fluoxetine has been researched along with Drug Overdose in 39 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This prospective, multicentre cohort study compared the hospital and physician costs associated with TCA and fluoxetine drug overdoses." | 9.08 | Acute medical costs of fluoxetine versus tricyclic antidepressants. A prospective multicentre study of antidepressant drug overdoses. ( Brent, J; Heiligenstein, JH; Kulig, K; Palmer, CS; Phillips, SD; Reblando, JA; Revicki, DA, 1997) |
| " We present the case of a young man who developed an acute akathisia and dystonia after inadvertent overdose of olanzapine (Zyprexa) in the setting of a recent discontinuation of fluoxetine." | 7.73 | Acute olanzapine-induced akathisia and dystonia in a patient discontinued from fluoxetine. ( Dufel, S; Paige, T; Vena, J, 2006) |
| "A 19-year-old man who attempted suicide by ingesting approximately 600 mg fluoxetine (Prozac) and 140 mg loxapine (Loxitane) had two episodes of atrial flutter shortly thereafter." | 7.69 | Mixed fluoxetine/loxapine overdose and atrial flutter. ( Martin, TG; Roberge, RJ, 1994) |
| "Fluoxetine is a selective serotonin reuptake inhibitor that is less frequently associated with severe toxicity in acute overdose compared with other psychotropic medications." | 6.44 | Generalized seizures after acute fluoxetine overdose in four adolescents. ( Kolbeck, MK; Nacca, N; Schult, RF, 2024) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 5.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "He had a generalised tonic/clonic seizure at 6 hours postingestion." | 5.48 | Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( Lee-Kelland, R; Mappa, P; Zehra, S, 2018) |
| "Fluoxetine (Prozac) is a widely prescribed drug in adults and children, and it has an active metabolite, norfluoxetine, with a prolonged elimination time." | 5.33 | Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. ( Anderson, CL; Anson, BD; Delisle, BP; Eckhardt, LL; Gillman, BM; Holzem, KM; January, CT; Klemens, CA; Makielski, JC; Rajamani, S; Valdivia, CR, 2006) |
| " This prospective, multicentre cohort study compared the hospital and physician costs associated with TCA and fluoxetine drug overdoses." | 5.08 | Acute medical costs of fluoxetine versus tricyclic antidepressants. A prospective multicentre study of antidepressant drug overdoses. ( Brent, J; Heiligenstein, JH; Kulig, K; Palmer, CS; Phillips, SD; Reblando, JA; Revicki, DA, 1997) |
| " We present the case of a young man who developed an acute akathisia and dystonia after inadvertent overdose of olanzapine (Zyprexa) in the setting of a recent discontinuation of fluoxetine." | 3.73 | Acute olanzapine-induced akathisia and dystonia in a patient discontinued from fluoxetine. ( Dufel, S; Paige, T; Vena, J, 2006) |
| "Previous case reports of seizures following fluoxetine overdose have not adequately ruled out ingestion of other substances and have lacked documentation of increased serum drug levels." | 3.69 | Seizure after isolated fluoxetine overdose. ( Braitberg, G; Curry, SC, 1995) |
| "A 19-year-old man who attempted suicide by ingesting approximately 600 mg fluoxetine (Prozac) and 140 mg loxapine (Loxitane) had two episodes of atrial flutter shortly thereafter." | 3.69 | Mixed fluoxetine/loxapine overdose and atrial flutter. ( Martin, TG; Roberge, RJ, 1994) |
| "Fluoxetine is a selective serotonin reuptake inhibitor that is less frequently associated with severe toxicity in acute overdose compared with other psychotropic medications." | 2.44 | Generalized seizures after acute fluoxetine overdose in four adolescents. ( Kolbeck, MK; Nacca, N; Schult, RF, 2024) |
| "English-language articles identified through MEDLINE (1985 through 1997), and case reports from the American Association of Poison Control Centers (AAPCC) (1987 through 1996) and United States Food and Drug Administration (FDA) adverse event database (through 1997) that describe findings of fatal and nonfatal overdoses involving SSRIs alone or in combination with other ingestants were reviewed." | 2.40 | SSRI safety in overdose. ( Barbey, JT; Roose, SP, 1998) |
