Page last updated: 2024-10-27

fluoxetine and Autism

fluoxetine has been researched along with Autism in 41 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
"A positive effect of fluoxetine has been shown in some children with autism."9.15Effects of fluoxetine treatment on striatal dopamine transporter binding and cerebrospinal fluid insulin-like growth factor-1 in children with autism. ( Kokki, H; Kuikka, J; Makkonen, I; Riikonen, R; Turpeinen, U, 2011)
"Retrospective chart reviews of seven adolescent and young adults with autistic disorder treated with fluoxetine alone or in combination with other medications were performed."9.08Fluoxetine in treatment of adolescent patients with autism: a longitudinal open trial. ( Fatemi, SH; Khan, L; Realmuto, GM; Thuras, P, 1998)
"Thirty-seven children, aged between 2 and 7 years, with idiopathic autism underwent an open-label trial of fluoxetine treatment."7.70Effects of fluoxetine treatment in young children with idiopathic autism. ( DeLong, GR; McSwain Kamran, M; Teague, LA, 1998)
"An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation."7.68Fluoxetine treatment of children and adults with autistic disorder and mental retardation. ( Cook, EH; Jaselskis, C; Leventhal, BL; Rowlett, R, 1992)
"Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that reduces obsessive-compulsive symptoms."6.94The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder. ( Arnold, LE; Attalla, A; Bregman, JD; Cartwright, C; Childress, A; Chugani, H; Frazier, J; Ginsberg, L; Handen, BL; Hendren, R; Herscu, P; King, B; Kolevzon, A; Melmed, R; Minshew, N; Mintz, M; Murphy, T; Owley, T; Sikich, L; Snape, MF, 2020)
"Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning, suggesting dissociated underlying serotonin abnormalities."6.80Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism. ( Barrett, N; Brammer, M; Chantiluke, K; Giampietro, V; Murphy, DG; Rubia, K; Simmons, A, 2015)
"A positive effect of fluoxetine has been shown in some children with autism."5.15Effects of fluoxetine treatment on striatal dopamine transporter binding and cerebrospinal fluid insulin-like growth factor-1 in children with autism. ( Kokki, H; Kuikka, J; Makkonen, I; Riikonen, R; Turpeinen, U, 2011)
"The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders."5.09Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study. ( Bienstock, C; Buchsbaum, BR; Buchsbaum, MS; Cartwright, C; Haznedar, MM; Hollander, E; Mosovich, S; Robins, D; Solimando, A; Spiegel-Cohen, J; Tang, C; Wei, TC, 2001)
"Retrospective chart reviews of seven adolescent and young adults with autistic disorder treated with fluoxetine alone or in combination with other medications were performed."5.08Fluoxetine in treatment of adolescent patients with autism: a longitudinal open trial. ( Fatemi, SH; Khan, L; Realmuto, GM; Thuras, P, 1998)
" Search terms included autism, autistic disorder, citalopram, fluoxetine, fluvoxamine, paroxetine, selective serotonin-reuptake inhibitors, and sertraline."4.82Treating functional impairment of autism with selective serotonin-reuptake inhibitors. ( Eichner, SF; Jones, JR; Moore, ML, 2004)
"We isolated deep layer prefrontal circuits in brain slices then used single-photon GCaMP imaging to record activity from many (50 to 100) neurons simultaneously to study patterns of spontaneous activity generated by these circuits under normal conditions and in two etiologically distinct models of autism: mice exposed to valproic acid in utero and Fmr1 knockout mice."3.83Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. ( Horn, ME; Luongo, FJ; Sohal, VS, 2016)
