mk 936 profile

ID Source	ID
PubMed CID	9920327
CHEMBL ID	3215298
SCHEMBL ID	22740
MeSH ID	M0139099

Synonym
avomec
agri-mek
HY-15311
mk-936
CS-0721
bovitin
duotin
mk-0936
duomectin
doratect
SCHEMBL22740
CHEMBL3215298
avermectin b1a-avermectin b1b mixt.
abamectin 100 microg/ml in acetonitrile
IBSREHMXUMOFBB-JFUDTMANSA-N
AKOS037515751

Excerpt	Relevance	Reference
" The compounds were tested at their respective maximum field recommended concentration (MFRC), and, when strong lethal effects were observed, a dose-response assay with a dilution series of the MFRC was undertaken to calculate LC(50) values."	( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010)	0.36
" For oral exposures via treated sugar water, the dose-response assay showed the LC(50) values for abamectin, bifenazate, bifenthrin and etoxazole to be 1/15 MFRC (1."	( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010)	0.36

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Adenosine receptor A3	Homo sapiens (human)	IC50 (µMol)	0.8700	0.0000	1.8940	8.5470	AID625196
Adenosine receptor A3	Homo sapiens (human)	Ki	0.4920	0.0000	0.9306	10.0000	AID625196
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.8700	0.0002	1.8742	10.0000	AID625196
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.4920	0.0001	0.9490	10.0000	AID625196
D(1A) dopamine receptor	Homo sapiens (human)	IC50 (µMol)	6.1190	0.0003	1.8473	9.2250	AID625252
D(1A) dopamine receptor	Homo sapiens (human)	Ki	3.0600	0.0001	0.8363	10.0000	AID625252
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.8700	0.0000	1.8194	10.0000	AID625196
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.4920	0.0000	0.9650	10.0000	AID625196
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
inflammatory response	Adenosine receptor A3	Homo sapiens (human)
signal transduction	Adenosine receptor A3	Homo sapiens (human)
activation of adenylate cyclase activity	Adenosine receptor A3	Homo sapiens (human)
regulation of heart contraction	Adenosine receptor A3	Homo sapiens (human)
negative regulation of cell population proliferation	Adenosine receptor A3	Homo sapiens (human)
response to wounding	Adenosine receptor A3	Homo sapiens (human)
regulation of norepinephrine secretion	Adenosine receptor A3	Homo sapiens (human)
negative regulation of cell migration	Adenosine receptor A3	Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activity	Adenosine receptor A3	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Adenosine receptor A3	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Adenosine receptor A3	Homo sapiens (human)
temperature homeostasis	D(1A) dopamine receptor	Homo sapiens (human)
conditioned taste aversion	D(1A) dopamine receptor	Homo sapiens (human)
behavioral fear response	D(1A) dopamine receptor	Homo sapiens (human)
regulation of protein phosphorylation	D(1A) dopamine receptor	Homo sapiens (human)
synaptic transmission, dopaminergic	D(1A) dopamine receptor	Homo sapiens (human)
response to amphetamine	D(1A) dopamine receptor	Homo sapiens (human)
protein import into nucleus	D(1A) dopamine receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	D(1A) dopamine receptor	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	D(1A) dopamine receptor	Homo sapiens (human)
activation of adenylate cyclase activity	D(1A) dopamine receptor	Homo sapiens (human)
adenylate cyclase-activating dopamine receptor signaling pathway	D(1A) dopamine receptor	Homo sapiens (human)
synapse assembly	D(1A) dopamine receptor	Homo sapiens (human)
memory	D(1A) dopamine receptor	Homo sapiens (human)
mating behavior	D(1A) dopamine receptor	Homo sapiens (human)
grooming behavior	D(1A) dopamine receptor	Homo sapiens (human)
adult walking behavior	D(1A) dopamine receptor	Homo sapiens (human)
visual learning	D(1A) dopamine receptor	Homo sapiens (human)
response to xenobiotic stimulus	D(1A) dopamine receptor	Homo sapiens (human)
astrocyte development	D(1A) dopamine receptor	Homo sapiens (human)
dopamine transport	D(1A) dopamine receptor	Homo sapiens (human)
transmission of nerve impulse	D(1A) dopamine receptor	Homo sapiens (human)
neuronal action potential	D(1A) dopamine receptor	Homo sapiens (human)
