Page last updated: 2024-10-27

fluoxetine and HIV Coinfection

fluoxetine has been researched along with HIV Coinfection in 16 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

ExcerptRelevanceReference
" Participants were diagnosed with depressive disorders and randomly assigned to receive directly observed therapy with fluoxetine or a referral to community mental health treatment."5.24Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial. ( Bangsberg, DR; Dilley, JW; Grelotti, DJ; Hammer, GP; Karasic, DH; Sorensen, JL; Tsai, AC, 2017)
" To determine whether effective depression treatment could reduce the frequency of sexual risk behavior, we analyzed secondary outcome data from a 36-week, two-arm, parallel-design, randomized controlled trial, in which homeless and marginally housed, HIV-infected persons with comorbid depressive disorders were randomized to receive either: (a) directly observed treatment with the antidepressant medication fluoxetine, or (b) referral to a local public mental health clinic."5.17Does effective depression treatment alone reduce secondary HIV transmission risk? Equivocal findings from a randomized controlled trial. ( Bangsberg, DR; Charlebois, ED; Dilley, JW; Hammer, GP; Karasic, DH; Mimiaga, MJ; Safren, SA; Sorensen, JL; Tsai, AC, 2013)
"We conducted a nonblinded, randomized controlled trial of once-weekly fluoxetine, directly observed for 24 weeks, then self-administered for 12 weeks (n = 137 persons with major or minor depressive disorder or dysthymia)."5.17Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: a randomized controlled trial. ( Bangsberg, DR; Charlebois, ED; Dilley, JW; Hammer, GP; Karasic, DH; Moss, AR; Ragland, K; Sorensen, JL; Tsai, AC, 2013)
" Health workers should be mindful of dosing to minimise side effects and considerate of the additional pill burden."1.91The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective. ( Gaynes, BN; Hosseinipour, MC; Kulisewa, K; Minnick, CE; Mphonda, S; Pence, BW; Sansbury, G; Stockton, MA; Udedi, MM, 2023)
"We conclude that screening for and treating depression among PLHIV in SSA with fluoxetine would be effective in improving HIV treatment outcomes and would be highly cost-effective."1.62Health outcomes and cost-effectiveness of treating depression in people with HIV in Sub-Saharan Africa: a model-based analysis. ( Arjmand, IK; Bendavid, E; Brandeau, ML; Zhong, H, 2021)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (37.50)18.2507
2000's4 (25.00)29.6817
2010's4 (25.00)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Kulisewa, K1
Minnick, CE1
Stockton, MA1
Gaynes, BN1
Hosseinipour, MC1
Mphonda, S1
Sansbury, G1
Udedi, MM1
Pence, BW1
Zhong, H1
Arjmand, IK1
Brandeau, ML1
Bendavid, E1
Tsai, AC3
Mimiaga, MJ1
Dilley, JW3
Hammer, GP3
Karasic, DH3
Charlebois, ED2
Sorensen, JL3
Safren, SA1
Bangsberg, DR3
Wagner, GJ1
Ngo, VK1
Nakasujja, N1
Akena, D1
Aunon, F1
Musisi, S1
Grelotti, DJ1
Ragland, K1
Moss, AR1
Krupitsky, EM1
Zvartau, EE1
Masalov, DV1
Tsoy, MV1
Burakov, AM1
Egorova, VY1
Didenko, TY1
Romanova, TN1
Ivanova, EB1
Bespalov, AY1
Verbitskaya, EV1
Neznanov, NG1
Grinenko, AY1
O'Brien, CP1
Woody, GE1
Judd, FK1
Mijch, AM1
Cockram, A1
Ferrando, SJ1
Goldman, JD1
Charness, WE1
Schwartz, JA1
McDaniel, JS1
Snowden, H1
Woolridge, M1
Renfrew, M1
DeSilva, KE1
Le Flore, DB1
Marston, BJ1
Rimland, D1
Darko, W1
Guharoy, R1
Rose, F1
Lehman, D1
Pappas, V1
Rosenthal, E1
Bodokh, I1
Chichmanian, RM1
Pesce, A1
Vinti, H1
Reboulot, B1
Cassuto, JP1
Fernandez, F1
Levy, JK1
Perkins, DO1
Evans, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Depression Treatment to Improve Antiretroviral Adherence[NCT00338767]Phase 2150 participants (Actual)Interventional2001-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluoxetine and HIV Coinfection

