mice. ( Avitsur, R; Levy, S; Svirsky, N, 2016) |
| "Fluoxetine (FLX) is an antidepressant worldwide prescribed throughout life stages, including pregnancy and breastfeeding." | 3.83 | Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine? ( Barbosa, DS; Ceravolo, GS; Gameiro, JG; Higachi, L; Higashi, CM; Matsumoto, AK; Moreira, EG; Moura, KF; Oliveira, LC, 2016) |
| "Early life stress increases risks of fear and anxiety related disorders in adulthood, which may be alleviated by fluoxetine treatment." | 3.81 | Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors. ( Cao, J; Mao, RR; Xiong, GJ; Xu, L; Yang, Y, 2015) |
| " At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 3.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
| "Fluoxetine is an antidepressant that has been largely used for treatment of depression in pregnancy." | 3.80 | Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation. ( Gomes, MV; Moreira, EG; Oliveira, JF; Pelosi, GG; Rodrigues, GM; Silva, AS; Toffoli, LV, 2014) |
| "Several epidemiological studies have reported an association between arsenic exposure and increased rates of psychiatric disorders, including depression, in exposed populations." | 3.80 | Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism. ( Allan, AM; Solomon, BR; Tyler, CR; Ulibarri, AL, 2014) |
| "This study evaluated the reproductive effects of fluoxetine exposure in utero and during lactation on pregnancy outcomes and the sexual development of offspring." | 3.79 | In utero and lactational exposure to fluoxetine in Wistar rats: pregnancy outcomes and sexual development. ( Boareto, AC; Dalsenter, PR; Kienast, MF; Lourenço, EL; Martino-Andrade, AJ; Morais, RN; Müller, JC; Spercoski, KM; Zaia, RM, 2013) |
| "Fifteen female rats were separated into three groups (n = 5) and treated with 10 mg/kg/day of test substances on the ninth, tenth and eleventh day of pregnancy: G1, fluoxetine; G2, imipramine hydrochloride; G3 (control), saline." | 3.76 | Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study. ( Borato, CE; Costa, AM; Esteves, A; Swerts, CA; Swerts, MS, 2010) |
| "Here, we used fluoxetine, a selective serotonin re-uptake inhibitor, at a dose of 10 mg/kg, administered for 20 days during pregnancy in 12 Wistar rats to examine the influence of this drug on the development of the enamel organ of the upper first molars of rat fetuses at 17 days of intra-uterine life (i." | 3.76 | Morphological analysis of the enamel organ in rats treated with fluoxetine. ( Castro, RM; Evêncio, LB; Leão, JC; Porter, SR; Silva, IH, 2010) |
| "This study investigates fluoxetine (FLX) exposure as an etiology for altered gestational length and adverse pregnancy outcomes." | 3.76 | Impact of antenatal selective serotonin reuptake inhibitor exposure on pregnancy outcomes in mice. ( Ansorge, M; Bauer, S; Gyamfi, C; Monk, C; Myers, M, 2010) |
| "Among the significant associations found, an association between maternal use of fluoxetine and infantile hypertrophic pyloric stenosis (IHPS) was of particular interest." | 3.76 | Fluoxetine and infantile hypertrophic pylorus stenosis: a signal from a birth defects-drug exposure surveillance study. ( Bakker, MK; de Jong-Van den Berg, LT; De Walle, HE; Wilffert, B, 2010) |
| " We present the occurrence of Goldenhar syndrome in an infant born to a woman with a history of prenatal Fluoxetine ingestion throughout her pregnancy." | 3.76 | Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence? ( Awwad, J; Farra, C; Majdalani, M; Mikati, M; Yazbeck, N; Yunis, K, 2010) |
| " Her mother had been taking fluoxetine (20 mg daily) during the second and third trimesters of her pregnancy." | 3.74 | Prolonged neonatal complications after in utero exposure to fluoxetine. ( Alehan, F; Gürakan, B; Saygi, S; Tarcan, A, 2008) |
| " A high dose of in utero fluoxetine resulted in a decrease in birth weight of the offspring and also reduced weight gain during the preweaning period." | 3.74 | Developmental and behavioral consequences of prenatal fluoxetine. ( Ashok, KP; Bairy, I; Bairy, KL; Madhyastha, S; Malini, S, 2007) |
| "Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation." | 3.74 | Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. ( Costa, LC; Lisboa, SF; Moreira, EG; Oliveira, PE; Venâncio, EJ, 2007) |
| " As compared with controls, fluoxetine exposure resulted in fetal pulmonary hypertension as evidenced by an increase in the weight ratio of the right ventricle to the left ventricle plus septum (P = 0." | 3.74 | Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat. ( Belik, J; Fornaro, E; Li, D; Pan, J, 2007) |
| " Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) antidepressant, has been widely prescribed for depression during pregnancy and/or lactation." | 3.74 | Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice. ( de Faria, MJ; Gerardin, DC; Gouvêa, TS; Moreira, EG; Morimoto, HK, 2008) |
| " In this study, we report that the depression-like behavior in MeHg-exposed male mice is reversed by chronic treatment with the antidepressant fluoxetine." | 3.74 | Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. ( Castrén, E; Ceccatelli, S; Karpova, N; Onishchenko, N; Sabri, F, 2008) |
| "Depression during pregnancy is frequently treated with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (FX), commonly known as Prozac (Eli Lilly & Co, Indianapolis, IN)." | 3.73 | Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep. ( Chien, C; Gruber, N; Kennaway, DJ; McMillen, IC; Morrison, JL; Riggs, KW; Rurak, DW, 2005) |
| "Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions." | 3.73 | The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat. ( Elliott, DL; Greenhill, KW; Hofler, VE; Johns, JM; Joyner, PW; Knupp, K; Lomas, LM; McMurray, MS; Middleton, CL; Walker, CH, 2005) |
| "Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery." | 3.73 | Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. ( Fitzgerald, C; Grunau, RE; Kent, N; Kim, J; Misri, S; Oberlander, TF; Riggs, KW; Rurak, DW, 2006) |
| " Her mother was on 20 mg of fluoxetine throughout her pregnancy." | 3.73 | Fluoxetine withdrawal syndrome in the newborn. ( Anbu, AT; Theodore, A, 2006) |
| " The low birth weight infants had been exposed to relatively high doses of fluoxetine (40-80 mg/d) throughout pregnancy." | 3.72 | Birth outcomes after prenatal exposure to antidepressant medication. ( Altshuler, L; Haynes, D; Hendrick, V; Hwang, S; Smith, LM; Suri, R, 2003) |
| "Depression during pregnancy is frequently treated with the selective serotonin reuptake inhibitor, fluoxetine (FX)." | 3.72 | Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes. ( Chien, C; Gruber, N; McMillen, IC; Morrison, JL; Riggs, KW; Rurak, DW, 2004) |
| "Citalopram, fluoxetine and desmethylfluoxetine all cross the human placenta, and may, therefore, affect the perinatal outcome of infants exposed to these drugs during pregnancy." | 3.71 | Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta. ( Ekblad, U; Heikkine, T; Laine, K, 2002) |
| " The women were on stable daily doses of fluoxetine (10-60 mg/day) and all but two took the medication during the last trimester of pregnancy." | 3.71 | Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. ( Altshuler, LL; Fukuchi, A; Hendrick, V; Hostetter, A; Hwang, S; Leight, K; Mintz, J; Stowe, ZN; Suri, R, 2001) |
| "The aim of the present study was to compare the toxic effects of fluoxetine (F) (8 and 16 mg/kg) and venlafaxine (V) (40 and 80 mg/kg) administered during the third week of pregnancy on early development of rats." | 3.70 | Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy. ( Altenburg, SP; da-Silva, VA; Lindsey, CJ; Malheiros, LR; Thomaz, TG, 1999) |
| "Prospectively identified fluoxetine-exposed pregnancies were evaluated to determine whether fluoxetine, a serotonin reuptake inhibitor commonly used for the treatment of depression and obsessive-compulsive disorder, might be associated with neonatal complications after maternal fluoxetine exposure during the third trimester through delivery." | 3.69 | Effects of third trimester fluoxetine exposure on the newborn. ( Goldstein, DJ, 1995) |
| "The rate of spontaneous pregnancy loss did not differ significantly between the women treated with fluoxetine and the control women (10." | 3.69 | Birth outcomes in pregnant women taking fluoxetine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL, 1996) |
| "We studied the children of 80 mothers who had received a tricyclic antidepressant drug during pregnancy, 55 children whose mothers had received fluoxetine during pregnancy, and 84 children whose mothers had not been exposed during pregnancy to any agent known to affect the fetus adversely." | 3.69 | Neurodevelopment of children exposed in utero to antidepressant drugs. ( Gardner, HA; Koren, G; Kulin, N; Nulman, I; Rovet, J; Stewart, DE; Theis, JG; Wolpin, J, 1997) |
| "We evaluated outcomes of all pregnancies identified prospectively with confirmed first-trimester fluoxetine exposure contained in the Eli Lilly and Company worldwide fluoxetine pregnancy registry." | 3.69 | Effects of first-trimester fluoxetine exposure on the newborn. ( Corbin, LA; Goldstein, DJ; Sundell, KL, 1997) |