dentate gyrus development	D(1A) dopamine receptor	Homo sapiens (human)
striatum development	D(1A) dopamine receptor	Homo sapiens (human)
cerebral cortex GABAergic interneuron migration	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of cell migration	D(1A) dopamine receptor	Homo sapiens (human)
peristalsis	D(1A) dopamine receptor	Homo sapiens (human)
operant conditioning	D(1A) dopamine receptor	Homo sapiens (human)
synaptic transmission, glutamatergic	D(1A) dopamine receptor	Homo sapiens (human)
regulation of dopamine metabolic process	D(1A) dopamine receptor	Homo sapiens (human)
vasodilation	D(1A) dopamine receptor	Homo sapiens (human)
dopamine metabolic process	D(1A) dopamine receptor	Homo sapiens (human)
maternal behavior	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of potassium ion transport	D(1A) dopamine receptor	Homo sapiens (human)
glucose import	D(1A) dopamine receptor	Homo sapiens (human)
habituation	D(1A) dopamine receptor	Homo sapiens (human)
sensitization	D(1A) dopamine receptor	Homo sapiens (human)
behavioral response to cocaine	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosol	D(1A) dopamine receptor	Homo sapiens (human)
regulation of dopamine uptake involved in synaptic transmission	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	D(1A) dopamine receptor	Homo sapiens (human)
prepulse inhibition	D(1A) dopamine receptor	Homo sapiens (human)
phospholipase C-activating dopamine receptor signaling pathway	D(1A) dopamine receptor	Homo sapiens (human)
long-term synaptic potentiation	D(1A) dopamine receptor	Homo sapiens (human)
long-term synaptic depression	D(1A) dopamine receptor	Homo sapiens (human)
cellular response to catecholamine stimulus	D(1A) dopamine receptor	Homo sapiens (human)
modification of postsynaptic structure	D(1A) dopamine receptor	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of neuron migration	D(1A) dopamine receptor	Homo sapiens (human)
positive regulation of MAPK cascade	D(1A) dopamine receptor	Homo sapiens (human)
adenylate cyclase-activating adrenergic receptor signaling pathway	D(1A) dopamine receptor	Homo sapiens (human)
dopamine receptor signaling pathway	D(1A) dopamine receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G protein-coupled adenosine receptor activity	Adenosine receptor A3	Homo sapiens (human)
dopamine neurotransmitter receptor activity, coupled via Gs	D(1A) dopamine receptor	Homo sapiens (human)
G-protein alpha-subunit binding	D(1A) dopamine receptor	Homo sapiens (human)
dopamine neurotransmitter receptor activity	D(1A) dopamine receptor	Homo sapiens (human)
protein binding	D(1A) dopamine receptor	Homo sapiens (human)
heterotrimeric G-protein binding	D(1A) dopamine receptor	Homo sapiens (human)
dopamine binding	D(1A) dopamine receptor	Homo sapiens (human)
arrestin family protein binding	D(1A) dopamine receptor	Homo sapiens (human)
G protein-coupled receptor activity	D(1A) dopamine receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Adenosine receptor A3	Homo sapiens (human)
presynaptic membrane	Adenosine receptor A3	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Adenosine receptor A3	Homo sapiens (human)
dendrite	Adenosine receptor A3	Homo sapiens (human)
plasma membrane	Adenosine receptor A3	Homo sapiens (human)
synapse	Adenosine receptor A3	Homo sapiens (human)
nucleus	D(1A) dopamine receptor	Homo sapiens (human)
endoplasmic reticulum membrane	D(1A) dopamine receptor	Homo sapiens (human)
plasma membrane	D(1A) dopamine receptor	Homo sapiens (human)
cilium	D(1A) dopamine receptor	Homo sapiens (human)
presynaptic membrane	D(1A) dopamine receptor	Homo sapiens (human)
dendritic spine	D(1A) dopamine receptor	Homo sapiens (human)
postsynaptic membrane	D(1A) dopamine receptor	Homo sapiens (human)
ciliary membrane	D(1A) dopamine receptor	Homo sapiens (human)
non-motile cilium	D(1A) dopamine receptor	Homo sapiens (human)
glutamatergic synapse	D(1A) dopamine receptor	Homo sapiens (human)
GABA-ergic synapse	D(1A) dopamine receptor	Homo sapiens (human)
G protein-coupled receptor complex	D(1A) dopamine receptor	Homo sapiens (human)
plasma membrane	D(1A) dopamine receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (110)