" We differentiated and treated human SK-N-SH neuroblastoma cells with a mixture (fluoxetine, carbamazepine and venlafaxine) and valproate (used as a positive control to induce autism-associated profiles), followed by transcriptome analysis with RNA-Seq approach."3.83Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders. ( Kaushik, G; Thomas, MA; Xia, Y; Yang, L, 2016)
"One hundred and twenty-nine children, 2 to 8 years old, with idiopathic autistic spectrum disorder diagnosed by standard instruments (Childhood Austim Ratings Scale and Autism Diagnostic Observation Schedule) were treated with fluoxetine (0."3.71Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement. ( Burch, S; DeLong, GR; Ritch, CR, 2002)
"Twenty-one pediatric subjects with diagnoses of autistic disorder or other pervasive developmental disorders, 6-15 years old and stabilized with a consistent dose of fluvoxamine or fluoxetine, were recruited for the study; 16 successfully completed the imaging protocol."3.71Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders. ( Cowan, C; Dager, SR; Dawson, G; Strauss, WL; Unis, AS, 2002)
"Thirty-seven children, aged between 2 and 7 years, with idiopathic autism underwent an open-label trial of fluoxetine treatment."3.70Effects of fluoxetine treatment in young children with idiopathic autism. ( DeLong, GR; McSwain Kamran, M; Teague, LA, 1998)
"An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation."3.68Fluoxetine treatment of children and adults with autistic disorder and mental retardation. ( Cook, EH; Jaselskis, C; Leventhal, BL; Rowlett, R, 1992)
"Depressive illness in a patient with Down's syndrome and autism responded to fluoxetine."3.68Depression in autistic disorder. ( Ghaziuddin, M; Tsai, L, 1991)
"Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that reduces obsessive-compulsive symptoms."2.94The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder. ( Arnold, LE; Attalla, A; Bregman, JD; Cartwright, C; Childress, A; Chugani, H; Frazier, J; Ginsberg, L; Handen, BL; Hendren, R; Herscu, P; King, B; Kolevzon, A; Melmed, R; Minshew, N; Mintz, M; Murphy, T; Owley, T; Sikich, L; Snape, MF, 2020)
"Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning, suggesting dissociated underlying serotonin abnormalities."2.80Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism. ( Barrett, N; Brammer, M; Chantiluke, K; Giampietro, V; Murphy, DG; Rubia, K; Simmons, A, 2015)
"improves the core features of autism (social interaction, communication and behavioural problems);2."2.49Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). ( Brignell, A; Hazell, P; Randall, M; Silove, N; Williams, K, 2013)
"improves the core features of autism (social interaction, communication and behavioural problems); 2."2.46Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). ( Hazell, P; Silove, N; Wheeler, DM; Williams, K, 2010)
"A majority of cases of idiopathic autism in children likely result from unknown environmental triggers in genetically susceptible individuals."1.46Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations. ( Kaushik, G; Pfau, JC; Thomas, MA; Xia, Y, 2017)
"Idiopathic autism, caused by genetic susceptibility interacting with unknown environmental triggers, has increased dramatically in the past 25 years."1.38Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism. ( Klaper, RD; Thomas, MA, 2012)
"We report 2 patients with autism and mental retardation who developed catatonic symptoms at the onset of puberty."1.36Onset of catatonia at puberty: electroconvulsive therapy response in two autistic adolescents. ( Barbosa, V; Ghaziuddin, M; Ghaziuddin, N; Gih, D; Maixner, DF, 2010)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (41.46)18.2507
2000's7 (17.07)29.6817
2010's13 (31.71)24.3611
2020's4 (9.76)2.80