| "To evaluate premenstrual daily dosing with fluoxetine for treatment of premenstrual dysphoric disorder." | 2.70 | Premenstrual daily fluoxetine for premenstrual dysphoric disorder: a placebo-controlled, clinical trial using computerized diaries. ( Brown, EW; Cohen, LS; Freeman, E; Halbreich, U; McCray, S; Miner, C; Sundell, K, 2002) |
| " Differences in treatment-emergent adverse events, unplanned pregnancies, and 17-item Hamilton Depression Scale (HAMD-17) scores were analyzed." | 2.70 | Safety and efficacy of fluoxetine in patients who receive oral contraceptive therapy. ( Brown, EB; Koke, SC; Miner, CM, 2002) |
| "Down syndrome affects more than 5 million people globally." | 2.50 | Prenatal treatment of Down syndrome: a reality? ( Bianchi, DW; Delabar, JM; Guedj, F, 2014) |
| "Depression has a female sex predilection with 2 to 3% of the pregnant women population presently requiring treatment with selective serotonin reuptake inhibitors (SSRI)." | 2.44 | Fetal and neonatal effects of maternal drug treatment for depression. ( Belik, J, 2008) |
| "Fluoxetine now has largely (albeit not completely) substituted older and less safe drugs such as tricyclic antidepressants." | 2.43 | Fluoxetine metabolism and pharmacological interactions: the role of cytochrome p450. ( Forti, GC; Mandrioli, R; Raggi, MA, 2006) |
| "SRI use during pregnancy is associated with preterm premature rupture of membranes (PPROM) and subsequent preterm birth." | 1.91 | The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation. ( Abrahams, VM; Fabrizio, VA; Hong, S; Lindsay, CV; Lynn, T; Norwitz, ER; Wilcox, M; Yonkers, KA, 2023) |
| " We found that these effects were differential between female mice dosed lactationally or peripartally, and there were also impacts on maternal mammary gland at weaning in both of these groups." | 1.91 | In utero, lactational, or peripartal fluoxetine administration has differential implications on the murine maternal skeleton. ( Brettingen, LJ; Charles, JF; Fricke, HP; Hernandez, LL; Krajco, CJ; Perry, MJ; Reisner, MA; Wake, LA, 2023) |
| "Depression is a disabling psychiatric disorder affecting millions of people all around the world." | 1.62 | SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class. ( Amini-Khoei, H; Dehpour, AR; Ershadi, ASB; Hosseini, MJ, 2021) |
| "Fexofenadine is a well-identified in vivo probe substrate of P-glycoprotein (P-gp) and/or organic anion transporting polypeptide (OATP)." | 1.62 | Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model. ( Bapat, P; Berger, H; de Carvalho Cavalli, R; de Lima Moreira, F; Koren, G; Lanchote, VL; Lubetsky, A; Pinto, L, 2021) |
| "Fluoxetine (FLX) is a pharmaceutical used to treat affective disorders in humans, but as environmental contaminant also affects inadvertently exposed fish in urban watersheds." | 1.51 | Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission. ( Haddad, M; Martinez, R; Mennigen, JA; Navarro-Martin, L; Trudeau, VL; Vera-Chang, MN; Zon, J, 2019) |
| "DOK7 congenital myasthenic syndrome (DOK7-CMS) generally presents early in life and is treated with salbutamol or ephedrine." | 1.48 | DOK7 myasthenic syndrome with subacute adult onset during pregnancy and partial response to fluoxetine. ( Basto, JP; Cruz, S; Peres, J; Salgado, V; Santos, L; Santos, M; Tavares, P; Valverde, AH, 2018) |
| " The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol." | 1.46 | Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol. ( Czaja, N; Kus, K; Nowakowska, E; Ratajczak, P; Zaprutko, T, 2017) |
| "Women with major depressive disorder during pregnancy often use selective serotonin reuptake inhibitors (SSRIs) antidepressants." | 1.46 | Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: role for glucocorticoid insensitivity. ( Avitsur, R, 2017) |
| " On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression." | 1.46 | Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Chamera, K; Głombik, K; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2017) |
| "Stress during pregnancy is associated with lifetime negative consequences for the offspring." | 1.46 | Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? ( Avitsur, R, 2017) |
| "Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation." | 1.43 | In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring. ( Anselmo-Franci, JA; Ceravolo, GS; de Azevedo Camin, N; Dos Santos, AH; Gerardin, DC; Kiss, AC; Mesquita, Sde F; Moreira, EG; Pelosi, GG; Vieira, ML, 2016) |
| "Psychoactive pharmaceuticals have been found as teratogens at clinical dosage during pregnancy." | 1.43 | Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers. ( Aho, K; Bearden, S; Finney, B; Huber, DP; Kaushik, G; Thomas, MA; Zarbalis, KS, 2016) |
| "Major depression is one of the most prevalent mental disorders in the population." | 1.40 | Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. ( Lin, YL; Wang, S, 2014) |
| "Fluoxetine is a selective serotonin reuptake inhibitor used to treat depression in pregnant and nursing women." | 1.40 | Fluoxetine induces changes in the testicle and testosterone in adult male rats exposed via placenta and lactation. ( Amorim, MJ; Andrade, AJ; da Silva Junior, VA; de Morais, RN; de Torres, SM; Monteiro Filho, WO; Tenorio, BM, 2014) |
| " Accordingly, pharmacokinetic analysis of a series of fluoxetine and norfluoxetine administrations to pregnant baboons was performed." | 1.40 | Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.). ( Garland, M; Shoulson, RL; Stark, RL, 2014) |
| "Fluoxetine or vehicle was administered to the dam during the postpartum period via osmotic minipump implants (Alzet) for 28 days." | 1.38 | Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam. ( Charlier, TD; Crispin, HT; Fillet, M; Houbart, V; Pawluski, JL; Steinbusch, HW; van den Hove, DL, 2012) |
| "Fluoxetine treatment inhibited TREK-1 and TREK-2, members of the two-pore domain K(+) channel family expressed in mouse embryos, activities, indicating that fluoxetine-induced membrane depolarization in late 2-cells might have resulted from TREK inhibition." | 1.38 | Dual effects of fluoxetine on mouse early embryonic development. ( Cho, YW; Choe, C; Han, J; Han, S; Kang, D; Kim, CW; Kim, EJ; Lee, JI; Tak, HM; Yoon, SY, 2012) |
| "Fluoxetine treatment generated a further increase in muscularisation and did not significantly modify the hyperoxia-induced reductions in alveolar density and increases in the endocrine cells." | 1.38 | Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats. ( Baraldi, M; Chiandetti, L; De Caro, R; Fornaro, E; Grisafi, D; Macchi, V; Masola, V; Onisto, M; Porzionato, A; Salmaso, R; Tassone, E; Zaramella, P, 2012) |
| "Fluoxetine-treated dams gave birth to litters 15% smaller than usual and to pups of reduced weight (until postnatal day 7)." | 1.37 | Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. ( Afrasiab-Middelman, A; Dederen, JP; Homberg, JR; Jonkers, M; Kiliaan, AJ; Korte-Bouws, GA; Martens, GJ; Olivier, JD; Peeters, EJ; Roelofs, JJ; Schubert, D; Vallès, A; van Heesch, F, 2011) |
| "Fluoxetine was associated with an increased risk of isolated ventricular septal defects (adjusted OR 2." | 1.37 | Selective serotonin reuptake inhibitors and risk for major congenital anomalies. ( Artama, M; Gissler, M; Malm, H; Ritvanen, A, 2011) |
| "We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5." | 1.37 | [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats]. ( Akulova, VK; Fedotova, YO; Ordian, NÉ; Pivina, SG, 2011) |
| " Dam dosing was adjusted to reflect the 50th and 85th percentiles of serum concentrations observed in pregnant women." | 1.37 | Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk. ( Bourke, CH; Capello, CF; Nemeroff, A; Newport, DJ; Owens, MJ; Ritchie, JC; Stowe, ZN, 2011) |
| "Pretreatment with fasudil, a Rho kinase inhibitor, blunted the effects of 5-HT infusion." | 1.37 | Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. ( Abman, SH; Delaney, C; Gien, J; Grover, TR; Roe, G, 2011) |
| "It is important that variations in drug metabolism during pregnancy be considered as these changes may necessitate a dosage adjustment to ensure that therapeutic failure does not occur during pregnancy." | 1.36 | Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach. ( Baumer, C; Koren, G; O'Brien, L; Sachs, H; Thieme, D, 2010) |
| "Fluoxetine treatment (5mg/kg body mass, 21day, intraperitoneally) induced a decrease in B(max) and in the amount of Hsp70 co-immunoprecipitated with the glucocorticoid receptor only in males, and stimulated the association of the receptor with Hsp90 in females." | 1.36 | Sexually dimorphic functional alterations of rat hepatic glucocorticoid receptor in response to fluoxetine. ( Adzic, M; Djordjevic, A; Djordjevic, J; Elaković, I; Matić, G; Radojcić, M; Vasiljević, D, 2010) |
| "Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 1.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
| " These effects were similar to the effects induced for subchronic and chronic administration of the antidepressant fluoxetine (5 mg/kg sc), a selective serotonin re-uptake inhibitor." | 1.33 | Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. ( Bonilla-Jaime, H; Vázquez-Palacios, G; Velázquez-Moctezuma, J, 2005) |
| "Fluoxetine is an antidepressant drug, only recently discovered to be a QT interval prolonging agent." | 1.33 | Prolonged QT interval in an infant of a fluoxetine treated mother. ( Dubnov, G; Fogelman, R; Merlob, P, 2005) |