Assay ID	Title	Year	Journal	Article
AID1112321	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant vigour at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104408	Contact toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 18 mg a.i./l applied on the dorsal thorax for 11 weeks measured once a week for 11 weeks relative to control	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112348	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 5 L/hectare measured after 50 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104202	Insecticidal activity against adult female imidacloprid-resistant Bemisia tabaci B-biotype NJ-Imi (sweet potato whitefly) (G30) in cotton leaf discs assessed as mortality treated for 10 secs prior to adult infestation measured after 72 hr by leaf-dip bioa	2009	Pest management science, Nov, Volume: 65, Issue:11	Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci.
AID1112038	Insecticidal activity against third-instar larvae of fufenozide-susceptible Plutella xylostella (diamondback moth) assessed as mortality by leaf-dip bioassay method	2012	Pest management science, Feb, Volume: 68, Issue:2	Cross-resistance patterns and fitness in fufenozide-resistant diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae).
AID1111182	Insecticidal activity against B-biotype thiamethoxam-resistant Bemisia tabaci (sweet potato whitefly) in cabbage leaf assessed as mortality after 48 hr by leaf disk assay	2010	Pest management science, Mar, Volume: 66, Issue:3	Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1111404	Nematicidal activity against Bursaphelenchus xylophilus assessed as mortality at 0.34 mg/l after 48 hr	2010	Pest management science, Jun, Volume: 66, Issue:6	Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.
AID1112360	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 5 L/hectare measured after 20 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1110865	Insecticidal activity against spirodiclofen-resistant Tetranychus urticae SR-VP (two-spotted spider mite) adults in kidney bean leaf disks assessed as mortality measured after 2 days	2009	Pest management science, Apr, Volume: 65, Issue:4	Genetic and biochemical analysis of a laboratory-selected spirodiclofen-resistant strain of Tetranychus urticae Koch (Acari: Tetranychidae).
AID1112320	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant vigour at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112353	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 7.5 L/hectare measured after 60 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112337	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as medium fruit yield at 7.5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104923	Insecticidal activity against Bemisia tabaci (sweet potato whitefly) infested cucumber leaves assessed as mortality after 48 hr by leaf dip method	2011	Pest management science, Jan, Volume: 67, Issue:1	Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1112368	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant vigour at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112328	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in root galling index at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112369	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant vigour at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1110868	Insecticidal activity against spirodiclofen-susceptible Tetranychus urticae LS-VL (two-spotted spider mite) adults in kidney bean leaf disks assessed as mortality after 2 day	2009	Pest management science, Apr, Volume: 65, Issue:4	Genetic and biochemical analysis of a laboratory-selected spirodiclofen-resistant strain of Tetranychus urticae Koch (Acari: Tetranychidae).
AID1112324	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1105275	Insecticidal activity against Tetranychus evansi R2 in clean French bean leaf assessed as mortality at 26 degC and 16 hr day length measured after 48 hr by microimmersion protocol	2011	Pest management science, Aug, Volume: 67, Issue:8	Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel.
AID1104204	Insecticidal activity against adult female imidacloprid-susceptible Bemisia tabaci B-biotype NJ (sweet potato whitefly) in cotton leaf discs assessed as mortality treated for 10 secs prior to adult infestation measured after 72 hr by leaf-dip bioassay	2009	Pest management science, Nov, Volume: 65, Issue:11	Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci.
AID1112326	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112365	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as fresh root weight at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104351	Contact toxicity against Aphidius colemani assessed as mortality at 8.5 mg a.i./l	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112372	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant height at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104437	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through sugar water measured after 1 week	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112356	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 5 L/hectare measured after 40 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112336	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as medium fruit yield at 5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112345	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as extra-large fruit yield at 7.5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1105278	Insecticidal activity against Tetranychus evansi ST JEA in clean French bean leaf assessed as mortality at 26 degC and 16 hr day length measured after 48 hr by microimmersion protocol	2011	Pest management science, Aug, Volume: 67, Issue:8	Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel.
AID1111181	Cross resistant, ratio of LC50 for B-biotype thiamethoxam-resistant Bemisia tabaci (sweet potato whitefly) to LC50 for B-biotype thiamethoxam-sensitive Bemisia tabaci (sweet potato whitefly)	2010	Pest management science, Mar, Volume: 66, Issue:3	Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1112361	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 7.5 L/hectare measured after 20 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112026	Insecticidal activity against Drosophila suzukii assessed as mortality at 3.31 g/ha by direct application at 22 degC measured after 24 hr	2011	Pest management science, Nov, Volume: 67, Issue:11	Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1112354	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 10 L/hectare measured after 60 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112350	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 10 L/hectare measured after 50 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1105277	Insecticidal activity against Tetranychus evansi TOR in clean French bean leaf assessed as mortality at 26 degC and 16 hr day length measured after 48 hr by microimmersion protocol	2011	Pest management science, Aug, Volume: 67, Issue:8	Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel.
