Page last updated: 2024-09-27

Premenstrual Dysphoric Disorder

A condition in which a woman suffers from severe depression, irritability, and tension before MENSTRUATION. Premenstrual dysphoric disorder (PMDD) may involve a wide range of physical or emotional symptoms, which are more severe and debilitating than those seen with premenstrual syndrome (PMS), and which include at least one mood-related symptom. Symptoms usually stop when, or shortly after, menstruation begins.

Synonyms(2)

Synonym
Premenstrual Dysphoric Disorder
Premenstrual Dysphoric Syndrome

Research

Studies (69)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's32 (46.38)28.8240
2020's37 (53.62)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low90
agmatine0low10
inositol0low10
melatonin0medium32
caffeine0low10
citalopram0low10
fluoxetine0low10
lidocaine0medium11
oxybutynin0low10
corticosterone0low10
estrone0medium11
androsterone0medium11
glutamine0low10
ethinyl estradiol0medium32
desoxycorticosterone0medium11
pregnenolone0medium11
limestone0low10
megestrol0low10
pregnanolone0medium155
estradiol-3-sulfate0medium11
sertraline0medium31
drospirenone0medium21
nomegestrol acetate0low10
ulipristal acetate0medium21
drospirenone and ethinyl estradiol combination0medium21
ramelteon0low10
oxytocin0low10
leuprolide0medium21
pregnanediol0medium11
dutasteride0medium11
pituitrin0low10
quetiapine fumarate0medium11
leptin0low20