| "Treatment with fluoxetine reversed these changes, as in SC rats." | 1.32 | Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. ( Dean-McKinney, T; Klausner, AP; Lee, KS; Na, YG; Steers, WD; Tuttle, JB, 2003) |
| " Dose-response curves for the inhibitory effect of clonidine showed subsensitivity of alpha2-adrenergic autoreceptors in protein-deprived rats, a phenomenon reversed by fluoxetine treatment." | 1.32 | Locus coeruleus activity in perinatally protein-deprived rats: effects of fluoxetine administration. ( Cuadra, GR; Orsingher, OA; Ramírez, OA; Sodero, AO; Valdomero, A, 2004) |
| " However, there is no data on the dosage of selective serotonin uptake inhibitors (SSRIs) required to maintain symptom resolution in women treated for major depression during pregnancy." | 1.31 | Dose of selective serotonin uptake inhibitors across pregnancy: clinical implications. ( Hostetter, A; Llewellyn, A; McLaughlin, E; Stowe, ZN; Strader, JR, 2000) |
| "Nisoxetine is a selective ligand for the norepinephrine transporter." | 1.30 | Placental norepinephrine transporter development in the ovine fetus. ( Blount, I; Bzoskie, I; Humme, J; Kashiwai, K; Padbury, JF, 1997) |
| "Fluoxetine is a widely used serotonin reuptake inhibitor effective in the treatment of depression." | 1.29 | A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats. ( Acuff-Smith, KD; Buelke-Sam, J; Fisher, JE; Moran, MS; Schilling, MA; Vorhees, CV, 1994) |
| "Fluvoxamine was shown to be a safe drug and no unexpected or previously undetected drug-related events were encountered." | 1.29 | Prescription-event monitoring of 10,401 patients treated with fluvoxamine. ( Edwards, JG; Inman, WH; Pearce, GL; Wilton, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (2.45) | 18.7374 |
| 1990's | 47 (14.37) | 18.2507 |
| 2000's | 86 (26.30) | 29.6817 |
| 2010's | 134 (40.98) | 24.3611 |
| 2020's | 52 (15.90) | 2.80 |
| Authors | Studies |
|---|---|
| Sylte, OC | 1 |
| Johansen, JS | 1 |
| Heinla, I | 3 |
| Houwing, DJ | 9 |
| Olivier, JDA | 6 |
| Heijkoop, R | 4 |
| Snoeren, EMS | 4 |
| Marks, C | 1 |
| Silvola, R | 1 |
| Teal, E | 1 |
| Quinney, SK | 1 |
| Haas, DM | 1 |
| Leussis, MP | 1 |
| Thanos, JM | 1 |
| Powers, A | 1 |
| Peterson, E | 1 |
| Head, JP | 1 |
| McGovern, NJ | 1 |
| Malarkey, FJ | 1 |
| Drake, A | 1 |
| Ramsteijn, AS | 3 |
| Verkaik-Schakel, RN | 1 |
| Plösch, T | 1 |
| Sheftel, CM | 1 |
| Sartori, LC | 1 |
| Hunt, ER | 1 |
| Manuel, RSJ | 1 |
| Bell, AM | 1 |
| Domingues, RR | 1 |
| Wake, LA | 2 |
| Scharpf, BR | 1 |
| Vezina, CM | 2 |
| Charles, JF | 4 |
| Hernandez, LL | 4 |
| Linhares, SSG | 2 |
| Meurer, YDSR | 2 |
| Aquino, A | 1 |
| Câmara, DA | 2 |
| Brandão, LEM | 2 |
| Dierschnabel, AL | 1 |
| Fiuza, FP | 2 |
| Lima, RH | 2 |
| Engelberth, RC | 1 |
| Cavalcante, JS | 2 |
| Biancardi, V | 1 |
| Patrone, LGA | 1 |
| Vicente, MC | 1 |
| Marques, DA | 1 |
| Bícego, KC | 1 |
| Funk, GD | 1 |
| Gargaglioni, LH | 1 |
| Andrade, C | 1 |
| Arzuaga, AL | 1 |
| Edmison, DD | 1 |
| Mroczek, J | 1 |
| Larson, J | 1 |
| Ragozzino, ME | 1 |
| Chen, J | 1 |
| Zhu, W | 1 |
| Zeng, X | 1 |
| Yang, K | 1 |
| Peng, H | 1 |
| Hu, L | 1 |
| de Aquino, ACQ | 1 |
| Engelberth, RCJG | 1 |
| Fabrizio, VA | 2 |
| Lindsay, CV | 2 |
| Wilcox, M | 2 |
| Hong, S | 2 |
| Lynn, T | 2 |
| Norwitz, ER | 2 |
| Yonkers, KA | 3 |
| Abrahams, VM | 2 |
| Logue, TC | 1 |
| Wen, T | 1 |
| Huang, Y | 1 |
| Wright, JD | 1 |
| D'Alton, ME | 1 |
| Friedman, AM | 1 |
| Desaunay, P | 1 |
| Eude, LG | 1 |
| Dreyfus, M | 1 |
| Alexandre, C | 1 |
| Fedrizzi, S | 1 |
| Alexandre, J | 1 |
| Uguz, F | 1 |
| Guénolé, F | 1 |
| Pawluski, JL | 15 |
| Murail, P | 1 |
| Grudet, F | 1 |
| Bys, L | 1 |
| Golubeva, AV | 1 |
| Bastiaanssen, T | 1 |
| Oberlander, TF | 2 |
| Cryan, JF | 1 |
| O'Mahony, SM | 1 |
| Charlier, TD | 8 |
| Lan, Z | 1 |
| Tachibana, RO | 1 |
| Kanno, K | 1 |
| Speck, ML | 1 |
| Gomes, ALA | 1 |
| Rojas, CS | 1 |
| Willig, JB | 1 |
| Herrmann, AP | 1 |
| Pilger, DA | 1 |
| Rates, SMK | 1 |
| Pestana, JE | 1 |
| Graham, BM | 1 |
| Gallo, MT | 1 |
| Brivio, P | 1 |
| Dolci, B | 1 |
| Fumagalli, F | 1 |
| Calabrese, F | 1 |
| Prowse, KL | 1 |
| Law, H | 1 |
| Raez-Villanueva, S | 1 |
| Markovic, F | 1 |
| Wang, M | 1 |
| Borojevic, R | 1 |
| Parsons, SP | 1 |
| Vincent, AD | 1 |
| Holloway, AC | 4 |
| Ratcliffe, EM | 1 |
| Fricke, HP | 2 |
| Krajco, CJ | 1 |
| Perry, MJ | 1 |
| Reisner, MA | 1 |
| Brettingen, LJ | 1 |
| Arumugasaamy, N | 2 |
| Gudelsky, A | 1 |
| Hurley-Novatny, A | 2 |
| Kim, PCW | 2 |
| Fisher, JP | 2 |
| Vera-Chang, MN | 3 |
| Moon, TW | 2 |
| Trudeau, VL | 3 |
| Yang, C | 1 |
| Si, J | 1 |
| Suo, L | 1 |
| Zhang, Y | 1 |
| Li, J | 1 |
| Hudon Thibeault, AA | 2 |
| López de Los Santos, Y | 1 |
| Doucet, N | 1 |
| Sanderson, JT | 3 |
| Vaillancourt, C | 3 |
| Lembong, J | 1 |
| Jašarević, E | 1 |
| Bale, TL | 1 |
| Olivier, JD | 2 |
| Svensson, M | 1 |
| Reimers, A | 1 |
| Reis, M | 1 |
| Schuttel, K | 1 |
| Struik, EL | 1 |
| Arling, C | 1 |
| Pinto, L | 2 |
| Moreira, FL | 1 |
| Nardotto, GHB | 2 |
| Cavalli, RC | 2 |
| Moisés, ECD | 2 |
| Duarte, G | 2 |
| Lanchote, VL | 3 |
| Hegstad, J | 1 |
| Huijgens, PT | 1 |
| Christodoulos, IN | 1 |
| Chyou, TY | 1 |
| Nishtala, PS | 1 |
| Butkevich, IP | 4 |
| Mikhailenko, VA | 4 |
| Laureano-Melo, R | 1 |
| Dos-Santos, RC | 1 |
| da Conceição, RR | 1 |
| de Souza, JS | 1 |
| da Silva Lau, R | 1 |
| da Silva Souza Silva, S | 1 |
| Marinho, BG | 1 |
| Giannocco, G | 1 |
| Ahmed, RG | 1 |
| da Silva Côrtes, W | 1 |
| Visco, DB | 1 |
| Manhães-de-Castro, R | 3 |
| da Silva, MM | 1 |
| Dantas-Alves, JS | 1 |
| Costa-de-Santana, BJR | 1 |
| Braz, GRF | 1 |
| da Silva, AI | 1 |
| Lagranha, CJ | 1 |
| Toscano, AE | 2 |
| Campos, RMM | 1 |
| Gouveia, HJCB | 1 |
| Lacerda, DC | 1 |
| Pereira, SDC | 1 |
| Paz, IAASG | 1 |
| Dantas Alves, JS | 1 |
| Tikker, L | 1 |
| Casarotto, P | 1 |
| Singh, P | 1 |
| Biojone, C | 1 |
| Piepponen, TP | 1 |
| Estartús, N | 1 |
| Seelbach, A | 1 |
| Sridharan, R | 1 |
| Laukkanen, L | 1 |
| Castrén, E | 3 |
| Partanen, J | 1 |
| Sjaarda, LA | 1 |
| Radoc, JG | 1 |
| Flannagan, KS | 1 |
| Mumford, SL | 1 |
| Kim, K | 1 |
| Perkins, NJ | 1 |
| Silver, RM | 1 |
| Schisterman, EF | 1 |
| Si, Y | 1 |
| Xue, X | 1 |
| Liu, S | 1 |
| Feng, C | 1 |
| Zhang, H | 1 |
| Zhang, S | 1 |
| Ren, Y | 1 |
| Ma, H | 1 |
| Dong, Y | 1 |
| Li, H | 1 |
| Xie, L | 1 |
| Zhu, Z | 1 |
| Vershinina, EA | 1 |
| Van der Knaap, N | 1 |
| Wiedermann, D | 1 |
| Schubert, D | 2 |
| Hoehn, M | 1 |
| Homberg, JR | 7 |
| Cavalcanti, CCL | 1 |
| Da Silva Aragão, R | 1 |
| Cadena-Burbano, EV | 1 |
| Oliveira, TRDP | 1 |
| Silva, JM | 1 |
| Benjamim, RAC | 1 |
| Lago, AB | 1 |
| Silva, EHM | 1 |
| Costa, TL | 1 |
| Zaidan, H | 1 |
| Galiani, D | 1 |
| Gaisler-Salomon, I | 1 |
| Ershadi, ASB | 1 |
| Amini-Khoei, H | 1 |
| Hosseini, MJ | 3 |
| Dehpour, AR | 1 |
| Clementelli, C | 1 |
| Arita, Y | 1 |
| Ahmed, S | 1 |
| Pijush, DB | 1 |
| Jeong Park, H | 1 |
| Levenson, AS | 1 |
| Peltier, MR | 1 |
| Bapat, P | 1 |
| de Lima Moreira, F | 1 |
| Lubetsky, A | 1 |
| de Carvalho Cavalli, R | 1 |
| Berger, H | 1 |
| Koren, G | 13 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363] | 1,228 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| Antidepressant Use During Pregnancy[NCT00279370] | 283 participants (Actual) | Observational | 1999-09-30 | Completed | |||
| Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226] | 1,431 participants (Actual) | Observational | 2007-09-30 | Completed | |||
| Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127] | 20 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery
| Intervention | participants (Number) |
|---|---|
| Aspirin | 7 |
| Placebo | 5 |
(NCT00467363)
Timeframe: 8-weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 374 |
| Placebo | 346 |
Implantation failures (NCT00467363)
Timeframe: 8 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 28 |
| Placebo | 27 |
(NCT00467363)
Timeframe: within 6 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 3 |
| Placebo | 3 |
(NCT00467363)
Timeframe: until 40 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 4 |
| Placebo | 6 |
(NCT00467363)
Timeframe: within 8-weeks of gestation
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 394 |
| Placebo | 363 |
Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery
| Intervention | livebirths (Number) |
|---|---|
| Aspirin | 309 |
| Placebo | 286 |
(NCT00467363)
Timeframe: 8 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 0 |
| Placebo | 0 |
(NCT00467363)
Timeframe: until delivery
| Intervention | participants (Number) |
|---|---|
| Aspirin | 32 |
| Placebo | 30 |
Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 56 |
| Placebo | 53 |
(NCT00467363)
Timeframe: until delivery
| Intervention | infants (Number) |
|---|---|
| Aspirin | 22 |
| Placebo | 31 |
birthweight (NCT00467363)
Timeframe: until delivery
| Intervention | grams (Mean) |
|---|---|
| Aspirin | 3327 |
| Placebo | 3315 |
(NCT00467363)
Timeframe: 40 weeks
| Intervention | participants (Number) |
|---|---|
| Aspirin | 2 |
| Placebo | 2 |
30 reviews available for fluoxetine and Pregnancy
| Article | Year |
|---|---|
Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses.