AID1112380	Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as per seed	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112378	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as reduction in root galling index at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112364	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as fresh root weight at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112896	Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae (green peach aphid) 4106A membrane at 1 ppm after 70 min	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1112022	Insecticidal activity against Drosophila suzukii assessed as male mortality at 112.3 g/ha by direct application at 22 degC measured after 24 hr	2011	Pest management science, Nov, Volume: 67, Issue:11	Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1111221	Insecticidal activity against young stage of Cacopsylla melanoneura in apple plant assessed as mortality at 16.6 g/ha treated for 14 days measured after 7 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112377	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as reduction in root galling index at 5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112037	Resistance ratio, ratio of LC50 for third-instar larvae of fufenozide-resistant Plutella xylostella (diamondback moth) to LC50 for third-instar larvae of fufenozide-susceptible Plutella xylostella	2012	Pest management science, Feb, Volume: 68, Issue:2	Cross-resistance patterns and fitness in fufenozide-resistant diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae).
AID1112346	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as extra-large fruit yield at 10 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104431	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through pollen for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1104412	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through pollen measured after 3 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112325	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112373	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant height at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104360	Toxicity against po dosed worker Bombus terrestris (bumblebee) administered through sugar water for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112039	Insecticidal activity against third-instar larvae of fufenozide-resistant Plutella xylostella (diamondback moth) assessed as mortality by leaf-dip bioassay method	2012	Pest management science, Feb, Volume: 68, Issue:2	Cross-resistance patterns and fitness in fufenozide-resistant diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae).
AID1111243	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 1 hr measured after 3 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112352	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 5 L/hectare measured after 60 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112357	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 7.5 L/hectare measured after 40 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1111242	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as reduction of progeny per female at 16.6 g/ha treated for 1 hr measured after 7 days	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112334	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as marketable yield at 10 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1111236	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as reduction of progeny per female at 16.6 g/ha treated for 14 days measured after 7 days	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1111239	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as reduction of progeny per female at 16.6 g/ha treated for 7 days measured after 7 days	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112349	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant height at 7.5 L/hectare measured after 50 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112374	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) assessed as mortality after 48 hr	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104920	Insecticidal activity against Bemisia tabaci (sweet potato whitefly) infested cabbage leaves assessed as mortality after 48 hr by leaf dip method	2011	Pest management science, Jan, Volume: 67, Issue:1	Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1104411	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through pollen measured after 7 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1105276	Insecticidal activity against Tetranychus evansi R1 in clean French bean leaf assessed as mortality at 26 degC and 16 hr day length measured after 48 hr by microimmersion protocol	2011	Pest management science, Aug, Volume: 67, Issue:8	Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel.
AID1112341	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as large fruit yield at 7.5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112379	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as reduction in root galling index at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1111223	Insecticidal activity against young stage of Cacopsylla melanoneura in apple plant assessed as mortality at 16.6 g/ha treated for 1 hr measured after 7 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1111238	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 14 days measured after 1 day relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1111183	Insecticidal activity against B-biotype thiamethoxam-sensitive Bemisia tabaci (sweet potato whitefly) in cabbage leaf assessed as mortality after 48 hr by leaf disk assay	2010	Pest management science, Mar, Volume: 66, Issue:3	Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1112021	Insecticidal activity against Drosophila suzukii assessed as male mortality at 41 g/ha by direct application at 22 degC measured after 24 hr	2011	Pest management science, Nov, Volume: 67, Issue:11	Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID547621	Cytotoxicity against BESM cells after 88 hrs by HTS assay	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
AID1111241	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 7 days measured after 1 day relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112020	Insecticidal activity against Drosophila suzukii assessed as male mortality at 3.31 g/ha by direct application at 22 degC measured after 24 hr	2011	Pest management science, Nov, Volume: 67, Issue:11	Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID547804	Selectivity window, ratio of EC50 for BESM cells to EC50 for Trypanosoma cruzi amastigotes infected in BESM cells	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
AID1112362	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 10 L/hectare measured after 20 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104449	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through sugar water for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112342	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as large fruit yield at 10 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104354	Contact toxicity against Apis mellifera (honey bee) assessed per bee after 24 hr	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1104479	Contact toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l applied on the dorsal thorax for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112366	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as fresh root weight at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104436	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through sugar water measured after 7 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1104200	Resistance factor, ratio of LC50 for adult female Bemisia tabaci B-biotype NJ-Imi (sweet potato whitefly) (G30) to LC50 for adult female B-type Bemisia tabaci NJ	2009	Pest management science, Nov, Volume: 65, Issue:11	Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci.
