Page last updated: 2024-10-27

fluoxetine and Post-Natal Depression

fluoxetine has been researched along with Post-Natal Depression in 31 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
" PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids."4.12Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. ( Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W, 2022)
" The women were on stable daily doses of fluoxetine (10-60 mg/day) and all but two took the medication during the last trimester of pregnancy."3.71Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. ( Altshuler, LL; Fukuchi, A; Hendrick, V; Hostetter, A; Hwang, S; Leight, K; Mintz, J; Stowe, ZN; Suri, R, 2001)
"Postnatal depression is a common disorder that can have adverse short- and long-term effects on maternal morbidity, the new infant and the family as a whole."2.50Antidepressant treatment for postnatal depression. ( Howard, LM; Karia, AM; McGeown, HR; Molyneaux, E; Trevillion, K, 2014)
"Women with postnatal depression can be effectively treated with fluoxetine, which is as effective as a course of cognitive-behavioural counselling in the short-term."2.41Antidepressant drug treatment for postnatal depression. ( Crawley, H; Hoffbrand, S; Howard, L, 2001)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (22.58)18.2507
2000's13 (41.94)29.6817
2010's6 (19.35)24.3611
2020's5 (16.13)2.80

Authors

AuthorsStudies
Chen, J1
Zhu, W1
Zeng, X1
Yang, K1
Peng, H1
Hu, L1
Guo, YJ1
Shan, YM1
Wang, ZJ1
Shen, ZF1
Qiu, W2
Duarte-Guterman, P1
Eid, RS1
Go, KA2
Lamers, Y2
Galea, LAM4
Bashiri, H1
Houwing, DJ1
Homberg, JR1
Salari, AA1
Gobinath, AR2
Wong, S1
Chow, C2
Lieblich, SE1
Barr, AM1
Hu, Z1
Du, X1
Yang, Y1
Botchway, BOA1
Fang, M1
Arbabi, L1
Baharuldin, MT1
Moklas, MA1
Fakurazi, S1
Muhammad, SI1
Molyneaux, E1
Howard, LM1
McGeown, HR1
Karia, AM1
Trevillion, K1
Workman, JL1
Kitay, NF1
Brummelte, S1
Kashani, L1
Eslatmanesh, S1
Saedi, N1
Niroomand, N1
Ebrahimi, M1
Hosseinian, M1
Foroughifar, T1
Salimi, S1
Akhondzadeh, S1
Lanza di Scalea, T1
Wisner, KL2
Suri, R2
Stowe, ZN2
Hendrick, V2
Hostetter, A2
Widawski, M1
Altshuler, LL2
Sohn, E1
Howard, L4
Sanders, J1
Whitty, P1
Murray, D1
Devitt, P1
Rojas, G1
Fritsch, R1
Solis, J1
Jadresic, E1
Castillo, C1
González, M1
Guajardo, V1
Lewis, G1
Peters, TJ1
Araya, R1
Parry, BL2
Perel, JM1
Findling, RL1
Symonds, A1
Appleby, L1
Warner, R1
Whitton, A1
Faragher, B1
Dalton, K1
Herxheimer, A1
Pasco, J1
Gupta, S1
Masand, PS1
Rangwani, S1
Gard, PR1
Mandy, A1
Sutcliffe, MA1
Hoffbrand, S1
Crawley, H1
Nordeng, H1
Bergsholm, YK1
Bøhler, E1
Spigset, O1
Newton, RP1
Mintz, J1
Hwang, S1
Leight, K1
Fukuchi, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Clinical Trial for the Treatment of Postnatal Depression[NCT00518830]230 participants (Actual)Interventional2004-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for fluoxetine and Post-Natal Depression

ArticleYear
Antidepressant treatment for postnatal depression.
    The Cochrane database of systematic reviews, 2014, Sep-11, Issue:9

    Topics: Adult; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Depression, Postpartum; F

2014
Antidepressant medication use during breastfeeding.
    Clinical obstetrics and gynecology, 2009, Volume: 52, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Citalopram; Depression, Postpartum; Female

2009
Postnatal depression.
    Clinical evidence, 2004, Issue:12

    Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post

2004
Postnatal depression.
    Clinical evidence, 2005, Issue:14

    Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post

2005
Postnatal depression.
    Clinical evidence, 2006, Issue:15

    Topics: Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Counseling; Depression, Post

2006
Perimenopausal depression.
    The American journal of psychiatry, 2008, Volume: 165, Issue:1

    Topics: Administration, Cutaneous; Combined Modality Therapy; Comorbidity; Depression, Postpartum; Depressiv

2008
Antidepressant treatment during breast-feeding.
    The American journal of psychiatry, 1996, Volume: 153, Issue:9

    Topics: Age Factors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Breast Feeding; Depression, Po

1996
Selective serotonin reuptake inhibitors in pregnancy and lactation.
    Obstetrical & gynecological survey, 1998, Volume: 53, Issue:12

    Topics: Animals; Breast Feeding; Depression; Depression, Postpartum; Female; Fluoxetine; Humans; Pregnancy;

1998
Antidepressant drug treatment for postnatal depression.
    The Cochrane database of systematic reviews, 2001, Issue:2