Topics: Antidepressive Agents; Child; Female; Fluoxetine; Humans; Infant, Newborn; Paroxetine; Pregnancy; Pr | 2023 |
Foetal ductus arteriosus constriction unrelated to non-steroidal anti-Inflammatory drugs: a case report and literature review.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Cesarean Section; Constriction; C | 2021 |
Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Second-Generation; Depression; Female; Fluoxetin | 2017 |
Therapeutic strategies for congenital myasthenic syndromes.
Topics: Adrenergic beta-Agonists; Breast Feeding; Cholinergic Antagonists; Cholinesterase Inhibitors; Female | 2018 |
Long-lasting neurotoxic effects of exposure to methylmercury during development.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Proliferation; Cellular Senescence; Depressi | 2013 |
The fetal safety of fluoxetine: a systematic review and meta-analysis.
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Cohort Studies; Depression; Female; Fluoxetine; H | 2013 |
Long-term outcomes of developmental exposure to fluoxetine: a review of the animal literature.
Topics: Animals; Anxiety; Brain; Depression; Female; Fluoxetine; Humans; Pregnancy; Prenatal Exposure Delaye | 2013 |
Prenatal treatment of Down syndrome: a reality?
Topics: Animals; Animals, Newborn; Apigenin; Catechin; Choline; Disease Models, Animal; Down Syndrome; Dyrk | 2014 |
Antenatal depression: guidelines for when to use pharmacotherapy.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Female; Fluoxetine; Humans; Inf | 2008 |
Fetal and neonatal effects of maternal drug treatment for depression.
Topics: Animals; Depression; Female; Fetal Diseases; Fluoxetine; Gastrointestinal Diseases; Humans; Hyperten | 2008 |
Antidepressant medication use during breastfeeding.
Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Citalopram; Depression, Postpartum; Female | 2009 |
Risks associated with in utero and lactation exposure to selective serotonin reuptake inhibitors (SSRIs).
Topics: Adult; Breast Feeding; Cardiovascular Abnormalities; Congenital Abnormalities; Female; Fluoxetine; H | 2010 |
Use of selective serotonin reuptake inhibitors during pregnancy and risk of major and cardiovascular malformations: an update.
Topics: Abnormalities, Drug-Induced; Cardiovascular Abnormalities; Citalopram; Depression; Female; Fluoxetin | 2010 |
Safety and side effect profile of fluoxetine.
Topics: Adolescent; Adult; Biotransformation; Bipolar Disorder; Cardiovascular Diseases; Child; Comorbidity; | 2004 |
Postnatal depression.
Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post | 2004 |
Fluoxetine during pregnancy: impact on fetal development.
Topics: Animals; Antidepressive Agents, Second-Generation; Circadian Rhythm; Depression; Disease Models, Ani | 2005 |
Fluoxetine metabolism and pharmacological interactions: the role of cytochrome p450.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluoxetine; Humans; Lactation; P | 2006 |
Postnatal depression.
Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post | 2005 |
Postnatal depression.
Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post | 2006 |
[New developments in hypericum extracts: data on efficacy and interactions].
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridg | 2007 |
Psychotropic drugs in pregnancy and lactation.
Topics: Clozapine; Embryonic and Fetal Development; Female; Fluoxetine; Humans; Lactation; Lithium; Mental D | 1994 |
Antidepressant treatment during breast-feeding.
Topics: Age Factors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Breast Feeding; Depression, Po | 1996 |
The safety of fluoxetine during pregnancy and lactation.
Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents, Second-Generation; Breast Feeding; Fema | 1996 |
Selective serotonin reuptake inhibitors in pregnancy and lactation.
Topics: Animals; Breast Feeding; Depression; Depression, Postpartum; Female; Fluoxetine; Humans; Pregnancy; | 1998 |
Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studies.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; E | 2000 |
Fluoxetine: a suitable long-term treatment.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Tricyclic; Chemistry, Pharmaceutical; Child; Chi | 2001 |
Chronobiological basis of female-specific mood disorders.
Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P | 2001 |
Depression during pregnancy: diagnosis and treatment options.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depress | 2002 |
Review of fluoxetine and its clinical applications in premenstrual dysphoric disorder.
Topics: Antidepressive Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Interactions; Fe | 2002 |
The safety of fluoxetine--an update.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Fluoxetine; Humans; Male | 1988 |
8 trials available for fluoxetine and Pregnancy
| Article | Year |
|---|---|
Fluoxetine treatment for anxiety in women undergoing in vitro fertilization.
Topics: Adult; Anxiety; Double-Blind Method; Female; Fertilization in Vitro; Fluoxetine; Folic Acid; Humans; | 2009 |
Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Hum | 2010 |
Premenstrual daily fluoxetine for premenstrual dysphoric disorder: a placebo-controlled, clinical trial using computerized diaries.
Topics: Diagnosis, Computer-Assisted; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administra | 2002 |
Safety and efficacy of fluoxetine in patients who receive oral contraceptive therapy.
Topics: Antidepressive Agents, Second-Generation; Contraceptives, Oral; Double-Blind Method; Drug Interactio | 2002 |
Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation.
Topics: Adult; Child Development; Female; Fluoxetine; Humans; Infant, Newborn; Lactation; Male; Milk, Human; | 2003 |
A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Apgar Score; Female; Fetal B | 2004 |
Birth outcomes following prenatal exposure to fluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Apgar Score; Birth Weight; Female; Fluoxetine; Gest | 2000 |
Chronobiological basis of female-specific mood disorders.
Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P | 2001 |
290 other studies available for fluoxetine and Pregnancy
| Article | Year |
|---|---|
Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment.
Topics: Animals; Behavior, Animal; Female; Fluoxetine; Male; Pregnancy; Prenatal Exposure Delayed Effects; R | 2021 |
Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study.
Topics: Antidepressive Agents; Bupropion; Citalopram; Duloxetine Hydrochloride; Escitalopram; Female; Fluoxe | 2021 |
Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Communication; Depression; Female; Flu | 2021 |
Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats.
Topics: Animals; Epigenesis, Genetic; Female; Fluoxetine; Gene Expression; Hippocampus; Humans; Male; Myelin | 2022 |
Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone.
Topics: Animals; Calcium; Female; Fluoxetine; Humans; Lactation; Mammary Glands, Human; Mice; Mice, Inbred C | 2022 |
Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5-HT expression in male and female adult Wistar rats.
Topics: Animals; Antidepressive Agents; Circadian Rhythm; Female; Fluoxetine; Locomotion; Male; Neuropeptide | 2022 |
Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats.
Topics: Animals; Carbon Dioxide; Female; Fluoxetine; Humans; Hypercapnia; Hyperventilation; Male; Placenta; | 2022 |
Psychotropic Drugs With Long Half-Lives: Implications for Drug Discontinuation, Occasional Missed Doses, Dosing Interval, and Pregnancy Planning.
Topics: Female; Fluoxetine; Half-Life; Humans; Pregnancy; Psychotropic Drugs; Substance Withdrawal Syndrome; | 2022 |
Prenatal stress and fluoxetine exposure in mice differentially affect repetitive behaviors and synaptic plasticity in adult male and female offspring.
Topics: Animals; Autism Spectrum Disorder; Female; Fluoxetine; Humans; Male; Mice; Mice, Inbred C57BL; Neuro | 2023 |
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone; | 2022 |
Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring.
Topics: Animals; Anxiety; Female; Fluoxetine; Humans; Male; Placenta; Pregnancy; Prenatal Exposure Delayed E | 2022 |
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation.
Topics: Antidepressive Agents; Extraembryonic Membranes; Female; Fetal Membranes, Premature Rupture; Fluoxet | 2023 |
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation.
Topics: Antidepressive Agents; Extraembryonic Membranes; Female; Fetal Membranes, Premature Rupture; Fluoxet | 2023 |
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation.
Topics: Antidepressive Agents; Extraembryonic Membranes; Female; Fetal Membranes, Premature Rupture; Fluoxet | 2023 |
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation.
Topics: Antidepressive Agents; Extraembryonic Membranes; Female; Fetal Membranes, Premature Rupture; Fluoxet | 2023 |
Continuation of psychiatric medications during pregnancy.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Depression; Female; Fluoxetine; Humans; Pharmaceutical P | 2023 |
Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome-gut-brain axis.
Topics: Animals; Antidepressive Agents; Brain-Gut Axis; Female; Fluoxetine; Humans; Pregnancy; Prenatal Expo | 2023 |
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring.
Topics: Animals; Female; Fluoxetine; Humans; Lactation; Maternal Exposure; Mice; Pregnancy; Prenatal Exposur | 2023 |
Environmental enrichment affects behavioral and pharmacological response to antidepressants in CF1 mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Bupropion; Fema | 2023 |
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychologica | 2023 |
Perinatal serotonergic manipulation shapes anhedonic and cognitive behaviors in a sex- and age-dependent manner: Identification of related biological functions at central and peripheral level.
Topics: Animals; Anxiety; Behavior, Animal; Biomarkers; Brain; Cognition; Female; Fluoxetine; Humans; Male; | 2023 |
Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.
Topics: Animals; Colitis; Female; Fluoxetine; Humans; Inflammation; Male; Pregnancy; Prenatal Exposure Delay | 2023 |
In utero, lactational, or peripartal fluoxetine administration has differential implications on the murine maternal skeleton.
Topics: Animals; Bone and Bones; Bone Development; Female; Fluoxetine; Humans; Lactation; Mice; Pregnancy; P | 2023 |
Model Placental Barrier Phenotypic Response to Fluoxetine and Sertraline: A Comparative Study.