AID1112330	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in root galling index at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112375	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant height at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1111222	Insecticidal activity against young stage of Cacopsylla melanoneura in apple plant assessed as mortality at 16.6 g/ha treated for 7 days measured after 7 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1104353	Toxicity against po dosed Apis mellifera (honey bee) assessed per bee after 24 hr	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1104461	Contact toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l applied on the dorsal thorax measured after 3 to 4 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1112331	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as marketable yield at 5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104925	Insecticidal activity against Bemisia tabaci (sweet potato whitefly) infested poinsettia leaves assessed as mortality after 48 hr by leaf dip method	2011	Pest management science, Jan, Volume: 67, Issue:1	Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1110859	Resistance ratio of LC50 for spirodiclofen-resistant Tetranychus urticae SR-VP (two-spotted spider mite) adults to LC50 for spirodiclofen-susceptible Tetranychus urticae LS-VL (two-spotted spider mite) adults	2009	Pest management science, Apr, Volume: 65, Issue:4	Genetic and biochemical analysis of a laboratory-selected spirodiclofen-resistant strain of Tetranychus urticae Koch (Acari: Tetranychidae).
AID1112322	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as plant vigour at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1111394	Nematicidal activity against Bursaphelenchus xylophilus in pot-grown three-year-old trees of Pinus densiflora assessed as reduction of disease incidence at 2% treated 3 months before inoculation measured after 9 months by measuring dead trees	2010	Pest management science, Jun, Volume: 66, Issue:6	Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.
AID1104924	Insecticidal activity against Bemisia tabaci (sweet potato whitefly) infested cotton leaves assessed as mortality after 48 hr by leaf dip method	2011	Pest management science, Jan, Volume: 67, Issue:1	Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1112023	Insecticidal activity against Drosophila suzukii assessed as male mortality at 2.3 g/ha by direct application at 22 degC measured after 24 hr	2011	Pest management science, Nov, Volume: 67, Issue:11	Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1111392	Nematicidal activity against Bursaphelenchus xylophilus in pot-grown three-year-old trees of Pinus densiflora assessed as reduction of disease incidence at 2% treated 3 months before inoculation measured after 9 months by measuring dead trees relative to	2010	Pest management science, Jun, Volume: 66, Issue:6	Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.
AID1112333	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as marketable yield at 7.5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112340	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as large fruit yield at 5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104378	Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 18 mg a.i./l, po administered through pollen for 11 weeks measured once a week for 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1104922	Insecticidal activity against Bemisia tabaci (sweet potato whitefly) infested tomato leaves assessed as mortality after 48 hr by leaf dip method	2011	Pest management science, Jan, Volume: 67, Issue:1	Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae).
AID1112339	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as medium fruit yield at 10 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1104435	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through sugar water measured after 11 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1111237	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 14 days measured after 3 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1112344	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as extra-large fruit yield at 5 L/hectare	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112329	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in root galling index at 7.5 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID547622	Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
AID1111240	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 7 days measured after 3 days relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1111244	Insecticidal activity against adult of Cacopsylla melanoneura in apple plant assessed as overwintered female mortality at 16.6 g/ha treated for 1 hr measured after 1 day relative to control	2010	Pest management science, Mar, Volume: 66, Issue:3	Effectiveness of five insecticides for the control of adults and young stages of Cacopsylla melanoneura (Förster) (Hemiptera: Psyllidae) in a semi-field trial.
AID1111400	Nematicidal activity against Bursaphelenchus xylophilus in pot-grown three-year-old trees of Pinus densiflora assessed as reduction of disease incidence at 3.6 mg/seedlings treated 7 days before inoculation measured after 1 month by measuring dead seedlin	2010	Pest management science, Jun, Volume: 66, Issue:6	Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.
AID1104434	Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 18 mg a.i./l, po administered through sugar water measured after 9 weeks	2010	Pest management science, Jul, Volume: 66, Issue:7	Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.
AID1111396	Nematicidal activity against Bursaphelenchus xylophilus in pot-grown three-year-old trees of Pinus densiflora assessed as reduction of disease incidence at 3.6 mg/seedlings treated 7 days before inoculation measured after 1 month by measuring dead seedlin	2010	Pest management science, Jun, Volume: 66, Issue:6	Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.
AID1112370	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato plant under greenhouse condition assessed as plant vigour at 10 L/hectare measured after 30 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
AID1112358	Nematicidal activity against second-stage juvenile Meloidogyne incognita (root-knot nematode) infested tomato field assessed as reduction in number of nematodes in soil at 10 L/hectare measured after 40 days	2012	Pest management science, Jun, Volume: 68, Issue:6	Effect of abamectin on root-knot nematodes and tomato yield.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (15.38)	29.6817
2010's	11 (84.62)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
tacrine Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.	2.05	1	acridines; aromatic amine	EC 3.1.1.7 (acetylcholinesterase) inhibitor
amiodarone Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.	2.05	1	1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound	cardiovascular drug
amitriptyline Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.. amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.	2.05	1	carbotricyclic compound; tertiary amine	adrenergic uptake inhibitor; antidepressant; environmental contaminant; tropomyosin-related kinase B receptor agonist; xenobiotic
azelastine azelastine: azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia. azelastine : A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.	2.05	1	monochlorobenzenes; phthalazines; tertiary amino compound	anti-allergic agent; anti-asthmatic drug; bronchodilator agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; H1-receptor antagonist; platelet aggregation inhibitor
carvedilol [no description available]	2.05	1	carbazoles; secondary alcohol; secondary amino compound	alpha-adrenergic antagonist; antihypertensive agent; beta-adrenergic antagonist; cardiovascular drug; vasodilator agent
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	3.16	5	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
clomipramine Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.. clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.	2.05	1	dibenzoazepine	anticoronaviral agent; antidepressant; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; serotonergic antagonist; serotonergic drug; serotonin uptake inhibitor