ArticleYear
Psychopharmacotherapy of psychiatric syndromes in asymptomatic and symptomatic HIV infection.
    Psychiatric medicine, 1991, Volume: 9, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antidepressive Agents; Anxiety Disorders; Bupropion; Depr

1991

Trials

6 trials available for fluoxetine and HIV Coinfection

ArticleYear
Does effective depression treatment alone reduce secondary HIV transmission risk? Equivocal findings from a randomized controlled trial.
    AIDS and behavior, 2013, Volume: 17, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Comorbidity; Depression; Female; Fluoxetine; Follow

2013
Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial.
    AIDS care, 2017, Volume: 29, Issue:3

    Topics: Adult; Antidepressive Agents; Depressive Disorder; Female; Fluoxetine; HIV Infections; Humans; Ill-H

2017
Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: a randomized controlled trial.
    American journal of public health, 2013, Volume: 103, Issue:2

    Topics: Adult; Anti-Retroviral Agents; Antidepressive Agents, Second-Generation; CD4 Lymphocyte Count; CD4-P

2013
Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia.
    Journal of substance abuse treatment, 2006, Volume: 31, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Combined Modality Therapy; Double-Blind Method; Dru

2006
Selective serotonin reuptake inhibitor treatment of depression in symptomatic HIV infection and AIDS. Improvements in affective and somatic symptoms.
    General hospital psychiatry, 1997, Volume: 19, Issue:2

    Topics: 1-Naphthylamine; Acquired Immunodeficiency Syndrome; Adaptation, Psychological; Adult; Depressive Di

1997
Double-blind comparison of fluoxetine and desipramine in the treatment of depressed women with advanced HIV disease: a pilot study.
    Depression and anxiety, 1999, Volume: 9, Issue:2

    Topics: Adult; Depressive Disorder; Desipramine; Double-Blind Method; Female; Fluoxetine; HIV Infections; Hu

1999

Other Studies

9 other studies available for fluoxetine and HIV Coinfection

ArticleYear
The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective.
    Global public health, 2023, Volume: 18, Issue:1

    Topics: Amitriptyline; Antidepressive Agents; Depression; Fluoxetine; HIV Infections; Humans; Malawi; Pilot

2023
Health outcomes and cost-effectiveness of treating depression in people with HIV in Sub-Saharan Africa: a model-based analysis.
    AIDS care, 2021, Volume: 33, Issue:4

    Topics: Adult; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Cost-Benefit Analysis; Depression;

2021
Impact of antidepressant therapy on cognitive aspects of work, condom use, and psychosocial well-being among HIV clients in Uganda.
    International journal of psychiatry in medicine, 2014, Volume: 48, Issue:3

    Topics: Adult; Antidepressive Agents; Cognition Disorders; Condoms; Depressive Disorder, Major; Developing C

2014
Fluoxetine treatment of depressed patients with HIV infection.
    The Australian and New Zealand journal of psychiatry, 1995, Volume: 29, Issue:3

    Topics: Adjustment Disorders; Adult; Antidepressive Agents, Second-Generation; Antiviral Agents; Depressive

1995
Galactorrhoea, hyperprolactinaemia, and protease inhibitors.
    Lancet (London, England), 2001, Feb-10, Volume: 357, Issue:9254

    Topics: Drug Therapy, Combination; Female; Fluoxetine; Galactorrhea; HIV Infections; HIV Protease Inhibitors

2001
Serotonin syndrome in HIV-infected individuals receiving antiretroviral therapy and fluoxetine.
    AIDS (London, England), 2001, Jul-06, Volume: 15, Issue:10

    Topics: Adult; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Cytochrome P-450 Enzyme System; De

2001
Myoclonus secondary to the concurrent use of trazodone and fluoxetine.
    Veterinary and human toxicology, 2001, Volume: 43, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Drug Synergism; Fluoxetine; HIV Infecti

2001
[Lyell's syndrome in 2 HIV infected patients. Sulfamides are not the only culprits].
    Presse medicale (Paris, France : 1983), 1991, Sep-28, Volume: 20, Issue:30

    Topics: Acquired Immunodeficiency Syndrome; Adult; Chlormezanone; Fluoxetine; HIV Infections; Humans; Male;

1991
Fluoxetine treatment of depression in patients with HIV infection.
    The American journal of psychiatry, 1991, Volume: 148, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Depressive Disorder; Fluoxetine; HIV Infections; Humans;

1991