Topics: Cell Membrane Permeability; Extracellular Matrix; Female; Fluoxetine; Human Umbilical Vein Endotheli | 2019 |
Cortisol disruption and transgenerational alteration in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure.
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fluoxetine; Gene Expression Regulation, D | 2019 |
Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Depression; Disease Mo | 2019 |
Serotonin and serotonin reuptake inhibitors alter placental aromatase.
Topics: Aromatase; Cells, Cultured; Citalopram; Female; Fluoxetine; Humans; Molecular Docking Simulation; Pa | 2019 |
Assessing SSRIs' effects on fetal cardiomyocytes utilizing placenta-fetus model.
Topics: Animals; Biomarkers; Calcium; Coculture Techniques; Creatine Kinase, MB Form; Female; Fetus; Fluoxet | 2019 |
Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression.
Topics: Amino Acids; Animals; Antidepressive Agents, Second-Generation; Bacteria; Depression; Feces; Female; | 2020 |
[Pharmacokinetics of antidepressants during pregnancy].
Topics: Antidepressive Agents; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Paroxetine; Pregnancy; P | 2020 |
Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.
Topics: Affect; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Anim | 2020 |
Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure.
Topics: Adult; Altruism; Animals; Behavior, Animal; Female; Fluoxetine; Humans; Male; Pregnancy; Prenatal Ex | 2020 |
Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.
Topics: Adult; Antidepressive Agents, Second-Generation; ATP Binding Cassette Transporter, Subfamily B; Case | 2020 |
Female rat sexual behavior is unaffected by perinatal fluoxetine exposure.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Estrus; Female; Fluoxetine; Pregnancy; Preoptic | 2020 |
Safety of fluoxetine use in children and adolescents: a disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Antidepressive Agents, Second-Generation; Anxie | 2020 |
Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Buspirone; Female; Fluoxetine; Inflammation; Male; | 2020 |
Perinatal fluoxetine treatment promotes long-term behavioral changes in adult mice.
Topics: Animals; Animals, Newborn; Anxiety; Cognitive Dysfunction; Female; Fluoxetine; Hippocampus; Male; Mi | 2020 |
Early life fluoxetine treatment causes long-term lean phenotype in skeletal muscle of rats exposed to maternal lard-based high-fat diet.
Topics: Animals; Animals, Newborn; Body Weight; Citrate (si)-Synthase; Diet, High-Fat; Dietary Fats; Eating; | 2020 |
Neonatal fluoxetine exposure delays reflex ontogeny, somatic development, and food intake similarly in male and female rats.
Topics: Animals; Body Weight; Female; Fluoxetine; Male; Pregnancy; Rats; Selective Serotonin Reuptake Inhibi | 2021 |
Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.
Topics: Animals; Anxiety; Behavior, Animal; Brain Chemistry; Dorsal Raphe Nucleus; Fear; Female; Fluoxetine; | 2020 |
Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss.
Topics: Abortion, Spontaneous; Adult; Citalopram; Female; Fertility; Fluoxetine; Humans; Live Birth; Pregnan | 2020 |
CRTC1 signaling involvement in depression-like behavior of prenatally stressed offspring rat.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Female; Fluoxetine; Male; | 2021 |
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation.
Topics: Animals; Buspirone; Female; Fluoxetine; Male; Pain; Pregnancy; Rats | 2021 |
Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.
Topics: Animals; Antidepressive Agents; Brain; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Magn | 2021 |
High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine.
Topics: Animals; Anxiety; Behavior, Animal; Diet, High-Fat; Disease Models, Animal; Energy Intake; Female; F | 2021 |
Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.
Topics: Animals; Female; Fluoxetine; Gene Expression; MicroRNAs; Oocytes; Phenotype; Pregnancy; Prenatal Exp | 2021 |
SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cognitive Dysfunction; Depression; Female; Fluoxet | 2021 |
Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta.
Topics: Biomarkers; Brain-Derived Neurotrophic Factor; Cytokines; Depressive Disorder; Female; Fluoxetine; H | 2021 |
Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model.
Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Drug Interactions; Female; Fluoxeti | 2021 |
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Brain; Depression, Postpartum; Disease Models, Animal; Female; | 2021 |
Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice.
Topics: Animals; Brain; Cell Adhesion Molecules; Disease Models, Animal; Embryo, Mammalian; Female; Fluoxeti | 2021 |
A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Fluoxetine; Mice; Pregna | 2021 |
Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.
Topics: Anxiety; Citalopram; Female; Fluoxetine; Humans; Patch-Clamp Techniques; Pregnancy; Selective Seroto | 2021 |
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams.
Topics: Animals; Corticosterone; Depression, Postpartum; Depressive Disorder, Major; Female; Fluoxetine; Hum | 2021 |
Maternal fluoxetine reduces hippocampal inflammation and neurogenesis in adult offspring with sex-specific effects of periadolescent oxytocin.
Topics: Adult Children; Animals; Autism Spectrum Disorder; Doublecortin Protein; Female; Fluoxetine; Hippoca | 2021 |
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Female; Fluoxetine; Hippocampus; L | 2021 |
Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Depression; Female; Fluoxetine; Food Pre | 2021 |
Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Avoidance Learning; Central Nervous System Depressants; | 2017 |
Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: role for glucocorticoid insensitivity.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depres | 2017 |
Behavioural outcomes of adult female offspring following maternal stress and perinatal fluoxetine exposure.
Topics: Aging; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Female; Fluoxetine; Ma | 2017 |
Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression.
Topics: 14-3-3 Proteins; Animals; Antidepressive Agents; Cathepsin D; COP9 Signalosome Complex; Depression; | 2017 |
Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development.
Topics: Animals; Corticosterone; Doublecortin Protein; Female; Fluoxetine; Hippocampus; Male; Neurogenesis; | 2017 |
Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis.
Topics: Animals; Animals, Newborn; Epigenesis, Genetic; Female; Fluoxetine; Incidence; Inflammasomes; Lipoge | 2017 |
Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Female; Fluoxetine; Hippocampus; Hypothalamo-Hypophy | 2017 |
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Disease Models, Animal; Female; Fluoxetine; | 2017 |
Intrauterine and lactation exposure to fluoxetine blunted in the offspring the aortic adaptive response induced by acute restraint stress.
Topics: Adaptation, Physiological; Animals; Aorta; Female; Fluoxetine; Lactation; Male; Nitric Oxide; Pregna | 2017 |
Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring.
Topics: Age Factors; Animals; Animals, Newborn; Disks Large Homolog 4 Protein; Drug Administration Schedule; | 2018 |
Short communication: Effects of fluoxetine on lactation at weaning in sheep.
Topics: Animals; Body Weight; Female; Fluoxetine; Lactation; Milk; Pregnancy; Selective Serotonin Reuptake I | 2018 |
Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam.
Topics: Animals; Behavior, Animal; Corticosterone; Female; Fluoxetine; Hippocampus; Maternal Behavior; Neuro | 2018 |
DOK7 myasthenic syndrome with subacute adult onset during pregnancy and partial response to fluoxetine.
Topics: Adult; Female; Fluoxetine; Humans; Muscle Proteins; Muscle Weakness; Myasthenic Syndromes, Congenita | 2018 |
Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Female; Flu | 2018 |
Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Animals, Newborn; Anxiety; Anxiety Disorders; Behavio | 2018 |
Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors.
Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Depression; Female; Fluoxetine; Hippocampu | 2018 |
Intrauterine and lactational exposure to fluoxetine enhances endothelial modulation of aortic contractile response in adult female rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Aorta, Thoracic; Cyclooxygenase 1; Dose-Response | 2018 |
Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics.
Topics: Apoptosis; Cell Culture Techniques; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Fem | 2019 |
Male rats with same-sex preference show higher immobility in the forced swim test, but similar effects of fluoxetine and desipramine than males that prefer females.
Topics: Animals; Desipramine; Female; Fluoxetine; Immobility Response, Tonic; Letrozole; Male; Motor Activit | 2018 |
Peripartum Fluoxetine Reduces Maternal Trabecular Bone After Weaning and Elevates Mammary Gland Serotonin and PTHrP.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Cancellous Bone; Female; Fluoxetine; Lactation; M | 2018 |
Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight; Cognition; Female; Fluoxetine; Ma | 2018 |
Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring's brain and affects the social interaction of rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; DNA Methylation; Epigenesis, Genetic; Female; Fl | 2018 |
Perinatal fluoxetine has enduring sexually differentiated effects on neurobehavioral outcomes related to social behaviors.
Topics: Animals; Female; Fluoxetine; Hippocampus; Male; Neurogenesis; Neuronal Plasticity; Pregnancy; Pregna | 2019 |
Pharmacokinetics and Transplacental Transfer of Fluoxetine Enantiomers and Their Metabolites in Pregnant Women.
Topics: Adult; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Humans; Pregnancy; Stereoisomerism; Young Adult | 2019 |
Effects of selective serotonin-reuptake inhibitors (SSRIs) in JEG-3 and HIPEC cell models of the extravillous trophoblast.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Cell Line; Cell Line, Tumor; Cell Movement; Ce | 2018 |
Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Family Characteristics; Femal | 2018 |
Prenatal Stimulation of 5-HT
Topics: Adaptation, Psychological; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buspirone; Depressi | 2019 |
In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Development; Female; Fluoxetine; Maternal Exposure; | 2019 |
Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o
Topics: Animals; Anxiety; Depression; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Male; Prefron | 2019 |
Postnatal outcomes in lambs exposed antenatally and acutely postnatally to fluoxetine.
Topics: Animals; Animals, Newborn; Female; Fluoxetine; Heart Rate; Maternal Exposure; Pregnancy; Prenatal Ex | 2019 |
Maternal exposure to fluoxetine during gestation and lactation does not alter plasma concentrations of testosterone, oestrogen or corticosterone in peripubertal offspring.
Topics: Animals; Corticosterone; Estrogens; Female; Fluoxetine; Male; Maternal Exposure; Placenta; Pregnancy | 2019 |
Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission.
Topics: Animals; Environmental Pollutants; Female; Fluoxetine; Hydrocortisone; Larva; Male; Maternal Exposur | 2019 |
Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.
Topics: Action Potentials; Animals; Behavior, Animal; Female; Fluoxetine; Interneurons; Male; Memory, Short- | 2019 |
Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Environment; Female; Fluoxetine; Pregnancy; Pr | 2019 |
Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats.