| " Generally, newer drugs including fluoxetine have a more favourable adverse effect profile." | 2.38 | Toxicity of antidepressants: comparisons with fluoxetine. ( Henry, JA, 1992) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 1.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "He had a generalised tonic/clonic seizure at 6 hours postingestion." | 1.48 | Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( Lee-Kelland, R; Mappa, P; Zehra, S, 2018) |
| "Carbamazepine (CBZ) is an antiepileptic drug used as a mood stabilizer in child psychiatry." | 1.42 | [Carbamazepine and psychotropic treatment interaction: Two case studies of carbamazepine overdosage]. ( Askenazy, F; Dor, E; Fernandez, A; Menard, ML; Thümmler, S, 2015) |
| "Fluoxetine (Prozac) is a widely prescribed drug in adults and children, and it has an active metabolite, norfluoxetine, with a prolonged elimination time." | 1.33 | Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. ( Anderson, CL; Anson, BD; Delisle, BP; Eckhardt, LL; Gillman, BM; Holzem, KM; January, CT; Klemens, CA; Makielski, JC; Rajamani, S; Valdivia, CR, 2006) |
| " These children will have no adverse effects or only minimal effects and require no emergency treatment or gastric decontamination." | 1.32 | Fluoxetine exposures: are they safe for children? ( Baker, SD; Morgan, DL, 2004) |
| "Free fluoxetine concentration was determined in the diluted filtrate by a reversed-phase high-performance liquid chromatography method." | 1.30 | An in vitro evaluation of fluoxetine adsorption by activated charcoal and desorption upon addition of polyethylene glycol-electrolyte lavage solution. ( Atta-Politou, J; Havariotou, M; Kolioliou, M; Koupparis, MA; Koutselinis, A, 1998) |
| "Fluoxetine is a selective serotonin reuptake inhibitor used for the treatment of major depression." | 1.30 | A fatal drug interaction between clozapine and fluoxetine. ( Ferslew, KE; Hagardorn, AN; Harlan, GC; McCormick, WF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (43.59) | 18.2507 |
| 2000's | 12 (30.77) | 29.6817 |
| 2010's | 7 (17.95) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, IZ | 1 |
| Ng, M | 1 |
| Sewa, DW | 1 |
| Yao, YJ | 1 |
| Jose, MC | 1 |
| Tan, KBK | 1 |
| Ponampalam, R | 1 |
| Campbell, S | 1 |
| Otten, H | 1 |
| Anand, V | 1 |
| Kolbeck, MK | 1 |
| Schult, RF | 1 |
| Nacca, N | 1 |
| Little, K | 1 |
| Lin, CM | 1 |
| Reynolds, PM | 1 |
| Lee-Kelland, R | 1 |
| Zehra, S | 1 |
| Mappa, P | 1 |
| Eren Cevik, S | 1 |
| Tasyurek, T | 1 |
| Guneysel, O | 1 |
| Fernandez, A | 1 |
| Dor, E | 1 |
| Menard, ML | 1 |
| Askenazy, F | 1 |
| Thümmler, S | 1 |
| McLean, TR | 1 |
| McLean, AB | 1 |
| Neckelmann, D | 1 |
| Maehlum, E | 1 |
| Waage, IM | 1 |
| Velez, LI | 1 |
| Feng, SY | 1 |
| Neerman, MF | 1 |
| Szólics, M | 1 |
| Chaudhry, M | 1 |
| Ljubisavljevic, M | 1 |
| Corr, P | 1 |
| Samir, HA | 1 |
| van Gorkom, KN | 1 |
| Eichhorn, M | 1 |
| Eich, P | 1 |
| Bateman, DN | 1 |
| Chick, J | 1 |
| Good, AM | 1 |
| Kelly, CA | 1 |
| Masterton, G | 1 |
| Jaffe, R | 1 |
| Leavitt, R | 1 |
| Wind, T | 1 |
| Baker, SD | 1 |
| Morgan, DL | 1 |
| Sabbioni, C | 1 |
| Bugamelli, F | 1 |
| Varani, G | 1 |
| Mercolini, L | 1 |
| Musenga, A | 1 |
| Saracino, MA | 1 |
| Fanali, S | 1 |
| Raggi, MA | 1 |
| Giroud, C | 1 |
| Michaud, K | 1 |
| Sporkert, F | 1 |
| Eap, C | 1 |
| Augsburger, M | 1 |
| Cardinal, P | 1 |
| Mangin, P | 1 |
| Egberts, TC | 1 |
| Vena, J | 1 |
| Dufel, S | 1 |
| Paige, T | 1 |
| Hancox, JC | 1 |
| Mitcheson, JS | 1 |
| Rajamani, S | 1 |
| Eckhardt, LL | 1 |
| Valdivia, CR | 1 |
| Klemens, CA | 1 |
| Gillman, BM | 1 |
| Anderson, CL | 1 |
| Holzem, KM | 1 |
| Delisle, BP | 1 |
| Anson, BD | 1 |