    Topics: Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Depression, Postpartum; Female;

2001
Chronobiological basis of female-specific mood disorders.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:5 Suppl

    Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P

2001

Trials

4 trials available for fluoxetine and Post-Natal Depression

ArticleYear
Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial.
    Pharmacopsychiatry, 2017, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Crocus; Depression, Postpartum; Double-Blind Method; Female; Fluoxetine; Humans;

2017
Treatment of postnatal depression in low-income mothers in primary-care clinics in Santiago, Chile: a randomised controlled trial.
    Lancet (London, England), 2007, Nov-10, Volume: 370, Issue:9599

    Topics: Adult; Ambulatory Care Facilities; Antidepressive Agents, Second-Generation; Chile; Depression, Post

2007
A controlled study of fluoxetine and cognitive-behavioural counselling in the treatment of postnatal depression.
    BMJ (Clinical research ed.), 1997, Mar-29, Volume: 314, Issue:7085

    Topics: Adult; Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Combined Modality The

1997
Chronobiological basis of female-specific mood disorders.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:5 Suppl

    Topics: Antidepressive Agents, Second-Generation; Chronobiology Phenomena; Cross-Over Studies; Depression, P

2001

Other Studies

18 other studies available for fluoxetine and Post-Natal Depression

ArticleYear
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
    Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:3

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone;

2022
Efficacy of transcranial magnetic stimulation and fluoxetine in the treatment of postpartum depression: A protocol for systematic review and meta-analysis.
    Medicine, 2020, May-22, Volume: 99, Issue:21

    Topics: Adult; Combined Modality Therapy; Depression, Postpartum; Female; Fluoxetine; Humans; Meta-Analysis

2020
Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy.
    Neuropharmacology, 2020, 09-15, Volume: 175

    Topics: Animals; Depression, Postpartum; Disease Models, Animal; Female; Fluoxetine; Frontal Lobe; Hippocamp

2020
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.
    Scientific reports, 2021, 04-19, Volume: 11, Issue:1

    Topics: Animals; Anxiety; Anxiety Disorders; Brain; Depression, Postpartum; Disease Models, Animal; Female;

2021
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams.
    Psychoneuroendocrinology, 2021, Volume: 130

    Topics: Animals; Corticosterone; Depression, Postpartum; Depressive Disorder, Major; Female; Fluoxetine; Hum

2021
Maternal exercise increases but concurrent maternal fluoxetine prevents the increase in hippocampal neurogenesis of adult offspring.
    Psychoneuroendocrinology, 2018, Volume: 91

    Topics: Animals; Anxiety; Corticosterone; Depression, Postpartum; Disease Models, Animal; Doublecortin Domai

2018
Progesterone and fluoxetine treatments of postpartum depressive-like behavior in rat model.
    Cell biology international, 2019, Volume: 43, Issue:5

    Topics: Animals; Behavior, Animal; Depression, Postpartum; Disease Models, Animal; Female; Fluoxetine; Hippo

2019
Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats.
    Behavioural brain research, 2014, Sep-01, Volume: 271

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Cytokines; Depression, Postpartum;

2014
Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis.
    Neuropharmacology, 2016, Volume: 105

    Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Corticosterone; Dentate Gyrus;

2016
Estimates of nursing infant daily dose of fluoxetine through breast milk.
    Biological psychiatry, 2002, Sep-01, Volume: 52, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Breast Feeding; Depression, Postpartum; Female; Flu

2002
Nursing kids on prozac.
    U.S. news & world report, 2003, Oct-13, Volume: 135, Issue:12

    Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Depression, Postpartum; Female; Fluoxetine

2003
Delusions or obsessions: the same only different? A case report.
    Psychopathology, 2006, Volume: 39, Issue:1

    Topics: Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Delusions; Depression, Postpartum; D

2006
The mind and the butt.
    Psychiatric services (Washington, D.C.), 1996, Volume: 47, Issue:2

    Topics: Adult; Buttocks; Combined Modality Therapy; Depression, Postpartum; Female; Fluoxetine; Humans; Obse

1996
Treatment of postnatal depression. Additional information would enhance value of study.
    BMJ (Clinical research ed.), 1997, Jul-12, Volume: 315, Issue:7100

    Topics: Antidepressive Agents, Second-Generation; Depression, Postpartum; Female; Fluoxetine; Humans; Patien

1997
Emergency medicine. Is this a drug reaction?
    Australian family physician, 1998, Volume: 27, Issue:5

    Topics: Adult; Analgesics, Opioid; Biliary Tract Diseases; Colic; Depression, Postpartum; Diagnosis, Differe

1998
Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression.
    Biological psychiatry, 1999, Apr-15, Volume: 45, Issue:8

    Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidepressive Agents; Ant

1999
[The transfer of selective serotonin reuptake inhibitors to human milk].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001, Jan-20, Volume: 121, Issue:2

    Topics: Antidepressive Agents; Breast Feeding; Citalopram; Depression, Postpartum; Female; Fluoxetine; Fluvo

2001
Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk.
    Biological psychiatry, 2001, Nov-15, Volume: 50, Issue:10

    Topics: Breast Feeding; Depression, Postpartum; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans

2001