Topics: Animals; Antidepressive Agents; Benzylamines; Disease Models, Animal; Drug Administration Schedule; | 2019 |
Perinatal fluoxetine exposure results in social deficits and reduced monoamine oxidase gene expression in mice.
Topics: Animals; Antidepressive Agents; Autism Spectrum Disorder; Behavior, Animal; Brain; Exploratory Behav | 2020 |
Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Antidepressive Agents; Depression; Female; Fluoxetine; Hypot | 2013 |
In utero and lactational exposure to fluoxetine in Wistar rats: pregnancy outcomes and sexual development.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Estrogens; Female; Fluoxet | 2013 |
Perinatal exposure to fluoxetine via placenta and lactation inhibits the testicular development in male rat offspring.
Topics: Animals; Body Weight; Female; Fluoxetine; Lactation; Male; Maternal Exposure; Organ Size; Pregnancy; | 2013 |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats.
Topics: Aging; Amygdala; Animals; Female; Fluoxetine; Lactation; Male; Paraventricular Hypothalamic Nucleus; | 2013 |
Windows of vulnerability: maternal separation, age, and fluoxetine on adolescent depressive-like behavior in rats.
Topics: Age Factors; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Depression; Female | 2013 |
Developmental fluoxetine exposure facilitates sexual behavior in female offspring.
Topics: Anal Canal; Analysis of Variance; Animals; Animals, Newborn; Brain; Estradiol; Estrous Cycle; Female | 2014 |
Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Cell Proliferation; Depression; Fema | 2014 |
Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.
Topics: Animals; Animals, Newborn; Brain; Cell Proliferation; Disease Models, Animal; Down Syndrome; Female; | 2014 |
Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Brain; DNA Methylation; Exp | 2014 |
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Differentiation; Cell Proliferation; Cells, | 2014 |
Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Cytokines; Depression, Postpartum; | 2014 |
Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism.
Topics: Animals; Antidepressive Agents, Second-Generation; Arsenic; Depression; Female; Fluoxetine; Helpless | 2014 |
Fluoxetine induces changes in the testicle and testosterone in adult male rats exposed via placenta and lactation.
Topics: Animals; Female; Fluoxetine; Lactation; Male; Maternal Exposure; Placenta; Pregnancy; Rats; Selectiv | 2014 |
Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Conditioning, Classical; Fear; Female; Fluoxetine; M | 2014 |
Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity.
Topics: Animals; Animals, Newborn; Female; Fluoxetine; Hippocampus; Humans; Male; Maternal Exposure; Neuroge | 2015 |
[The influence of selective serotonin re-uptake inhibitor fluoxetine on inotropic function of myocardium in the ontogenesis of rats].
Topics: Age Factors; Animals; Animals, Newborn; Cardiotonic Agents; Dose-Response Relationship, Drug; Female | 2014 |
Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3β/β-catenin signaling.
Topics: Animals; beta Catenin; Cell Proliferation; Female; Fluoxetine; Glycogen Synthase Kinase 3; Glycogen | 2014 |
"Prozac Baby" - 25 years of motherisk research into SSRIs and alcohol in pregnancy.
Topics: Abnormalities, Drug-Induced; Alcohol Drinking; Antidepressive Agents, Second-Generation; Depression; | 2014 |
Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Conditioning, Clas | 2015 |
Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.).
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fetus; Fluoxetine; Humans; Papio; Pregnan | 2014 |
Fetal ductus arteriosus constriction and closure: analysis of the causes and perinatal outcome related to 45 consecutive cases.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Caffeine; Central N | 2016 |
Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats.
Topics: Adiposity; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Diabetes | 2015 |
Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; CLOCK Proteins; Estrus; Female; Fluoxetine; Gene | 2015 |
Serotonin syndrome in a breast-fed neonate.
Topics: Adult; Bottle Feeding; Breast Feeding; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newb | 2015 |
Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Cell Count; Extracellular Matrix Proteins; Female; Fl | 2015 |
Prenatal fluoxetine exposure affects cytokine and behavioral response to an immune challenge.
Topics: Age Factors; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Body Weight; C | 2015 |
Effects of treatment with fluoxetine on mandibular development: A morphological study in rats.
Topics: Animals; Animals, Newborn; Body Weight; Female; Fluoxetine; Male; Mandible; Pregnancy; Prenatal Expo | 2015 |
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Circadian Rhythm; Corticosteron | 2015 |
Neonatal serotonin reuptake inhibition reduces hypercaloric diet effects on fat mass and hypothalamic gene expression in adult rats.
Topics: Adipose Tissue; Age Factors; Animals; Animals, Newborn; Body Weight; Cholesterol; Diet; Eating; Fema | 2015 |
Prenatal exposure to selective serotonin reuptake inhibitors (SSRI) increases aggression and modulates maternal behavior in offspring mice.
Topics: Aggression; Animals; Behavior, Animal; Female; Fluoxetine; Male; Maternal Behavior; Mice; Pregnancy; | 2016 |
Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Gene Expression | 2015 |
Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning.
Topics: Animals; Dopamine; Female; Fluoxetine; Hippocampus; Male; Prefrontal Cortex; Pregnancy; Prenatal Exp | 2016 |
Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Femal | 2016 |
Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Epigenesis, | 2016 |
Fluoxetine-induced toxicity results in human placental glutathione S-transferase-π (GST-π) dysfunction.
Topics: Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Female; Fluoxetine; Glut | 2016 |
Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring.
Topics: Aggression; Animals; Behavior, Animal; Brain; Disease Models, Animal; Female; Fluoxetine; Male; Mate | 2016 |
Perinatal Fluoxetine Exposure Impairs the CO2 Chemoreflex. Implications for Sudden Infant Death Syndrome.
Topics: Animals; Animals, Newborn; Brain Stem; Carbon Dioxide; Female; Fluoxetine; Humans; Hypercapnia; Infa | 2016 |
Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine?
Topics: Animals; Antidepressive Agents, Second-Generation; Blood Vessels; Female; Fish Oils; Fluoxetine; Fol | 2016 |
Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams.
Topics: Animals; Antidepressive Agents; Brain; Depression; Depressive Disorder; Female; Fluoxetine; Hippocam | 2016 |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Estradiol; Estrous Cycle; Female; Fertility; Fluo | 2016 |
Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Female; Fluoxetine; Intestinal Absorption; Liver; Ma | 2016 |
Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; | 2016 |
Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring.
Topics: Animals; Animals, Newborn; Anxiety Disorders; Corticosterone; Depressive Disorder; Disease Models, A | 2016 |
Prenatal SSRI alters the hormonal and behavioral responses to stress in female mice: Possible role for glucocorticoid resistance.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Female; Fluoxetine; Hypothalamo-Hypophyseal Syst | 2016 |
Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Topics: Animals; Aorta; Ductus Arteriosus; Female; Fluoxetine; Immunohistochemistry; Mice; Myography; Persis | 2016 |
Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?
Topics: Age Factors; Analysis of Variance; Animals; Body Weight; Disease Models, Animal; Eating; Female; Flu | 2017 |
The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Female; Fluoxetine; Lung; Pregnancy; Rats; Rats, W | 2016 |
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.
Topics: Aromatase; Cell Line, Tumor; Coculture Techniques; Estradiol; Estrogens; Female; Fluoxetine; Humans; | 2017 |
Circadian behavior of adult mice exposed to stress and fluoxetine during development.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Circadian Rhythm; Female; Fluoxet | 2017 |
Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Female; Fluoxetine; Gene Expression; Imi | 2017 |
Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cardiomyopathy, Dilated; Female; Fluoxeti | 2008 |
Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Adult; Antidepressive Agents, Second-Generation; Bir | 2008 |
Maternal depression is a common complication among pregnant women occurring approximately 2-3% of this population. Introduction.
Topics: Brain Diseases; Depression; Female; Fluoxetine; Humans; Infant, Newborn; Infant, Premature; Infant, | 2008 |
Prolonged neonatal complications after in utero exposure to fluoxetine.
Topics: Adult; Diagnosis, Differential; Female; Fluoxetine; Humans; Infant, Newborn; Neonatal Abstinence Syn | 2008 |
Effect of exposure to selective serotonin reuptake inhibitors in utero on fetal growth: potential role for the IGF-I and HPA axes.
Topics: Adult; Birth Weight; Case-Control Studies; Citalopram; Female; Fetal Blood; Fetal Development; Fetal | 2009 |
Are selective serotonin reuptake inhibitors cardiac teratogens? Echocardiographic screening of newborns with persistent heart murmur.
Topics: Case-Control Studies; Echocardiography; Female; Fluoxetine; Heart Murmurs; Humans; Infant, Newborn; | 2009 |
Effects of fluoxetine and imipramine in rat fetuses treated during a critical gestational period: a macro and microscopic study.
Topics: Animals; Antidepressive Agents; Brain; Dopamine Uptake Inhibitors; Female; Fetal Weight; Fetus; Fluo | 2010 |
Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach.
Topics: Adult; Antidepressive Agents; Citalopram; Cyclohexanols; Female; Fluoxetine; Gas Chromatography-Mass | 2010 |
Sexually dimorphic functional alterations of rat hepatic glucocorticoid receptor in response to fluoxetine.
Topics: Animals; Antidepressive Agents; Cellulose; DNA; Female; Fluoxetine; Glucocorticoids; HSP70 Heat-Shoc | 2010 |
Morphological analysis of the enamel organ in rats treated with fluoxetine.
Topics: Amelogenesis; Animals; Enamel Organ; Female; Fluoxetine; Models, Animal; Pregnancy; Random Allocatio | 2010 |
Impact of antenatal selective serotonin reuptake inhibitor exposure on pregnancy outcomes in mice.
Topics: Animals; Animals, Newborn; Birth Rate; Female; Fluoxetine; Litter Size; Live Birth; Mice; Pregnancy; | 2010 |
Fluoxetine and infantile hypertrophic pylorus stenosis: a signal from a birth defects-drug exposure surveillance study.
Topics: Abnormalities, Drug-Induced; Confidence Intervals; Female; Fluoxetine; Humans; Infant; Infant, Newbo | 2010 |
Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence?