Authors

AuthorsStudies
Gioia, R1
Seri, T1
Diamanti, T1
Fimmanò, S1
Vitale, M1
Ahlenius, H1
Kokaia, Z1
Tirone, F1
Micheli, L1
Biagioni, S1
Lupo, G1
Rinaldi, A1
De Jaco, A1
Cacci, E1
Arora, A1
Becker, M1
Marques, C1
Oksanen, M1
Li, D1
Mastropasqua, F1
Watts, ME1
Arora, M1
Falk, A1
Daub, CO1
Lanekoff, I1
Tammimies, K1
King, BH1
Ne'eman, A1
Albrecht, K1
Kapp, SK1
Kaushik, G2
Xia, Y2
Pfau, JC1
Thomas, MA3
Lu, ZA1
Mu, W1
Osborne, LM1
Cordner, ZA1
Herscu, P1
Handen, BL1
Arnold, LE1
Snape, MF1
Bregman, JD1
Ginsberg, L1
Hendren, R1
Kolevzon, A1
Melmed, R1
Mintz, M1
Minshew, N1
Sikich, L1
Attalla, A1
King, B1
Owley, T1
Childress, A1
Chugani, H1
Frazier, J1
Cartwright, C2
Murphy, T1
Williams, K2
Brignell, A1
Randall, M1
Silove, N2
Hazell, P3
Chantiluke, K1
Barrett, N1
Giampietro, V1
Brammer, M1
Simmons, A1
Murphy, DG1
Rubia, K1
Mouti, A1
Reddihough, D1
Marraffa, C1
Wray, J1
Lee, K1
Kohn, M1
Luongo, FJ1
Horn, ME1
Sohal, VS1
Yang, L1
Ghaziuddin, N2
Gih, D1
Barbosa, V1
Maixner, DF1
Ghaziuddin, M3
Wheeler, DM1
Chadman, KK1
Makkonen, I1
Kokki, H1
Kuikka, J1
Turpeinen, U1
Riikonen, R1
Klaper, RD1
DeLong, GR2
Ritch, CR1
Burch, S1
Albertini, G3
Majolini, L3
Di Gennaro, G3
Quarato, P3
Scoppetta, C3
Onorati, P3
Moore, ML1
Eichner, SF1
Jones, JR1
Hollander, E3
Phillips, A1
Chaplin, W2
Zagursky, K1
Novotny, S1
Wasserman, S2
Iyengar, R1
Anagnostou, E1
Esposito, K1
Soorya, L1
Koshes, RJ1
Damore, J1
Stine, J1
Brody, L1
Fatemi, SH1
Realmuto, GM1
Khan, L1
Thuras, P1
Teague, LA1
McSwain Kamran, M1
Branford, D1
Bhaumik, S1
Naik, B1
Storch, DD1
Blatt, SD1
Meguid, V1
Church, CC1
Botash, AS1
Jean-Louis, F1
Siripornsawan, MP1
Weinberger, HL1
Granana, N1
Tuchman, RF1
Peral, M1
Alcamí, M1
Gilaberte, I1
Buchsbaum, MS1
Haznedar, MM1
Tang, C1
Spiegel-Cohen, J1
Wei, TC1
Solimando, A1
Buchsbaum, BR1
Robins, D1
Bienstock, C1
Mosovich, S1
Strauss, WL1
Unis, AS1
Cowan, C1
Dawson, G1
Dager, SR1
Rickards, EH1
Prendergast, M1
Cook, EH1
Rowlett, R1
Jaselskis, C1
Leventhal, BL1
Tsai, L2
Todd, RD1
Hamdan-Allen, G1
Friedman, EH1
Mehlinger, R1
Scheftner, WA1
Poznanski, E1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study Of Fluoxetine In Autism: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group 14-Week Study To Investigate The Effect Of Fluoxetine Orally Dissolving Tablet (ODT) On Repetitive Behaviors In Childhood And Adolescent Autistic Disorder.[NCT00515320]Phase 3158 participants (Actual)Interventional2007-08-31Completed
A Double Blind, Randomized, Placebo-Controlled Study of CM-AT for the Treatment of Autism in Children With All Levels of Fecal Chymotrypsin (FCT)[NCT02410902]Phase 3190 participants (Actual)Interventional2015-05-13Completed
An Open-Label Extension Study of CM-AT for the Treatment of Children With Autism With All Levels of Fecal Chymotrypsin[NCT02649959]Phase 3405 participants (Anticipated)Interventional2015-10-31Active, not recruiting
[NCT00004486]45 participants Interventional1998-09-30Completed
Galantamine Versus Placebo in Childhood Autism[NCT00252603]Phase 320 participants Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Primary Outcome Measurements to Determine Efficacy of Treatment With CM-AT Versus Placebo for Changes in the Aberrant Behavior Checklist Subscale for Irritability / Agitation (ABC-I) Between Baseline and Week 12/Termination Visit

Primary outcome measurements to determine efficacy of treatment with CM-AT versus Placebo for changes in the Aberrant Behavior Checklist (ABC) - Community sub scale for Irritability/Agitation (ABC-I) between baseline (subject's initial measurement) and Week 12/Termination (subject's final measurement) visit. Participants were between 3 through to 6 years old inclusive and took 900mg CM-AT or Placebo three times daily. The ABC-I is one of five discrete sub scales measured by the ABC. The scale range is 0-45. A higher score reflects higher severity of symptoms (irritability). Scores are obtained via Parent Rated Questionnaire. Parents respond to a series of questions on a scale directly into an electronic data capture system (EDC), responding: 0 = not at all a problem 1 = the behavior is a problem but slight in degree 2 = the problem is moderately serious 3 = the problem is severe in degree. The score was automatically calculated by the EDC. (NCT02410902)
Timeframe: Screening through Week 12/Termination

Interventionunits on a scale (Mean)
CM-AT-8.0
Placebo-5.5

Secondary Outcome Measurements of Changes in the Aberrant Behavior Checklist Checklist Subscale for Lethargy / Social Withdrawal (ABC-L) Between Baseline and Week 12/Termination Visit

Secondary outcome measurements to determine efficacy of treatment with CM-AT versus Placebo for changes in the Aberrant Behavior Checklist- Community (ABC) sub scale for Lethargy / Social Withdrawal (ABC-L) between baseline (subject's initial measurement) and Week 12/Termination (subject's final measurement) visit. Participants were between 3 through to 6 years old inclusive and took 900mg CM-AT or Placebo three times daily. The ABC-L is one of five discrete sub scales measured by the ABC. The scale range is 0-48. A higher score reflects higher severity of symptoms (lethargy). Scores are obtained via Parent Rated Questionnaire. Parents respond to a series of questions on a scale directly into an electronic data capture system (EDC), responding: 0 = not at all a problem 1 = the behavior is a problem but slight in degree 2 = the problem is moderately serious 3 = the problem is severe in degree. (NCT02410902)
Timeframe: Screening through Week 12/Termination.