cypermethrin cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.	2.05	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound	agrochemical; molluscicide; pyrethroid ester acaricide; pyrethroid ester insecticide
diazinon Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.	2.06	1	organic thiophosphate; pyrimidines	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; nematicide; xenobiotic
doxazosin Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.. doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.	2.05	1	aromatic amine; benzodioxine; monocarboxylic acid amide; N-acylpiperazine; N-arylpiperazine; quinazolines	alpha-adrenergic antagonist; antihyperplasia drug; antihypertensive agent; antineoplastic agent; vasodilator agent
endosulfan Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.	2.06	1	cyclic sulfite ester; cyclodiene organochlorine insecticide	acaricide; agrochemical; GABA-gated chloride channel antagonist; persistent organic pollutant
fipronil fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.	2.76	3	(trifluoromethyl)benzenes; dichlorobenzene; nitrile; primary amino compound; pyrazoles; sulfoxide
fluphenazine [no description available]	2.05	1	N-alkylpiperazine; organofluorine compound; phenothiazines	anticoronaviral agent; dopaminergic antagonist; phenothiazine antipsychotic drug
fluoxetine Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.	2.05	1	(trifluoromethyl)benzenes; aromatic ether; secondary amino compound
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	2.05	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
homochlorocyclizine homochlorocyclizine: RN given refers to parent cpd	2.05	1	diarylmethane
lomerizine lomerizine: used to treat migraines	2.05	1	diarylmethane
loperamide Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.. loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.	2.05	1	monocarboxylic acid amide; monochlorobenzenes; piperidines; tertiary alcohol	anticoronaviral agent; antidiarrhoeal drug; mu-opioid receptor agonist
loratadine Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.. loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.	2.05	1	benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide	anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist
malathion Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.	2.06	1	diester; ethyl ester; organic thiophosphate
methomyl Methomyl: A carbamate insecticide with anticholinesterase activity.. methomyl : A carbamate ester obtained by the formal condensation of methylcarbamic acid with the hydroxy group of 1-(methylsulfanyl)acetaldoxime.	2.47	2	aliphatic sulfide; carbamate ester	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; nematicide; xenobiotic
naftopidil [no description available]	2.05	1	piperazines
nefazodone nefazodone: may be useful as an opiate adjunct	2.05	1	aromatic ether; monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; triazoles	alpha-adrenergic antagonist; analgesic; antidepressant; serotonergic antagonist; serotonin uptake inhibitor
oxolinic acid quinolone antibiotic : An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton.	2.05	1	aromatic carboxylic acid; organic heterotricyclic compound; oxacycle; quinolinemonocarboxylic acid; quinolone antibiotic	antibacterial drug; antifungal agent; antiinfective agent; antimicrobial agent; enzyme inhibitor
perphenazine Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.. perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.	2.05	1	N-(2-hydroxyethyl)piperazine; N-alkylpiperazine; organochlorine compound; phenothiazines	antiemetic; dopaminergic antagonist; phenothiazine antipsychotic drug
prazosin Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.. prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.	2.05	1	aromatic ether; furans; monocarboxylic acid amide; piperazines; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
promazine Promazine: A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.. promazine : A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.	2.05	1	phenothiazines; tertiary amine	antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; muscarinic antagonist; phenothiazine antipsychotic drug; serotonergic antagonist
raloxifene raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.	2.05	1	1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
butyl phosphorotrithioate butyl phosphorotrithioate: a herbicide	2.05	1	organic thiophosphate	defoliant
sibutramine sibutramine: serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride	2.05	1	organochlorine compound; tertiary amino compound	anti-obesity agent; serotonin uptake inhibitor
imatinib [no description available]	2.05	1	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
piperonyl butoxide [no description available]	2.05	1	benzodioxoles	pesticide synergist
norethindrone acetate norethisterone acetate : A 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.	2.05	1	3-oxo-Delta(4) steroid; acetate ester; terminal acetylenic compound	progestin; synthetic oral contraceptive
carbaryl Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.. carbaryl : A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.	2.06	1	carbamate ester; naphthalenes	acaricide; agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant growth retardant
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.05	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
dinoseb dinoseb: RN given refers to parent cpd; structure. dinoseb : A racemate composed of equimolar amounts of (R)- and (S)-dinoseb.. 2-(butan-2-yl)-4,6-dinitrophenol : A dinitrophenol that is 2,4-dinitrophenol substituted by a butan-2-yl group at position 2.	2.08	1	dinitrophenol
phenothiazine 10H-phenothiazine : The 10H-tautomer of phenothiazine.	2.05	1	phenothiazine	ferroptosis inhibitor; plant metabolite; radical scavenger
cyproterone acetate [no description available]	2.05	1	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; chlorinated steroid; steroid ester	androgen antagonist; geroprotector; progestin
kainic acid Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.	2.05	1	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist
allethrins Allethrins: Synthetic analogs of the naturally occurring insecticides cinerin, jasmolin, and pyrethrin. (From Merck Index, 11th ed)	2.06	1	cyclopropanecarboxylate ester	pyrethroid ester insecticide
3,3',4',5-tetrachlorosalicylanilide 3,3',4',5-tetrachlorosalicylanilide : A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.	2.05	1	dichlorobenzene; salicylanilides	drug allergen
dienochlor dienochlor: structure	2.05	1	organochlorine compound
carbamothioic acid, s,s'-(2-(dimethylamino)-1,3-propanediyl) ester carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester: RN given refers to parent cpd; Padan refers to mono-HCl	2.05	1	nereistoxin analogue insecticide
metergoline Metergoline: A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.. metergoline : An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.	2.05	1	carbamate ester; ergoline alkaloid	dopamine agonist; geroprotector; serotonergic antagonist
isopropyl 4,4'-dibromobenzilate isopropyl 4,4'-dibromobenzilate: active substance in fumigant strips for mites	2.05	1
clobetasol propionate Clobetasol Propionate: This is the form in trademark preparations.. clobetasol propionate : The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.	2.05	1	11beta-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; chlorinated steroid; fluorinated steroid; glucocorticoid	anti-inflammatory drug
pirimiphos methyl pirimiphos methyl: structure. pirimiphos-methyl : An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.	2.08	1	aminopyrimidine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide
