Page last updated: 2024-10-27

fluoxetine and Cancer of Colon

fluoxetine has been researched along with Cancer of Colon in 11 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
" In this study, we investigated the effects of fluoxetine, desipramine, and mirtazapine on the liver metastasis of murine C26 colon carcinoma (cc)."8.31Stimulatory effect of fluoxetine and desipramine, but not mirtazapine on C26 colon carcinoma hepatic metastases formation: association with cytokines. ( Arteta, B; Curzytek, K; Grygier, B; Kubera, M; Maes, M; Malicki, S, 2023)
"Treatment with fluoxetine had no effect on tumor growth, muscle wasting, fatigue behavior, or cytokine expression in the brain."5.42Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. ( Bicer, S; Devine, R; Godbout, JP; Jing, R; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015)
"Pretreatment with fluoxetine attenuated the increased IκB kinase (IKK) and IκBα phosphorylation induced by TNF-α."5.37Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice. ( Jung, HC; Kim, IK; Kim, JM; Kim, JS; Kim, N; Koh, SJ; Song, IS, 2011)
" In this study, we investigated the effects of fluoxetine, desipramine, and mirtazapine on the liver metastasis of murine C26 colon carcinoma (cc)."4.31Stimulatory effect of fluoxetine and desipramine, but not mirtazapine on C26 colon carcinoma hepatic metastases formation: association with cytokines. ( Arteta, B; Curzytek, K; Grygier, B; Kubera, M; Maes, M; Malicki, S, 2023)
" We demonstrated the combinations of doxorubicin (DOX) + artesunate, DOX + chloroquine, paclitaxel (PTX) + fluoxetine, PTX + fluphenazine, and PTX + benztropine induce significant cytotoxicity in Michigan Cancer Foundation-7 (MCF-7) breast cancer cells."4.12Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. ( Duarte, D; Nunes, M; Ricardo, S; Vale, N, 2022)
"Treatment with fluoxetine had no effect on tumor growth, muscle wasting, fatigue behavior, or cytokine expression in the brain."1.42Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. ( Bicer, S; Devine, R; Godbout, JP; Jing, R; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015)
"Colon cancer is one of the most common tumors in the human population."1.42Oncostatic effects of fluoxetine in experimental colon cancer models. ( Alho, EJ; Friedrich, M; Garcia, SB; Gasser, M; Heinsen, H; Heinze, KG; Kannen, V; Mönch, R; Scholz, CJ; Silva, WA; Stopper, H; Waaga-Gasser, AM, 2015)
"Pretreatment with fluoxetine attenuated the increased IκB kinase (IKK) and IκBα phosphorylation induced by TNF-α."1.37Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice. ( Jung, HC; Kim, IK; Kim, JM; Kim, JS; Kim, N; Koh, SJ; Song, IS, 2011)
"Fluoxetine (FLX) is a drug commonly used as antidepressant."1.37Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats. ( Bonato, PS; Brandão, ML; Carvalho, MC; Ferreira, FR; Garcia, SB; Jabor, VA; Kannen, V; Marini, T; Silva, WA; Turatti, A; Zanette, DL, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Duarte, D1
Nunes, M1
Ricardo, S1
Vale, N1
Kubera, M1
Arteta, B1
Grygier, B1
Curzytek, K1
Malicki, S1
Maes, M1
Hassan, ESG1
Hassanein, NM1
Sayed Ahmed, HM1
Norden, DM1
Devine, R1
Bicer, S1
Jing, R1
Reiser, PJ1
Wold, LE1
Godbout, JP1
McCarthy, DO1
Kannen, V3
Garcia, SB3
Silva, WA3
Gasser, M1
Mönch, R1
Alho, EJ1
Heinsen, H1
Scholz, CJ1
Friedrich, M1
Heinze, KG1
Waaga-Gasser, AM2
Stopper, H2
Argov, M1
Kashi, R1
Peer, D1
Margalit, R1
Koh, SJ1
Kim, JM1
Kim, IK1
Kim, N1
Jung, HC1
Song, IS1
Kim, JS1
Marini, T1
Turatti, A1
Carvalho, MC1
Brandão, ML1
Jabor, VA1
Bonato, PS1
Ferreira, FR1
Zanette, DL2
Hintzsche, H1
Parish, JM1
Tutton, PJ1
Barkla, DH1

Other Studies

11 other studies available for fluoxetine and Cancer of Colon

ArticleYear
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
    Biomolecules, 2022, Oct-16, Volume: 12, Issue:10

    Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transp

2022
Stimulatory effect of fluoxetine and desipramine, but not mirtazapine on C26 colon carcinoma hepatic metastases formation: association with cytokines.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Animals; Antidepressive Agents; Carcinoma; Colonic Neoplasms; Cytokines; Desipramine; Fluoxetine; Li

2023
Probing the chemoprevention potential of the antidepressant fluoxetine combined with epigallocatechin gallate or kaempferol in rats with induced early stage colon carcinogenesis.
    Journal of pharmacological sciences, 2021, Volume: 145, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Apoptosis; Catechin; Cell Pr

2021
Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.
    Physiology & behavior, 2015, Mar-01, Volume: 140

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Brain; Colo

2015
Oncostatic effects of fluoxetine in experimental colon cancer models.
    Cellular signalling, 2015, Volume: 27, Issue:9

    Topics: Animals; Caco-2 Cells; Cell Hypoxia; Colonic Neoplasms; Fluoxetine; G1 Phase; Humans; Mice; Mice, In

2015
Treatment of resistant human colon cancer xenografts by a fluoxetine-doxorubicin combination enhances therapeutic responses comparable to an aggressive bevacizumab regimen.
    Cancer letters, 2009, Feb-08, Volume: 274, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothe

2009
Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 301, Issue:1

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Fluoxetine; Humans;

2011
Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats.
    Toxicology letters, 2011, Jul-28, Volume: 204, Issue:2-3

    Topics: Animals; Cell Proliferation; Colon; Colonic Neoplasms; Cyclooxygenase 2; Fluoxetine; Male; Precancer

2011
Antiproliferative effects of fluoxetine on colon cancer cells and in a colonic carcinogen mouse model.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Cycle; Cell Proliferation; Cell Trans

2012
"I can't sleep at night" an unusual case of insomnia.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2005, Jul-15, Volume: 1, Issue:3

    Topics: Aged; Anemia, Iron-Deficiency; Blood Transfusion; Colonic Neoplasms; Combined Modality Therapy; Cont

2005
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
    British journal of cancer, 1982, Volume: 46, Issue:2

    Topics: Animals; Cell Division; Cell Line; Citalopram; Colonic Neoplasms; Epithelium; Fluoxetine; Intestines

1982