Interventionunits on a scale (Mean)
CM-AT-7.9
Placebo-6.6

Reviews

4 reviews available for fluoxetine and Autism

ArticleYear
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
    The Cochrane database of systematic reviews, 2013, Aug-20, Issue:8

    Topics: Adult; Age Factors; Autistic Disorder; Child; Child Development Disorders, Pervasive; Citalopram; Fe

2013
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
    The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8

    Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum

2010
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
    The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8

    Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum

2010
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
    The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8

    Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum

2010
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
    The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8

    Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum

2010
Treating functional impairment of autism with selective serotonin-reuptake inhibitors.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:9

    Topics: Autistic Disorder; Citalopram; Clinical Trials as Topic; Fluoxetine; Fluvoxamine; Humans; Paroxetine

2004
Sudden infant death syndrome, child sexual abuse, and child development.
    Current opinion in pediatrics, 1999, Volume: 11, Issue:2

    Topics: Autistic Disorder; Child; Child Abuse, Sexual; Child, Preschool; Condylomata Acuminata; Fluoxetine;

1999

Trials

9 trials available for fluoxetine and Autism

ArticleYear
The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder.
    Journal of autism and developmental disorders, 2020, Volume: 50, Issue:9

    Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Bli

2020
Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:7

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain Mapping; Child;

2015
Fluoxetine for Autistic Behaviors (FAB trial): study protocol for a randomized controlled trial in children and adolescents with autism.
    Trials, 2014, Jun-16, Volume: 15

    Topics: Adolescent; Adolescent Behavior; Autistic Disorder; Child; Child Behavior; Double-Blind Method; Drug

2014
Effects of fluoxetine treatment on striatal dopamine transporter binding and cerebrospinal fluid insulin-like growth factor-1 in children with autism.
    Neuropediatrics, 2011, Volume: 42, Issue:5

    Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Corpus Striatum; Dopamine Plasma Membrane Tr

2011
A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:3

    Topics: Administration, Oral; Adolescent; Autistic Disorder; Child; Cross-Over Studies; Cumulative Trauma Di

2005
Divalproex versus placebo for the prevention of irritability associated with fluoxetine treatment in autism spectrum disorder.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Antimanic Agents; Autistic Disorder; Child; Double-Blind M

2006
Fluoxetine in treatment of adolescent patients with autism: a longitudinal open trial.
    Journal of autism and developmental disorders, 1998, Volume: 28, Issue:4

    Topics: Adolescent; Adult; Autistic Disorder; Behavioral Symptoms; Child; Female; Fluoxetine; Humans; Longit

1998
Fluoxetine in children with autism.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:12

    Topics: Autistic Disorder; Child; Child Behavior Disorders; Child, Preschool; Female; Fluoxetine; Humans; Ma

1999
Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study.
    The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:2

    Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Asperger Syndrome; Autistic D

2001

Other Studies

28 other studies available for fluoxetine and Autism

ArticleYear
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine.
    Journal of neurochemistry, 2023, Volume: 165, Issue:3

    Topics: Animals; Antidepressive Agents; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal;

2023
Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics.
    Scientific reports, 2023, 06-29, Volume: 13, Issue:1

    Topics: Autism Spectrum Disorder; Autistic Disorder; Fluoxetine; Humans; Induced Pluripotent Stem Cells; Res

2023
Fluoxetine and Repetitive Behaviors in Children and Adolescents With Autism Spectrum Disorder.
    JAMA, 2019, 10-22, Volume: 322, Issue:16

    Topics: Adolescent; Autism Spectrum Disorder; Autistic Disorder; Child; Cognition; Compulsive Behavior; Fluo

2019
Obsessive-Compulsive Behaviors in Autism.
    JAMA, 2020, 02-25, Volume: 323, Issue:8

    Topics: Adolescent; Autism Spectrum Disorder; Autistic Disorder; Child; Compulsive Behavior; Fluoxetine; Hum

2020
Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations.
    Neuroscience letters, 2017, Nov-20, Volume: 661

    Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Carbamazepine; Environment; Female; Flu

2017
Eighteen-year-old man with autism, obsessive compulsive disorder and a
    BMJ case reports, 2018, Jul-09, Volume: 2018