amitraz amitraz: ixodicide (tick control); structure. amitraz : A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.	2.46	2	formamidines; tertiary amino compound	acaricide; environmental contaminant; insecticide; xenobiotic
diflubenzuron Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.. diflubenzuron : A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.	2.47	2	benzoylurea insecticide; monochlorobenzenes	insect sterilant
permethrin hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141	2.06	1	cyclopropanecarboxylate ester; cyclopropanes	agrochemical; ectoparasiticide; pyrethroid ester acaricide; pyrethroid ester insecticide; scabicide
decamethrin decamethrin: pyrethroid insecticide; RN given refers to cpd without isomeric designation; structure	2.05	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organobromine compound	agrochemical; antifeedant; calcium channel agonist; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; pyrethroid ester insecticide
dibutylaminosulfenylcarbofuran dibutylaminosulfenylcarbofuran: RN given refers to cpd with unspecified thio moieties	2.46	2	1-benzofurans; carbamate ester	acaricide; agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
bopindolol bopindolol: RN given refers to cpd without isomeric designation. bopindolol : A racemate comprising of equal amounts of (R)-bopindolol and (S)-bopindolol. It is a non-selective antagonist of beta1- and beta2-adrenoceptors and a prodrug in which the ester group is hydrolysed to form the corresponding hydroxy derivative.. 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate : A methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group.	2.05	1	aromatic ether; benzoate ester; methylindole; secondary amino compound
fenpropathrin, (+-)-isomer fenpropathrin: RN given refers to cpd without isomeric designation. fenpropathrin : A cyclopropanecarboxylate ester obtained by formal condensation between 2,2,3,3-tetramethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.	2.06	1	aromatic ether; cyclopropanecarboxylate ester	agrochemical; pyrethroid ester acaricide; pyrethroid ester insecticide
fenoxycarb fenoxycarb: used against mosquitoes (Diptera:Culicidae); structure given in first source. fenoxycarb : A carbamate ester that is the O-ethyl carbamate of 2-(4-phenoxyphenoxy)ethylamine.	2.05	1	aromatic ether; carbamate ester	environmental contaminant; insecticide; juvenile hormone mimic; xenobiotic
nelfinavir Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.	2.05	1	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor
dyclonine hydrochloride dyclonine hydrochloride : The hydrochloride salt of dyclonine.	2.05	1	hydrochloride	topical anaesthetic
ethofenprox ethofenprox: synthetic pyrethroid for insecticidal efficacy against mosquito larvae & on non-target organisms. etofenprox : An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.	2.05	1	aromatic ether	pyrethroid ether insecticide
ergocornine ergocornine: a component of ergotoxine; minor descriptor (75-86); on-line & INDEX MEDICUS search ERGOLINES (75-86); RN given refers to ((5'alpha)-isomer). ergocornine : Ergotaman bearing a hydroxy group at the 12' position, isopropyl groups at the 2' and 5'alpha positions, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid.	2.05	1	ergot alkaloid
clofentezine clofentezine: acaricide, primarily a mite ovicide; structure given in first source. clofentezine : A tetrazine that is 1,2,4,5-tetrazine in which both of the hydrogens have been replaced by o-chlorophenyl groups.	2.05	1	monochlorobenzenes; organochlorine acaricide; tetrazine	mite growth regulator; tetrazine acaricide
1-benzylimidazole 1-benzylimidazole: inhibits human thromboxane synthetase	2.05	1
1,2-dibenzoyl-tert-butylhydrazine 1,2-dibenzoyl-tert-butylhydrazine: structure given in first source	2.07	1	bisacylhydrazine insecticide
4-chloro-n-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1h-pyrazole-5-carboxamide [no description available]	2.46	2	pyrazole acaricide; pyrazole insecticide	mitochondrial NADH:ubiquinone reductase inhibitor
fenazaquin fenazaquin: an experimental miticide	2.05	1	quinazolines	acaricide; mitochondrial NADH:ubiquinone reductase inhibitor
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.08	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
hexafluoron hexafluoron: insect growth regulator against mosquito larva; the active agent in Sonet, a Russian product, is hexaflumuron. hexaflumuron : An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.	2.07	1	aromatic ether; benzoylurea insecticide; dichlorobenzene; N-acylurea; organochlorine insecticide; organofluorine insecticide
cadusafos cadusafos: pesticide; structure in first source	2.07	1	organic thiophosphate; organothiophosphate insecticide	agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
pyridaben [no description available]	2.46	2	organochlorine acaricide; organochlorine insecticide; pyridazinone	mitochondrial NADH:ubiquinone reductase inhibitor
tebufenozide tebufenozide: structure given in first source. tebufenozide : A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by tert-butyl, 3,5-dimethylbenzoyl and 4-ethylbenzoyl groups respectively. It is an insecticide used widely against caterpillars.	2.07	1	carbohydrazide	ecdysone agonist; environmental contaminant; xenobiotic
chlorfenapyr chlorfenapyr: an experimental pour-on formulation, a new generation pyrethroid available to producers. chlorfenapyr : A member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. A proinsecticide used for termite control and crop protection against several insects and mite pests.	2.47	2	hemiaminal ether; monochlorobenzenes; nitrile; organochlorine acaricide; organochlorine insecticide; organofluorine acaricide; organofluorine insecticide; pyrroles	proacaricide; proinsecticide
acequinocyl acequinocyl: structure in first source. acequinocyl : An acetate ester consisting of 1,4-naphthoquinone bearing acetoxy and dodecyl substituents at positions 2 and 3 respectively.	2.46	2	1,4-naphthoquinones; acetate ester	acaricide; mitochondrial cytochrome-bc1 complex inhibitor
novaluron novaluron: insecticide	2.06	1	aromatic ether; benzoylurea insecticide; monochlorobenzenes; organofluorine compound
u 74006f tirilazad: a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox	2.05	1	corticosteroid hormone
cyfluthrin cyfluthrin: effective against mosquitoes. cyfluthrin : A carboxylic ester obtained by formal condensation between 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid and (4-fluoro-3-phenoxyphenyl)(hydroxy)acetonitrile.	2.06	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound; organofluorine compound	agrochemical; pyrethroid ester insecticide
methoxyfenozide methoxyfenozide: structure in first source. methoxyfenozide : A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by 3-methoxy-2-methylbenzoyl, 3,5-dimethylbenzoyl, and tert-butyl groups respectively.	2.07	1	carbohydrazide; monomethoxybenzene	environmental contaminant; insecticide; xenobiotic
thiacloprid thiacloprid: structure in first source. (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid.. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.	2.47	2	monochloropyridine; nitrile; thiazolidines	environmental contaminant; neonicotinoid insectide; xenobiotic
desloratadine desloratadine: major metabolite of loratadine. desloratadine : Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.	2.05	1	benzocycloheptapyridine	anti-allergic agent; cholinergic antagonist; drug metabolite; H1-receptor antagonist
docetaxel [no description available]	2.05	1	hydrate; secondary alpha-hydroxy ketone	antineoplastic agent
borneo Borneo: An island in the Malay Archipelago, east of Sumatra, north of Java, and west of Celebes. It is the third largest island in the world. Its name is a Portuguese alteration of BRUNEI, located on it. (From Webster's New Geographical Dictionary, 1988, p163; Room, Brewer's Dictionary of Names, 1992, p73)	2.46	2	organofluorine acaricide