| Makielski, JC | 1 |
| January, CT | 1 |
| Vitiello, B | 1 |
| Pearson, JL | 1 |
| Power, BM | 1 |
| Pinder, M | 1 |
| Hackett, LP | 1 |
| Ilett, KF | 1 |
| Braitberg, G | 1 |
| Curry, SC | 1 |
| Feierabend, RH | 1 |
| Jick, SS | 1 |
| Dean, AD | 1 |
| Jick, H | 1 |
| Roberge, RJ | 1 |
| Martin, TG | 1 |
| Murray, V | 1 |
| Druid, H | 1 |
| Holmgren, P | 1 |
| Tsitoura, A | 1 |
| Atta-Politou, J | 2 |
| Koupparis, MA | 2 |
| Kolioliou, M | 1 |
| Havariotou, M | 1 |
| Koutselinis, A | 1 |
| Gross, R | 1 |
| Dannon, PN | 1 |
| Lepkifker, E | 1 |
| Zohar, J | 1 |
| Kotler, M | 1 |
| Nudelman, E | 1 |
| Vinuela, LM | 1 |
| Cohen, CI | 1 |
| Ferslew, KE | 1 |
| Hagardorn, AN | 1 |
| Harlan, GC | 1 |
| McCormick, WF | 1 |
| Barbey, JT | 1 |
| Roose, SP | 1 |
| Revicki, DA | 1 |
| Palmer, CS | 1 |
| Phillips, SD | 1 |
| Reblando, JA | 1 |
| Heiligenstein, JH | 1 |
| Brent, J | 1 |
| Kulig, K | 1 |
| Henry, JA | 1 |
| Rosenstein, DL | 1 |
| Takeshita, J | 1 |
| Nelson, JC | 1 |
| Moore, JL | 1 |
| Rodriguez, R | 1 |
4 reviews available for fluoxetine and Drug Overdose
| Article | Year |
|---|---|
Hageseth's principle of extraterritorial jurisdiction and international telemedicine.
Topics: Adult; Drug Overdose; Fluoxetine; Humans; International Cooperation; Internet; Licensure, Medical; M | 2008 |
Benign course in a child with a massive fluoxetine overdose.
Topics: Adolescent; Adult; Child, Preschool; Drug Overdose; Female; Fluoxetine; Humans; Infant; Male; Middle | 1995 |
SSRI safety in overdose.
Topics: Adult; Child; Citalopram; Drug Overdose; Fluoxetine; Fluvoxamine; Humans; Paroxetine; Poison Control | 1998 |
Toxicity of antidepressants: comparisons with fluoxetine.
Topics: Antidepressive Agents; Drug Overdose; Fluoxetine; Humans; Suicide | 1992 |
1 trial available for fluoxetine and Drug Overdose
| Article | Year |
|---|---|
Acute medical costs of fluoxetine versus tricyclic antidepressants. A prospective multicentre study of antidepressant drug overdoses.
Topics: Adult; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Depressive Disorder; Drug Overdose; | 1997 |
34 other studies available for fluoxetine and Drug Overdose
| Article | Year |
|---|---|
Use of extracorporeal membrane oxygenation in massive amlodipine overdose.
Topics: Albumins; Amlodipine; Antidotes; Calcium; Calcium Channel Blockers; Charcoal; Drug Overdose; Extraco | 2022 |
CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose.
Topics: Cytochrome P-450 Enzyme System; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fluo | 2023 |
Generalized seizures after acute fluoxetine overdose in four adolescents.
Topics: Adolescent; Child; Drug Overdose; Fluoxetine; Humans; Seizures; Selective Serotonin Reuptake Inhibit | 2024 |
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H | 2018 |
Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis.
Topics: Adolescent; Depressive Disorder; Diagnosis, Differential; Drug Overdose; Fluoxetine; Humans; Male; R | 2018 |
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov | 2014 |
[Carbamazepine and psychotropic treatment interaction: Two case studies of carbamazepine overdosage].
Topics: Adolescent; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Drug | 2015 |
Sertindole and fluoxetine overdose with benign outcome.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Azabicyclo Compounds; Blood P | 2010 |
A dispensing error resulting in possible fluoxetine overdose and subsequent discontinuation syndrome in a child.
Topics: Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug Overdose; Fluoxetine; Gastroesophageal Ref | 2010 |
Neuroimaging findings in a case of fluoxetine overdose.
Topics: Adult; Drug Overdose; Fluorodeoxyglucose F18; Fluoxetine; Humans; Image Interpretation, Computer-Ass | 2012 |
[Dextromethorphane intoxication under co-medication with cytochrome P450-inhibitor fluoxetin: prolonged and accentuated signs of intoxication].
