| Assay ID | Title | Year | Journal | Article |
|---|
| AID620666 | Hypothermic effect in Swiss albino mouse assessed as change in body temperature at 0.1 mg/kg, sc measured after 120 mins | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID1063809 | Displacement of [3H]WAY100635 from 5-HT1A receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. |
| AID620483 | Hypothermic effect in Swiss albino mouse assessed as change in body temperature at 0.1 mg/kg, sc measured after 60 mins | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID625368 | Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID374435 | Induction of hypothermia in Albino Swiss mouse assessed as change in body temperature pretreated for 30 mins at 0.1 mg/kg, ip measured 30 mins after drug dose | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1. |
| AID248875 | In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID449453 | Agonist activity at 5HT1A receptor in Swiss albino mouse assessed as increase in rectal temperature at 0.1 mg/kg, sc after 60 mins | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID1278120 | Induction of hypothermia in Swiss albino mouse assessed as decrease in body temperature at 0.1 mg/kg, ip administered 60 mins before test and measured after 30 to 120 mins by thermistor thermometer analysis | 2016 | European journal of medicinal chemistry, Mar-03, Volume: 110 | Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus. |
| AID1278130 | Induction of lower lip retraction in Wistar rat assessed as lower lip retraction at 0.1 mg/kg, sc dosed 15 mins before test measured after 15 to 45 mins | 2016 | European journal of medicinal chemistry, Mar-03, Volume: 110 | Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus. |
| AID268272 | Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
| AID625367 | Displacement of [3H]GR127543 from 5HT1D receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID374436 | Induction of hypothermia in Albino Swiss mouse assessed as change in body temperature pretreated for 30 mins at 0.1 mg/kg, ip measured 60 mins after drug dose | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1. |
| AID239577 | Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cells | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID449545 | Behavioral activity in Wistar rat assessed as reduction of 8-OH-DPAT-induced lower lip retraction at 10 to 20 mg/kg, ip administered 15 mins before 8-OH-DPAT challenge | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID388706 | Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding relative to 8-OH-DPAT | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. |
| AID620477 | Hypothermic effect in Swiss albino mouse assessed as change in body temperature at 0.1 mg/kg, sc measured after 30 mins | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID239285 | Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]8-OH-DPAT | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
| Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. |
| AID625370 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID625503 | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation counting | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID247122 | Agonist activity in forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor compared to 8-OH-DPAT | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID242572 | In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID750635 | Antagonist activity at 5HT1A receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 assessed as inhibition of agonist-induced response at 10 uM incubated for 60 mins in incubator followed by 15 mins at room temperature by FLIPR assay rel | 2013 | Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
| Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. |
| AID449454 | Agonist activity at 5HT1A receptor in Swiss albino mouse assessed as increase in rectal temperature at 0.1 mg/kg, sc after 90 mins | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID268275 | Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-stimulated cAMP production relative to 8-OH-DPAT | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
| AID625365 | Displacement of [3H]prazosin from Alpha-1B receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID449461 | Agonist activity at 5HT1A receptor in Swiss albino mouse assessed as decrease in rectal temperature at 5 mg/kg, ip after 60 mins in the presence of WAY 100635 administered 15 mins before drug challenge | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID625363 | Displacement of [3H]N-methylspiperone from dopamine D4 receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID240454 | Percent maximal response of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID620733 | Antipsychotic activity in 8-OH-DPAT-stimulated rat assessed as lower lip retractions at 0.1 mg/kg, iv administered 45 mins before 8-OH-DPAT challenge measured after 15 to 45 mins (Rvb = 2.9 retractions) | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID625366 | Displacement of [3H]prazosin from alpha1A receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID388704 | Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. |
| AID625359 | Lipophilicity, log D of the compound at pH 7.4 | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID247047 | Effective dose on the 8-OH-DPAT induced response at 1 mg/kg sc in presence of 8-OH-DPAT (Effective dose value for 8-OH-DPAT = 0.13) | 2005 | Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
| Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. |
| AID449455 | Agonist activity at 5HT1A receptor in Swiss albino mouse assessed as increase in rectal temperature at 0.1 mg/kg, sc after 120 mins | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID620489 | Hypothermic effect in Swiss albino mouse assessed as change in body temperature at 0.1 mg/kg, sc measured after 90 mins | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID449053 | Effect on hypothermia in Swiss albino mouse assessed as change in rectal body temperature at 0.1 mg/kg, sc after 30 mins by inducible hypothermia test | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. |
| AID750634 | Antagonist activity at 5HT1A receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 assessed as inhibition of agonist-induced response incubated for 60 mins in incubator followed by 15 mins at room temperature by FLIPR assay | 2013 | Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
| Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. |
| AID449052 | Effect on hypothermia in Swiss albino mouse assessed as change in rectal body temperature at 0.1 mg/kg, sc after 60 mins by inducible hypothermia test | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. |
| AID625364 | Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID1278132 | Inhibition of 8-OH-DPAT-induced lower lip retraction in Wistar rat at 0.1 mg/kg, sc dosed 15 mins before 8-OH-DPAT | 2016 | European journal of medicinal chemistry, Mar-03, Volume: 110 | Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus. |
| AID268274 | Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. |
| AID620729 | Induction of 5HT1A receptor in rat assesses as lower lip retractions at 0.1 mg/kg, iv after 15 mins (Rvb = 0.1 +/- 0.1 retractions) | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1. |
| AID625369 | Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
| Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
| AID374437 | Induction of hypothermia in Albino Swiss mouse assessed as change in body temperature pretreated for 30 mins at 0.1 mg/kg, ip measured 90 mins after drug dose | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1. |
| AID449050 | Effect on hypothermia in Swiss albino mouse assessed as change in rectal body temperature at 0.1 mg/kg, sc after 120 mins by inducible hypothermia test | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. |
| AID449051 | Effect on hypothermia in Swiss albino mouse assessed as change in rectal body temperature at 0.1 mg/kg, sc after 90 mins by inducible hypothermia test | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. |
| AID374438 | Induction of hypothermia in Albino Swiss mouse assessed as change in body temperature pretreated for 30 mins at 0.1 mg/kg, ip measured 120 mins after drug dose | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4
| Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1. |
| AID449452 | Agonist activity at 5HT1A receptor in Swiss albino mouse assessed as increase in rectal temperature at 0.1 mg/kg, sc after 30 mins | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives. |
| AID388705 | Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |