fluoxetine and lidocaine

fluoxetine has been researched along with lidocaine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's2 (7.14)18.2507
2000's10 (35.71)29.6817
2010's14 (50.00)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Caron, G; Ermondi, G1
Abraham, MH; Acree, WE; Ibrahim, A1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Ahman, M; Holmén, AG; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Sen, S; Sinha, N1
Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bennis, K; Ducki, S; Lesage, F; Vivier, D1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abrahamsson, T; Carlsson, L1
Chen, NH; Reith, ME1
Bayer, BM; Berkeley, MB; Daussin, S; Hernandez, MC1
Atan, A; Aydoğanli, L; Başar, MM1
Swant, J; Thompson, AM; Wagner, JJ1
Ahmed, SI; Kayigil, O; Metin, A1
Holman, JR; Kimmer, SL; Lo, V; Mercado, MG; Wanserski, G1
Escher, BI; Neuwoehner, J1
Abreu, MS; Barcellos, LJ; Giacomini, AC; Kalueff, AV1
Bracke, F; Frieling, H; Leffler, A1

Reviews

3 review(s) available for fluoxetine and lidocaine

ArticleYear
Ion channels as therapeutic targets: a drug discovery perspective.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Drug Discovery; Humans; Ion Channels; Models, Molecular; Phylogeny

2013
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship

2016
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for fluoxetine and lidocaine

ArticleYear
Comparison of the efficacy of fluoxetine alone vs. fluoxetine plus local lidocaine ointment in the treatment of premature ejaculation.
    Archivos espanoles de urologia, 2000, Volume: 53, Issue:9

    Topics: Administration, Topical; Adult; Ejaculation; Fluoxetine; Humans; Lidocaine; Male; Middle Aged; Ointments; Sexual Dysfunction, Physiological; Time Factors

2000

Other Studies

24 other study(ies) available for fluoxetine and lidocaine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Animals; Antidepressive Agents; Biological Transport, Active; Chromatography, High Pressure Liquid; Clonidine; Coronary Disease; Desipramine; Fluoxetine; Heart; Isomerism; Lidocaine; Male; Maprotiline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains

1988
Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships.
    Journal of neurochemistry, 1994, Volume: 63, Issue:5

    Topics: Animals; Biogenic Monoamines; Citalopram; Cocaine; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Lidocaine; Ligands; Male; Microdialysis; Movement; Norepinephrine; Piperazines; Rats; Serotonin; Tetrodotoxin; Ventral Tegmental Area

1994
In vitro effects of cocaine, lidocaine and monoamine uptake inhibitors on lymphocyte proliferative responses.
    Immunopharmacology and immunotoxicology, 1994, Volume: 16, Issue:2

    Topics: Animals; B-Lymphocytes; Cells, Cultured; Cocaine; Desipramine; Fluoxetine; Lidocaine; Lymphocyte Activation; Male; Mitogens; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes

1994
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
    Neuropharmacology, 2005, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin

2005
Does lidocaine ointment addition increase fluoxetine efficacy in the same group of patients with premature ejaculation?
    Urologia internationalis, 2005, Volume: 75, Issue:3

    Topics: Administration, Oral; Administration, Topical; Adult; Anesthetics, Local; Drug Therapy, Combination; Ejaculation; Fluoxetine; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Ointments; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Surveys and Questionnaires; Treatment Outcome

2005
Clinical inquiries. What's the best drug treatment for premature ejaculation?
    The Journal of family practice, 2008, Volume: 57, Issue:3

    Topics: Anesthetics, Local; Antidepressive Agents; Clomipramine; Ejaculation; Fluoxetine; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Paroxetine; Phosphodiesterase Inhibitors; Prilocaine; Sertraline; Sexual Dysfunction, Physiological; Sexual Dysfunctions, Psychological; Treatment Outcome

2008
The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model.
    Aquatic toxicology (Amsterdam, Netherlands), 2011, Jan-17, Volume: 101, Issue:1

    Topics: Amines; Fluoxetine; Hydrogen-Ion Concentration; Kinetics; Lidocaine; Liposomes; Models, Chemical; Propranolol; Quantitative Structure-Activity Relationship; Scenedesmus; Trimipramine; Water

2011
The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish.
    Physiology & behavior, 2016, Apr-01, Volume: 157

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Antidepressive Agents, Second-Generation; Anxiety; Disease Models, Animal; Female; Fluoxetine; Hydrocortisone; Lidocaine; Locomotion; Male; Odorants; Olfaction Disorders; Statistics, Nonparametric; Zebrafish

2016
Antidepressants Are Poor Inhibitors of Heat-Evoked Ion Currents Mediated by TRPM2.
    Pharmacology, 2022, Volume: 107, Issue:9-10

    Topics: Adenosine Diphosphate Ribose; Amitriptyline; Animals; Antidepressive Agents; Citalopram; Duloxetine Hydrochloride; Fluoxetine; HEK293 Cells; Hot Temperature; Humans; Ketamine; Lidocaine; Mice; Paroxetine; Pregabalin; Sertraline; TRPM Cation Channels

2022