Topics: Adult; Antitussive Agents; Cytochrome P-450 Enzyme Inhibitors; Depressive Disorder, Major; Dextromet | 2002 |
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Ove | 2004 |
QTc prolongation in multiple drug overdose.
Topics: Adult; Bupropion; Drug Overdose; Fluoxetine; Humans; Long QT Syndrome; Male; Piperazines; Psychotic | 2004 |
Fluoxetine exposures: are they safe for children?
Topics: Acute Disease; Age Distribution; Child Welfare; Child, Preschool; Coma; Diarrhea; Dose-Response Rela | 2004 |
A rapid HPLC-DAD method for the analysis of fluoxetine and norfluoxetine in plasma from overdose patients.
Topics: Antidepressive Agents, Second-Generation; Calibration; Chromatography, High Pressure Liquid; Drug Ov | 2004 |
A fatal overdose of cocaine associated with coingestion of marijuana, buprenorphine, and fluoxetine. Body fluid and tissue distribution of cocaine and its metabolites determined by hydrophilic interaction chromatography-mass spectrometry(HILIC-MS).
Topics: Analgesics, Opioid; Biotransformation; Buprenorphine; Cannabinoids; Chromatography, Liquid; Cocaine; | 2004 |
Causal or casual?
Topics: Antidepressive Agents, Second-Generation; Citalopram; Cyclohexanols; Drug Overdose; Fluoxetine; Huma | 2005 |
Acute olanzapine-induced akathisia and dystonia in a patient discontinued from fluoxetine.
Topics: Accidents; Acute Disease; Adult; Akathisia, Drug-Induced; Benzodiazepines; Drug Overdose; Dystonia; | 2006 |
Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.
Topics: Antidepressive Agents, Second-Generation; Drug Overdose; Ether-A-Go-Go Potassium Channels; Female; F | 2006 |
Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Blotting, Western; Cell Line; Cell Membrane; Cisapr | 2006 |
A depressed adolescent at high risk of suicidal behavior.
Topics: Acetaminophen; Adolescent; Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Th | 2008 |
Fatal serotonin syndrome following a combined overdose of moclobemide, clomipramine and fluoxetine.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy | 1995 |
Seizure after isolated fluoxetine overdose.
Topics: Adolescent; Chromatography, High Pressure Liquid; Drug Overdose; Female; Fluoxetine; Humans; Seizure | 1995 |
Antidepressants and suicide.
Topics: Adult; Aged; Antidepressive Agents; Case-Control Studies; Cohort Studies; Depression; Drug Administr | 1995 |
Mixed fluoxetine/loxapine overdose and atrial flutter.
Topics: Adult; Atrial Flutter; Drug Overdose; Fluoxetine; Humans; Loxapine; Male; Suicide, Attempted | 1994 |
Laryngeal dystonia.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Drug Overdose; Drug Synergism; Dystonia; Ethanol; | 1995 |
[A case report. Fatal case of acute fluoxetine poisoning].
Topics: Antidepressive Agents, Second-Generation; Drug Overdose; Fatal Outcome; Female; Fluoxetine; Humans; | 1996 |
In vitro adsorption study of fluoxetine onto activated charcoal at gastric and intestinal pH using high performance liquid chromatography with fluorescence detector.
Topics: Adsorption; Body Fluids; Charcoal; Chromatography, High Pressure Liquid; Drug Overdose; Fluoxetine; | 1997 |
An in vitro evaluation of fluoxetine adsorption by activated charcoal and desorption upon addition of polyethylene glycol-electrolyte lavage solution.
Topics: Adsorption; Charcoal; Chromatography, High Pressure Liquid; Drug Overdose; Evaluation Studies as Top | 1998 |
Generalized seizures caused by fluoxetine overdose.
Topics: Adult; Antidepressive Agents, Second-Generation; Drug Overdose; Fluoxetine; Humans; Male; Seizures; | 1998 |
Safety in overdose of quetiapine: a case report.
Topics: Adult; Antipsychotic Agents; Charcoal; Dibenzothiazepines; Drug Overdose; Fluoxetine; Gastric Lavage | 1998 |
A fatal drug interaction between clozapine and fluoxetine.
Topics: Antipsychotic Agents; Clozapine; Drug Interactions; Drug Overdose; Fatal Outcome; Fluoxetine; Humans | 1998 |
Fluoxetine-induced elevation and prolongation of tricyclic levels in overdose.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Drug Overdose; Drug Therap | 1991 |
Toxicity of fluoxetine in overdose.
Topics: Adult; Drug Overdose; Female; Fluoxetine; Humans; Suicide, Attempted | 1990 |