    Topics: Adolescent; Anorexia; Autistic Disorder; Fluoxetine; Humans; Male; Nerve Tissue Proteins; Obsessive-

2018
Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism.
    Biological psychiatry, 2016, Apr-15, Volume: 79, Issue:8

    Topics: Action Potentials; Animals; Attention; Autistic Disorder; Calcium; Disease Models, Animal; Fluoxetin

2016
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders.
    BMC genomics, 2016, 06-29, Volume: 17 Suppl 3

    Topics: Animals; Autistic Disorder; Carbamazepine; Cell Line, Tumor; Environmental Pollutants; Fluoxetine; G

2016
Onset of catatonia at puberty: electroconvulsive therapy response in two autistic adolescents.
    The journal of ECT, 2010, Volume: 26, Issue:4

    Topics: Adolescent; Age of Onset; Aggression; Antidepressive Agents, Second-Generation; Antipsychotic Agents

2010
Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 97, Issue:3

    Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Risper

2011
Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Autistic Disorder; Carbamazepine; Cell Adhesion Molecules; Cyclohexanols; Cyprinidae; Fluox

2012
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.
    Developmental medicine and child neurology, 2002, Volume: 44, Issue:10

    Topics: Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; Cluster Analysis; Depressive Disorder,

2002
Oral dyskinesia induced by fluoxetine therapy for infantile autism.
    Pediatric neurology, 2004, Volume: 31, Issue:1

    Topics: Autistic Disorder; Dyskinesia, Drug-Induced; Fluoxetine; Humans; Infant; Male; Selective Serotonin R

2004
Use of fluoxetine for obsessive-compulsive behavior in adults with autism.
    The American journal of psychiatry, 1997, Volume: 154, Issue:4

    Topics: Adult; Autistic Disorder; Female; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder

1997
Medication-induced hypomania in Asperger's disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:3

    Topics: Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Bipolar Disorder

1998
Effects of fluoxetine treatment in young children with idiopathic autism.
    Developmental medicine and child neurology, 1998, Volume: 40, Issue:8

    Topics: Antidepressive Agents; Autistic Disorder; Child; Child, Preschool; Female; Fluoxetine; Humans; Langu

1998
Selective serotonin re-uptake inhibitors for the treatment of perseverative and maladaptive behaviours of people with intellectual disability.
    Journal of intellectual disability research : JIDR, 1998, Volume: 42 ( Pt 4)

    Topics: Adult; Autistic Disorder; Drug Therapy, Combination; England; Female; Fluoxetine; Humans; Intellectu

1998
Medication-induced hypomania in Asperger's disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:2

    Topics: Affective Symptoms; Attention Deficit and Disruptive Behavior Disorders; Autistic Disorder; Child; C

1999
A child with severe head banging.
    Seminars in pediatric neurology, 1999, Volume: 6, Issue:3

    Topics: Autistic Disorder; Child; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Selective Seroton

1999
Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders.
    The American journal of psychiatry, 2002, Volume: 159, Issue:5

    Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Brain; Brain Chemistry; Child; Child Development

2002
Fluoxetine and serotonin in autism.
    The American journal of psychiatry, 1992, Volume: 149, Issue:6

    Topics: Autistic Disorder; Fluoxetine; Humans; Serotonin

1992
Fluoxetine treatment of children and adults with autistic disorder and mental retardation.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Autistic Disorder; Child; Female; Fluoxetine; Humans; Intellectual Disability; Ma

1992
Depression in autistic disorder.
    The British journal of psychiatry : the journal of mental science, 1991, Volume: 159

    Topics: Adolescent; Arousal; Autistic Disorder; Depressive Disorder; Down Syndrome; Fluoxetine; Humans; Male

1991
Fluoxetine in autism.
    The American journal of psychiatry, 1991, Volume: 148, Issue:8

    Topics: Adolescent; Adult; Autistic Disorder; Child; Drug Administration Schedule; Female; Fluoxetine; Human

1991
Brief report: trichotillomania in an autistic male.
    Journal of autism and developmental disorders, 1991, Volume: 21, Issue:1

    Topics: Adolescent; Arousal; Autistic Disorder; Fluoxetine; Follow-Up Studies; Humans; Male; Stereotyped Beh

1991
Adverse effects of fluoxetine.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:3

    Topics: Adult; Autistic Disorder; Drug Administration Schedule; Female; Fluoxetine; Humans

1991
Fluoxetine in autism with depression.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Autistic Disorder; Depressive Disorder; Female; Fluoxetine; Humans; Male

1991
Fluoxetine and autism.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1990, Volume: 29, Issue:6

    Topics: Adult; Autistic Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fl

1990