bifenazate bifenazate: an acaricide. bifenazate : A carboxylic ester obtained by formal condensation of 2-(4-methoxy[1,1'-biphenyl]-3-yl)hydrazinecarboxylic acid with 2-propanol.	2.46	2	carboxylic ester	acaricide
spirodiclofen spirodiclofen: an acaricide	2.46	2	dichlorobenzene; gamma-lactone; organochlorine acaricide; oxaspiro compound
scorpions [no description available]	2.08	1	dinotefuran; oxolanes	neonicotinoid insectide
prizes acetamiprid: structure in first source. (E)-acetamiprid : The (E)-stereoisomer of acetamiprid.. acetamiprid : A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.	3.16	5	carboxamidine; monochloropyridine; nitrile	environmental contaminant; neonicotinoid insectide; xenobiotic
terconazole terconazole: structure & RN for (cis)-isomer from first source. terconazole : A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-terconazole. It has broad-spectrum antifungal activitiy and is used for the treatment of vaginal yeast infections (Candida).. (2R,4S)-terconazole : A 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine in which positions 2 and 4 of the 1,3-dioxolane moiety have R and S configuration, respectively.	2.05	1	1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine
dihydroergocristine monomesylate dihydroergocristine mesylate : The methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia.	2.05	1	methanesulfonate salt	alpha-adrenergic antagonist; geroprotector; vasodilator agent
sm 8668 Sch 39304: Sch 42427 is the active entantiomer of the antifungal agent Sch 39304 which consists of Sch 42426 & Sch 42427; Sch 42426, the (S,S)-isomer, is inactive	2.05	1
posaconazole [no description available]	2.05	1	aromatic ether; conazole antifungal drug; N-arylpiperazine; organofluorine compound; oxolanes; triazole antifungal drug; triazoles	trypanocidal drug
benztropine Benztropine: A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.. benzatropine : Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.	2.05	1	diarylmethane
nitenpyram nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source. (E)-nitenpyram : A nitenpyram in which the double bond has E configuration.. nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.	2.75	3	chloropyridyl insecticide; nitenpyram
diethyl maleate diethyl maleate : A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.	2.05	1	ethyl ester; maleate ester	glutathione depleting agent
mycophenolate mofetil mycophenolate mofetil : A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.	2.05	1	carboxylic ester; ether; gamma-lactone; phenols; tertiary amino compound	anticoronaviral agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; immunosuppressive agent; prodrug
vinorelbine [no description available]	2.05	1	acetate ester; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; ring assembly; vinca alkaloid	antineoplastic agent; photosensitizing agent
furazolidone [no description available]	2.05	1
nitrofurazone Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.	2.05	1
thiamethoxam [no description available]	2.98	4
2,3-n-octanoylsphingosine N-octanoylsphingosine : An N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl.	2.05	1	N-acylsphingosine
bifenthrin bifenthrin: a type I pyrethroid. bifenthrin : A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.. kappa-bifenthrin : A carboxylic ester obtained by formal condensation of the carboxy group of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylic acid with the hydroxy group of [(2-methyl-1,1'-biphenyl)-3-yl]methanol.	2.98	4	carboxylic ester; cyclopropanecarboxylate ester; cyclopropanes; organochlorine compound; organofluorine compound	pyrethroid ester acaricide; pyrethroid ester insecticide
flucycloxuron [no description available]	2.05	1	flucycloxuron
nifurtimox Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.	2.05	1	nitrofuran antibiotic
aldicarb Aldicarb: Carbamate derivative used as an insecticide, acaricide, and nematocide.. aldicarb : The oxime carbamate resulting from the addition of 2-methyl-2-(methylsulfanyl)propanaldoxime to methyl isocyanate. A member of the class of oxime carbamate insecticides, aldicarb is a mixture of E and Z isomers; it is not known which isomer is more active.	2.08	1
phoxim phoxim: structure	2.07	1
nifursol [no description available]	2.05	1
fenpyroximate fenpyroximate: structure in first source	2.46	2	pyrazole acaricide; tert-butyl ester	mitochondrial NADH:ubiquinone reductase inhibitor
naloxonazine naloxonazine: binds irreversibly to opiate receptor sites; structure given in first source	2.05	1
rwj 68354 [no description available]	2.05	1
spiromesifen spiromesifen: insecticide; structure in first source. spiromesifen : A butenolide that is but-2-en-4-olide bearing a 2,4,6-trimethylphenyl group at position 3, a 3,3-dimethylbutyryloxy group at position 4 and a spiro-fused cyclopentyl ring at position 5.	2.46	2	butenolide	insecticide
pydrin, (s-(r,r))-isomer [no description available]	2.06	1	fenvalerate	agrochemical; pyrethroid ester insecticide
chlorantranilipole chlorantranilipole: anthranilic diamide insecticide.that disrupts mating in codling moth (Lepidoptera: Tortricidae). chlorantraniliprole : A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes.	2.48	2	monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide	ryanodine receptor agonist
sulfoxaflor sulfoxaflor: insecticide targeting sap-feeding pests; structure in first source. sulfoxaflor : A mixture of the four diastereoisomers arising from the two tetrahedral stereocentres of [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide (the sulfur atom and the carbon attached to position 3 of the pyridine ring). [Both E- and Z-isomers involving the S=N double bond and the cyano group exist, but they interconvert rapidly at r.t.]. A nicotinic acetylcholine receptor agonist in insects, sulfoxaflor is used as an insecticide, particularly for the control of aphids.. [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide : A member of the class of pyridines that is 5-ethyl-2-trifluoromethylpyridine in which the ethyl group is substituted at position 1 by an N-cyano-S-methylsulfonimidoyl group. The insecticide sulfoxalor is a mixture of the four possible stereoisomers arising from the two tetrahedral stereocentres.	2.08	1	nitrile; organofluorine compound; pyridines; sulfoximide
fufenozide fufenozide: non-steroidal ecdysone agonist	2.07	1
oxytetracycline, anhydrous Oxytetracycline: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.. oxytetracycline : A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.	2.05	1
imidacloprid (E)-imidacloprid : The E-isomer of imidacloprid.	2.75	3	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
clothianidin (E)-clothianidin : A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety.	2.08	1	1,3-thiazoles; 2-nitroguanidine derivative; clothianidin; organochlorine compound	environmental contaminant; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic

Condition	Indicated	Relationship Strength	Studies	Trials
American Trypanosomiasis [description not available]	0	2.05	1	0
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	0	2.05	1	0

mk 936

Cross-References

Synonyms (16)

Research Excerpts

Dosage Studied

Protein Targets (4)

Inhibition Measurements

Biological Processes (61)

Molecular Functions (9)

Ceullar Components (15)

Bioassays (110)

Research

Studies (13)

Study Types

mk 936

Cross-References

Synonyms (16)

Research Excerpts

Dosage Studied

Protein Targets (4)

Inhibition Measurements

Biological Processes (61)

Molecular Functions (9)

Ceullar Components (15)

Bioassays (110)

Research

Studies (13)

Study Types

Related Drugs (113)

Related Conditions (2)