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Second-Generation; Female; Fluoxetine; Go | 2010 |
Neuraxial anaesthesia for caesarean section in a patient with narcolepsy and cataplexy.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Antidepressive Agents, Second-Generation; Benz | 2010 |
Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antidepressive Agents; Arthritis, Rheumatoid; Carbamaz | 2011 |
Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Female; Fluoxetine; | 2011 |
Antidepressant use during pregnancy. FPIN’s clinical inquiries.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclo | 2011 |
Selective serotonin reuptake inhibitors and risk for major congenital anomalies.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Alcohol Drinking; Female; Finland; Fluoxetine; Heart | 2011 |
[Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
Topics: Age Factors; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Behavi | 2011 |
Fluoxetine in early pregnancy: cardiac birth defects.
Topics: Female; Fluoxetine; Heart Defects, Congenital; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 2011 |
Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk.
Topics: Aging; Animals; Anxiety; Brain; Central Nervous System; Female; Fetus; Fluoxetine; Image Processing, | 2011 |
Mother-infant antidepressant concentrations, maternal depression, and perinatal events.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Dose-Res | 2011 |
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Female; Fe | 2011 |
Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Body Weight; Depression; Doublecortin Dom | 2011 |
Selective serotonin reuptake inhibitors and risk for major congenital anomalies.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Paroxetine; Pregnancy; Selective Serotonin | 2011 |
Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour.
Topics: Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Female; Fluoxetine; Mice; Neurons; Pregnancy; P | 2012 |
Selective serotonin reuptake inhibitors and risk for major congenital anomalies.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Paroxetine; Pregnancy; Selective Serotonin | 2011 |
Fluoxetine protects neurons against microglial activation-mediated neurotoxicity.
Topics: Animals; Cells, Cultured; Female; Fluoxetine; Microglia; Neurons; Neuroprotective Agents; Neurotoxic | 2012 |
Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Count; Corticosterone; Disease Models, Anima | 2012 |
Selective serotonin reuptake inhibitors and risk for major congenital anomalies.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Paroxetine; Pregnancy; Selective Serotonin | 2012 |
GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Drug Delivery Systems; Femal | 2012 |
Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats.
Topics: Animals; Anxiety; Anxiety Disorders; Brain; Corticosterone; Dopamine; Female; Fluoxetine; Hippocampu | 2012 |
Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response.
Topics: Acute-Phase Reaction; Amphetamine; Animals; Antipsychotic Agents; Aripiprazole; Disease Models, Anim | 2012 |
Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Feeding Behavior; Female; Fluoxetine; Gene Exp | 2012 |
Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone.
Topics: Animals; Behavior, Animal; Dexamethasone; Early Medical Intervention; Female; Fluoxetine; Glucocorti | 2012 |
Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats?
Topics: Animals; Antidepressive Agents; Female; Fluoxetine; Hypericum; Male; Maternal-Fetal Exchange; Pregna | 2013 |
The effects of perinatal fluoxetine treatment on the circadian system of the adult mouse.
Topics: Animals; Behavior, Animal; Circadian Clocks; Darkness; Female; Fluoxetine; Gestational Age; Light; M | 2013 |
Behavioural outcomes of perinatal maternal fluoxetine treatment.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Body Weight; | 2012 |
Dual effects of fluoxetine on mouse early embryonic development.
Topics: Animals; Blastocyst; Blotting, Western; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kina | 2012 |
Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Base Sequence; Bronchopulmonary | 2012 |
Developmental fluoxetine exposure and prenatal stress alter sexual differentiation of the brain and reproductive behavior in male rat offspring.
Topics: Anal Canal; Animals; Brain; Ejaculation; Estradiol; Female; Fluoxetine; Genitalia, Male; Male; Midli | 2013 |
Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.
Topics: Citalopram; Female; Fluoxetine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Prospective St | 2002 |
Management of major depression during pregnancy.
Topics: Adult; Antidepressive Agents; Behavior Therapy; Depressive Disorder; Female; Fluoxetine; Humans; Pre | 2002 |
Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Child; Child Behavior; Child, Preschool; De | 2002 |
Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats.
Topics: Acetylcholine; Animals; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Pregnancy; Pr | 2002 |
Birth outcomes after prenatal exposure to antidepressant medication.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2003 |
Placental passage of antidepressant medications.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Dose-Response Relationship, Drug; Fem | 2003 |
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Amitriptyline; Animals; Animals | 2003 |
Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Clomipramine; Depressive Disorder; Escape Reactio | 2003 |
Serotonergic symptoms in neonates exposed to SSRIs during pregnancy.
Topics: Chemical and Drug Induced Liver Injury; Depression; Female; Fluoxetine; Humans; Infant, Newborn; Pre | 2003 |
Stereoselective pharmacokinetics of fluoxetine and norfluoxetine enantiomers in pregnant sheep.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Female; Fetus; Fluoxetine; Half-Life; In | 2004 |
Self-induced hyperemesis in pregnancy.
Topics: Adult; Antidepressive Agents, Second-Generation; Anxiety; Depression; Female; Fluoxetine; Humans; Hy | 2004 |
[To enhance the study of the diagnosis and treatment of psychoses during pregnancy and postpartum stage].
Topics: Antidepressive Agents, Second-Generation; Female; Fluoxetine; Humans; Postpartum Period; Pregnancy; | 2003 |
Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Second-Generation; Carbon Dioxide; Fema | 2004 |
Neonatal complications after intrauterine exposure to SSRI antidepressants.
Topics: Antidepressive Agents; Citalopram; Depression; Female; Fluoxetine; Fluvoxamine; Follow-Up Studies; F | 2004 |
The impact of depression and fluoxetine treatment on obstetrical outcome.
Topics: Adult; Antidepressive Agents, Second-Generation; Case-Control Studies; Confidence Intervals; Depress | 2004 |
3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B.
Topics: Cell Line, Tumor; Cell Survival; Choriocarcinoma; Dopamine; Drug Interactions; Female; Fluoxetine; H | 2004 |
Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring.
Topics: Animals; Disease Models, Animal; Female; Fluoxetine; Guinea Pigs; Pain Threshold; Pregnancy; Prenata | 2005 |
Locus coeruleus activity in perinatally protein-deprived rats: effects of fluoxetine administration.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Antidepressive Agent | 2004 |
Development of the norepinephrine transporter in the rat CNS.
Topics: Animals; Animals, Newborn; Central Nervous System; Female; Fluoxetine; Gene Expression Regulation, D | 2005 |
Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepr | 2005 |
Fluoxetine use in early pregnancy.
Topics: Adult; Antidepressive Agents, Second-Generation; Female; Fluoxetine; Humans; Infant, Newborn; Infant | 2004 |
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal- | 2005 |
Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos.
Topics: Animals; Antidepressive Agents, Second-Generation; Blastocyst; Cell Communication; Cricetinae; Femal | 2005 |
Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep.
Topics: Animals; Blood Pressure; Circadian Rhythm; Electrocardiography; Female; Fluoxetine; Heart Rate; Infu | 2005 |
The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat.
Topics: Aggression; Animals; Behavior, Animal; Brain; Dopamine Uptake Inhibitors; Dose-Response Relationship | 2005 |
Prolonged QT interval in an infant of a fluoxetine treated mother.
Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Electrocardiography; Female; Fluoxeti | 2005 |
Neonatal signs after in utero exposure to selective serotonin reuptake inhibitors.
Topics: Female; Fluoxetine; Humans; Infant Behavior; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; | 2005 |
Delusions or obsessions: the same only different? A case report.
Topics: Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Delusions; Depression, Postpartum; D | 2006 |
Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding.
Topics: Adult; Aging; Antidepressive Agents, Second-Generation; Breast Feeding; Depressive Disorder, Major; | 2006 |
Fluoxetine withdrawal syndrome in the newborn.
Topics: Depressive Disorder; Female; Fluoxetine; Follow-Up Studies; Humans; Infant, Newborn; Neonatal Abstin | 2006 |
Altered serotonergic function of dorsal raphe nucleus in perinatally protein-deprived rats: effects of fluoxetine administration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Dose-Response Relationship, Drug | 2006 |
Prevalence and patterns of antidepressant drug use during pregnancy.
Topics: Adolescent; Adult; Age Factors; Antidepressive Agents; Benzodiazepines; Databases, Factual; Depressi | 2006 |
Exposure to rosiglitazone and fluoxetine in the first trimester of pregnancy.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Fluoxetine; Humans; Hypoglycemic Agents; Infant; Infant, N | 2006 |
The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine.
Topics: Animals; Antidepressive Agents, Second-Generation; Desipramine; Dose-Response Relationship, Drug; Fe | 2006 |
Developmental and behavioral consequences of prenatal fluoxetine.
Topics: Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Dose-Response Relat | 2007 |
Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Female; F | 2007 |
Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system.
Topics: Algorithms; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bin | 2007 |
Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Female; Fetal Diseases; Fluoxetine; Gestational A | 2007 |
Teratogenic effects of maternal antidepressant exposure on neural substrates of drug-seeking behavior in offspring.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Arousal; Brain; Cell | 2008 |
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Chemistry | 2007 |
Decreased noradrenergic and serotonergic reactivity of vas deferens of newborn rats from mothers treated with the serotonin reuptake inhibitor fluoxetine during pregnancy and breast-feeding.
Topics: Animals; Animals, Newborn; Barium; Birth Weight; Calcium; Dose-Response Relationship, Drug; Electric | 2007 |
Poor neonatal adaptation in term infant. Fluoxetine toxicity.
Topics: Depression; Female; Fluoxetine; Humans; Infant, Newborn; Male; Maternal Welfare; Pregnancy; Prenatal | 2008 |
Altered water-maze search behavior in adult guinea pigs following chronic prenatal ethanol exposure: lack of mitigation by postnatal fluoxetine treatment.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Body Weight; Drug Interactions; Eating; Electric | 2008 |
Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice.
Topics: Animals; Body Weight; Copulation; Female; Fluoxetine; Genitalia, Male; Lactation; Male; Mice; Motiva | 2008 |
Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Epigenesis, Genetic; Female; Fluoxetine; Gen | 2008 |
Serotonergic control of oxytocin release during suckling in the rat: opposite effects in conscious and anesthetized rats.
Topics: Anesthesia; Animals; Animals, Suckling; Cyproheptadine; Female; Fenclonine; Fluoxetine; Lactation; O | 1983 |
Hormone ontogeny in the ovine fetus. XI. The Serotoninergic regulation of growth hormone and prolactin secretion.
Topics: 5-Hydroxytryptophan; Animals; Female; Fluoxetine; Gestational Age; Growth Hormone; Hypothalamo-Hypop | 1980 |
Suppression of prolactin secretion by benzodiazepines in vivo.
Topics: 5-Hydroxytryptophan; Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Female; F | 1982 |
Studies on a neuronal-like transport system for serotonin in two cell lines.
Topics: Animals; Cell Line; Clomipramine; Female; Fluoxetine; Kinetics; Mice; Neurons; Pregnancy; Serotonin | 1982 |
A case of lipomeningocele reported with fluoxetine (and alprazolam, vitamins B1 and B6, heptaminol) prescribed during pregnancy.
Topics: Adult; Alprazolam; Depression; Drug Therapy, Combination; Female; Fluoxetine; Heptaminol; Humans; In | 1995 |
A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Female; Fluoxetine; Litter Size; Male; Motor Activity | 1994 |
Prescription-event monitoring of 10,401 patients treated with fluvoxamine.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depressive Disorder; Drug Monitoring; Drug Prescriptions | 1994 |
Developmental toxicology studies of fluoxetine hydrochloride administered orally to rats and rabbits.
Topics: Administration, Oral; Animals; Body Weight; Embryonic and Fetal Development; Female; Fetal Death; Fl | 1994 |
Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Stem; Carrier Proteins; Cells, Cultured; Clorgyline; F | 1993 |
Delayed decreases in brain 5-hydroxytryptamine2A/2C receptor density and function in male rat progeny following prenatal fluoxetine.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cerebral Cortex; Female; Fluoxetine; Hypothalamu | 1994 |
Serotonin and cardiac morphogenesis in the mouse embryo.
Topics: 1-Naphthylamine; Animals; Carrier Proteins; Cell Division; Cell Movement; Female; Fetal Heart; Fluox | 1993 |
Psychotropic medications during pregnancy: risk to the fetus.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Pregnancy; Pregnancy Complications; Pregnan | 1993 |
Fluoxetine hydrochloride (Prozac) toxicity in a neonate.
Topics: Female; Fluoxetine; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects | 1993 |
In utero exposure to fluoxetine HCl increases hematoma frequency at birth.
Topics: Animals; Animals, Newborn; Birth Weight; Female; Fetal Viability; Fluoxetine; Hematoma; Male; Pregna | 1993 |
Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac)
Topics: Antidepressive Agents, Tricyclic; Female; Fluoxetine; Humans; Pregnancy; Pregnancy Outcome; Pregnanc | 1993 |
Effects of third trimester fluoxetine exposure on the newborn.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; D | 1995 |
Birth outcomes in pregnant women taking fluoxetine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Affective Symptoms; Birth Weight; Case-Co | 1996 |
Treating depression in pregnancy.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Depression; Female; Fluoxetine; Humans; Infant, | 1996 |
First-trimester exposure to fluoxetine (prozac). Does it affect pregnancy outcome?
Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Female; Fluoxetine; Humans; Pregnancy | 1996 |
Neurodevelopment of children exposed in utero to antidepressant drugs.
Topics: Adult; Antidepressive Agents, Tricyclic; Aptitude Tests; Child; Child Behavior; Child, Preschool; De | 1997 |
Effect of prenatal fluoxetine (Prozac) exposure on brain serotonin neurons in prepubescent and adult male rat offspring.
Topics: Age Factors; Animals; Brain; Female; Fetus; Fluoxetine; Frontal Lobe; Hydroxyindoleacetic Acid; Male | 1997 |
Birth outcomes in pregnant women taking fluoxetine.
Topics: Abnormalities, Drug-Induced; Adult; Clinical Trials as Topic; Depression; Female; Fluoxetine; Humans | 1997 |
Gender-related differences exist in cortical [3H]nisoxetine binding and are not affected by prenatal morphine exposure.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Female; Fluoxetine; Hypothalamus; Kinetics; Male; Morp | 1997 |
Placental norepinephrine transporter development in the ovine fetus.
Topics: Animals; Binding Sites; Biological Transport; Carrier Proteins; Female; Fetus; Fluoxetine; Norepinep | 1997 |
Birth outcomes in pregnant women taking fluoxetine.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1997 |
Birth outcomes in pregnant women taking fluoxetine.
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1997 |
Effects of first-trimester fluoxetine exposure on the newborn.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adverse Drug Reaction Reporting Systems; Antidep | 1997 |
Potential fluoxetine chloride (Prozac) toxicity in a newborn.
Topics: Adult; Antidepressive Agents, Second-Generation; Female; Fetus; Fluoxetine; Follow-Up Studies; Human | 1997 |
Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Female; Fluoxetine; Humans; | 1998 |
Use of serotonin reuptake inhibitors by women of childbearing potential.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents; Female; Fluoxetine; Humans; Pregnancy; Pregnancy Outc | 1998 |
Effects of prenatal cocaine exposure on serotonin and norepinephrine transporter density in the rat brain.
Topics: Aging; Animals; Brain; Carrier Proteins; Cocaine; Female; Fluoxetine; Male; Membrane Glycoproteins; | 1998 |
SSRIs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newbo | 1998 |
Prenatal exposure to fluoxetine (Prozac) produces site-specific and age-dependent alterations in brain serotonin transporters in rat progeny: evidence from autoradiographic studies.
Topics: Age Factors; Animals; Autoradiography; Brain Chemistry; Carrier Proteins; Female; Fetus; Fluoxetine; | 1998 |
Outcome of children exposed in utero to fluoxetine: a critical review.
Topics: Adult; Child Development; Child, Preschool; Depressive Disorder; Female; Fluoxetine; Humans; Infant; | 1998 |
Fluoxetine and pregnancy a safe mix?
Topics: Depression; Female; Fibromyalgia; Fluoxetine; Humans; Pregnancy; Pregnancy Complications; Safety; Se | 1998 |
Antidepressants inhibit the glucocorticoid stimulation of thyrotropin releasing hormone expression in cultured hypothalamic neurons.
Topics: Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Dexamethasone; Dose-Response Relationshi | 1998 |
Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Birth Weight; Body Weight; Cycl | 1999 |
Effect of prenatal diazepam, phenobarbital, haloperidol and fluoxetine exposure on foot shock induced aggression in rats.
Topics: Aggression; Animals; Diazepam; Drug Evaluation, Preclinical; Electroshock; Female; Fluoxetine; Halop | 1998 |
Molecular cloning, expression and characterization of a bovine serotonin transporter.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; | 1999 |
Cocaine up-regulates norepinephrine transporter binding in the rat placenta.
Topics: Animals; Body Weight; Brain Chemistry; Carrier Proteins; Cell Membrane; Cocaine; Eating; Female; Flu | 1999 |
Effect of fluoxetine on contractile activity of pregnant rat uterine rings.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, | 2000 |
Dose of selective serotonin uptake inhibitors across pregnancy: clinical implications.
Topics: Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2000 |
Depression among pregnant adolescents: an integrated treatment approach.
Topics: Adolescent; Combined Modality Therapy; Depressive Disorder; Electroconvulsive Therapy; Female; Fluox | 2001 |
[Fluoxetine--safe during pregnancy and breast feeding].
Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Female; Fluoxetine; Humans; Pregnancy; Sel | 2001 |
Evidence based information on drug use during pregnancy: a survey of community pharmacists in three countries.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Antitrichomonal Agents; Canada; Ca | 2001 |
Serotonin reuptake inhibitor antidepressants and pregnancy: many unanswered questions.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Second-Generation; Child; Child, Preschool; Clin | 1999 |
Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety, Separation; Apoptosis; Cell Division; De | 2001 |
Fetal behavioural state changes following maternal fluoxetine infusion in sheep.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Carbon Dioxide; Electrooculogra | 2001 |
Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk.
Topics: Breast Feeding; Depression, Postpartum; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans | 2001 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |
Cardiac arrhythmia in a newborn infant associated with fluoxetine use during pregnancy.
Topics: Arrhythmias, Cardiac; Electrocardiography; Female; Fluoxetine; Humans; Infant, Newborn; Male; Matern | 2002 |
SSRIs in pregnancy--are they safe?
Topics: Animals; Antidepressive Agents, Second-Generation; Contraindications; Depression; Female; Fetus; Flu | 2002 |
Effect of maternal fluoxetine administration on uterine blood flow, fetal blood gas status, and growth.
Topics: Acid-Base Equilibrium; Animals; Antidepressive Agents, Second-Generation; Blood Gas Analysis; Blood | 2002 |
Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts.
Topics: Animals; Antidepressive Agents; Binding Sites; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; | 2002 |
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Diseases; Animals; Animals, Newborn; Borna Disease; B | 2002 |
Effects of serotonin neurotoxins on pituitary hormone release.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Female; Fluoxetine; Growth Hormone; Luteinizi | 1978 |
Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors.
Topics: 1-Naphthylamine; Abnormalities, Drug-Induced; Amitriptyline; Animals; Cell Death; Cell Division; Epi | 1992 |
Does continuous use of fluoxetine during the first trimester of pregnancy present a high risk for malformation or abnormal development to the exposed fetus?
Topics: Abnormalities, Drug-Induced; Female; Fluoxetine; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Tri | 1992 |
A patient of mine missed a period while taking fluoxetine; it turned out that she was not pregnant. However, the question arose about the safety of fluoxetine during pregnancy. What is known?
Topics: Dysmenorrhea; Female; Fluoxetine; Humans; Pregnancy; Pregnancy Complications | 1992 |
Can a woman breastfeed while taking Prozac?
Topics: Adult; Breast Feeding; Female; Fluoxetine; Humans; Lactation; Pregnancy | 1991 |
Effects of endothelial cell removal on alpha-adrenoceptor-mediated responses of aortae of pregnant rats.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Dose-Response Relationship, Drug; Endothelium, | 1990 |
Interaction of fluoxetine with the human placental serotonin transporter.
Topics: Carrier Proteins; Female; Fluoxetine; Humans; In Vitro Techniques; Microvilli; Paroxetine; Piperidin | 1990 |
Placental transfer and fetal distribution of fluoxetine in the rat.
Topics: Animals; Autoradiography; Female; Fetus; Fluoxetine; Maternal-Fetal Exchange; Placenta; Pregnancy; R | 1989 |
Effect of serotonin antagonists on prolactin and progesterone secretion in rats: evidence that the stimulatory and inhibitory actions of serotonin on prolactin release may be mediated through different receptors.
Topics: 5-Hydroxytryptophan; Animals; Female; Fenclonine; Fluoxetine; Indoles; Ketanserin; Pregnancy; Proest | 1988 |