Protein Targets (463)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Cruzipain1001
thioredoxin reductase8008
15-lipoxygenase, partial2002
NFKB1 protein, partial3003
TDP1 protein140014
euchromatic histone-lysine N-methyltransferase 2140014
lethal factor (plasmid)2002
Solute carrier family 22 member 20203
Solute carrier family 22 member 1 0404
Polyamine oxidase 10101
Solute carrier family 22 member 30102
Solute carrier family 22 member 30203
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Nischarin0101
Solute carrier family 22 member 10303
Deoxyhypusine synthase0101
Solute carrier family 22 member 20304
Chain A, retinol dehydratase0101
acetylcholinesterase1001
RAR-related orphan receptor gamma120012
GLI family zinc finger 3110011
AR protein140014
estrogen receptor 2 (ER beta)6006
progesterone receptor9009
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha100010
pregnane X nuclear receptor110011
estrogen nuclear receptor alpha130013
v-jun sarcoma virus 17 oncogene homolog (avian)6006
histone acetyltransferase KAT2A isoform 13003
Gamma-aminobutyric acid receptor subunit pi5409
Voltage-dependent calcium channel gamma-2 subunit6006
Sex hormone-binding globulin0066
Corticosteroid-binding globulin0505
Glucose-6-phosphate 1-dehydrogenase0202
Androgen receptor0606
Gamma-aminobutyric acid receptor subunit beta-15409
Gamma-aminobutyric acid receptor subunit delta5409
Gamma-aminobutyric acid receptor subunit gamma-254110
Glutamate receptor 26006
Gamma-aminobutyric acid receptor subunit alpha-55409
Gamma-aminobutyric acid receptor subunit alpha-35409
Gamma-aminobutyric acid receptor subunit gamma-15409
Gamma-aminobutyric acid receptor subunit alpha-25409
Gamma-aminobutyric acid receptor subunit alpha-45409
Gamma-aminobutyric acid receptor subunit gamma-35409
Gamma-aminobutyric acid receptor subunit alpha-65409
Solute carrier organic anion transporter family member 1A10404
Gamma-aminobutyric acid receptor subunit alpha-154110
Gamma-aminobutyric acid receptor subunit beta-35409
Gamma-aminobutyric acid receptor subunit beta-254110
TAR DNA-binding protein 436006
G-protein coupled bile acid receptor 10011
GABA theta subunit5409
Gamma-aminobutyric acid receptor subunit epsilon5409
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase4004
GLS protein4004
nuclear receptor subfamily 1, group I, member 37007
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor4004
thyroid stimulating hormone receptor4004
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 18008
thyroid hormone receptor beta isoform a4004
thyroid hormone receptor beta isoform 2100010
DNA polymerase beta2002
nuclear factor erythroid 2-related factor 2 isoform 18008
nuclear receptor ROR-gamma isoform 12002
geminin110011
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M13003
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011011
Potassium channel subfamily K member 20213
Bile salt export pump014014
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Cholinesterase0202
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30303
Replicase polyprotein 1ab0101
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0404
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0416
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0012
Canalicular multispecific organic anion transporter 1010010
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Guanine deaminase0101
ATP-dependent phosphofructokinase5005
aldehyde dehydrogenase 1 family, member A14004
EWS/FLI fusion protein3003
NPC intracellular cholesterol transporter 1 precursor3003
D(1A) dopamine receptor5005
survival motor neuron protein isoform d3003
Sodium-dependent noradrenaline transporter0202
5-hydroxytryptamine receptor 40606
Aldo-keto reductase family 1 member B1010010
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0606
Aldo-keto reductase family 1 member B10101
5-hydroxytryptamine receptor 1A0101
Aromatase0101
Sodium-dependent noradrenaline transporter 010212
Sodium-dependent dopamine transporter0404
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0606
Sodium-dependent serotonin transporter010414
Sodium-dependent serotonin transporter0404
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0808
5-hydroxytryptamine receptor 70101
Spike glycoprotein5005
Sodium-dependent dopamine transporter 09211
Potassium voltage-gated channel subfamily H member 20808
Sigma intracellular receptor 20303
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0202
Nuclear receptor subfamily 3 group C member 3 0606
Ataxin-25005
Sigma non-opioid intracellular receptor 10909
Sigma non-opioid intracellular receptor 10303
Transporter0404
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
pregnane X receptor2002
GALC protein3003
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nonstructural protein 13003
G7007
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
IDH15005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
nuclear factor erythroid 2-related factor 2 isoform 24004
heat shock protein beta-12002
mitogen-activated protein kinase 13003
serine/threonine-protein kinase mTOR isoform 13003
cytochrome P450 3A4 isoform 15005
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 7007
Mineralocorticoid receptor 0011
C-8 sterol isomerase0101
Nuclear receptor ROR-gamma3003
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
SMAD family member 23003
USP1 protein, partial4004
SMAD family member 33003
Microtubule-associated protein tau3003
cytochrome P450 family 3 subfamily A polypeptide 47007
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma6006
nuclear receptor subfamily 1, group I, member 22002
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
PPM1D protein3003
cytochrome P450 2D63003
ATPase family AAA domain-containing protein 52002
potassium voltage-gated channel subfamily H member 2 isoform d2002
Cellular tumor antigen p537007
3-oxo-5-alpha-steroid 4-dehydrogenase 10101
Glycine receptor subunit alpha-10011
3-oxo-5-alpha-steroid 4-dehydrogenase 20202
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase0101
Multidrug resistance-associated protein 1 0101
endonuclease IV1001
ATAD5 protein, partial5005
arylsulfatase A3003
activating transcription factor 62002
Bloom syndrome protein isoform 14004
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
glucokinase regulatory protein1001
DNA polymerase iota isoform a (long)3003
lamin isoform A-delta108008
Rap guanine nucleotide exchange factor 32002
Estrogen receptor0427
Steryl-sulfatase0101
Aromatase0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Mu-type opioid receptor0213
Alpha-synuclein0101
Mu-type opioid receptor0011
Inositol monophosphatase 11001
Cytochrome P450 1B10303
Estrogen receptor beta0225
Ghrelin O-acyltransferase0101
Luciferase1001
interleukin 82002
hypoxia-inducible factor 1 alpha subunit3003
Fumarate hydratase3003
caspase 7, apoptosis-related cysteine protease3003
thyroid stimulating hormone receptor2002
polyprotein3003
67.9K protein2002
caspase-33003
lysosomal alpha-glucosidase preproprotein1001
Vpr1001
peripheral myelin protein 225005
Cytochrome P450 2B10101
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Cytochrome P450 3A40303
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Alpha-1B adrenergic receptor0404
Glycine receptor subunit beta0202
Cytochrome P450 2B60101
UDP-glucuronosyltransferase 1A1 0102
Glycine receptor subunit alpha-20202
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Glycine receptor subunit alpha-30202
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Alpha-1A adrenergic receptor0505
Sulfotransferase 1A10214
Aldehyde oxidase0101
Nuclear receptor subfamily 1 group I member 3 0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10202
regulator of G-protein signaling 44004
Histone H2A.x2002
Caspase-71001
caspase-31001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Albumin0011
Sodium channel protein type 1 subunit alpha0303
ATP-dependent translocase ABCB10202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0303
Cytochrome P450 2C80101
Cytochrome P450 2D60303
Muscarinic acetylcholine receptor M10607
Cytochrome P450 2C9 0202
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit alpha-10213
Alpha-2B adrenergic receptor0404
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Muscarinic acetylcholine receptor M30404
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Alpha-1D adrenergic receptor0202
Potassium voltage-gated channel subfamily C member 10101
5-hydroxytryptamine receptor 2A0404
Gamma-aminobutyric acid receptor subunit beta-30213
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-50213
Cytochrome P450 2C190303
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40213
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60202
Cytochrome P450 2J20202
D(2) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Gamma-aminobutyric acid receptor subunit alpha-60213
Sigma non-opioid intracellular receptor 10101
Transporter0101
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
Histamine H3 receptor0202
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0022
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B1001
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
neuropeptide S receptor isoform A1001
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60022
Gamma-aminobutyric acid receptor subunit gamma-20022
Gamma-aminobutyric acid receptor subunit delta0022
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20022
Gamma-aminobutyric acid receptor subunit alpha-30022
Gamma-aminobutyric acid receptor subunit gamma-30022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10022
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10123
Gamma-aminobutyric acid receptor subunit beta-30022
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50022
Gamma-aminobutyric acid receptor subunit pi0022
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40022
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0022
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10022
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, Glutamine Binding Protein0011
flap endonuclease 13003
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0001
Amino acid transporter0101
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
Amyloid-beta precursor protein0202
Sodium/myo-inositol cotransporter 20101
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
Chain A, Beta-lactamase5005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
Progesterone receptor0123
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Potassium channel subfamily K member 30101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, 2-oxoglutarate Oxygenase1001
ClpP1001
aryl hydrocarbon receptor1001
cytochrome P450 2D6 isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
M-phase phosphoprotein 81001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cytochrome P450 2C11 0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0314
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0314
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Carboxylic ester hydrolase 0101
thioredoxin glutathione reductase1001
Muscarinic acetylcholine receptor M20416
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
D(3) dopamine receptor0202
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Guanine nucleotide-binding protein G1001
Lanosterol 14-alpha demethylase0101
glp-1 receptor, partial1001
Smad31001
vitamin D3 receptor isoform VDRA1001
Transcriptional activator protein LuxR0101
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
D(1B) dopamine receptor0101
D(4) dopamine receptor0101
Melanocortin receptor 50202
Envelope glycoprotein0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]